目的探讨右侧额下回(inferior frontal gyrus,IFG)重复高精度经颅直流电刺激(high-definition transcranial direct current stimulation,HD-tDCS)干预对健康成年人执行功能的3个核心子成分(工作记忆、抑制、认知灵活性)的影响。方法纳...目的探讨右侧额下回(inferior frontal gyrus,IFG)重复高精度经颅直流电刺激(high-definition transcranial direct current stimulation,HD-tDCS)干预对健康成年人执行功能的3个核心子成分(工作记忆、抑制、认知灵活性)的影响。方法纳入2023-07/2023-12月某空军院校青年男性军人70名,采用随机数字表法分为刺激组(n=36)与对照组(n=34)。刺激组采用HD-tDCS干预刺激IFG,刺激强度设置为2 mA,单次20 min;对照组使用假刺激模式干预刺激IFG,仅在刺激阶段开始与结束时的30 s发生电流的快速提升,当达到2 mA时迅速降至0 mA。两组每天刺激1次,共刺激7次。使用2-back任务、色词Stroop任务及数字转换任务对干预前后军人的工作记忆、抑制及认知灵活性进行评估。结果与对照组比较,刺激组干预后Stroop效应与转换成本显著降低(P均<0.05),而2-back任务的正确率、反应时差异均无统计学意义(P均>0.05)。结论右侧IFG重复HD-tDCS能够有效提升军人抑制及认知灵活性等执行功能,为重复无创电刺激缓解临床患者执行功能损伤,制定针对性干预计划提供了启发与新视角。展开更多
Endodermal cells and starch-accumulating amyloplasts are well-known gravity sensors initiating shoot gravitropism in Arabidopsis thaliana.The transcription factors SHR and SGR1 regulate endodermal cell formation,while...Endodermal cells and starch-accumulating amyloplasts are well-known gravity sensors initiating shoot gravitropism in Arabidopsis thaliana.The transcription factors SHR and SGR1 regulate endodermal cell formation,while PGM has been demonstrated to regulate starch biosynthesis within chloroplasts,which eventually leads to starch accumulation in amyloplasts.However,the molecular mechanisms of gravity sensing in monocot shoots remain largely unexplored.In this study,we investigated the roles of these genes in rice(Oryza sativa),a model monocot,using CRISPR-Cas9 to generate single,double,and higher-order mutants.The rice genome harbors two orthologs each of SHR and SGR and a single ortholog of PGM.Our results revealed that single mutants of OsPGM,but not OsSHR or OsSGR,showed compromised shoot gravitropism.However,double mutants shr1shr2 and sgr1sgr2 displayed wider tiller angles and reduced gravity sensing,suggesting functional redundancy within each gene pair.Higher-order mutants exhibited progressively severe phenotypes,with quintuple mutants almost unresponsive to gravity stimulation.These findings suggest that these genes act additively through distinct but converging pathways in shoot gravitropism regulation.This study provides novel insights into the molecular mechanisms underlying gravity sensing in monocots and offers valuable knowledge for precision breeding to optimize rice architecture.展开更多
Pancreatic cancer(PC)is a highly aggressive cancer characterized by a unique tumor microenvironment(TME)that confers resistance to traditional therapies.As the dominant stromal cells in the TME,cancer-associated fibro...Pancreatic cancer(PC)is a highly aggressive cancer characterized by a unique tumor microenvironment(TME)that confers resistance to traditional therapies.As the dominant stromal cells in the TME,cancer-associated fibroblasts(CAFs)promote PC progression by modulating the extracellular matrix and interacting with surrounding cells.Numerous PC treatment strategies targeting CAFs have been explored in the past decade.However,targeting different subtypes of CAFs leads to varying therapeutic outcomes,highlighting the intricate and multifaceted nature of CAFs.The heterogeneity and dynamism of CAFs increase the complexity and challenges associated with tumor therapeutics.Currently,combination therapies incorporating CAF-targeted approaches in PC treatment have shown encouraging outcomes in select clinical trials.A comprehensive understanding of CAFs is essential for developing individualized therapeutic approaches.This review outlines the current knowledge of CAF heterogeneity,crosstalk with surrounding cells,and strategies for targeting CAFs in PC,aiming to keep researchers and clinicians up-to-date with the latest information on CAFs in PC.展开更多
