Magnetic absorbers with high permeability have significant advantages in lowfrequency and broadband electromagnetic wave(EMW)absorption.However,the insufficient magnetic loss and inherent high conductivity of existing...Magnetic absorbers with high permeability have significant advantages in lowfrequency and broadband electromagnetic wave(EMW)absorption.However,the insufficient magnetic loss and inherent high conductivity of existing magnetic absorbers limit the further expansion of EMW absorption bandwidth.Herein,the spinel(FeCoNiCrCu)_(3)O_(4) high-entropy oxides(HEO)are successfully constructed on the surface of FeCoNiCr_(0.4)Cu_(0.2) high-entropy alloys(HEA)through low-temperature oxygen bath treatment.On the one hand,HEO and HEA have different magnetocrystalline anisotropies,which is conducive to achieving continuous natural resonance to improve magnetic loss.On the other hand,HEO with low conductivity can serve as an impedance matching layer,achieving magneto-electric co-modulation.When the thickness is 5 mm,the minimum reflection loss(RL)value and absorption bandwidth(RL<−5 dB)of bi-phase high-entropy composites(BPHEC)can reach−12.8 dB and 633 MHz,respectively.The RCS reduction value of multilayer sample with impedance gradient characteristic can reach 18.34 dB m^(2).In addition,the BPHEC also exhibits temperaturestable EMW absorption performance,high Curie temperature,and oxidation resistance.The absorption bandwidth maintains between 593 and 691 MHz from−50 to 150℃.This work offers a new and tunable strategy toward modulating the electromagnetic genes for temperature-stable ultra-broadband megahertz EMW absorption.展开更多
Diplodia tip blight,caused by Diplodia sapinea,is a global pine necrotic disease causing heavy economic losses to the pine industry.Chemical control,its main current management,easily induces pathogen resistance and e...Diplodia tip blight,caused by Diplodia sapinea,is a global pine necrotic disease causing heavy economic losses to the pine industry.Chemical control,its main current management,easily induces pathogen resistance and environmental pollution,which biological control avoids.This study investigated juniper essential oil’s efficacy against the disease on Mongolian Scots pine(Pinus sylvestris var.mongolica)and its induced resistance mechanisms via pot experiments,physiological assays(defense enzyme activities,resistant substances)and metabolomic sequencing(secondary metabolites).Results showed varied efficacy:three foliar sprays of 10μL mL^(-1) oil achieved the best control phenylalanine ammonia-lyase(PAL),polyphenol oxidase(82.9%).The 20μL mL^(-1) treatment significantly increased(PPO)activities,and contents of lignin,flavonoids and total phenolics.Metabolomic analysis showed 326 upregulated and 527 downregulated different metabolites in essential oilinduced and pathogen-inoculated pines,compared to 483 upregulated and 277 downregulated metabolites in noninduced but inoculated pines.The differentially expressed metabolites in treated pines were primarily enriched in pathways related to amino acid metabolism and plant secondary metabolite biosynthesis,with notably increased expression levels of ferulic acid,scopoletin,pipecolic acid,D-proline,and DL-arginine.Therefore,juniper essential oil protects against D.sapinea by inducing systemic acquired resistance in Mongolian Scots pine.In conclusion,juniper essential oil controls D.sapinea by inducing systemic acquired resistance(SAR)in Mongolian Scots pine,clarifying the molecular mechanism and supporting biological control of the disease.展开更多
AIM: To assess the value of ultrasonography (US) in evaluation of proximal gastric accommodation disorder in patients with functional dyspepsia (FD). METHODS: Between April 2011 and March 2012, 45 patients with FD and...AIM: To assess the value of ultrasonography (US) in evaluation of proximal gastric accommodation disorder in patients with functional dyspepsia (FD). METHODS: Between April 2011 and March 2012, 45 patients with FD and 27 healthy volunteers were enrolled in this study. Two-dimensional ultrasound (2DUS) and 3-dimensional ultrasound (3DUS) were performed sequentially to measure proximal gastric area (PGA), maximal proximal gastric diameter (MPGD), and proximal gastric volume (PGV). These values were measured separately in the two groups every other 5 min for a duration of 25 min after the beginning of ingestion of a test meal. Air pocket grading was done separately for images of 2DUS and blocks of 3DUS obtained at five scanning time points. RESULTS: Both PGA and PGV of patients were significantly smaller than healthy controls (P = 0.000 and 0.002, respectively). Comparing the two parameters between the groups at each time point, the differences were also statistically significant (P = 0.000-0.013), except at 10 min for the PGV (P = 0.077). However, no overall difference was found between the groups in the MPGD measurements (P = 0.114), though it was statistically significant at a 20-minute examination point (P = 0.026). A total of 360 sets or blocks of images were obtained for both 2DUS and 3DUS. For the images analyzed by 2DUS, none were excluded because of gastric gas, and 50 (13.9%) and 310 (86.1%) sets were determined as air pockets grades 1 and 2, respectively. For the images analyzed by 3DUS, 23 (6.4%) blocks were excluded from the measurement due to presence of a large fundus air pocket (grade 3); fifty (13.9%) and 287 (79.7%) blocks were also graded as 1 and 2, respectively. CONCLUSION: Measurement of both PGA and PGV by 2DUS and 3DUS could be useful for assessment of the proximal gastric accommodation.展开更多
