TiBw/TC4composite was brazed to Ti60alloy successfully using TiZrNiCu amorphous filler alloy,and the interfacialmicrostructures and mechanical properties were characterized by SEM,EDX,XRD and universal tensile testing...TiBw/TC4composite was brazed to Ti60alloy successfully using TiZrNiCu amorphous filler alloy,and the interfacialmicrostructures and mechanical properties were characterized by SEM,EDX,XRD and universal tensile testing machine.The typicalinterfacial microstructure was TiBw/TC4composite/β-Ti+TiB whiskers/(Ti,Zr)2(Ni,Cu)intermetallic layer/β-Ti/Ti60alloy whenbeing brazed at940°C for10min.The interfacial microstructure evolution was influenced strongly by the diffusion and reactionbetween molten fillers and the substrates.Increasing brazing temperature decreased the thickness of brittle(Ti,Zr)2(Ni,Cu)intermetallic layer,which disappeared finally when the brazing temperature exceeded1020°C.Fracture analyses indicated thatcracks were initialized in the brittle intermetallic layer when(Ti,Zr)2(Ni,Cu)phase existed in the brazing seam.The maximumaverage shear strength of joints reached368.6MPa when brazing was conducted at1020°C.Further increasing brazing temperatureto1060°C,the shear strength was decreased due to the formation of coarse lamellar(α+β)-Ti structure.展开更多
We present a comprehensive investigation on CrAlGe and realize that it is an itinerant ferromagnet with strong tunability of the Curie temperature T_(C)and the spontaneous momentμ_(0)depending on annealing heat treat...We present a comprehensive investigation on CrAlGe and realize that it is an itinerant ferromagnet with strong tunability of the Curie temperature T_(C)and the spontaneous momentμ_(0)depending on annealing heat treatment.While the value of T_(C) was previously reported to be 80 K withμ_(0)≈0.41μB,in this work the two quantities attain values as high as 170 K and 0.66μ_(B),respectively.Heat treatment does not cause changes of the lattice parameters and symmetry,but results in a slight narrowing of the Bragg peaks.The strong tunability of the itinerant ferromagnetism indicates significantly tunable hybridization between the Cr 3d electrons and the conduction bands,in agreement with the dominant Cr–Al/Ge bonds of this compound.Further tuning along the same line towards even stronger or weaker itinerant ferromagnetism promises an interesting follow-up to clarify the localized-itinerant duality of the 3d electrons in this compound.展开更多
Correction to:Signal Transduction and Targeted Therapy https://doi.org/10.1038/sigtrans.2017.13,published online 26 May 2017.After publication of the article,1 the author noticed inadvertent errors in the GAPDH Wester...Correction to:Signal Transduction and Targeted Therapy https://doi.org/10.1038/sigtrans.2017.13,published online 26 May 2017.After publication of the article,1 the author noticed inadvertent errors in the GAPDH Western blot panels of MM.1R cells(control,NC siRNA,and siCIP2A)in Figure 2e,as well as the GAPDH Western blot panels of MM.1R cells(control,NC siRNA,siCIP2A,siCIP2A+OA)in Figure 4e.展开更多
Cancerous inhibitor of protein phosphatase 2A(CIP2A),an endogenous protein phosphatase 2A(PP2A)inhibitor,has been identified as an oncoprotein in promoting cancer initiation and progression of several types of cancer....Cancerous inhibitor of protein phosphatase 2A(CIP2A),an endogenous protein phosphatase 2A(PP2A)inhibitor,has been identified as an oncoprotein in promoting cancer initiation and progression of several types of cancer.However,the expression and the role played by CIP2A in the pathogenesis of multiple myeloma(MM)remain unclear.In this study,we showed that CIP2A was overexpressed in human MM cell lines and MM patients’bone marrow tissues.Clinicopathologic analysis showed that CIP2A expression was significantly correlated with clinical stage and percent of plasma cells in bone marrow.Kaplan–Meier analysis revealed that patients with high CIP2A expression presented with poorer overall survival rates than those