During the construction of bank slopes involving pile driving,ensuring slope stability is crucial.This requires the design of appropriate support systems and a thorough evaluation of the failure mechanisms of pile str...During the construction of bank slopes involving pile driving,ensuring slope stability is crucial.This requires the design of appropriate support systems and a thorough evaluation of the failure mechanisms of pile structures under dynamic loading conditions.Based on the Huarong Coal Wharf project,various support schemes are analyzed using numerical simulation methods to calculate and compare slope stability coefficients.The optimal scheme is then identified.Under the selected support scheme,a numerical model of double-row suspended steel sheet piles is developed to investigate the dynamic response of the pile structures under pile driving loads.A time-history analysis is performed to assess the slope’s dynamic stability.The results show that the maximum displacements of the upper and lower steel sheet pile rows are 2.51 and 3.14 cm,respectively.The maximum principal stresses remain below 20 MPa in both rows,while the maximum von Mises stresses are 20.85 MPa for the upper row and 25.40 MPa for the lower row.The dominant frequencies of the steel sheet pile structures fall between 30 and 35 Hz,with a frequency bandwidth ranging from 0 to 500 Hz.The stability coefficient of the pile structures varies over time during the pile driving process,ultimately reaching a value of 1.26—exceeding the required safety threshold.This research provides practical guidance for designing support systems in wharf piling projects and offers a reliable basis for evaluating the safety performance of steel sheet piles in bank slopes.展开更多
Background:Type 2 diabetes(T2D)accounts for the majority of diabetes incidences and remains a widespread global chronic disorder.Apart from early lifestyle changes,intervention options for T2D are mainly pharmaceutica...Background:Type 2 diabetes(T2D)accounts for the majority of diabetes incidences and remains a widespread global chronic disorder.Apart from early lifestyle changes,intervention options for T2D are mainly pharmaceutical.Methods:Repetitive transcranial magnetic stimulation(rTMS)has been approved by the FDA as a therapeutic intervention option for major depressive disorders,with further studies also indicating its role in energy metabolism and appetite.Considering its safe and non-invasive properties,we evaluated the effects of rTMS on systemic metabolism using T2D rats.Results:We observed that rTMS improved glucose tolerance and insulin sensitivity in T2D rats after a 10-day exposure.Improved systemic insulin sensitivity was main-tained after a 21-day treatment period,accompanied by modest yet significant weight loss.Circulating serum lipid levels,including those of cholesteryl ester,tryglyceride and ceramides,were also reduced following rTMS application.RNA-seq analyses fur-ther revealed a changed expression profile of hepatic genes that are related to sterol production and fatty acid metabolism.Altered expression of hypothalamic genes that are related to appetite regulation,neural activity and ether lipid metabolism were also implicated.Conclusion:In summary,our data report a positive impact of rTMS on systemic insu-lin sensitivity and weight management of T2D rats.The underlying mechanisms via which rTMS regulates systemic metabolic parameters partially involve lipid utilization in the periphery as well as central regulation of energy intake and lipid metabolism.展开更多
