The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central n...The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be used to treat these disorders. We concluded that there are few clinical drugs that can improve the pathology these diseases by acting on potassium or calcium ions. Although a few novel ion-channelspecific modulators have been discovered, meaningful therapies have largely not yet been realized. The lack of target-specific drugs, their requirement to cross the blood–brain barrier, and their exact underlying mechanisms all need further attention. This review aims to explain the urgent problems that need research progress and provide comprehensive information aiming to arouse the research community's interest in the development of ion channel-targeting drugs and the identification of new therapeutic targets for that can increase the cure rate of nervous system diseases and reduce the occurrence of adverse reactions in other systems.展开更多
The aim of this study was to investigate the role of Dendrobium officinale crude polysaccharides(DOPS)and D.officinale purified polysaccharides(DOPS100)in attenuating immune dysfunction in subfertile mice.The results ...The aim of this study was to investigate the role of Dendrobium officinale crude polysaccharides(DOPS)and D.officinale purified polysaccharides(DOPS100)in attenuating immune dysfunction in subfertile mice.The results of the study revealed several noteworthy findings.First,DOPS and DOPS100 treatments led to significant improvement in weight gain and reversal of fatigue-related behaviors compared to the normal group.Second,both DOPS and DOPS100 showed effectiveness in reducing immune organ swelling,modulating immunoglobulin A(IgA)and immunoglobulin M(IgM)levels,and restoring complement(C3c and C4)levels.In addition,they demonstrated a significant ability to enhance the integrity of the intestinal mechanical barrier by differentially upregulating the tight junction proteins Occludin and Zonula occludens 1(ZO-1).In addition,it was found that DOPS100 specifically enhanced the CD4^(+)-T helper 17 cell(Th17)/regulatory T cell(Treg)immune axis in the gut,as evidenced by increased expression of forkhead box protein 3(Foxp3)as well as decreased expression of retinoic acid receptor-related orphan receptor γt(RORγt),and further modulation of interleukin 10(IL-10),interleukin 22(IL-22),and interleukin 17A(IL-17A)expression levels of inflammatory factors.These findings collectively suggest that DOPS100 holds significant potential in improving sub-healthy status by repairing the intestinal barrier,restoring local immune homeostasis,and activating the intestinal immune regulatory network.The study’s outcomes provide valuable insights into the therapeutic implications of DOPS and DOPS100 in addressing immune dysfunction in sub-healthy conditions.展开更多
Sharp eyespot(Rhizoctonia cerealis)is a widespread soil-borne fungal disease that poses a severe threat to wheat health,and it is one of the main obstacles to achieving stable and high-quality wheat yields in China.Ou...Sharp eyespot(Rhizoctonia cerealis)is a widespread soil-borne fungal disease that poses a severe threat to wheat health,and it is one of the main obstacles to achieving stable and high-quality wheat yields in China.Our collaborative team has developed a novel,efficient,and low-toxicity fungicide named Y17991(N-(2-(2,4-bis-(trifluoromethyl)phenoxy)phenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide).Preliminary laboratory tests confirmed the significant inhibitory effect of this agent on R.cerealis.Large-area field trials also demonstrated its efficacy,with a disease prevention index of 83.52%,which is 1.97%greater than that of the widely used thifluzamide,and it significantly increased the wheat yield.Moreover,this study explored the impacts of Y17991 on the structure and function of the microbial community in wheat rhizosphere soil.Bacterial communities were more strongly affected than fungal communities.Y17991 significantly modulated key amino acid metabolic pathways and certain biosynthetic processes in diseased wheat rhizospheres,and it also enhanced certain biosynthetic pathways and metabolic activities in healthy wheat rhizospheres.Additionally,the application of Y17991 regulated rhizosphere metabolites,thus exerting significant control over the microbial community.We identified 15 microbial strains potentially involved in the prevention and treatment of R.cerealis,and Y17991 treatment promoted the growth of Pedobacter and Bacillus strains.These strains not only aid in plant growth but they also have the potential for disease prevention.In summary,Y17991 application at a reasonable dose does not cause significant disruption to nontarget rhizosphere microbial communities.In future studies,we will continue to investigate the impacts of Y17991 on nonmicrobial components in soil ecosystems,such as protozoa and nematodes.Our research provides a theoretical basis for the scientific application and promotion of new fungicides and offers a significant reference for establishing a comprehensive system for assessing the ecological impact of pesticides on the environment.展开更多