Karst in interbedded carbonates and evaporites has been reported to have important and complex impacts on reservoir. It is significant for exploration and karst geology. Here, we report such a new case from Middle Tri...Karst in interbedded carbonates and evaporites has been reported to have important and complex impacts on reservoir. It is significant for exploration and karst geology. Here, we report such a new case from Middle Triassic Leikoupo Formation of Sichuan Basin, Southwest China. Stratigraphic incompleteness and the occurrence of unconformity provide evidence for the presence of eogenetic karst. Under the impact of this eogenetic karst, residual weathered and solution-collapse breccia, solution pores and silicification and dedolomitization have been observed. Classic stratigraphic zonation of karst is not readily distinguishable, which is ascribed to the stratigraphic collapse of carbonate rocks resulting from the dissolution of evaporites by lateral subsurface fluid flow. In terms of impact on reservoir quality, karst can generally improve the initial physical property of the porous layers in theory. However, subsurface fluid flow dissolved the evarporitic beds and facilitated the collapse of overlying strata. As a consequence, the lateral continuity of the reservoirs would be destroyed, and relatively high-quality reservoirs can only be developed with little collapse of overlying strata, reflecting reservoir heterogeneities. This may be a general feature of reservoir formation under the impact of karst in interbedded carbonates and evaporites.展开更多
Due to the complex pathophysiological mechanism, spinal cord injury (SCI) has become one of the most intractable central nervous system (CNS) diseases to therapy. Stem cell transplantation, mesenchymal stem cells (MSC...Due to the complex pathophysiological mechanism, spinal cord injury (SCI) has become one of the most intractable central nervous system (CNS) diseases to therapy. Stem cell transplantation, mesenchymal stem cells (MSCs) particularly, appeals to more and more attention along with the encouraging therapeutic results for the functional regeneration of SCI. However, traditional cell transplantation strategies have some limitations, including the unsatisfying survival rate of MSCs and their random diffusion from the injection site to ambient tissues. The application of biomaterials in tissue engineering provides a new horizon. Biomaterials can not only confine MSCs in the injured lesions with higher cell viability, but also promote their therapeutic efficacy. This review summarizes the strategies and advantages of biomaterials reinforced MSCs transplantation to treat SCI in recent years,which are clarified in the light of various therapeutic effects in pathophysiological aspects of SCI.展开更多
Objective: This study aimed to determine if gastric cardia adenocarcinoma(GCA) risk was associated with the lys(A or *2) allele at the rs671(glu504lys) polymorphism within the aldehyde dehydrogenase 2(ALDH2) gene in a...Objective: This study aimed to determine if gastric cardia adenocarcinoma(GCA) risk was associated with the lys(A or *2) allele at the rs671(glu504lys) polymorphism within the aldehyde dehydrogenase 2(ALDH2) gene in a Chinese Han population. We also aimed to investigate ALDH2 genotypic distributions between subjects from high- and low-incidence areas for both GCA and esophageal squamous cell carcinoma(ESCC).Methods: We designed a case-control study including 2,686 patients with GCA and 3,675 control subjects from high- and lowincidence areas for both GCA and ESCC in China. Taq Man allele discrimination assay was used to genotype the rs671 polymorphism. χ~2 test and binary logistic regression analysis were used to estimate the odds ratios for the development of GCA,and multivariate ordinal logistic regression was used to analyze ALDH2 genotypic distributions among different groups.Results: Compared with ALDH2*1/*1 homozygotes, ALDH2*1/*2 and ALDH2*2/*2 carriers did not increase the risk for GCA in the Chinese Han population(P>0.05). Interestingly, the ratio of homozygous or heterozygous ALDH2 *2 carriers in highincidence areas for both GCA and ESCC was lower than that in low-incidence areas(P<0.001).Conclusions: Genotypes of rs671 at ALDH2 may not increase GCA susceptibility in Chinese Han populations. In addition, the ALDH2 genotypic distribution differs between Chinese Han populations from high- and low-incidence areas for both GCA and ESCC. Our findings may shed light on the possible genetic mechanism for the dramatic geographic differences of GCA occurrence in China.展开更多
