The increasing interconnection of modern industrial control systems(ICSs)with the Internet has enhanced operational efficiency,but alsomade these systemsmore vulnerable to cyberattacks.This heightened exposure has dri...The increasing interconnection of modern industrial control systems(ICSs)with the Internet has enhanced operational efficiency,but alsomade these systemsmore vulnerable to cyberattacks.This heightened exposure has driven a growing need for robust ICS security measures.Among the key defences,intrusion detection technology is critical in identifying threats to ICS networks.This paper provides an overview of the distinctive characteristics of ICS network security,highlighting standard attack methods.It then examines various intrusion detection methods,including those based on misuse detection,anomaly detection,machine learning,and specialised requirements.This paper concludes by exploring future directions for developing intrusion detection systems to advance research and ensure the continued security and reliability of ICS operations.展开更多
Probiotics can regulate the body’s immune system through both non-specific and specific immunity,thereby regulating host health.In terms of non-specific immune regulation,probiotics can activate the intrinsic immune ...Probiotics can regulate the body’s immune system through both non-specific and specific immunity,thereby regulating host health.In terms of non-specific immune regulation,probiotics can activate the intrinsic immune system,regulate the mucosal barrier function,and play an immune role by influencing the activity of intrinsic immune cells such as macrophages,dendritic cells and natural killer cells,as well as their differentiation and maturation;in terms of specific immune regulation,probiotics play a role in regulating the immunoglobulin level and the maturation of B cells.Probiotics can also regulate T-cell differentiation according to the condition of the body,thus regulating specific immunity.Many studies have focused on the role of probiotics in metabolism and nutrition,and the mechanisms involved in the immunomodulatory role of probiotics have only been partially described.This review summarises the role of common probiotics such as Lactobacillus plantarum and Lactobacillus rhamnosus in immunomodulation as well as their mechanisms,describing the currently known mechanisms of immunomodulation by probiotics in improving the host immune system.A deeper understanding of probiotics and their specific mechanisms of action will facilitate the use of probiotics for immunomodulation in clinical medicine,functional foods,and other areas.This will also contribute to the development and research of engineered probiotics,next-generation probiotics,and other new functional probiotics with immunomodulatory effects.展开更多
In contrast to research on active sites in nanomaterials,lithium tantalate single crystals,known for their exceptional optical properties and long-range ordered lattice structure,present a promising avenue for in-dept...In contrast to research on active sites in nanomaterials,lithium tantalate single crystals,known for their exceptional optical properties and long-range ordered lattice structure,present a promising avenue for in-depth exploration of photocatalytic reaction systems with fewer constraints imposed by surface chemistry.Typically,the isotropy of a specific facet provides a perfect support for studying heteroatom doping.Herein,this work delves into the intrinsic catalytic sites for photocatalytic nitrogen fixation in iron-doped lithium tantalate single crystals.The presence of iron not only modifies the electronic structure of lithium tantalate,improving its light absorption capacity,but also functions as an active site for the nitrogen adsorption and activation.The photocatalytic ammonia production rate of the iron-doped lithium tantalate in pure water is maximum 26.95μg cm^(−2)h^(−1),which is three times higher than that of undoped lithium tantalate.The combination of first-principles simulations with in situ characterizations confirms that iron doping promotes the rate-determining step and changes the pathway of hydrogenation to associative alternating.This study provides a new perspective on in-depth investigation of intrinsic catalytic active sites in photocatalysis and other catalytic processes.展开更多