Vibration energy harvesting presents a significant opportunity for powering wireless sensor networks and internet of things(IoT)devices,offering a sustainable alternative to traditional battery-based power sources.How...Vibration energy harvesting presents a significant opportunity for powering wireless sensor networks and internet of things(IoT)devices,offering a sustainable alternative to traditional battery-based power sources.However,environmental vibrations are predominantly low-frequency,which presents a significant challenge to the efficient conversion of such energy.To address this challenge,this paper proposes a novel twodegree-of-freedom(2-DOF)energy harvester.The first layer of the harvester incorporates a piezoelectric composite beam(PCB)paired with permanent magnets to form a negative stiffness mechanism(NSM),which counteracts the stiffness of linear springs,thereby achieving quasi-zero stiffness(QZS)or bistable characteristics.The second layer integrates piezoelectric transduction units with triboelectric nanogenerator(TENG)units to further enhance the efficiency of low-frequency vibration energy conversion.By considering the modal characteristics of the PCB,this paper establishes the electromechanical coupling equations of the harvester from an energy perspective.The mechanical responses of the masses in both layers,as well as the electrical outputs of the PCB,are analytically solved.Furthermore,the effects of the system parameters on the efficiency of low-frequency vibration energy harvesting are thoroughly analyzed.This work provides a theoretical foundation for the development of self-powered IoT sensor nodes,enabling efficient energy harvesting from ambient low-frequency vibrations.展开更多
Ultra-performance liquid chromatography-mass spectrometry(UPLC-MS)technology was employed to analyze the chemical composition of three Clematidis Radix et Rhizoma sourced from different origins.Common characteristic c...Ultra-performance liquid chromatography-mass spectrometry(UPLC-MS)technology was employed to analyze the chemical composition of three Clematidis Radix et Rhizoma sourced from different origins.Common characteristic components were identified through comprehensive literature review and the integration of fragment ion data.A rheumatoid arthritis(AA)model was induced in Sprague-Dawley(SD)rats using Freund’s complete adjuvant,and simultaneous administration of extracts from the three original plants of Clematidis Radix et Rhizoma,along with different doses of magnoflorine,was conducted to evaluate differences in therapeutic efficacy.A common characteristic component was identified,magnoflorine,present in Clematis chinensis Osbeck.Clematis hexapetala Pall.,and Clematis manshurica Rupr.Extracts from all three original plants,as well as each dose group of the Rhizomas of Clematis chinensis Osbeck.Clematis hexapetala Pall.,Clematis manshurica Rupr.,and magnoflorine,demonstrated efficacy in alleviating rheumatoid arthritis symptoms by enhancing cellular infiltration,reducing vascular opacification,and lowering serum levels of inflammatory factors.Magnoflorine has the potential to be used as a quality marker for the three original plants of Clematidis Radix et Rhizoma.Additionally,both the three original plants and magnoflorine exhibit therapeutic potential for rheumatoid arthritis,which provides a solid theoretical and experimental basis for the establishment of more scientifically grounded quality standards of Clematidis Radix et Rhizoma and promotes the rational utilization of medicinal resources.展开更多
The effects of direct aging(DA)on the microstructure and mechanical properties of TiB_(2)/AlSi7Mg alloys fabricated via laser powder bed fusion(LPBF)were systematically investigated.DA significantly improves strength ...The effects of direct aging(DA)on the microstructure and mechanical properties of TiB_(2)/AlSi7Mg alloys fabricated via laser powder bed fusion(LPBF)were systematically investigated.DA significantly improves strength while maintaining satisfactory ductility.Optimal performance is obtained through under-aging(UA)at 150℃ for 4 h,resulting in a yield strength of 361 MPa,tensile strength of 503 MPa,and elongation of 9.1%in the horizontal direction.DA does not substantially alter the grain size or cellular structure but pro-motes the formation of nanoprecipitates within theα-Al matrix.Specifically,UA induces dot-like and needle-like Si precipitates,whereas over-aging(OA)additionally generates short rod-likeβ'-Mg_(1.8)Si phases.The strengthening mechanism is attributed to the Hall-Petch ef-fect associated with grain and cell boundaries,and the Orowan mechanism induced by nanoprecipitates.Work-hardening behavior is gov-erned by interactions between dislocations and nanoprecipitates.The OA sample exhibits rapid saturation of work hardening due to a high initial hardening rate and dynamic recovery of dislocations,resulting in limited uniform elongation.In contrast,the UA sample demon-strates a more balanced work hardening response.These findings provide theoretical and experimental validation of DA as an effective post-processing approach aimed at enhancing the performance of LPBF Al-Si-Mg alloys in engineering applications.展开更多
Enterovirus D68(EV-D68)and enterovirus A71(EV-A71)are two major types of enteroviruses that pose emerging challenges to public health and have the potential to cause outbreaks,yet their pathogenic mechanisms remain la...Enterovirus D68(EV-D68)and enterovirus A71(EV-A71)are two major types of enteroviruses that pose emerging challenges to public health and have the potential to cause outbreaks,yet their pathogenic mechanisms remain largely unexplored.Arrestin domain containing 3(ARRDC3)is a vital regulator of glucose metabolism,cancer development,and inflammation.Whether ARRDC3 contributes to innate antiviral immunity is undefined.Here,we found that enterovirus infection induces ARRDC3 expression at both the mRNA and protein levels,thereby inhibiting enterovirus replication.Moreover,we demonstrate that the expression of Yes-associated protein(YAP),a key effector of the Hippo pathway,is severely downregulated by ARRDC3 via lysosomal pathway.YAP facilitates enterovirus replication by suppressing the interferon pathway during the later stage of enterovirus infection,independent of its transcriptional activity.Finally,the ARRDC3-YAP pathway exhibits a broad-spectrum antiviral effect in various viral infections,including those caused by human parainfluenza virus type 3(HPIV3)and vesicular stomatitis virus(VSV).Collectively,our results identify the critical role of ARRDC3 and its negative regulatory effect on YAP in the innate antiviral response,suggesting a novel therapeutic strategy against virus infection.展开更多