Phosphor-in-glass(PiG)is a potential color convertor for high power WLEDs.A novel glass matrix with advanced performance is still a challenge.Recently,Eu^(3+)doped glass matrix has attracted much consideration mainly ...Phosphor-in-glass(PiG)is a potential color convertor for high power WLEDs.A novel glass matrix with advanced performance is still a challenge.Recently,Eu^(3+)doped glass matrix has attracted much consideration mainly due to its red compensation.A new borophosphate matrix to realize Eu^(3+)red light was designed in the Na_(2)O-ZnO-P_(2)O_(5)-B_(2)O_(3)-Eu_(2)O_(3)system.Meanwhile,a series of PiGs composed of different concentrations of Y3Al5O12:Ce phosphor and the matrix were also fabricated by re-sintering.The crystallization of Eu^(3+)based phosphate offers a novel red emission quenching apart from normal concentration quenching in the glass system.No direct energy transfer but only little reabso rption occurs between Eu^(3+)and Ce^(3+)ions.The Ce^(3+)concentration effect is obvious on the electroluminescent color.The optimized color rendering index of 79.7,the CIE coordinates near natural white and the range of CCT from 3943 to 6097 K were obtained for the packaged white light emitting diodes(WLEDs)together with the excellent CCT stability higher than about 97.5%and the quadruple thermal conductivity than that of silicon resin.The work implies borophosphate glass based PiGs with fine transparence and energy conversion efficiency are promising for excellent WLEDs,while the LED by using the PiG sample without any yellow phosphor doped is of high color purity and has a potential use as the 465 nm blue source.展开更多
Traumatic spinal cord injury is a fatal acute event without effective clinical therapies.Following the trauma,immediate neural protection and microenvironment mitigation are vitally important for nerve tissue repair,w...Traumatic spinal cord injury is a fatal acute event without effective clinical therapies.Following the trauma,immediate neural protection and microenvironment mitigation are vitally important for nerve tissue repair,where stem cell-based therapies could be eclipsed by the deficiency of cells due to the hostile microenvironment as well as the transport and preservation processes.Effective emergency strategies are required to be convenient,biocompatible,and stable.Herein,we assess an emergency cell-free treatment using mesenchymal stem cell-derived exosomes,which have proven capable of comprehensive mitigation of the inhibitory lesion microenvironment.The clinically validated fibrin glue is utilized to encapsulate the exosomes and in-situ gelates in transected rat spinal cords to provide a substrate for exosome delivery as well as nerve tissue growth.The emergency treatment alleviates the inflammatory and oxidative microenvironment,inducing effective nerve tissue repair and functional recovery.The therapy presents a promising strategy for effective emergency treatment of central nervous system trauma。展开更多
Wastewater-based epidemiology(WBE)has emerged as an effective environmental surveillance tool in monitoring fecal-oral pathogen infections within a community.Congruently,SARS-Co V-2,the etiologic agent of COVID-19,has...Wastewater-based epidemiology(WBE)has emerged as an effective environmental surveillance tool in monitoring fecal-oral pathogen infections within a community.Congruently,SARS-Co V-2,the etiologic agent of COVID-19,has been demonstrated to infect the gastrointestinal tissues,and be shed in feces.In the present study,SARS-Co V-2 RNA was concentrated from wastewater,sludge,surface water,ground water,sediment,and soil samples of municipal and hospital wastewater systems and related environments in Wuhan during the COVID-19 middle and low risk periods,and the viral RNA copies quantified using reverse transcription quantitative polymerase chain reaction(RT-q PCR).From the findings of this study,during the middle risk period,one influent sample and three secondary effluents collected from waste water treatment plant 2,as well as two samples from Jinyintan Hospital wastewater system influent were SARS-Co V-2 RNA positive.One sludge sample collected from Guanggu Branch of Tongji Hospital,which was obtained during the low risk period,was also positive for SARS-Co V-2 RNA.These study findings demonstrate the significance of WBE in continuous surveillance of SARS-Co V-2 at the community level,even when the COVID-19 prevalence is low.Overall,this study can be used as an important reference for contingency management of wastewater treatment plants and COVID-19 prevention and control departments of Wuhan.展开更多
