General anesthesia,pivotal for surgical procedures,requires precise depth monitoring to mitigate risks ranging from intraoperative awareness to postoperative cognitive impairments.Traditional assessment methods,relyin...General anesthesia,pivotal for surgical procedures,requires precise depth monitoring to mitigate risks ranging from intraoperative awareness to postoperative cognitive impairments.Traditional assessment methods,relying on physiological indicators or behavioral responses,fall short of accurately capturing the nuanced states of unconsciousness.This study introduces a machine learning-based approach to decode anesthesia depth,leveraging EEG data across different anesthesia states induced by propofol and esketamine in rats.Our findings demonstrate the model’s robust predictive accuracy,underscored by a novel intrasubject dataset partitioning and a 5-fold cross-validation method.The research diverges from conventional monitoring by utilizing anesthetic infusion rates as objective indicators of anesthesia states,highlighting distinct EEG patterns and enhancing prediction accuracy.Moreover,the model’s ability to generalize across individuals suggests its potential for broad clinical application,distinguishing between anesthetic agents and their depths.Despite relying on rat EEG data,which poses questions about real-world applicability,our approach marks a significant advance in anesthesia monitoring.展开更多
Background:The outcomes of pediatric patients with acute lymphoblastic leukemia(ALL)remain far less than favorable.While apigenin is an anti-cancer agent,studies on the mechanism by which it regulates ALL cell cycle p...Background:The outcomes of pediatric patients with acute lymphoblastic leukemia(ALL)remain far less than favorable.While apigenin is an anti-cancer agent,studies on the mechanism by which it regulates ALL cell cycle progression are inadequate.Ferroptosis and AMP-activated protein kinase(AMPK)signaling are important processes for ALL patients.However,it remains unclear whether apigenin works by affecting AMPK and apoptosis.Materials and Methods:SUP-B15 and T-cell Jurkat ALL cells were treated with apigenin,and cell viability and apoptosis were measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)and terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)assays,respectively.The thiobarbituric acid-reactive substances(TBARS)assay was used to evaluate lipid peroxidation.Intracellular Fe2+levels were measured using a commercial kit.Corresponding proteins were detected by western blotting.Results:Results showed that apigenin reduced cell viability and the levels of Ki67 and proliferating cell nuclear antigen(PCNA)expression in a concentration-dependent manner in both types of ALL cells.Apigenin also exerted anti-apoptotic effects on SUP-B15 and Jurkat cells.Apigenin activated AMP-activated protein kinase(AMPK)signaling and induced ferroptosis,and those effects were attenuated by inhibition of AMPK.Eventually,the reduced cell proliferation and increased cell apoptosis caused by apigenin in ALL cells were partly abolished by AMPK inhibition.Conclusion:In summary,apigenin exerted anti-leukemia activity in ALL cells,and that effect was partially achieved by activation of AMPK signaling.Our findings suggest apigenin as a potential drug for treatment of ALL.展开更多
Electrode materials that rely on conversion reactions for lithium-ion batteries(LIBs)possess high energy densities.However,a key issue in their design is bolstering their stability and minimizing volume variations dur...Electrode materials that rely on conversion reactions for lithium-ion batteries(LIBs)possess high energy densities.However,a key issue in their design is bolstering their stability and minimizing volume variations during lithiation and delithiation.Herein,an effect-ive strategy was devised to fulfill the fully reversible conversion reaction for lithium storage in CoMoO_(4) through the hybridization of Co-MoO_(3).CoMoO_(3)/CoMoO_(4) with a nanorod structure was synthesized via one-step annealing treatment after a solvothermal process.In such a structure,the CoMoO_(3)/CoMoO_(4) nanorod can considerably boost mechanical robustness and offer ample space to counteract volume fluctuations throughout successive cycles owing to the cooperative interaction between CoMoO_(3) and CoMoO_(4).CoMoO_(3)/CoMoO_(4) exhib-ited superior lithium-storage capacity(919.6 mAh/g at 0.1 A/g after 200 cycles)and cycling stability(683.4 mAh/g at 1 A/g after 600 cycles).CoMoO_(3)/CoMoO_(4) showed a high potential as an anode material for LIBs.展开更多
CRISPR/Cas9-based gene editing research has advanced greatly and shows broad potential for practical application in life sciences,but the Cas9 system is often constrained by the requirement of a protospacer adjacent m...CRISPR/Cas9-based gene editing research has advanced greatly and shows broad potential for practical application in life sciences,but the Cas9 system is often constrained by the requirement of a protospacer adjacent motif(PAM)at the target site.While xCas9,a variant derived from Streptococcus pyogenes Cas9(SpCas9),can recognize a broader range of PAMs,its application in non-model insects is lacking.In this study,we explored xCas9 activity in gene editing by selecting corazonin(Crz)and the target sites with various PAMs in Locusta migratoria,a destructive insect pest worldwide.We found that xCas9 could cleave the target site with AG PAM while SpCas9 could not,although xCas9 appeared to have lower activity than SpCas9 at the canonical NGG PAMs.The