A porous lanthanum(La)carbonate-carbon composite(LaCC)was prepared by vacuum-freeze-drying and pyrolysis techniques to remove phosphorus(P)from wastewater.Using polyethylene glycol as a carbon skeleton template,and th...A porous lanthanum(La)carbonate-carbon composite(LaCC)was prepared by vacuum-freeze-drying and pyrolysis techniques to remove phosphorus(P)from wastewater.Using polyethylene glycol as a carbon skeleton template,and the organic ligands are removed during pyrolysis,resulting in the creation of many pore structures.The LaCC showed excellent P removal performance and selectivity over a wide p H range(3–10).It exhibited a rapid adsorption rate and could hold up to 119.5 mg P/g.Fixed-bed column experiments showed that under dynamic conditions,just 1 g of LaCC effectively treated 60 L of P-contaminated wastewater with an initial concentration of 2 mg/L,meeting the primary discharge standard of<0.5 mg/L according to the comprehensive sewage guidelines of China.Bacterial experiments showed that the LaCC could inhibit the growth of Escherichia coli,indicating that it has both P removal and bacterial inhibition effects,which can greatly improve the application range of adsorbents.展开更多
Background:Reinforcing-reducing manipulations are a crucial part of acupuncture therapy.The reinforcing manipulation with heat sensation(RMHS) and the reducing manipulation by inducing cool sensation(RMCS) are two rep...Background:Reinforcing-reducing manipulations are a crucial part of acupuncture therapy.The reinforcing manipulation with heat sensation(RMHS) and the reducing manipulation by inducing cool sensation(RMCS) are two representative methods of reinforcing-reducing manipulations.This trial aims to investigate the characteristic of cerebral responses to these two typical acupuncture manipulations.Methods:A total of 35 healthy participants will be included and receive acupuncture stimulation with RMHS and RMCS in a random order.The psychology,cognition,and body constitution of participants will be measured by the Self-rating Anxiety Scale(SAS),the Self-rating Depression Scale(SDS),the mindful attention awareness scale(MAAS),the Constitution in Chinese Medicine Questionnaire(CCMQ),and the needle sensation will be evaluated after each acupuncture stimulation immediately.The cerebral activity changes elicited by RMHS and RMCS will be detected by functional near-infrared spectroscopy(fNIRS)and analyzed with the general linear model-based activation and the channel-to-channel functional connectivity.Discussion:This trial will investigate the cerebral response induced by RMHS and RMCS by real-time fNIRS,so as to map the characteristics of the central responses’ patterns to these two manipulations and preliminarily explore the mechanism of traditional acupuncture manipulations.展开更多
目的:基于佛罗里达大学质子放疗中心(University of Florida Health Proton Therapy Institute,UFHPTI)质子加速器在笔形束扫描模式下的临床实验数据,在DeepPlan中构建相应模型,验证模型构建的准确性并初步应用于临床前列腺癌的剂量计...目的:基于佛罗里达大学质子放疗中心(University of Florida Health Proton Therapy Institute,UFHPTI)质子加速器在笔形束扫描模式下的临床实验数据,在DeepPlan中构建相应模型,验证模型构建的准确性并初步应用于临床前列腺癌的剂量计算。方法:在DeepPlan质子模块中建立UFHPTI质子加速器的笔形束计算模型,并将剂量计算结果与临床实验数据进行对比,包括30组积分深度剂量(Integrated Depth Dose,IDD)、30组空气中质子束斑发散大小、1组多能量多点照射下的纵向扩展布拉格峰(Spread Out Bragg Peak,SOBP)和横向剂量分布,以此验证模型构建的准确性。最后以UFHPTI的两个前列腺癌临床放疗计划为指导,将DeepPlan计算结果与商用放疗计划系统RayStation计算结果通过PTW公司的VeriSoft软件进行gamma分析。结果:DeepPlan质子模块计算产生的30组IDD与UFHPTI加速器的临床实验数据平均相对误差为0.01%,最大相对误差为0.23%;30组空气质子束斑发散大小与临床实验数据平均相对误差为0.15%,最大相对误差为1.14%。在多能量多点照射下,DeepPlan质子模块计算产生的SOBP与临床实验数据平均相对误差为1.07%,最大相对误差为3.91%;横向剂量分布和临床实验数据平均相对误差为1.92%,最大相对误差为4.09%。针对两个前列腺癌的放疗计划,DeepPlan质子模块与RayStation计算的三维剂量结果在以3 mm/3%的标准下每个子野的gamma通过率都达到95%以上,其中病例1两个子野(270°和90°方向)的gamma通过率分别为96.4%和97.5%,病例2两个子野(270°和90°方向)的gamma通过率分别为99.3%和98.9%。结论:在DeepPlan中构建了与UFHPTI质子加速器相匹配的笔形束模型,该模型可初步应用于临床前列腺癌的剂量计算。展开更多