Due to its synergistic effects and reduced side effects,combination therapy has become an important strategy for treating complex diseases.In traditional Chinese medicine(TCM),the“monarch,minister,assistant,envoy”co...Due to its synergistic effects and reduced side effects,combination therapy has become an important strategy for treating complex diseases.In traditional Chinese medicine(TCM),the“monarch,minister,assistant,envoy”compatibilities theory provides a systematic framework for drug compatibility and has guided the formation of a large number of classic formulas.However,due to the complex compositions and diverse mechanisms of action of TCM,it is difficult to comprehensively reveal its potential synergistic patterns using traditional methods.Synergistic prediction based on molecular compatibility theory provides new ideas for identifying combinations of active compounds in TCM.Compared to resource-intensive traditional experimental methods,artificial intelligence possesses the ability to mine synergistic patterns from multi-omics and structural data,providing an efficient means for modeling and optimizing TCM combinations.This paper systematically reviews the application progress of AI in the synergistic prediction of TCM active compounds and explores the challenges and prospects of its application in modeling combination relationships,thereby contributing to the modernization of TCM theory and methodological innovation.展开更多
The challenge of low temperature and rapid diffusion bonding of a Ni-based superalloy was hereby addressed by using a Ni nano-coating and a spark plasma sintering(SPS).It successfully produced a Nibased superalloy joi...The challenge of low temperature and rapid diffusion bonding of a Ni-based superalloy was hereby addressed by using a Ni nano-coating and a spark plasma sintering(SPS).It successfully produced a Nibased superalloy joint with 337 MPa shear strength at 500℃ for 30 min,which is approximately 400℃ lower than the traditional hot pressure diffusion bonding(HPDB)temperature.The microstructure and mechanical properties of the joints were systematically investigated.It is revealed that the pulsed current and ultra-fine grains(19 nm)in the Ni nano-coating could significantly facilitate voids closure.The voids closure mechanisms involved(i)pulsed current strengthened plastic deformation,(ii)pulsed current strengthened surface source diffusion,(iii)pulsed current strengthened bonding interface diffusion,(iv)grain growth dividing the initial large voids into nano-voids,and(v)massive grain boundaries(GBs),lattice defects,and local high-temperature strengthened GBs diffusion.Furthermore,the GBs migration across the interface was investigated,and the results revealed that the GBs migration and fine grains(350 nm)near the bonding interface together increased the joint strength.展开更多
文摘The increasing interconnection of modern industrial control systems(ICSs)with the Internet has enhanced operational efficiency,but alsomade these systemsmore vulnerable to cyberattacks.This heightened exposure has driven a growing need for robust ICS security measures.Among the key defences,intrusion detection technology is critical in identifying threats to ICS networks.This paper provides an overview of the distinctive characteristics of ICS network security,highlighting standard attack methods.It then examines various intrusion detection methods,including those based on misuse detection,anomaly detection,machine learning,and specialised requirements.This paper concludes by exploring future directions for developing intrusion detection systems to advance research and ensure the continued security and reliability of ICS operations.
基金funded by Ausnutria-kabrita Research Fund(RS2022-14).
文摘Probiotics can regulate the body’s immune system through both non-specific and specific immunity,thereby regulating host health.In terms of non-specific immune regulation,probiotics can activate the intrinsic immune system,regulate the mucosal barrier function,and play an immune role by influencing the activity of intrinsic immune cells such as macrophages,dendritic cells and natural killer cells,as well as their differentiation and maturation;in terms of specific immune regulation,probiotics play a role in regulating the immunoglobulin level and the maturation of B cells.Probiotics can also regulate T-cell differentiation according to the condition of the body,thus regulating specific immunity.Many studies have focused on the role of probiotics in metabolism and nutrition,and the mechanisms involved in the immunomodulatory role of probiotics have only been partially described.This review summarises the role of common probiotics such as Lactobacillus plantarum and Lactobacillus rhamnosus in immunomodulation as well as their mechanisms,describing the currently known mechanisms of immunomodulation by probiotics in improving the host immune system.A deeper understanding of probiotics and their specific mechanisms of action will facilitate the use of probiotics for immunomodulation in clinical medicine,functional foods,and other areas.This will also contribute to the development and research of engineered probiotics,next-generation probiotics,and other new functional probiotics with immunomodulatory effects.