heritable homozygous Crz^(-/-)locust strain was generated by the application of xCas9.The Crz^(-/-)strain showed an albino body color,with significantly downregulated expression of several body color-related genes including Pale,Vermilion,Cinnabar,White andβ-carotene-binding protein.In addition,Crz^(-/-)mutants exhibited significantly reduced expression of Chitin synthase 1,along with a markedly lower chitin content as well as compact and rigid cuticles.Furthermore,Crz^(-/-)mutants displayed impaired performance under low-temperature stress,including prolonged lifespan,reduced body weight and smaller body size.Our results suggest that xCas9 is effective for insect genome editing,and Crz plays essential roles in insect body color,cuticle development and adaptation to low-temperature stress.The findings of this study extend the application of xCas9 in non-model insects and provide new insights into our understanding of the regulation of insect cuticle development and environmental adaptation.展开更多
Biodegradable magnesium(Mg)-based metals can undergo spontaneous corrosion and full degradation in the human body,releasing magnesium ions,hydroxides,and hydrogen.Mg and its alloys have shown preliminary success as an...Biodegradable magnesium(Mg)-based metals can undergo spontaneous corrosion and full degradation in the human body,releasing magnesium ions,hydroxides,and hydrogen.Mg and its alloys have shown preliminary success as an implantable biomaterial.Current research on biodegradable Mg-based metals addresses clinical challenges,including material design and preparation,property enhancement,and exploring relevant biological functions.This review provides a comprehensive overview of the biomedical applications of Mg-based implants across eight fields:cardiovascular,orthopedics,stomatology,general surgery,neurosurgery,fat metabolism,and other potential areas,building upon previously published work.The challenges and prospects of biodegradable Mg-based implants in these application fields are discussed.展开更多
The joining of Fe Cr Al alloy and Carbon Fiber Reinforced Thermoplastic Composites(CFRTP)presents a promising strategy for the development of lightweight and structurally reliable components.In this study,ultrasonic w...The joining of Fe Cr Al alloy and Carbon Fiber Reinforced Thermoplastic Composites(CFRTP)presents a promising strategy for the development of lightweight and structurally reliable components.In this study,ultrasonic welding,noted for its efficiency and environmentally sustainable characteristics,was employed to examine systematically examine the impact of surface texturing on joint performance.Two distinct categories of Fe Cr Al surface textures,discrete unit patterns and continuous groove structures,were created and subsequently welded with Short Carbon Fiber Reinforced Polyamide 6(SCFR-PA6).The wettability of molten SCFR-PA6 on the textured surfaces and the bonding strength of the resulting joints were evaluated,alongside comprehensive analyses of fracture surfaces and interfacial morphologies.The findings indicated that continuous groove textures significantly improved wettability in comparison to discrete unit textures.Notably,joints with continuous grid-like texturing exhibited complete resin infiltration and achieved the highest bonding strength of 18.26 MPa.This enhancement is primarily attributed to the continuous groove structures,which facilitate unobstructed resin flow and promote the effective extrusion of carbon fibers.A novel reinforcement strategy for metal/CFRTP joints is proposed,wherein interfacial texture design is used to regulate temperature distribution and resin flow dynamics during welding.These results offer critical insights into the optimization of metal/CFRTP joint design and manufacturing processes for advanced structural applications.展开更多
In recent years,the phenomenon of multistability has attracted wide attention.In this paper,a memristive chaotic system with extreme multistability is constructed by using a memristor.The dynamic behavior of the syste...In recent years,the phenomenon of multistability has attracted wide attention.In this paper,a memristive chaotic system with extreme multistability is constructed by using a memristor.The dynamic behavior of the system is analyzed by Poincar´e mapping,a time series diagram,and a bifurcation diagram.The results show that the new system has several significant characteristics.First,the new system has a constant Lyapunov exponent,transient chaos and one complete Feigenbaum tree.Second,the system has the phenomenon of bifurcation map shifts that depend on the initial conditions.In addition,we find periodic bursting oscillations,chaotic bursting oscillations,and the transition of chaotic bursting oscillations to periodic bursting oscillations.In particular,when the system parameters take different discrete values,the system generates a bubble phenomenon that varies with the initial conditions,and this bubble can be shifted with the initial values,which has rarely been seen in the previous literature.The implementation by field-programmable gate array(FPGA)and analog circuit simulation show close alignment with the MATLAB numerical simulation results,validating the system’s realizability.Additionally,the image encryption algorithm integrating DNA-based encoding and chaotic systems further demonstrates its practical applicability.展开更多