with low CIP2A expression.Moreover,CIP2A knockdown in MM cells resulted in attenuated proliferative abilities.In addition,CIP2A depletion sensitizes dexamethasone(Dex)-resistant cells to Dex.The effect of CIP2A on proliferation and Dex therapy was mediated by the inhibition of PP2A,which in turn activated Akt.In vivo studies confirmed that CIP2A regulated MM tumorigenesis and the phosphorylation of Akt.Taken together,our results suggest that CIP2A oncoprotein plays an important role in MM progression and could serve as a prognosis marker and a novel therapeutic target for the treatment of patients with MM.展开更多
Unusual designated-tailoring on the preferential growth of ZnO meso-/nanocrystals with different shapes and sizes was successfully achieved through a very facile precursor-hydrolysis process in a water/organic solvent...Unusual designated-tailoring on the preferential growth of ZnO meso-/nanocrystals with different shapes and sizes was successfully achieved through a very facile precursor-hydrolysis process in a water/organic solvent system.The shape-evolution of ZnO from mesocrystal to nanocrystal was achieved by increasing the amount of water in the reaction system under otherwise the same conditions,which can be attributed to selective-capping and preferential growth mechanisms based on DFT calculations.展开更多
基金Projects(51775138,U1537206)supported by the National Natural Science Foundation of ChinaProject(2015DFA50470)supported by the International Science&Technology Cooperation Program of ChinaProject(2017GGX40103)supported by the Key Research&Development Program of Shandong Province,China
文摘TiBw/TC4composite was brazed to Ti60alloy successfully using TiZrNiCu amorphous filler alloy,and the interfacialmicrostructures and mechanical properties were characterized by SEM,EDX,XRD and universal tensile testing machine.The typicalinterfacial microstructure was TiBw/TC4composite/β-Ti+TiB whiskers/(Ti,Zr)2(Ni,Cu)intermetallic layer/β-Ti/Ti60alloy whenbeing brazed at940°C for10min.The interfacial microstructure evolution was influenced strongly by the diffusion and reactionbetween molten fillers and the substrates.Increasing brazing temperature decreased the thickness of brittle(Ti,Zr)2(Ni,Cu)intermetallic layer,which disappeared finally when the brazing temperature exceeded1020°C.Fracture analyses indicated thatcracks were initialized in the brittle intermetallic layer when(Ti,Zr)2(Ni,Cu)phase existed in the brazing seam.The maximumaverage shear strength of joints reached368.6MPa when brazing was conducted at1020°C.Further increasing brazing temperatureto1060°C,the shear strength was decreased due to the formation of coarse lamellar(α+β)-Ti structure.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.52088101,11974389,and 12141002)the National Key Research and Development Program of China(Grant Nos.2021YFA0718702 and 2017YFA0303100)+1 种基金the Chinese Academy of Sciences through the Scientific Instrument Developing Project(Grant No.ZDKYYQ20210003)the Strategic Priority Research Program(Grant No.XDB33000000)。
文摘We present a comprehensive investigation on CrAlGe and realize that it is an itinerant ferromagnet with strong tunability of the Curie temperature T_(C)and the spontaneous momentμ_(0)depending on annealing heat treatment.While the value of T_(C) was previously reported to be 80 K withμ_(0)≈0.41μB,in this work the two quantities attain values as high as 170 K and 0.66μ_(B),respectively.Heat treatment does not cause changes of the lattice parameters and symmetry,but results in a slight narrowing of the Bragg peaks.The strong tunability of the itinerant ferromagnetism indicates significantly tunable hybridization between the Cr 3d electrons and the conduction bands,in agreement with the dominant Cr–Al/Ge bonds of this compound.Further tuning along the same line towards even stronger or weaker itinerant ferromagnetism promises an interesting follow-up to clarify the localized-itinerant duality of the 3d electrons in this compound.
