Background:Lead(Pb),a naturally occurring environmental contaminant,has been implicated in several pathological conditions of the cardiovascular and renal systems.Objective:The study was designed to evaluate the modul...Background:Lead(Pb),a naturally occurring environmental contaminant,has been implicated in several pathological conditions of the cardiovascular and renal systems.Objective:The study was designed to evaluate the modulatory roles of the polyphenol-rich fraction of Terminalia catappa on chronic lead acetate-induced cardiovascular and renal toxicities in rats.Methods:Thirty-six rats were randomly selected and divided into six groups of six rats each.Pb toxicity was induced by the administration of 100 mg/L Pb in drinking water for 12 weeks in groups B-F.Groups A and B were left untreated;groups C and D were treated with polyphenol-rich fraction of Terminalia catappa[PRFTC(100 and 200 mg/kg b.w.)];vitamin E(50 mg/kg b.w.)and lisinopril(10 mg/kg b.w.)were administered to groups E and F,respectively.Results:Exposure of rats to Pb induced significantly elevated(P<0.05)primary haemodynamic parameters,severe disseminated congestion of blood vessels and haemorrhages in the cardiac and renal tissues,significantly elevated(P<0.05)markers of oxidative stress markers of inflammation and myocardial infarction,but significantly decreased serum nitric oxide and the systemic antioxidants.Furthermore,rats exposed to Pb showed heightened immune-positive reactions to Caspase-3,a marker of apoptosis,in both renal and cardiac tissues.All manifestations of Pb-associated toxicities in the cardiovascular and renal systems were alleviated by the PRFTC treatment in rats.Conclusion:The polyphenol-rich fraction of T.catappa proved effective in the reduction of oxidative stressmediated derangements of the physiological homeostasis and decreased apoptosis in the cardiovascular and renal systems of rats chronically exposed to lead acetate toxicities and may therefore have therapeutic potential as a supplement that can be applied in chronic lead poisoning。展开更多
文摘Background:Lead(Pb),a naturally occurring environmental contaminant,has been implicated in several pathological conditions of the cardiovascular and renal systems.Objective:The study was designed to evaluate the modulatory roles of the polyphenol-rich fraction of Terminalia catappa on chronic lead acetate-induced cardiovascular and renal toxicities in rats.Methods:Thirty-six rats were randomly selected and divided into six groups of six rats each.Pb toxicity was induced by the administration of 100 mg/L Pb in drinking water for 12 weeks in groups B-F.Groups A and B were left untreated;groups C and D were treated with polyphenol-rich fraction of Terminalia catappa[PRFTC(100 and 200 mg/kg b.w.)];vitamin E(50 mg/kg b.w.)and lisinopril(10 mg/kg b.w.)were administered to groups E and F,respectively.Results:Exposure of rats to Pb induced significantly elevated(P<0.05)primary haemodynamic parameters,severe disseminated congestion of blood vessels and haemorrhages in the cardiac and renal tissues,significantly elevated(P<0.05)markers of oxidative stress markers of inflammation and myocardial infarction,but significantly decreased serum nitric oxide and the systemic antioxidants.Furthermore,rats exposed to Pb showed heightened immune-positive reactions to Caspase-3,a marker of apoptosis,in both renal and cardiac tissues.All manifestations of Pb-associated toxicities in the cardiovascular and renal systems were alleviated by the PRFTC treatment in rats.Conclusion:The polyphenol-rich fraction of T.catappa proved effective in the reduction of oxidative stressmediated derangements of the physiological homeostasis and decreased apoptosis in the cardiovascular and renal systems of rats chronically exposed to lead acetate toxicities and may therefore have therapeutic potential as a supplement that can be applied in chronic lead poisoning。