Current research on the fabrication of rolled composite plates primarily focuses on processing and bonding mechanisms.Compared with hot-rolling technology,the electrically assisted rolling process has demonstrated exc...Current research on the fabrication of rolled composite plates primarily focuses on processing and bonding mechanisms.Compared with hot-rolling technology,the electrically assisted rolling process has demonstrated excellent performance in interfacial bonding effects.However,the influence of different current loading modes on the interfacial recombination process of composite panels varies significantly.In this study,low-frequency electrically assisted rolling was used in the first pass to pre-bond a composite plate at a low reduction rate of 15%.High-frequency electrically assisted rolling was used during the second pass,and Al/Mg alloy composite plates were obtained.The interfacial microstructure and mechanical properties of the composite plate were coordinated regulation by designing the rolling reduction rate.The results showed the interfacial morphology of the alternating distribution of the melt-diffusion layer,diffusion layer,and the formation of a new Al/Mg bonding interface.At the melt-diffusion interface,the irregular intermetallic compounds(IMCs)and the new Al/Mg bonding interface were alternately distributed,and the IMCs contained theα-Mg,Mg17Al12,and Mg2Al3 phases.In addition,an extremely high shear strength of 78.26 MPa was achieved.Adhesion of the Mg alloy matrix was observed on the fracture surface of the Al alloy side.The high shear strength was mainly attributed to the formation of a unique interfacial structure and the appearance of a melt-diffusion layer.Compared to the diffusion-reduction interface,the regular rectangular IMCs and the new Al/Mg bonding interface were alternately distributed,and the IMCs consisted of the Mg17Al12 and Mg2Al3 phases.The shear test results showed that the shear strength of the interface reached 68.69 MPa,and a regular distribution of the Mg alloy matrix with dimples and the Al alloy matrix with a necking zone was observed on the fracture surface of the Al side.Tensile strength test results revealed a maximum value of 316.86 MPa for the Al/Mg alloy composite plate.The tensile and interfacial bonding strengths can be synchronously enhanced by coordinating the regulation of the interfacial structure.This study proposes a new electrically assisted rolling technology that is useful for the fabrication of composite plates with excellent mechanical properties.展开更多
Nano zero-valent iron(nZVI)is widely used in soil remediation due to its high reactivity.However,the easy agglomeration,poor antioxidant ability and passivation layer of Fe-Cr coprecipitates of nZVI have limited its a...Nano zero-valent iron(nZVI)is widely used in soil remediation due to its high reactivity.However,the easy agglomeration,poor antioxidant ability and passivation layer of Fe-Cr coprecipitates of nZVI have limited its application scale in Cr-contaminated soil remediation,especially in high concentration of Cr-contaminated soil.Herein,we found that the carboxymethyl cellulose on nZVI particles could increase the zeta potential value of soil and change the phase of nZVI.Along with the presence of biochar,97.0%and 96.6%Cr immobilization efficiency through CMC-nZVI/BC were respectively achieved in high and low concentrations of Cr-contaminated soils after 90-days remediation.In addition,the immobilization efficiency of Cr(VI)only decreased by 5.1%through CMC-nZVI/BC treatment after 10 weeks aging in air,attributing to the strong antioxidation ability.As for the surrounding Crcontaminated groundwater,the Cr(VI)removal capacity of CMC-nZVI/BC was evaluated under different reaction conditions through column experiments and COMSOL Multiphysics.CMC-nZVI/BC could efficiently remove 85%of Cr(VI)in about 400 hr when the initial Cr(VI)concentration was 40 mg/L and the flow rate was 0.5 mL/min.This study demonstrates that uniformly dispersed CMC-nZVI/BC has an excellent remediation effect on different concentrations of Cr-contaminated soils.展开更多
Arson presents a challenging crime scene for fire investigators worldwide. Key to the investigation of suspected arson cases is the analysis of fire debris for the presence of accelerants or ignitable liquids. This st...Arson presents a challenging crime scene for fire investigators worldwide. Key to the investigation of suspected arson cases is the analysis of fire debris for the presence of accelerants or ignitable liquids. This study has investigated the application and method development of vapor phase mid-Infrared (mid-IR) spectroscopy using a field portable quantum cascade laser (QCL) based system for the detection and identification of accelerant residues such as gasoline, diesel, and ethanol in fire debris. A searchable spectral library of various ignitable fluids and fuel components measured in the vapor phase was constructed that allowed for real-time identification of accelerants present in samples using software developed in-house. Measurement of vapors collected from paper material that had been doused with an accelerant followed by controlled burning and then extinguished with water showed that positive identification could be achieved for gasoline, diesel, and ethanol. This vapor phase mid-IR QCL method is rapid, easy to use, and has the sensitivity and discrimination capability that make it well suited for non-destructive crime scene sample analysis. Sampling and measurement can be performed in minutes with this 7.5 kg instrument. This vibrational spectroscopic method required no time-consuming sample pretreatment or complicated solvent extraction procedure. The results of this initial feasibility study demonstrate that this portable fire debris analyzer would greatly benefit arson investigators performing analysis on-site.展开更多
