本研究旨在探讨低聚木糖(xylooligosaccharides,XOS)对慢性腹泻的改善作用。基于随机平行对照实验原则,将临床慢性腹泻患者随机分为3组:安慰剂组(CK组,每天3 g麦芽糊精)、低剂量组(3X组,每天3 g XOS)和高剂量组(6X组,每天6 g XOS);干预...本研究旨在探讨低聚木糖(xylooligosaccharides,XOS)对慢性腹泻的改善作用。基于随机平行对照实验原则,将临床慢性腹泻患者随机分为3组:安慰剂组(CK组,每天3 g麦芽糊精)、低剂量组(3X组,每天3 g XOS)和高剂量组(6X组,每天6 g XOS);干预4周后,记录患者腹泻症状评分,测定患者血清生化指标、粪便中短链脂肪酸和肠道菌群的变化。随后用3组干预后患者粪菌液分别灌胃3组小鼠,连续灌胃24 d,测定其肠道通透性及炎症因子水平。结果表明,与安慰剂组相比,XOS干预患者4周后,患者腹泻症状和脂代谢有改善趋势,粪便中丁酸含量提高。与干预前相比,XOS干预患者粪便中Blautia、Bifidobacterium、Lachnospiraceae_unclassified等物种相对丰度增加,Prevotella等菌属相对丰度下降。与灌胃安慰剂组患者粪菌液的小鼠相比,灌胃XOS干预组患者粪菌液的小鼠肠道屏障趋于稳定状态,结肠炎症显著缓解,肠道通透性相关指标明显改善,血清中D-乳酸水平显著降低(P<0.05、P<0.01),闭锁小带蛋白(zonula occludens-1,ZO-1)和紧密连接蛋白Occludin表达量增加。综上,XOS在慢性腹泻的改善中发挥了较好的效果,具有潜在缓解慢性腹泻的作用。展开更多
In the Anthropocene era,human activities have become increasingly complex and diversified.The natural ecosystems need higher ecological resilience to ensure regional sustainable development due to rapid urbanization a...In the Anthropocene era,human activities have become increasingly complex and diversified.The natural ecosystems need higher ecological resilience to ensure regional sustainable development due to rapid urbanization and industrialization as well as other intensified human activities,especially in arid and semi-arid areas.In the study,we chose the economic belt on the northern slope of the Tianshan Mountains(EBNSTM)in Xinjiang Uygur Autonomous Region of China as a case study.By collecting geographic data and statistical data from 2010 and 2020,we constructed an ecological resilience assessment model based on the ecosystem habitat quality(EHQ),ecosystem landscape stability(ELS),and ecosystem service value(ESV).Further,we analyzed the temporal and spatial variation characteristics of ecological resilience in the EBNSTM from 2010 to 2020 by spatial autocorrelation analysis,and explored its responses to climate change and human activities using the geographically weighted regression(GWR)model.The results showed that the ecological resilience of the EBNSTM was at a low level and increased from 0.2732 to 0.2773 during 2010–2020.The spatial autocorrelation analysis of ecological resilience exhibited a spatial heterogeneity characteristic of"high in the western region and low in the eastern region",and the spatial clustering trend was enhanced during the study period.Desert,Gobi and rapidly urbanized areas showed low level of ecological resilience,and oasis and mountain areas exhibited high level of ecological resilience.Climate factors had an important impact on ecological resilience.Specifically,average annual temperature and annual precipitation were the key climate factors that improved ecological resilience,while average annual evapotranspiration was the main factor that blocked ecological resilience.Among the human activity factors,the distance from the main road showed a negative correlation with ecological resilience.Both night light index and PM2.5 concentration were negatively correlated with ecological resilience in the areas with better ecological conditions,whereas in the areas with poorer ecological conditions,the correlations were positive.The research findings could provide a scientific reference for protecting the ecological environment and promoting the harmony and stability of the human-land relationship in arid and semi-arid areas.展开更多