Owing to the unique advantages in flight altitude,dwelling time and wide coverage area,stratospheric airships provide permanent monitoring and surveillance for both civil and military applications.Here we propose a se...Owing to the unique advantages in flight altitude,dwelling time and wide coverage area,stratospheric airships provide permanent monitoring and surveillance for both civil and military applications.Here we propose a semi-rigid stratosphere airship design with circumferential high-pressure inflatable rings and a longitudinal carbon fiber skeleton supported inside.We perform numerical simulations to analyze the deformation characteristics during the whole ascending and descending process.An equivalent internal gradient pressure model of helium is established based on the capsule shape and buoyancy-weight equilibrium conditions.The implicit dynamic method is used to deal with the large deformation of the airship capsule under a low negative pressure condition.Deformation and load-bearing performance of the airship capsule,inflatable ring,skeleton,and suspension line are obtained under different working conditions.The results show that the airship,supported with the inflatable rings and the suspension lines,effectively maintains the shape and ensures the stiffness during the ascending,dwelling,and descending stages,especially suffering from negative pressure.展开更多
Objective:This study aims to investigate the effects of hydralazine on inflammation induced by spinal cord injury(SCI)in the central nervous system(CNS)and its mechanism in promoting the structural and functional reco...Objective:This study aims to investigate the effects of hydralazine on inflammation induced by spinal cord injury(SCI)in the central nervous system(CNS)and its mechanism in promoting the structural and functional recovery of the injured CNS.Methods:A compressive SCI mouse model was utilized for this investigation.Immunofluorescence and quantitative real-time polymerase chain reaction were employed to examine the levels of acrolein,acrolein-induced inflammation-related factors,and macrophages at the injury site and within the CNS.Western blotting was used to evaluate the activity of the phosphoinositide 3-kinase(PI3K)/AKT pathway to study macrophage regulation.The neuropathic pain and motor function recovery were evaluated by glutamic acid decarboxylase 65/67(GAD65/67),vesicular glutamate transporter 1(VGLUT1),paw withdrawal response,and Basso Mouse Scale score.Nissl staining and Luxol Fast Blue(LFB)staining were performed to investigate the structural recovery of the injured CNS.Results:Hydralazine downregulated the levels of acrolein,IL-1β,and TNF-αin the spinal cord.The downregulation of acrolein induced by hydralazine promoted the activation of the PI3K/AKT pathway,leading to M2 macrophage polarization,which protected neurons against SCI-induced inflammation.Additionally,hydralazine promoted the structural recovery of the injured spinal cord area.Mitigating inflammation and oxidative stress by hydralazine in the animal model alleviated neuropathic pain and altered neurotransmitter expression.Furthermore,hydralazine facilitated motor function recovery following SCI.Nissl staining and LFB staining indicated that hydralazine promoted the structural recovery of the injured CNS.Conclusion:Hydralazine,an acrolein scavenger,significantly mitigated SCI-induced inflammation and oxidative stress in vivo,modulated macrophage activation,and consequently promoted the structural and functional recovery of the injured CNS.展开更多
AIM:To investigate the short-term efficacy and safety of inebilizumab for neuromyelitis optica spectrum disorders(NMOSD).METHODS:A total of 33 patients with NMOSD treated with inebilizumab(Group INB,n=15)or rituximab(...AIM:To investigate the short-term efficacy and safety of inebilizumab for neuromyelitis optica spectrum disorders(NMOSD).METHODS:A total of 33 patients with NMOSD treated with inebilizumab(Group INB,n=15)or rituximab(Group RTX,n=18)in addition to high-dose glucocorticoids were included.Both groups underwent hormone shock therapy during the acute phase.Subsequently,Group INB received inebilizumab injections during the remission phase,while Group RTX received rituximab injections.A comparison of aquaporins 4(AQP4)titer values,peripheral blood B lymphocyte counts,and visual function recovery was conducted before and 8wk after treatment.Additionally,adverse reactions and patient tolerability were analyzed after using inebilizumab treatment regimes.RESULTS:Following inebilizumab treatment,there was a significantly improvement in the visual acuity of NMOSD patients(P<0.05),accompanied by a notable decrease in AQP4 titer values and B lymphocyte ratio(P<0.05).Moreover,inebilizumab treatment showed a partial effect in preventing optic nerve atrophy(P<0.05).However,there were no significant differences in other therapeutic effects compared to rituximab,which has previously demonstrated substantial therapeutic efficacy(P>0.05).Furthermore,inebilizumab exhibited higher safety levels than that of rituximab injections.CONCLUSION:The combination of inebilizumab and high-dose glucocorticoids proves to be effective.In comparison to rituximab injections,inebilizumab displays better tolerance and safety.Moreover,it demonstrates a partial effect in preventing optic nerve atrophy.Thus,it stands as an effective method to reduce the disability rates and improve the daily living ability of patients with NMOSD.展开更多