It is an important issue to numerically solve the time fractional Schrödinger equation on unbounded domains, which models the dynamics of optical solitons propagating via optical fibers. The perfectly matched lay...It is an important issue to numerically solve the time fractional Schrödinger equation on unbounded domains, which models the dynamics of optical solitons propagating via optical fibers. The perfectly matched layer approach is applied to truncate the unbounded physical domain, and obtain an initial boundary value problem on a bounded computational domain, which can be efficiently solved by the finite difference method. The stability of the reduced initial boundary value problem is rigorously analyzed. Some numerical results are presented to illustrate the accuracy and feasibility of the perfectly matched layer approach. According to these examples, the absorption parameters and the width of the absorption layer will affect the absorption effect. The larger the absorption width, the better the absorption effect. There is an optimal absorption parameter, the absorption effect is the best.展开更多
In this work,MoS2@montmorillonite nanosheets hollow microspheres(MoS2@MMTNS-HMS)with a novel morphology structure was successfully synthesized through loading MoS2 to the surface of MMTNS-HMS via hydrothermal method.T...In this work,MoS2@montmorillonite nanosheets hollow microspheres(MoS2@MMTNS-HMS)with a novel morphology structure was successfully synthesized through loading MoS2 to the surface of MMTNS-HMS via hydrothermal method.The novel material has been characterized through the measurements of SEM,TEM,Raman spectra and UV–vis absorption spectra.The results have shown that MoS2@MMTNS-HMS emerges higher light-utilization efficiency,density of edge active sites and separation of photoelectrons,owing to its unique hollow structure,vertically-aligned MoS2 nanosheets,which greatly enhances its photocatalytic activity.Furthermore,the cycle stability of MoS2@MMTNS-HMS is much higher than that of pristine MoS2,which is attributed to that MMTNS-HMS greatly inhibits the oxidation of MoS2 during photocatalytic.MoS2@MMTNS-HMS could be a promising photocatalyst for the applications in the elimination of organic pollutants.展开更多
Diabetes mellitus(DM)is a common multifactorial disease,causing various complications,such as chronic metabolism.The current therapies for diabetes mellitus are commercial diabetic drugs that have different definite s...Diabetes mellitus(DM)is a common multifactorial disease,causing various complications,such as chronic metabolism.The current therapies for diabetes mellitus are commercial diabetic drugs that have different definite side effect.However,polysaccharides mainly extracted from natural resources,have advantages of safety,accessibility,and anti-diabetic potential.We have summarized recent research of natural polysaccharides with hypoglycemic activities,focusing on different pharmacological mechanisms in various cell and animal models.The relationships of structure-hypoglycemic effect are also discussed in detail.This review could provide a comprehensive perspective for better understanding on development and mechanism of natural polysaccharides against diabetes mellitus,which have been required by clinical studies yet.展开更多
In this study,we developed a novel on-line solid phase extraction(SPE)-ultra-high-performance liquid chromatography tandem mass spectrometry(UHPLC-MS/MS)-based analytical method for simultaneously quantifying 12 illic...In this study,we developed a novel on-line solid phase extraction(SPE)-ultra-high-performance liquid chromatography tandem mass spectrometry(UHPLC-MS/MS)-based analytical method for simultaneously quantifying 12 illicit drugs and metabolites(methamphetamine,amphetamine,morphine,codeine,6-monoacetylmorphine,benzoylecgonine,3,4-methylenedioxymethamphetamine,3,4-methylenedioxyamphetamine,cocaine,ketamine,norketamine,and methcathinone)and cotinine(COT)in wastewater samples.The analysis was performed by loading 2 m L of the sample onto an Oasis hydrophilic-lipophilic balance cartridge and using a cleanup step(5%methanol)to eliminate interference with a total run time of 13 min.The isotope-labeled internal standard method was used to quantify the target substances and correct for unavoidable losses and matrix effects during the on-line SPE process.Typical analytical characteristics used for method validation were sensitivity,linearity,precision,repeatability,recovery,and matrix effects.The limit of detection(LOD)and limit of quantification(LOQ)of each target were set at 0.20 ng/L and 0.50 ng/L,respectively.The linearity was between 0.5 ng/L and250 ng/L,except for that of COT.The intra-and inter-day precisions were<10.45%and 25.64%,respectively,and the relative recovery ranged from 83.74%to 162.26%.The method was used to analyze various wastewater samples from 33 cities in China,and the results were compared with the experimental results of identical samples analyzed using off-line SPE.The difference rate was between 19.91%and-20.44%,and the error range could be considered acceptable.These findings showed that on-line SPE is a suitable alternative to off-line SPE for the analysis of illicit drugs in samples.展开更多
基金supported by grants from the Shanghai Municipal Health Commission(2023ZDFC0203)the National Natural Science Foundation of China(32171044).