For non-stationary complex dynamic systems,a standardized algorithm is developed to compute time correlation functions,addressing the limitations of traditional methods reliant on the stationary assumption.The propose...For non-stationary complex dynamic systems,a standardized algorithm is developed to compute time correlation functions,addressing the limitations of traditional methods reliant on the stationary assumption.The proposed algorithm integrates two-point and multi-point time correlation functions into a unified framework.Further,it is verified by a practical application in complex financial systems,demonstrating its potential in various complex dynamic systems.展开更多
Topography can strongly affect ground motion,and studies of the quantification of hill surfaces’topographic effect are relatively rare.In this paper,a new quantitative seismic topographic effect prediction method bas...Topography can strongly affect ground motion,and studies of the quantification of hill surfaces’topographic effect are relatively rare.In this paper,a new quantitative seismic topographic effect prediction method based upon the BP neural network algorithm and three-dimensional finite element method(FEM)was developed.The FEM simulation results were compared with seismic records and the results show that the PGA and response spectra have a tendency to increase with increasing elevation,but the correlation between PGA amplification factors and slope is not obvious for low hills.New BP neural network models were established for the prediction of amplification factors of PGA and response spectra.Two kinds of input variables’combinations which are convenient to achieve are proposed in this paper for the prediction of amplification factors of PGA and response spectra,respectively.The absolute values of prediction errors can be mostly within 0.1 for PGA amplification factors,and they can be mostly within 0.2 for response spectra’s amplification factors.One input variables’combination can achieve better prediction performance while the other one has better expandability of the predictive region.Particularly,the BP models only employ one hidden layer with about a hundred nodes,which makes it efficient for training.展开更多
This study investigated the effect of magnesium application on peanut growth and yield under two nitrogen(N)application rates in acidic soil in southern China.The chlorophyll content,net photosynthetic rate and dry ma...This study investigated the effect of magnesium application on peanut growth and yield under two nitrogen(N)application rates in acidic soil in southern China.The chlorophyll content,net photosynthetic rate and dry matter accumulation of the N-sensitive cultivar decreased under reduced N treatments,whereas no effect was observed on the relevant indicators in the N-insensitive variety GH1026.Mg application increased the net photosynthetic rate by increasing the expression of genes involved in chlorophyll synthesis and Rubisco activity in the leaves during the pegging stage under 50%N treatment,while no effect on the net photosynthetic rate was observed under the 100%N treatment.The rate of dry matter accumulation at the early growth stage,total dry matter accumulation and pod yield at harvest increased after Mg application under 50%N treatment by increasing the transportation of assimilates from stems and leaves to pods in both peanut varieties,whereas no effect was found under 100%N treatment.Moreover,Mg application increased the NUE under 50%N treatment.No improvement of NUE in either peanut variety was found under 100%N treatment,while Mg application under the 50%N treatment can obtain a higher economic benefit than the 100%N treatment.In acidic soil,application of 307.5 kg ha^(-1)of Mg sulfate fertilizer under 50%reduced nitrogen application is a suitable fertilizer management measure for improving carbon assimilation,NUE and achieve high peanut yields in southern China.展开更多
The Diagnostic and Statistical Manual of Mental Disorders,5th Edition(DSM-5)(American Psychiatric Association,2013)defines autism spectrum disorder(ASD)as a complex neurodevelopmental disorder that begins in early chi...The Diagnostic and Statistical Manual of Mental Disorders,5th Edition(DSM-5)(American Psychiatric Association,2013)defines autism spectrum disorder(ASD)as a complex neurodevelopmental disorder that begins in early childhood and is accompanied by social communication deficits and repetitive stereotyped behaviors.展开更多
Streptococcal toxic shock syndrome(STSS)is an acute,life-threatening illness caused by invasive group A Streptococcus(iGAS).The initial manifestations of STSS are atypical,and may progress to shock,multiple organ dysf...Streptococcal toxic shock syndrome(STSS)is an acute,life-threatening illness caused by invasive group A Streptococcus(iGAS).The initial manifestations of STSS are atypical,and may progress to shock,multiple organ dysfunction syndrome(MODS),and disseminated intravascular coagulation(DIC)quickly.展开更多