AIM： To investigate the role of subjective global assessment （SGA） in nutritional assessment and outcome prediction of Chinese patients with gastrointestinal cancer. METHODS： A total of 751 patients diagnosed with...AIM： To investigate the role of subjective global assessment （SGA） in nutritional assessment and outcome prediction of Chinese patients with gastrointestinal cancer. METHODS： A total of 751 patients diagnosed with gastrointestinal cancer between August 2004 and August 2006 were enrolled in this study. Within 72 h after admission, SGA, anthropometric parameters, and laboratory tests were used to assess the nutritional status of each patient. The outcome variables including hospital stay, complications, and in-hospital medical expenditure were also obtained.RESULTS： Based on the results of SGA, 389 （51.8%）, 332 （44.2%）, and 30 （4.0%） patients were classified into well nourished group （SGA-A）, mildly to moderately malnourished group （SGA-B）, and severely malnourished group （SGA-C）, respectively. The prevalence of malnutrition classified by SGA, triceps skinfold thickness （TSF）, mid-upper arm muscle circumference （MAMC）, albumin （ALB）, prealbumin （PA）, and body mass index （BMI） was 48.2%, 39.4%, 37.7%, 31.3%, 21.7%, and 9.6%, respectively. In addition, ANOVA tests revealed significant differences in body mass index （BMI）, TSF, PA, and ALB of patients in different SGA groups. The more severely malnourished the patient was, the lower the levels of BMI, TSF, PA, and ALB were （P 〈 0.05）. x^2 tests showed a significant difference in SGA classification between patients receiving different types of treatment （surgery vs chemotherapy/radiotherapy）. As the nutritional status classified by SGA deteriorated, the patients stayed longer in hospital and their medical expenditures increased significantly. Furthermore, multiple regression analysis showed that SGA and serum ALB could help predict the medical expenditures and hospital stay of patients undergoing surgery. The occurrence of complications increased in parallel with the increasing grade of SGA, and was the highest in the SGA-C group （23.3%） and the lowest in the SGA-A group （16.8%）. CONCLUSION： SGA is a reliable assessment too and helps to predict the hospital stay and medica expenditures of Chinese surgical gastrointestina cancer patients.展开更多
基金supported by grants from the Biological Breeding-National Science and Technology Major Project(2024ZD04077)the National Natural Science Foundation of China(31801323)+1 种基金the Innovation Program of the Chinese Academy of Agricultural Sciencesthe Science and Technology Innovation Project of the Shandong Academy of Agricultural Sciences(CXGC2023F14)。
文摘Endodermal cells and starch-accumulating amyloplasts are well-known gravity sensors initiating shoot gravitropism in Arabidopsis thaliana.The transcription factors SHR and SGR1 regulate endodermal cell formation,while PGM has been demonstrated to regulate starch biosynthesis within chloroplasts,which eventually leads to starch accumulation in amyloplasts.However,the molecular mechanisms of gravity sensing in monocot shoots remain largely unexplored.In this study,we investigated the roles of these genes in rice(Oryza sativa),a model monocot,using CRISPR-Cas9 to generate single,double,and higher-order mutants.The rice genome harbors two orthologs each of SHR and SGR and a single ortholog of PGM.Our results revealed that single mutants of OsPGM,but not OsSHR or OsSGR,showed compromised shoot gravitropism.However,double mutants shr1shr2 and sgr1sgr2 displayed wider tiller angles and reduced gravity sensing,suggesting functional redundancy within each gene pair.Higher-order mutants exhibited progressively severe phenotypes,with quintuple mutants almost unresponsive to gravity stimulation.These findings suggest that these genes act additively through distinct but converging pathways in shoot gravitropism regulation.This study provides novel insights into the molecular mechanisms underlying gravity sensing in monocots and offers valuable knowledge for precision breeding to optimize rice architecture.