文摘General anesthesia,pivotal for surgical procedures,requires precise depth monitoring to mitigate risks ranging from intraoperative awareness to postoperative cognitive impairments.Traditional assessment methods,relying on physiological indicators or behavioral responses,fall short of accurately capturing the nuanced states of unconsciousness.This study introduces a machine learning-based approach to decode anesthesia depth,leveraging EEG data across different anesthesia states induced by propofol and esketamine in rats.Our findings demonstrate the model’s robust predictive accuracy,underscored by a novel intrasubject dataset partitioning and a 5-fold cross-validation method.The research diverges from conventional monitoring by utilizing anesthetic infusion rates as objective indicators of anesthesia states,highlighting distinct EEG patterns and enhancing prediction accuracy.Moreover,the model’s ability to generalize across individuals suggests its potential for broad clinical application,distinguishing between anesthetic agents and their depths.Despite relying on rat EEG data,which poses questions about real-world applicability,our approach marks a significant advance in anesthesia monitoring.
基金supported by The National Natural Science Foundation of China(No.31902283)Research Foundation for Master students at the Affiliated Hospital of Zunyi Medical College(No.22-2018).
文摘Background:The outcomes of pediatric patients with acute lymphoblastic leukemia(ALL)remain far less than favorable.While apigenin is an anti-cancer agent,studies on the mechanism by which it regulates ALL cell cycle progression are inadequate.Ferroptosis and AMP-activated protein kinase(AMPK)signaling are important processes for ALL patients.However,it remains unclear whether apigenin works by affecting AMPK and apoptosis.Materials and Methods:SUP-B15 and T-cell Jurkat ALL cells were treated with apigenin,and cell viability and apoptosis were measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)and terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)assays,respectively.The thiobarbituric acid-reactive substances(TBARS)assay was used to evaluate lipid peroxidation.Intracellular Fe2+levels were measured using a commercial kit.Corresponding proteins were detected by western blotting.Results:Results showed that apigenin reduced cell viability and the levels of Ki67 and proliferating cell nuclear antigen(PCNA)expression in a concentration-dependent manner in both types of ALL cells.Apigenin also exerted anti-apoptotic effects on SUP-B15 and Jurkat cells.Apigenin activated AMP-activated protein kinase(AMPK)signaling and induced ferroptosis,and those effects were attenuated by inhibition of AMPK.Eventually,the reduced cell proliferation and increased cell apoptosis caused by apigenin in ALL cells were partly abolished by AMPK inhibition.Conclusion:In summary,apigenin exerted anti-leukemia activity in ALL cells,and that effect was partially achieved by activation of AMPK signaling.Our findings suggest apigenin as a potential drug for treatment of ALL.
基金supported by Jiangxi Provincial Natural Science Foundation,China(Nos.20242BAB25195 and 20224BAB211018)National Natural Science Foundation of China(No.12264029)+1 种基金the Scientific Research Foundation of Jiangxi Provincial Education Department,China(No.GJJ211944)the college Students’Innovation and Entrepreneurship Training program of Jiangxi Province,China.
文摘Electrode materials that rely on conversion reactions for lithium-ion batteries(LIBs)possess high energy densities.However,a key issue in their design is bolstering their stability and minimizing volume variations during lithiation and delithiation.Herein,an effect-ive strategy was devised to fulfill the fully reversible conversion reaction for lithium storage in CoMoO_(4) through the hybridization of Co-MoO_(3).CoMoO_(3)/CoMoO_(4) with a nanorod structure was synthesized via one-step annealing treatment after a solvothermal process.In such a structure,the CoMoO_(3)/CoMoO_(4) nanorod can considerably boost mechanical robustness and offer ample space to counteract volume fluctuations throughout successive cycles owing to the cooperative interaction between CoMoO_(3) and CoMoO_(4).CoMoO_(3)/CoMoO_(4) exhib-ited superior lithium-storage capacity(919.6 mAh/g at 0.1 A/g after 200 cycles)and cycling stability(683.4 mAh/g at 1 A/g after 600 cycles).CoMoO_(3)/CoMoO_(4) showed a high potential as an anode material for LIBs.
基金supported by the Key Research and Development Project of Henan Province,China(221111112200)the National Natural Science Foundation of China(32070502 and 32072419)+1 种基金the Fundamental Research Program of Shanxi Province,China(202303021224005)the Natural Science Foundation of Henan Province,China(232300420185).