Although visible femtosecond lasers based on nonlinear frequency conversion of Ti:sapphire femtosecond oscillators or near-infrared ultrafast lasers have been well developed,limitations in terms of footprint,cost,and ...Although visible femtosecond lasers based on nonlinear frequency conversion of Ti:sapphire femtosecond oscillators or near-infrared ultrafast lasers have been well developed,limitations in terms of footprint,cost,and efficiency have called for alternative laser solutions.The fiber femtosecond mode-locked oscillator as an ideal solution has achieved great success in the 0.9 to 3.5μm infrared wavelengths,but remains an outstanding challenge in the visible spectrum(390 to 780 nm).Here,we tackle this challenge by introducing a visible-wavelength mode-locked femtosecond fiber oscillator along with an amplifier.This fiber femtosecond oscillator emits red light at 635 nm,employs a figure-nine cavity configuration,applies a double-clad Pr3þ-doped fluoride fiber as the visible gain medium,incorporates a visible-wavelength phase-biased nonlinear amplifying loop mirror(PB-NALM)for mode locking,and utilizes a pair of customized high-efficiency and high-groove-density diffraction gratings for dispersion management.Visible self-starting mode locking established by the PB-NALM directly yields red laser pulses with a minimum pulse duration of 196 fs and a repetition rate of 53.957 MHz from the oscillator.Precise control of the grating pair spacing can switch the pulse state from a dissipative soliton or a stretched-pulse soliton to a conventional soliton.In addition,a chirped-pulse amplification system built alongside the oscillator immensely boosts the laser performance,resulting in an average output power over 1W,a pulse energy of 19.55 nJ,and a dechirped pulse duration of 230 fs.Our result represents a concrete step toward high-power femtosecond fiber lasers covering the visible spectral region and could have important applications in industrial processing,biomedicine,and scientific research.展开更多
It is common for datasets to contain both categorical and continuous variables. However, many feature screening methods designed for high-dimensional classification assume that the variables are continuous. This limit...It is common for datasets to contain both categorical and continuous variables. However, many feature screening methods designed for high-dimensional classification assume that the variables are continuous. This limits the applicability of existing methods in handling this complex scenario. To address this issue, we propose a model-free feature screening approach for ultra-high-dimensional multi-classification that can handle both categorical and continuous variables. Our proposed feature screening method utilizes the Maximal Information Coefficient to assess the predictive power of the variables. By satisfying certain regularity conditions, we have proven that our screening procedure possesses the sure screening property and ranking consistency properties. To validate the effectiveness of our approach, we conduct simulation studies and provide real data analysis examples to demonstrate its performance in finite samples. In summary, our proposed method offers a solution for effectively screening features in ultra-high-dimensional datasets with a mixture of categorical and continuous covariates.展开更多
Compared to drought-susceptible rice cultivars(DSRs),drought-resistance rice cultivars(DRRs)could drastically reduce the amount of irrigation water input and simultaneously result in higher grain yield under water-sav...Compared to drought-susceptible rice cultivars(DSRs),drought-resistance rice cultivars(DRRs)could drastically reduce the amount of irrigation water input and simultaneously result in higher grain yield under water-saving irrigation conditions.However,the mechanisms underlying these properties are unclear.We investigated how improved agronomic traits contribute to higher yield and higher water use efficiency(WUE)in DRRs than in DSRs under alternate wetting and drying(AWD).Two DRRs and two DSRs were field-grown in 2015 and 2016 using two different irrigation regimes:continuous flooding(CF)and AWD.Under CF,no statistical differences in grain yield and WUE were observed between DRRs and DSRs.Irrigation water under the AWD regime was 275–349 mm,an amount 49.8%–56.2% of that(552–620 mm)applied under the CF regime.Compared to CF,AWD significantly decreased grain yield in both DRRs and DSRs,with a more significant reduction in DSRs,and WUE was increased in DRRs,but not in DSRs,by 9.9%–23.0% under AWD.Under AWD,DRRs showed a 20.2%–26.2% increase in grain yield and an 18.6%–24.5% increase in WUE compared to DSRs.Compared to DSRs,DRRs showed less redundant vegetative growth,greater sink capacity,higher grain filling efficiency,larger root biomass,and deeper root distribution under AWD.We conclude that these improved agronomic traits exert positive influences on WUE in DRRs under AWD.展开更多
基金supported by the National Natural Science Foundation of China,Nos.81901098(to TC),82201668(to HL)Fujian Provincial Health Technology Project,No.2021QNA072(to HL)。
文摘The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be used to treat these disorders. We concluded that there are few clinical drugs that can improve the pathology these diseases by acting on potassium or calcium ions. Although a few novel ion-channelspecific modulators have been discovered, meaningful therapies have largely not yet been realized. The lack of target-specific drugs, their requirement to cross the blood–brain barrier, and their exact underlying mechanisms all need further attention. This review aims to explain the urgent problems that need research progress and provide comprehensive information aiming to arouse the research community's interest in the development of ion channel-targeting drugs and the identification of new therapeutic targets for that can increase the cure rate of nervous system diseases and reduce the occurrence of adverse reactions in other systems.