AIM: To explore an improved procedure involving incomplete fluid-air exchange for idiopathic macular hole(IMH), and the closure rate, visual function, and the visual field of macular holes(MHs) were evaluated.METHODS:...AIM: To explore an improved procedure involving incomplete fluid-air exchange for idiopathic macular hole(IMH), and the closure rate, visual function, and the visual field of macular holes(MHs) were evaluated.METHODS: This prospective randomized controlled study, included 40 eyes of 40 patients with IMH who were treated with pars plana vitrectomy and peeling of the internal limiting membrane. They were grouped by random digital table. Twenty-one eyes underwent incomplete fluidair exchange(IFA) and 19 eyes underwent traditional complete fluid-air exchange(CFA) as the control group. Outcomes included best-corrected visual acuity(BCVA), intraocular pressure, and optical coherence tomography, light adaptive electroretinography, and visual field evaluations.RESULTS: All MHs <400 μm were successfully closed. BCVAs before and 6 mo after surgery were 0.82±0.41 logMAR and 0.28±0.17 logMAR in IFA group and 0.86±0.34 logMAR and 0.34±0.23 logMAR in CFA group, respectively. The electroretinogram analysis of patients in IFA group revealed increases in b-wave amplitudes at 1, 3, and 6 mo after surgery. Additionally, patients in IFA group showed an amplitude increase of 28.6% from baseline at 6 mo(P<0.05), while no obvious improvements were noted in CFA group. Although there were no statistically significant improvements in either group, the IFA group showed a slight increase in mean sensitivity(P>0.05).CONCLUSION: IFA is a reliable method that offers comparable closure rate to CFA and facilitates improvements in visual function.展开更多
Industrial revolutions have a profound impact on energy and metal demand.Based on technological improvement,industrial transformation,and changes of energy and metal consumption in the United States,this paper identif...Industrial revolutions have a profound impact on energy and metal demand.Based on technological improvement,industrial transformation,and changes of energy and metal consumption in the United States,this paper identified the evolution characteristics of energy and metal demand driven by industrial revolutions,and analyzed the trends of energy and metal demand driven by the fourth industrial revolution which is happening currently.Results indicated that fossil fuels were the major energy sources which boosted up the past three industrial revolutions,whereas their consumption increased at a slowing pace as the economy was growing continually;after the third industrial revolution,the consumption of fossil fuels decoupled gradually with the economic growth.As the industrial structure transformed as the industrial revolutions went on,more and more metals were used in the industries,and the consumption of different metals showed different trends.In recent years,a new technological revolution has surged mainly driven by the overall application of new information technologies.The technological advance in information,new energies,new materials,etc.,will speed up the industrial transformation and exert a deep effect on the demand of energy and metals.It can be inferred that the ratio of clean,non-polluting,renewable energy will rise while the ratio of fossil fuels will drop in the energy demand,and the demand of rare metals will perhaps enter a fast-growing period,while the demand of traditional bulk metals will fluctuate at mid-high levels.Following the new industrial revolution,China should adopt an energy transition strategy of developing low-carbon and free-carbon technologies simultaneously,reinforce the domestic and international metal supply system with the aim of enhancing global governance capability,strengthen the deep development of rich rare metals and broaden the overseas supply channels of scare rare metals.展开更多