文摘CRISPR/Cas9-based gene editing research has advanced greatly and shows broad potential for practical application in life sciences,but the Cas9 system is often constrained by the requirement of a protospacer adjacent motif(PAM)at the target site.While xCas9,a variant derived from Streptococcus pyogenes Cas9(SpCas9),can recognize a broader range of PAMs,its application in non-model insects is lacking.In this study,we explored xCas9 activity in gene editing by selecting corazonin(Crz)and the target sites with various PAMs in Locusta migratoria,a destructive insect pest worldwide.We found that xCas9 could cleave the target site with AG PAM while SpCas9 could not,although xCas9 appeared to have lower activity than SpCas9 at the canonical NGG PAMs.The heritable homozygous Crz^(-/-)locust strain was generated by the application of xCas9.The Crz^(-/-)strain showed an albino body color,with significantly downregulated expression of several body color-related genes including Pale,Vermilion,Cinnabar,White andβ-carotene-binding protein.In addition,Crz^(-/-)mutants exhibited significantly reduced expression of Chitin synthase 1,along with a markedly lower chitin content as well as compact and rigid cuticles.Furthermore,Crz^(-/-)mutants displayed impaired performance under low-temperature stress,including prolonged lifespan,reduced body weight and smaller body size.Our results suggest that xCas9 is effective for insect genome editing,and Crz plays essential roles in insect body color,cuticle development and adaptation to low-temperature stress.The findings of this study extend the application of xCas9 in non-model insects and provide new insights into our understanding of the regulation of insect cuticle development and environmental adaptation.
基金supported by grants from the Fundamental Research Funds for the Central Universities(No.2232024D-34 and No 2232023A-10)the National Natural Science Foundation of China(No.52201300)+4 种基金the National Key R&D Program of China(No.2023YFC2416800)the Shanghai Pujiang Program(No.23PJ1400500 and No 23PJ1400600)the State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,Major/key program(No.23M1060280)the Science and Technology Project of Jiangsu Province(No.BE2022758)the Medicine-Engineering Interdisciplinary Project of Shanghai Xuhui District Dental Center(No.SHXYFYG202305).
文摘Biodegradable magnesium(Mg)-based metals can undergo spontaneous corrosion and full degradation in the human body,releasing magnesium ions,hydroxides,and hydrogen.Mg and its alloys have shown preliminary success as an implantable biomaterial.Current research on biodegradable Mg-based metals addresses clinical challenges,including material design and preparation,property enhancement,and exploring relevant biological functions.This review provides a comprehensive overview of the biomedical applications of Mg-based implants across eight fields:cardiovascular,orthopedics,stomatology,general surgery,neurosurgery,fat metabolism,and other potential areas,building upon previously published work.The challenges and prospects of biodegradable Mg-based implants in these application fields are discussed.
基金co-supported by the National Natural Science Foundation of China(No.52275360)。
文摘The joining of Fe Cr Al alloy and Carbon Fiber Reinforced Thermoplastic Composites(CFRTP)presents a promising strategy for the development of lightweight and structurally reliable components.In this study,ultrasonic welding,noted for its efficiency and environmentally sustainable characteristics,was employed to examine systematically examine the impact of surface texturing on joint performance.Two distinct categories of Fe Cr Al surface textures,discrete unit patterns and continuous groove structures,were created and subsequently welded with Short Carbon Fiber Reinforced Polyamide 6(SCFR-PA6).The wettability of molten SCFR-PA6 on the textured surfaces and the bonding strength of the resulting joints were evaluated,alongside comprehensive analyses of fracture surfaces and interfacial morphologies.The findings indicated that continuous groove textures significantly improved wettability in comparison to discrete unit textures.Notably,joints with continuous grid-like texturing exhibited complete resin infiltration and achieved the highest bonding strength of 18.26 MPa.This enhancement is primarily attributed to the continuous groove structures,which facilitate unobstructed resin flow and promote the effective extrusion of carbon fibers.A novel reinforcement strategy for metal/CFRTP joints is proposed,wherein interfacial texture design is used to regulate temperature distribution and resin flow dynamics during welding.These results offer critical insights into the optimization of metal/CFRTP joint design and manufacturing processes for advanced structural applications.
基金Project supported by the Natural Science Foundation of Hubei Province(Grant No.2024AFD068).
文摘In recent years,the phenomenon of multistability has attracted wide attention.In this paper,a memristive chaotic system with extreme multistability is constructed by using a memristor.The dynamic behavior of the system is analyzed by Poincar´e mapping,a time series diagram,and a bifurcation diagram.The results show that the new system has several significant characteristics.First,the new system has a constant Lyapunov exponent,transient chaos and one complete Feigenbaum tree.Second,the system has the phenomenon of bifurcation map shifts that depend on the initial conditions.In addition,we find periodic bursting oscillations,chaotic bursting oscillations,and the transition of chaotic bursting oscillations to periodic bursting oscillations.In particular,when the system parameters take different discrete values,the system generates a bubble phenomenon that varies with the initial conditions,and this bubble can be shifted with the initial values,which has rarely been seen in the previous literature.The implementation by field-programmable gate array(FPGA)and analog circuit simulation show close alignment with the MATLAB numerical simulation results,validating the system’s realizability.Additionally,the image encryption algorithm integrating DNA-based encoding and chaotic systems further demonstrates its practical applicability.