基金supported by the National Natural Science Foundation of China(82274134)the National Key R&D Plan(2017YFC1702200,2017YFC1702202)+1 种基金Key R&D Program Projects in Zhejiang Province(2020C04020)the Key Research and Development Program of Zhejiang Province(2025C02183).
文摘The aim of this study was to investigate the role of Dendrobium officinale crude polysaccharides(DOPS)and D.officinale purified polysaccharides(DOPS100)in attenuating immune dysfunction in subfertile mice.The results of the study revealed several noteworthy findings.First,DOPS and DOPS100 treatments led to significant improvement in weight gain and reversal of fatigue-related behaviors compared to the normal group.Second,both DOPS and DOPS100 showed effectiveness in reducing immune organ swelling,modulating immunoglobulin A(IgA)and immunoglobulin M(IgM)levels,and restoring complement(C3c and C4)levels.In addition,they demonstrated a significant ability to enhance the integrity of the intestinal mechanical barrier by differentially upregulating the tight junction proteins Occludin and Zonula occludens 1(ZO-1).In addition,it was found that DOPS100 specifically enhanced the CD4^(+)-T helper 17 cell(Th17)/regulatory T cell(Treg)immune axis in the gut,as evidenced by increased expression of forkhead box protein 3(Foxp3)as well as decreased expression of retinoic acid receptor-related orphan receptor γt(RORγt),and further modulation of interleukin 10(IL-10),interleukin 22(IL-22),and interleukin 17A(IL-17A)expression levels of inflammatory factors.These findings collectively suggest that DOPS100 holds significant potential in improving sub-healthy status by repairing the intestinal barrier,restoring local immune homeostasis,and activating the intestinal immune regulatory network.The study’s outcomes provide valuable insights into the therapeutic implications of DOPS and DOPS100 in addressing immune dysfunction in sub-healthy conditions.
基金supported by the National Natural Science Foundation of China(32270296)the Shenzhen Postdoctoral Scientific Research,China(77000-42100004)+1 种基金the Key Basic Research and Development Program of Hubei Province,China(2020BBA052)the Natural Science Foundation of Guangdong Province,China(2024A1515010498)and the Fundamental Research Funds for the Central Universities,Sun Yat-sen University,China.
文摘Sharp eyespot(Rhizoctonia cerealis)is a widespread soil-borne fungal disease that poses a severe threat to wheat health,and it is one of the main obstacles to achieving stable and high-quality wheat yields in China.Our collaborative team has developed a novel,efficient,and low-toxicity fungicide named Y17991(N-(2-(2,4-bis-(trifluoromethyl)phenoxy)phenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide).Preliminary laboratory tests confirmed the significant inhibitory effect of this agent on R.cerealis.Large-area field trials also demonstrated its efficacy,with a disease prevention index of 83.52%,which is 1.97%greater than that of the widely used thifluzamide,and it significantly increased the wheat yield.Moreover,this study explored the impacts of Y17991 on the structure and function of the microbial community in wheat rhizosphere soil.Bacterial communities were more strongly affected than fungal communities.Y17991 significantly modulated key amino acid metabolic pathways and certain biosynthetic processes in diseased wheat rhizospheres,and it also enhanced certain biosynthetic pathways and metabolic activities in healthy wheat rhizospheres.Additionally,the application of Y17991 regulated rhizosphere metabolites,thus exerting significant control over the microbial community.We identified 15 microbial strains potentially involved in the prevention and treatment of R.cerealis,and Y17991 treatment promoted the growth of Pedobacter and Bacillus strains.These strains not only aid in plant growth but they also have the potential for disease prevention.In summary,Y17991 application at a reasonable dose does not cause significant disruption to nontarget rhizosphere microbial communities.In future studies,we will continue to investigate the impacts of Y17991 on nonmicrobial components in soil ecosystems,such as protozoa and nematodes.Our research provides a theoretical basis for the scientific application and promotion of new fungicides and offers a significant reference for establishing a comprehensive system for assessing the ecological impact of pesticides on the environment.
基金supported by the National Key R&D Program of China(No.2024YFB3408700)the National Natural Science Foundation of China(Nos.12272129 and 12122206)+1 种基金the Natural Science Foundation of Hunan Province(Nos.2024JJ4004 and 2024JJ3003)the Postgraduate Scientific Research Innovation of Hunan Province(No.CX20240444)。
文摘Vibration energy harvesting presents a significant opportunity for powering wireless sensor networks and internet of things(IoT)devices,offering a sustainable alternative to traditional battery-based power sources.However,environmental vibrations are predominantly low-frequency,which presents a significant challenge to the efficient conversion of such energy.To address this challenge,this paper proposes a novel twodegree-of-freedom(2-DOF)energy harvester.The first layer of the harvester incorporates a piezoelectric composite beam(PCB)paired with permanent magnets to form a negative stiffness mechanism(NSM),which counteracts the stiffness of linear springs,thereby achieving quasi-zero stiffness(QZS)or bistable characteristics.The second layer integrates piezoelectric transduction units with triboelectric nanogenerator(TENG)units to further enhance the efficiency of low-frequency vibration energy conversion.By considering the modal characteristics of the PCB,this paper establishes the electromechanical coupling equations of the harvester from an energy perspective.The mechanical responses of the masses in both layers,as well as the electrical outputs of the PCB,are analytically solved.Furthermore,the effects of the system parameters on the efficiency of low-frequency vibration energy harvesting are thoroughly analyzed.This work provides a theoretical foundation for the development of self-powered IoT sensor nodes,enabling efficient energy harvesting from ambient low-frequency vibrations.