随着物联网(Internet of Things,IoT)、大数据等技术的发展,为新型智慧园区建设提供了新的机遇,而智慧园区的发展模式与体系结构也可以看作智慧城市的缩影。对新型智慧园区现状进行分析,从技术应用、网络架构、需求分析3个角度出发,探...随着物联网(Internet of Things,IoT)、大数据等技术的发展,为新型智慧园区建设提供了新的机遇,而智慧园区的发展模式与体系结构也可以看作智慧城市的缩影。对新型智慧园区现状进行分析,从技术应用、网络架构、需求分析3个角度出发,探讨了基于物联网的新型智慧园区设计方案,同时还讨论了物联网技术在新型智慧园区的具体应用场景,包括人脸识别、会议预约、交通管理以及智慧餐厅等,实现智慧园区服务管理水平的提高。展开更多
文摘本研究旨在探讨低聚木糖(xylooligosaccharides,XOS)对慢性腹泻的改善作用。基于随机平行对照实验原则,将临床慢性腹泻患者随机分为3组:安慰剂组(CK组,每天3 g麦芽糊精)、低剂量组(3X组,每天3 g XOS)和高剂量组(6X组,每天6 g XOS);干预4周后,记录患者腹泻症状评分,测定患者血清生化指标、粪便中短链脂肪酸和肠道菌群的变化。随后用3组干预后患者粪菌液分别灌胃3组小鼠,连续灌胃24 d,测定其肠道通透性及炎症因子水平。结果表明,与安慰剂组相比,XOS干预患者4周后,患者腹泻症状和脂代谢有改善趋势,粪便中丁酸含量提高。与干预前相比,XOS干预患者粪便中Blautia、Bifidobacterium、Lachnospiraceae_unclassified等物种相对丰度增加,Prevotella等菌属相对丰度下降。与灌胃安慰剂组患者粪菌液的小鼠相比,灌胃XOS干预组患者粪菌液的小鼠肠道屏障趋于稳定状态,结肠炎症显著缓解,肠道通透性相关指标明显改善,血清中D-乳酸水平显著降低(P<0.05、P<0.01),闭锁小带蛋白(zonula occludens-1,ZO-1)和紧密连接蛋白Occludin表达量增加。综上,XOS在慢性腹泻的改善中发挥了较好的效果,具有潜在缓解慢性腹泻的作用。
基金supported by the Third Xinjiang Scientific Expedition Program (2021xjkk0905).
文摘In the Anthropocene era,human activities have become increasingly complex and diversified.The natural ecosystems need higher ecological resilience to ensure regional sustainable development due to rapid urbanization and industrialization as well as other intensified human activities,especially in arid and semi-arid areas.In the study,we chose the economic belt on the northern slope of the Tianshan Mountains(EBNSTM)in Xinjiang Uygur Autonomous Region of China as a case study.By collecting geographic data and statistical data from 2010 and 2020,we constructed an ecological resilience assessment model based on the ecosystem habitat quality(EHQ),ecosystem landscape stability(ELS),and ecosystem service value(ESV).Further,we analyzed the temporal and spatial variation characteristics of ecological resilience in the EBNSTM from 2010 to 2020 by spatial autocorrelation analysis,and explored its responses to climate change and human activities using the geographically weighted regression(GWR)model.The results showed that the ecological resilience of the EBNSTM was at a low level and increased from 0.2732 to 0.2773 during 2010–2020.The spatial autocorrelation analysis of ecological resilience exhibited a spatial heterogeneity characteristic of"high in the western region and low in the eastern region",and the spatial clustering trend was enhanced during the study period.Desert,Gobi and rapidly urbanized areas showed low level of ecological resilience,and oasis and mountain areas exhibited high level of ecological resilience.Climate factors had an important impact on ecological resilience.Specifically,average annual temperature and annual precipitation were the key climate factors that improved ecological resilience,while average annual evapotranspiration was the main factor that blocked ecological resilience.Among the human activity factors,the distance from the main road showed a negative correlation with ecological resilience.Both night light index and PM2.5 concentration were negatively correlated with ecological resilience in the areas with better ecological conditions,whereas in the areas with poorer ecological conditions,the correlations were positive.The research findings could provide a scientific reference for protecting the ecological environment and promoting the harmony and stability of the human-land relationship in arid and semi-arid areas.
文摘随着物联网(Internet of Things,IoT)、大数据等技术的发展,为新型智慧园区建设提供了新的机遇,而智慧园区的发展模式与体系结构也可以看作智慧城市的缩影。对新型智慧园区现状进行分析,从技术应用、网络架构、需求分析3个角度出发,探讨了基于物联网的新型智慧园区设计方案,同时还讨论了物联网技术在新型智慧园区的具体应用场景,包括人脸识别、会议预约、交通管理以及智慧餐厅等,实现智慧园区服务管理水平的提高。