基金Supported by National Natural Science Foundation of China(Grant Nos.52075360,52275360,51805359).
文摘Current research on the fabrication of rolled composite plates primarily focuses on processing and bonding mechanisms.Compared with hot-rolling technology,the electrically assisted rolling process has demonstrated excellent performance in interfacial bonding effects.However,the influence of different current loading modes on the interfacial recombination process of composite panels varies significantly.In this study,low-frequency electrically assisted rolling was used in the first pass to pre-bond a composite plate at a low reduction rate of 15%.High-frequency electrically assisted rolling was used during the second pass,and Al/Mg alloy composite plates were obtained.The interfacial microstructure and mechanical properties of the composite plate were coordinated regulation by designing the rolling reduction rate.The results showed the interfacial morphology of the alternating distribution of the melt-diffusion layer,diffusion layer,and the formation of a new Al/Mg bonding interface.At the melt-diffusion interface,the irregular intermetallic compounds(IMCs)and the new Al/Mg bonding interface were alternately distributed,and the IMCs contained theα-Mg,Mg17Al12,and Mg2Al3 phases.In addition,an extremely high shear strength of 78.26 MPa was achieved.Adhesion of the Mg alloy matrix was observed on the fracture surface of the Al alloy side.The high shear strength was mainly attributed to the formation of a unique interfacial structure and the appearance of a melt-diffusion layer.Compared to the diffusion-reduction interface,the regular rectangular IMCs and the new Al/Mg bonding interface were alternately distributed,and the IMCs consisted of the Mg17Al12 and Mg2Al3 phases.The shear test results showed that the shear strength of the interface reached 68.69 MPa,and a regular distribution of the Mg alloy matrix with dimples and the Al alloy matrix with a necking zone was observed on the fracture surface of the Al side.Tensile strength test results revealed a maximum value of 316.86 MPa for the Al/Mg alloy composite plate.The tensile and interfacial bonding strengths can be synchronously enhanced by coordinating the regulation of the interfacial structure.This study proposes a new electrically assisted rolling technology that is useful for the fabrication of composite plates with excellent mechanical properties.
基金supported by the National Key Research and Development Program of China(No.2020YFC1808701)the Fundamental Research Funds for the Central Universities(No.buctrc202232).
文摘Nano zero-valent iron(nZVI)is widely used in soil remediation due to its high reactivity.However,the easy agglomeration,poor antioxidant ability and passivation layer of Fe-Cr coprecipitates of nZVI have limited its application scale in Cr-contaminated soil remediation,especially in high concentration of Cr-contaminated soil.Herein,we found that the carboxymethyl cellulose on nZVI particles could increase the zeta potential value of soil and change the phase of nZVI.Along with the presence of biochar,97.0%and 96.6%Cr immobilization efficiency through CMC-nZVI/BC were respectively achieved in high and low concentrations of Cr-contaminated soils after 90-days remediation.In addition,the immobilization efficiency of Cr(VI)only decreased by 5.1%through CMC-nZVI/BC treatment after 10 weeks aging in air,attributing to the strong antioxidation ability.As for the surrounding Crcontaminated groundwater,the Cr(VI)removal capacity of CMC-nZVI/BC was evaluated under different reaction conditions through column experiments and COMSOL Multiphysics.CMC-nZVI/BC could efficiently remove 85%of Cr(VI)in about 400 hr when the initial Cr(VI)concentration was 40 mg/L and the flow rate was 0.5 mL/min.This study demonstrates that uniformly dispersed CMC-nZVI/BC has an excellent remediation effect on different concentrations of Cr-contaminated soils.
文摘Arson presents a challenging crime scene for fire investigators worldwide. Key to the investigation of suspected arson cases is the analysis of fire debris for the presence of accelerants or ignitable liquids. This study has investigated the application and method development of vapor phase mid-Infrared (mid-IR) spectroscopy using a field portable quantum cascade laser (QCL) based system for the detection and identification of accelerant residues such as gasoline, diesel, and ethanol in fire debris. A searchable spectral library of various ignitable fluids and fuel components measured in the vapor phase was constructed that allowed for real-time identification of accelerants present in samples using software developed in-house. Measurement of vapors collected from paper material that had been doused with an accelerant followed by controlled burning and then extinguished with water showed that positive identification could be achieved for gasoline, diesel, and ethanol. This vapor phase mid-IR QCL method is rapid, easy to use, and has the sensitivity and discrimination capability that make it well suited for non-destructive crime scene sample analysis. Sampling and measurement can be performed in minutes with this 7.5 kg instrument. This vibrational spectroscopic method required no time-consuming sample pretreatment or complicated solvent extraction procedure. The results of this initial feasibility study demonstrate that this portable fire debris analyzer would greatly benefit arson investigators performing analysis on-site.