基金support from various sources including 2023 Basic Research Project of Colleges and Universities of Liaoning Provincial Department of Education(JYTZD2023137)Career Development Support Plan for Young and Middle-aged Teachers in Shenyang Pharmaceutical University(ZQN2021014)+2 种基金2024 Basic Scientific Research Funding Project of Liaoning Provincial Department of Education(LJ212410163051)Liaoning Province Science and Technology Plan Joint Plan(2024-MSLH-448)Liaoning Provincial Innovation Capacity Promotion Joint Fund(2022-NLTS-12-01).
文摘Ultra-performance liquid chromatography-mass spectrometry(UPLC-MS)technology was employed to analyze the chemical composition of three Clematidis Radix et Rhizoma sourced from different origins.Common characteristic components were identified through comprehensive literature review and the integration of fragment ion data.A rheumatoid arthritis(AA)model was induced in Sprague-Dawley(SD)rats using Freund’s complete adjuvant,and simultaneous administration of extracts from the three original plants of Clematidis Radix et Rhizoma,along with different doses of magnoflorine,was conducted to evaluate differences in therapeutic efficacy.A common characteristic component was identified,magnoflorine,present in Clematis chinensis Osbeck.Clematis hexapetala Pall.,and Clematis manshurica Rupr.Extracts from all three original plants,as well as each dose group of the Rhizomas of Clematis chinensis Osbeck.Clematis hexapetala Pall.,Clematis manshurica Rupr.,and magnoflorine,demonstrated efficacy in alleviating rheumatoid arthritis symptoms by enhancing cellular infiltration,reducing vascular opacification,and lowering serum levels of inflammatory factors.Magnoflorine has the potential to be used as a quality marker for the three original plants of Clematidis Radix et Rhizoma.Additionally,both the three original plants and magnoflorine exhibit therapeutic potential for rheumatoid arthritis,which provides a solid theoretical and experimental basis for the establishment of more scientifically grounded quality standards of Clematidis Radix et Rhizoma and promotes the rational utilization of medicinal resources.
基金supported by the National Natural Science Foundation of China(No.52204393)the Ningbo International Science and Technology Cooperation Program,China(No.2023H004).
文摘The effects of direct aging(DA)on the microstructure and mechanical properties of TiB_(2)/AlSi7Mg alloys fabricated via laser powder bed fusion(LPBF)were systematically investigated.DA significantly improves strength while maintaining satisfactory ductility.Optimal performance is obtained through under-aging(UA)at 150℃ for 4 h,resulting in a yield strength of 361 MPa,tensile strength of 503 MPa,and elongation of 9.1%in the horizontal direction.DA does not substantially alter the grain size or cellular structure but pro-motes the formation of nanoprecipitates within theα-Al matrix.Specifically,UA induces dot-like and needle-like Si precipitates,whereas over-aging(OA)additionally generates short rod-likeβ'-Mg_(1.8)Si phases.The strengthening mechanism is attributed to the Hall-Petch ef-fect associated with grain and cell boundaries,and the Orowan mechanism induced by nanoprecipitates.Work-hardening behavior is gov-erned by interactions between dislocations and nanoprecipitates.The OA sample exhibits rapid saturation of work hardening due to a high initial hardening rate and dynamic recovery of dislocations,resulting in limited uniform elongation.In contrast,the UA sample demon-strates a more balanced work hardening response.These findings provide theoretical and experimental validation of DA as an effective post-processing approach aimed at enhancing the performance of LPBF Al-Si-Mg alloys in engineering applications.
基金supported by the National Natural Science Foundation of China(31600139)the Chongqing Science and Technology Bureau(cstc2016jcyjA0020+3 种基金CSTB2024NSCQ-KJFZMSX0067)the Yuzhong District Science and Technology Commission(20190123)the Chongqing Municipal Education Commission(KJQN202300415)the Project of Undergraduates Innovating Experiment,and the Project of Tutorial System of Excellent Medical Undergraduates in the Lab Teaching and Management Center of Chongqing Medical University(S202410631068,LTMCMTS202458,LTMCMTS202459,LTMCMTS202460 and LTMCMTS202461).