基金supported by Natural Science Foundation of Shandong Province(Nos.ZR2022YQ42,ZR2021JQ15,ZR2021QE011,ZR2021ZD20,2022GJJLJRC-01)Innovative Team Project of Jinan(No.2021GXRC019)the National Natural Science Foundation of China(Nos.52022037,52202366).
文摘In contrast to research on active sites in nanomaterials,lithium tantalate single crystals,known for their exceptional optical properties and long-range ordered lattice structure,present a promising avenue for in-depth exploration of photocatalytic reaction systems with fewer constraints imposed by surface chemistry.Typically,the isotropy of a specific facet provides a perfect support for studying heteroatom doping.Herein,this work delves into the intrinsic catalytic sites for photocatalytic nitrogen fixation in iron-doped lithium tantalate single crystals.The presence of iron not only modifies the electronic structure of lithium tantalate,improving its light absorption capacity,but also functions as an active site for the nitrogen adsorption and activation.The photocatalytic ammonia production rate of the iron-doped lithium tantalate in pure water is maximum 26.95μg cm^(−2)h^(−1),which is three times higher than that of undoped lithium tantalate.The combination of first-principles simulations with in situ characterizations confirms that iron doping promotes the rate-determining step and changes the pathway of hydrogenation to associative alternating.This study provides a new perspective on in-depth investigation of intrinsic catalytic active sites in photocatalysis and other catalytic processes.
基金supported by the National Key Research and Development Program of China(No.2024YFC3506900)Science and Technology Program of Tianjin(No.24ZXZSSS00460)Special Project for Technological Innovation in New Productive Forces of Modern Chinese Medicines(No.24ZXZKSY00010)。
文摘Due to its synergistic effects and reduced side effects,combination therapy has become an important strategy for treating complex diseases.In traditional Chinese medicine(TCM),the“monarch,minister,assistant,envoy”compatibilities theory provides a systematic framework for drug compatibility and has guided the formation of a large number of classic formulas.However,due to the complex compositions and diverse mechanisms of action of TCM,it is difficult to comprehensively reveal its potential synergistic patterns using traditional methods.Synergistic prediction based on molecular compatibility theory provides new ideas for identifying combinations of active compounds in TCM.Compared to resource-intensive traditional experimental methods,artificial intelligence possesses the ability to mine synergistic patterns from multi-omics and structural data,providing an efficient means for modeling and optimizing TCM combinations.This paper systematically reviews the application progress of AI in the synergistic prediction of TCM active compounds and explores the challenges and prospects of its application in modeling combination relationships,thereby contributing to the modernization of TCM theory and methodological innovation.
基金financially supported by the National Nat-ural Science Foundation of China(Nos.U22A20185,52175302,and U21A20128)the National MCF Energy R&D Program(No.2019YFE03100100)the Fundamental Research Funds for the Central Universities(No.2022FRFK060009).
文摘The challenge of low temperature and rapid diffusion bonding of a Ni-based superalloy was hereby addressed by using a Ni nano-coating and a spark plasma sintering(SPS).It successfully produced a Nibased superalloy joint with 337 MPa shear strength at 500℃ for 30 min,which is approximately 400℃ lower than the traditional hot pressure diffusion bonding(HPDB)temperature.The microstructure and mechanical properties of the joints were systematically investigated.It is revealed that the pulsed current and ultra-fine grains(19 nm)in the Ni nano-coating could significantly facilitate voids closure.The voids closure mechanisms involved(i)pulsed current strengthened plastic deformation,(ii)pulsed current strengthened surface source diffusion,(iii)pulsed current strengthened bonding interface diffusion,(iv)grain growth dividing the initial large voids into nano-voids,and(v)massive grain boundaries(GBs),lattice defects,and local high-temperature strengthened GBs diffusion.Furthermore,the GBs migration across the interface was investigated,and the results revealed that the GBs migration and fine grains(350 nm)near the bonding interface together increased the joint strength.