文摘Correction to:Signal Transduction and Targeted Therapy https://doi.org/10.1038/sigtrans.2017.13,published online 26 May 2017.After publication of the article,1 the author noticed inadvertent errors in the GAPDH Western blot panels of MM.1R cells(control,NC siRNA,and siCIP2A)in Figure 2e,as well as the GAPDH Western blot panels of MM.1R cells(control,NC siRNA,siCIP2A,siCIP2A+OA)in Figure 4e.
基金This work was supported by grants from the National Natural Sciences Foundation of China(no.81400157)the Natural Science Foundation of Hubei Province(no.2016CFB528)+3 种基金the Foundation of Health and Family planning Commission of Hubei Province(no.WJ2017F065)the Faculty Development Grants from Hubei University of Medicine(nos 2014QDJZR08 and 2015QDJZR16)the Foundation of Hubei University of Medicine(no.FDFR201605)the Foundation for Innovative Research Team of Hubei University of Medicine(no.2014CXX05).
文摘Cancerous inhibitor of protein phosphatase 2A(CIP2A),an endogenous protein phosphatase 2A(PP2A)inhibitor,has been identified as an oncoprotein in promoting cancer initiation and progression of several types of cancer.However,the expression and the role played by CIP2A in the pathogenesis of multiple myeloma(MM)remain unclear.In this study,we showed that CIP2A was overexpressed in human MM cell lines and MM patients’bone marrow tissues.Clinicopathologic analysis showed that CIP2A expression was significantly correlated with clinical stage and percent of plasma cells in bone marrow.Kaplan–Meier analysis revealed that patients with high CIP2A expression presented with poorer overall survival rates than those with low CIP2A expression.Moreover,CIP2A knockdown in MM cells resulted in attenuated proliferative abilities.In addition,CIP2A depletion sensitizes dexamethasone(Dex)-resistant cells to Dex.The effect of CIP2A on proliferation and Dex therapy was mediated by the inhibition of PP2A,which in turn activated Akt.In vivo studies confirmed that CIP2A regulated MM tumorigenesis and the phosphorylation of Akt.Taken together,our results suggest that CIP2A oncoprotein plays an important role in MM progression and could serve as a prognosis marker and a novel therapeutic target for the treatment of patients with MM.
基金supported by the National Science Foundation of China(NSFC No.U1502274,51302213,51471132 and 51202191)the National High Technology Research and Development Program of China(863 Program,No.2015AA034304)+1 种基金the Pivot Innovation Team of Shaanxi Electric Materials and Infiltration Technique(2012KCT-25)the Hundred Talent Program of Shaanxi Province,and the Shaanxi Province Science Fund for Distinguished Young Scholars(2018JC-027).The authors thank Mr Haoqi Ren for the suggestions in revision.
文摘Unusual designated-tailoring on the preferential growth of ZnO meso-/nanocrystals with different shapes and sizes was successfully achieved through a very facile precursor-hydrolysis process in a water/organic solvent system.The shape-evolution of ZnO from mesocrystal to nanocrystal was achieved by increasing the amount of water in the reaction system under otherwise the same conditions,which can be attributed to selective-capping and preferential growth mechanisms based on DFT calculations.
基金supported by the National Natural Science Foundation of China (12141002,52088101,11874417,11974389,and 52172216)the Ministry of Science and Technology of China (2021YFA0718702)+5 种基金the Chinese Academy of Sciences through the Strategic Priority Research Programthe Scientific Instrument Developing Programthe Project for Young Scientists in Basic Research (XDB33000000,YJKYYQ20200017,and YSBR-057)the Chinese Postdoctoral Science Foundation (E0BK181)the funding support of the National Key Research and Development Program of China (2018YFA0702100)the support from the Key Research Project of Zhejiang Laboratory (2021PE0AC02)。