文摘Enterovirus D68(EV-D68)and enterovirus A71(EV-A71)are two major types of enteroviruses that pose emerging challenges to public health and have the potential to cause outbreaks,yet their pathogenic mechanisms remain largely unexplored.Arrestin domain containing 3(ARRDC3)is a vital regulator of glucose metabolism,cancer development,and inflammation.Whether ARRDC3 contributes to innate antiviral immunity is undefined.Here,we found that enterovirus infection induces ARRDC3 expression at both the mRNA and protein levels,thereby inhibiting enterovirus replication.Moreover,we demonstrate that the expression of Yes-associated protein(YAP),a key effector of the Hippo pathway,is severely downregulated by ARRDC3 via lysosomal pathway.YAP facilitates enterovirus replication by suppressing the interferon pathway during the later stage of enterovirus infection,independent of its transcriptional activity.Finally,the ARRDC3-YAP pathway exhibits a broad-spectrum antiviral effect in various viral infections,including those caused by human parainfluenza virus type 3(HPIV3)and vesicular stomatitis virus(VSV).Collectively,our results identify the critical role of ARRDC3 and its negative regulatory effect on YAP in the innate antiviral response,suggesting a novel therapeutic strategy against virus infection.
基金Project supported by the Postdoctoral Fellowship Program of China Postdoctoral Science Foundation(Grant No.GZC20231050)the National Natural Science Foundation of China(Grant Nos.12175193 and 11905183)the 13th Five-year plan for Education Science Funding of Guangdong Province(Grant No.2021GXJK349)。
文摘For non-stationary complex dynamic systems,a standardized algorithm is developed to compute time correlation functions,addressing the limitations of traditional methods reliant on the stationary assumption.The proposed algorithm integrates two-point and multi-point time correlation functions into a unified framework.Further,it is verified by a practical application in complex financial systems,demonstrating its potential in various complex dynamic systems.
基金supported by the National Natural Science Foundation of China(No.51878625)the Collaboratory for the Study of Earthquake Predictability in China Seismic Experimental Site(No.2018YFE0109700)the General Scientific Research Foundation of Shandong Earthquake Agency(No.YB2208).
文摘Topography can strongly affect ground motion,and studies of the quantification of hill surfaces’topographic effect are relatively rare.In this paper,a new quantitative seismic topographic effect prediction method based upon the BP neural network algorithm and three-dimensional finite element method(FEM)was developed.The FEM simulation results were compared with seismic records and the results show that the PGA and response spectra have a tendency to increase with increasing elevation,but the correlation between PGA amplification factors and slope is not obvious for low hills.New BP neural network models were established for the prediction of amplification factors of PGA and response spectra.Two kinds of input variables’combinations which are convenient to achieve are proposed in this paper for the prediction of amplification factors of PGA and response spectra,respectively.The absolute values of prediction errors can be mostly within 0.1 for PGA amplification factors,and they can be mostly within 0.2 for response spectra’s amplification factors.One input variables’combination can achieve better prediction performance while the other one has better expandability of the predictive region.Particularly,the BP models only employ one hidden layer with about a hundred nodes,which makes it efficient for training.
基金supported by the Guangdong Technical System of Peanut and Soybean Industry(2023KJ136-05)China Agriculture Research System(CARS-15)。
文摘This study investigated the effect of magnesium application on peanut growth and yield under two nitrogen(N)application rates in acidic soil in southern China.The chlorophyll content,net photosynthetic rate and dry matter accumulation of the N-sensitive cultivar decreased under reduced N treatments,whereas no effect was observed on the relevant indicators in the N-insensitive variety GH1026.Mg application increased the net photosynthetic rate by increasing the expression of genes involved in chlorophyll synthesis and Rubisco activity in the leaves during the pegging stage under 50%N treatment,while no effect on the net photosynthetic rate was observed under the 100%N treatment.The rate of dry matter accumulation at the early growth stage,total dry matter accumulation and pod yield at harvest increased after Mg application under 50%N treatment by increasing the transportation of assimilates from stems and leaves to pods in both peanut varieties,whereas no effect was found under 100%N treatment.Moreover,Mg application increased the NUE under 50%N treatment.No improvement of NUE in either peanut variety was found under 100%N treatment,while Mg application under the 50%N treatment can obtain a higher economic benefit than the 100%N treatment.In acidic soil,application of 307.5 kg ha^(-1)of Mg sulfate fertilizer under 50%reduced nitrogen application is a suitable fertilizer management measure for improving carbon assimilation,NUE and achieve high peanut yields in southern China.
基金supported by the Zhejiang Provincial Natural Science Foundation of China(No.LTGY24H090005)the Autism Research Special Fund of Zhejiang Foundation for Disabled Persons(No.2023006)。
文摘The Diagnostic and Statistical Manual of Mental Disorders,5th Edition(DSM-5)(American Psychiatric Association,2013)defines autism spectrum disorder(ASD)as a complex neurodevelopmental disorder that begins in early childhood and is accompanied by social communication deficits and repetitive stereotyped behaviors.