基金supported by the Natural Science Foundation of Hubei Province(Grant No.2025AFB849).
文摘Pancreatic cancer(PC)is a highly aggressive cancer characterized by a unique tumor microenvironment(TME)that confers resistance to traditional therapies.As the dominant stromal cells in the TME,cancer-associated fibroblasts(CAFs)promote PC progression by modulating the extracellular matrix and interacting with surrounding cells.Numerous PC treatment strategies targeting CAFs have been explored in the past decade.However,targeting different subtypes of CAFs leads to varying therapeutic outcomes,highlighting the intricate and multifaceted nature of CAFs.The heterogeneity and dynamism of CAFs increase the complexity and challenges associated with tumor therapeutics.Currently,combination therapies incorporating CAF-targeted approaches in PC treatment have shown encouraging outcomes in select clinical trials.A comprehensive understanding of CAFs is essential for developing individualized therapeutic approaches.This review outlines the current knowledge of CAF heterogeneity,crosstalk with surrounding cells,and strategies for targeting CAFs in PC,aiming to keep researchers and clinicians up-to-date with the latest information on CAFs in PC.
基金sponsored by Natural Science Research Project of Anhui Educational Committee(GrantNo.2022AH050810),NationalNatural Science Foundation of China(GrantNos.42402276,41972286,42072309,42102329)State Key Laboratory of Precision Blasting and Hubei Key Laboratory of Blasting Engineering,Jianghan University(No.PBSKL2023A1)the Open Fund of National Center for International Research on Deep Earth Drilling and Resource Development(No.DEDRD-2023-02).
文摘During the construction of bank slopes involving pile driving,ensuring slope stability is crucial.This requires the design of appropriate support systems and a thorough evaluation of the failure mechanisms of pile structures under dynamic loading conditions.Based on the Huarong Coal Wharf project,various support schemes are analyzed using numerical simulation methods to calculate and compare slope stability coefficients.The optimal scheme is then identified.Under the selected support scheme,a numerical model of double-row suspended steel sheet piles is developed to investigate the dynamic response of the pile structures under pile driving loads.A time-history analysis is performed to assess the slope’s dynamic stability.The results show that the maximum displacements of the upper and lower steel sheet pile rows are 2.51 and 3.14 cm,respectively.The maximum principal stresses remain below 20 MPa in both rows,while the maximum von Mises stresses are 20.85 MPa for the upper row and 25.40 MPa for the lower row.The dominant frequencies of the steel sheet pile structures fall between 30 and 35 Hz,with a frequency bandwidth ranging from 0 to 500 Hz.The stability coefficient of the pile structures varies over time during the pile driving process,ultimately reaching a value of 1.26—exceeding the required safety threshold.This research provides practical guidance for designing support systems in wharf piling projects and offers a reliable basis for evaluating the safety performance of steel sheet piles in bank slopes.