文摘It is an important issue to numerically solve the time fractional Schrödinger equation on unbounded domains, which models the dynamics of optical solitons propagating via optical fibers. The perfectly matched layer approach is applied to truncate the unbounded physical domain, and obtain an initial boundary value problem on a bounded computational domain, which can be efficiently solved by the finite difference method. The stability of the reduced initial boundary value problem is rigorously analyzed. Some numerical results are presented to illustrate the accuracy and feasibility of the perfectly matched layer approach. According to these examples, the absorption parameters and the width of the absorption layer will affect the absorption effect. The larger the absorption width, the better the absorption effect. There is an optimal absorption parameter, the absorption effect is the best.
基金The financial supports to this work from the National Natural Science Foundation of China under the projects Nos.51674183,51904215 and 51874220 are gratefully acknowledgedsupported by the Natural Science Foundation of Hubei Province of China(2018CFB468)the Excellent Dissertation Cultivation Funds of Wuhan University of Technology(2018-YS-050).
文摘In this work,MoS2@montmorillonite nanosheets hollow microspheres(MoS2@MMTNS-HMS)with a novel morphology structure was successfully synthesized through loading MoS2 to the surface of MMTNS-HMS via hydrothermal method.The novel material has been characterized through the measurements of SEM,TEM,Raman spectra and UV–vis absorption spectra.The results have shown that MoS2@MMTNS-HMS emerges higher light-utilization efficiency,density of edge active sites and separation of photoelectrons,owing to its unique hollow structure,vertically-aligned MoS2 nanosheets,which greatly enhances its photocatalytic activity.Furthermore,the cycle stability of MoS2@MMTNS-HMS is much higher than that of pristine MoS2,which is attributed to that MMTNS-HMS greatly inhibits the oxidation of MoS2 during photocatalytic.MoS2@MMTNS-HMS could be a promising photocatalyst for the applications in the elimination of organic pollutants.
基金financially supported by the National Natural Science Foundation of China(32201969)Natural Science Foundation of Henan Province(212300410297)+3 种基金Basic Research Plan of Higher Education School Key Scientific Research Project of Henan Province(21A550014)Doctoral Research Foundation of Zhengzhou University of Light Industry(2020BSJJ015)Program for Science and Technology Innovation Talents in Universities of Henan Province(20HASTIT037)Youth Talents Project of Henan Province(2020HYTP046).
文摘Diabetes mellitus(DM)is a common multifactorial disease,causing various complications,such as chronic metabolism.The current therapies for diabetes mellitus are commercial diabetic drugs that have different definite side effect.However,polysaccharides mainly extracted from natural resources,have advantages of safety,accessibility,and anti-diabetic potential.We have summarized recent research of natural polysaccharides with hypoglycemic activities,focusing on different pharmacological mechanisms in various cell and animal models.The relationships of structure-hypoglycemic effect are also discussed in detail.This review could provide a comprehensive perspective for better understanding on development and mechanism of natural polysaccharides against diabetes mellitus,which have been required by clinical studies yet.
基金supported by the National Key Research and Development Program of China(Grant No.:2018YFC0807402)the National Natural Science Foundation of China(Grant No.:82073810)。
文摘In this study,we developed a novel on-line solid phase extraction(SPE)-ultra-high-performance liquid chromatography tandem mass spectrometry(UHPLC-MS/MS)-based analytical method for simultaneously quantifying 12 illicit drugs and metabolites(methamphetamine,amphetamine,morphine,codeine,6-monoacetylmorphine,benzoylecgonine,3,4-methylenedioxymethamphetamine,3,4-methylenedioxyamphetamine,cocaine,ketamine,norketamine,and methcathinone)and cotinine(COT)in wastewater samples.The analysis was performed by loading 2 m L of the sample onto an Oasis hydrophilic-lipophilic balance cartridge and using a cleanup step(5%methanol)to eliminate interference with a total run time of 13 min.The isotope-labeled internal standard method was used to quantify the target substances and correct for unavoidable losses and matrix effects during the on-line SPE process.Typical analytical characteristics used for method validation were sensitivity,linearity,precision,repeatability,recovery,and matrix effects.The limit of detection(LOD)and limit of quantification(LOQ)of each target were set at 0.20 ng/L and 0.50 ng/L,respectively.The linearity was between 0.5 ng/L and250 ng/L,except for that of COT.The intra-and inter-day precisions were<10.45%and 25.64%,respectively,and the relative recovery ranged from 83.74%to 162.26%.The method was used to analyze various wastewater samples from 33 cities in China,and the results were compared with the experimental results of identical samples analyzed using off-line SPE.The difference rate was between 19.91%and-20.44%,and the error range could be considered acceptable.These findings showed that on-line SPE is a suitable alternative to off-line SPE for the analysis of illicit drugs in samples.