基金Zhejiang Province Health Innovative Talent Project(A0466)Key Projects of the Science and Technology Co-construction by National Administration of Traditional Chinese Medicine and Zhejiang Provincial Administration of Traditional Chinese Medicine(GZY-ZJ-KJ-23082).
文摘Streptococcal toxic shock syndrome(STSS)is an acute,life-threatening illness caused by invasive group A Streptococcus(iGAS).The initial manifestations of STSS are atypical,and may progress to shock,multiple organ dysfunction syndrome(MODS),and disseminated intravascular coagulation(DIC)quickly.
基金supported by the National Natural Science Foundation of China (Grant Nos.62022069,62235014,and 62305275)the Shenzhen Science and Technology Projects (Grant No.JCYJ20210324115813037)the China National Postdoctoral Program for Innovative Talents (Grant No.BX20230199).
文摘Although visible femtosecond lasers based on nonlinear frequency conversion of Ti:sapphire femtosecond oscillators or near-infrared ultrafast lasers have been well developed,limitations in terms of footprint,cost,and efficiency have called for alternative laser solutions.The fiber femtosecond mode-locked oscillator as an ideal solution has achieved great success in the 0.9 to 3.5μm infrared wavelengths,but remains an outstanding challenge in the visible spectrum(390 to 780 nm).Here,we tackle this challenge by introducing a visible-wavelength mode-locked femtosecond fiber oscillator along with an amplifier.This fiber femtosecond oscillator emits red light at 635 nm,employs a figure-nine cavity configuration,applies a double-clad Pr3þ-doped fluoride fiber as the visible gain medium,incorporates a visible-wavelength phase-biased nonlinear amplifying loop mirror(PB-NALM)for mode locking,and utilizes a pair of customized high-efficiency and high-groove-density diffraction gratings for dispersion management.Visible self-starting mode locking established by the PB-NALM directly yields red laser pulses with a minimum pulse duration of 196 fs and a repetition rate of 53.957 MHz from the oscillator.Precise control of the grating pair spacing can switch the pulse state from a dissipative soliton or a stretched-pulse soliton to a conventional soliton.In addition,a chirped-pulse amplification system built alongside the oscillator immensely boosts the laser performance,resulting in an average output power over 1W,a pulse energy of 19.55 nJ,and a dechirped pulse duration of 230 fs.Our result represents a concrete step toward high-power femtosecond fiber lasers covering the visible spectral region and could have important applications in industrial processing,biomedicine,and scientific research.
文摘It is common for datasets to contain both categorical and continuous variables. However, many feature screening methods designed for high-dimensional classification assume that the variables are continuous. This limits the applicability of existing methods in handling this complex scenario. To address this issue, we propose a model-free feature screening approach for ultra-high-dimensional multi-classification that can handle both categorical and continuous variables. Our proposed feature screening method utilizes the Maximal Information Coefficient to assess the predictive power of the variables. By satisfying certain regularity conditions, we have proven that our screening procedure possesses the sure screening property and ranking consistency properties. To validate the effectiveness of our approach, we conduct simulation studies and provide real data analysis examples to demonstrate its performance in finite samples. In summary, our proposed method offers a solution for effectively screening features in ultra-high-dimensional datasets with a mixture of categorical and continuous covariates.
基金the National Key Research and Development Program of China (2016YFD0300507,2016YFD0300108)the National Natural Science Foundation of China (31671630,31671638,31501264)the China Agriculture Research System (CARS-01)
文摘Compared to drought-susceptible rice cultivars(DSRs),drought-resistance rice cultivars(DRRs)could drastically reduce the amount of irrigation water input and simultaneously result in higher grain yield under water-saving irrigation conditions.However,the mechanisms underlying these properties are unclear.We investigated how improved agronomic traits contribute to higher yield and higher water use efficiency(WUE)in DRRs than in DSRs under alternate wetting and drying(AWD).Two DRRs and two DSRs were field-grown in 2015 and 2016 using two different irrigation regimes:continuous flooding(CF)and AWD.Under CF,no statistical differences in grain yield and WUE were observed between DRRs and DSRs.Irrigation water under the AWD regime was 275–349 mm,an amount 49.8%–56.2% of that(552–620 mm)applied under the CF regime.Compared to CF,AWD significantly decreased grain yield in both DRRs and DSRs,with a more significant reduction in DSRs,and WUE was increased in DRRs,but not in DSRs,by 9.9%–23.0% under AWD.Under AWD,DRRs showed a 20.2%–26.2% increase in grain yield and an 18.6%–24.5% increase in WUE compared to DSRs.Compared to DSRs,DRRs showed less redundant vegetative growth,greater sink capacity,higher grain filling efficiency,larger root biomass,and deeper root distribution under AWD.We conclude that these improved agronomic traits exert positive influences on WUE in DRRs under AWD.