基金National Key Technologies Research and Development Program of China,Grant/Award Number:2020YFA0803701National Natural Science Foundation of China,Grant/Award Number:52107241,81973699 and 82274361CAMS Innovation Fund for Medical Sciences,Grant/Award Number:2021-12M-1-052。
文摘Background:Type 2 diabetes(T2D)accounts for the majority of diabetes incidences and remains a widespread global chronic disorder.Apart from early lifestyle changes,intervention options for T2D are mainly pharmaceutical.Methods:Repetitive transcranial magnetic stimulation(rTMS)has been approved by the FDA as a therapeutic intervention option for major depressive disorders,with further studies also indicating its role in energy metabolism and appetite.Considering its safe and non-invasive properties,we evaluated the effects of rTMS on systemic metabolism using T2D rats.Results:We observed that rTMS improved glucose tolerance and insulin sensitivity in T2D rats after a 10-day exposure.Improved systemic insulin sensitivity was main-tained after a 21-day treatment period,accompanied by modest yet significant weight loss.Circulating serum lipid levels,including those of cholesteryl ester,tryglyceride and ceramides,were also reduced following rTMS application.RNA-seq analyses fur-ther revealed a changed expression profile of hepatic genes that are related to sterol production and fatty acid metabolism.Altered expression of hypothalamic genes that are related to appetite regulation,neural activity and ether lipid metabolism were also implicated.Conclusion:In summary,our data report a positive impact of rTMS on systemic insu-lin sensitivity and weight management of T2D rats.The underlying mechanisms via which rTMS regulates systemic metabolic parameters partially involve lipid utilization in the periphery as well as central regulation of energy intake and lipid metabolism.
基金supported by Science and Technology Talent and Platform Program of Yunnan Provincial Science and Technology Department(No.202305AM070001)Zhaotong Phoenix Plan(2021)+1 种基金Double-First Class University Plan(No.C176220100042)the Postgraduate Research and Innovation Foundation of Yunnan University(No.KC-23234662)。
文摘A porous lanthanum(La)carbonate-carbon composite(LaCC)was prepared by vacuum-freeze-drying and pyrolysis techniques to remove phosphorus(P)from wastewater.Using polyethylene glycol as a carbon skeleton template,and the organic ligands are removed during pyrolysis,resulting in the creation of many pore structures.The LaCC showed excellent P removal performance and selectivity over a wide p H range(3–10).It exhibited a rapid adsorption rate and could hold up to 119.5 mg P/g.Fixed-bed column experiments showed that under dynamic conditions,just 1 g of LaCC effectively treated 60 L of P-contaminated wastewater with an initial concentration of 2 mg/L,meeting the primary discharge standard of<0.5 mg/L according to the comprehensive sewage guidelines of China.Bacterial experiments showed that the LaCC could inhibit the growth of Escherichia coli,indicating that it has both P removal and bacterial inhibition effects,which can greatly improve the application range of adsorbents.
基金supported by grants from the National Natural Science Foundation of China (NO.81973960)the Sichuan Scientific and Technological Innovation Team (No.2019JDTD0011)。
文摘Background:Reinforcing-reducing manipulations are a crucial part of acupuncture therapy.The reinforcing manipulation with heat sensation(RMHS) and the reducing manipulation by inducing cool sensation(RMCS) are two representative methods of reinforcing-reducing manipulations.This trial aims to investigate the characteristic of cerebral responses to these two typical acupuncture manipulations.Methods:A total of 35 healthy participants will be included and receive acupuncture stimulation with RMHS and RMCS in a random order.The psychology,cognition,and body constitution of participants will be measured by the Self-rating Anxiety Scale(SAS),the Self-rating Depression Scale(SDS),the mindful attention awareness scale(MAAS),the Constitution in Chinese Medicine Questionnaire(CCMQ),and the needle sensation will be evaluated after each acupuncture stimulation immediately.The cerebral activity changes elicited by RMHS and RMCS will be detected by functional near-infrared spectroscopy(fNIRS)and analyzed with the general linear model-based activation and the channel-to-channel functional connectivity.Discussion:This trial will investigate the cerebral response induced by RMHS and RMCS by real-time fNIRS,so as to map the characteristics of the central responses’ patterns to these two manipulations and preliminarily explore the mechanism of traditional acupuncture manipulations.
文摘目的:基于佛罗里达大学质子放疗中心(University of Florida Health Proton Therapy Institute,UFHPTI)质子加速器在笔形束扫描模式下的临床实验数据,在DeepPlan中构建相应模型,验证模型构建的准确性并初步应用于临床前列腺癌的剂量计算。方法:在DeepPlan质子模块中建立UFHPTI质子加速器的笔形束计算模型,并将剂量计算结果与临床实验数据进行对比,包括30组积分深度剂量(Integrated Depth Dose,IDD)、30组空气中质子束斑发散大小、1组多能量多点照射下的纵向扩展布拉格峰(Spread Out Bragg Peak,SOBP)和横向剂量分布,以此验证模型构建的准确性。最后以UFHPTI的两个前列腺癌临床放疗计划为指导,将DeepPlan计算结果与商用放疗计划系统RayStation计算结果通过PTW公司的VeriSoft软件进行gamma分析。结果:DeepPlan质子模块计算产生的30组IDD与UFHPTI加速器的临床实验数据平均相对误差为0.01%,最大相对误差为0.23%;30组空气质子束斑发散大小与临床实验数据平均相对误差为0.15%,最大相对误差为1.14%。在多能量多点照射下,DeepPlan质子模块计算产生的SOBP与临床实验数据平均相对误差为1.07%,最大相对误差为3.91%;横向剂量分布和临床实验数据平均相对误差为1.92%,最大相对误差为4.09%。针对两个前列腺癌的放疗计划,DeepPlan质子模块与RayStation计算的三维剂量结果在以3 mm/3%的标准下每个子野的gamma通过率都达到95%以上,其中病例1两个子野(270°和90°方向)的gamma通过率分别为96.4%和97.5%,病例2两个子野(270°和90°方向)的gamma通过率分别为99.3%和98.9%。结论:在DeepPlan中构建了与UFHPTI质子加速器相匹配的笔形束模型,该模型可初步应用于临床前列腺癌的剂量计算。
基金Supported by Shanghai Municipal Health Bureau Foundation No. 054049
文摘AIM： To investigate the role of subjective global assessment （SGA） in nutritional assessment and outcome prediction of Chinese patients with gastrointestinal cancer. METHODS： A total of 751 patients diagnosed with gastrointestinal cancer between August 2004 and August 2006 were enrolled in this study. Within 72 h after admission, SGA, anthropometric parameters, and laboratory tests were used to assess the nutritional status of each patient. The outcome variables including hospital stay, complications, and in-hospital medical expenditure were also obtained.RESULTS： Based on the results of SGA, 389 （51.8%）, 332 （44.2%）, and 30 （4.0%） patients were classified into well nourished group （SGA-A）, mildly to moderately malnourished group （SGA-B）, and severely malnourished group （SGA-C）, respectively. The prevalence of malnutrition classified by SGA, triceps skinfold thickness （TSF）, mid-upper arm muscle circumference （MAMC）, albumin （ALB）, prealbumin （PA）, and body mass index （BMI） was 48.2%, 39.4%, 37.7%, 31.3%, 21.7%, and 9.6%, respectively. In addition, ANOVA tests revealed significant differences in body mass index （BMI）, TSF, PA, and ALB of patients in different SGA groups. The more severely malnourished the patient was, the lower the levels of BMI, TSF, PA, and ALB were （P 〈 0.05）. x^2 tests showed a significant difference in SGA classification between patients receiving different types of treatment （surgery vs chemotherapy/radiotherapy）. As the nutritional status classified by SGA deteriorated, the patients stayed longer in hospital and their medical expenditures increased significantly. Furthermore, multiple regression analysis showed that SGA and serum ALB could help predict the medical expenditures and hospital stay of patients undergoing surgery. The occurrence of complications increased in parallel with the increasing grade of SGA, and was the highest in the SGA-C group （23.3%） and the lowest in the SGA-A group （16.8%）. CONCLUSION： SGA is a reliable assessment too and helps to predict the hospital stay and medica expenditures of Chinese surgical gastrointestina cancer patients.