Recently,photothermal therapy(PTT)has been proved to have great potential in tumor therapy.In the last several years,MoS_(2),as one novel member of nanomaterials,has been applied into PTT due to its excellent photothe...Recently,photothermal therapy(PTT)has been proved to have great potential in tumor therapy.In the last several years,MoS_(2),as one novel member of nanomaterials,has been applied into PTT due to its excellent photothermal conversion efficacy.In this work,we applied fuorescence lifetime imaging microscopy(FLIM)techniques into monitoring the PPT-triggered cell death under MoS_(2) nanosheet treatment.Two types of MoS_(2) nanosheets(single layer nanosheets and few layer nanosheets)were obtained,both of which exhibited presentable photothermal conversion fficacy,leading to high cell death rates of 4T1 cells(mouse breast cancer cells)under PTT.Next,live cell images of 4T1 cells were obtained via directly labeling the mitochondria with Rodamine123,which were then continuously observed with FLIM technique.FLIM data showed that the fuorescence lifetimes of mitochondria targeting dye in cells treated with each type of MoS_(2) nanosheets significantly increased during PTT treatment.By contrast,the fuorescence lifetime of the same dye in control cells(without nanomaterials)remained constant after laser irradiation.These findings suggest that FLIM can be of great value in monitoring cell death process during PTT of cancer cells,which could provide dynamic data of the cellular microenvironment at single cell level in multiple biomedical applications.展开更多
Human mesenchymal stem cells(hMSCs) have tremendous promise for use in a variety of clinical applications.The ability of these cells to self-renew and differentiate into multiple tissues makes them an attractive cell ...Human mesenchymal stem cells(hMSCs) have tremendous promise for use in a variety of clinical applications.The ability of these cells to self-renew and differentiate into multiple tissues makes them an attractive cell source for a new generation of cell-based regenerative therapies.Encouraging results from clinical trials have also generated growing enthusiasm regarding MSC therapy and related treatment,but gaps remain in understanding MSC tissue repair mechanisms and in clinical strategies for efficient cell delivery and consistent therapeutic outcomes.For these reasons,discoveries from basic research and their implementation in clinical trials are essential to advance MSC therapy from the laboratory bench to the patient’s bedside.展开更多
0 INTRODUCTION To relieve the short supply of suitable land for residing,cultivating,and commerce,it is accepted to reclaim land from lakes,river estuaries,and coastal regions in many countries(Mancini et al.,2020).Th...0 INTRODUCTION To relieve the short supply of suitable land for residing,cultivating,and commerce,it is accepted to reclaim land from lakes,river estuaries,and coastal regions in many countries(Mancini et al.,2020).The large-scale reclamation activities have an irreversible effect on the mico-geomorphology and hydrodynamic system of seasonally flooded areas(Zhang et al.,2019;Yu et al.,2018).For example,coastal regions reclaimed extended the groundwater flow paths,as well as created groundwater level rise,resulting in water-logging in the reclaimed area(Hu et al.,2008).Similar changes in groundwater flow systems may alter groundwater-lake water interactions,and it can ultimately affect the water cycle in the lake areas.However,such detailed studies are presently lacking.In addition,natural exchanges between the lake and groundwater systems can be strongly affected by physical hydrological processes(Javadzadeh et al.,2020),chemical properties(Kamtchueng et al.,2015),and bioto behavior(Hancock et al.,2005).展开更多
The Editor-in-Chief has retracted this article on the corresponding authors'request.The corresponding authors on behalf of all the authors stated that the data presented in this article does not belong to the name...The Editor-in-Chief has retracted this article on the corresponding authors'request.The corresponding authors on behalf of all the authors stated that the data presented in this article does not belong to the named authors,but belongs to Prof.Sheng-xi Wu and Prof.Wang Xi of the Department of Neurobiology of the Fourth Military Medical University,Xi'an,China.展开更多
Ectopic breast tissue is reported to occur in 0.4% - 6% of women. Breast neoplasms may develop in ectopic breast tissue, as in eutopic breast tissue. The most frequent condition in ectopic breast is breast cancer. Fib...Ectopic breast tissue is reported to occur in 0.4% - 6% of women. Breast neoplasms may develop in ectopic breast tissue, as in eutopic breast tissue. The most frequent condition in ectopic breast is breast cancer. Fibroadenomas of ectopic breast tissue have been reported, but are rare. We report two cases of fibroadenomas of ectopic axillary breast tissues. The sonographic appearance of the nodules was spherical and hypoechoic. We found the component of breast tissue near the nodule. It is important to diagnose fibroadenomas of ectopic breast tissue before a histologic examination.展开更多
Objective:To explore the effect of Jianpi Wenshen Granules on the Controlling Nutritional Status(CONUT)score in elderly patients undergoing maintenance hemodialysis.Methods:Seventy elderly outpatients undergoing maint...Objective:To explore the effect of Jianpi Wenshen Granules on the Controlling Nutritional Status(CONUT)score in elderly patients undergoing maintenance hemodialysis.Methods:Seventy elderly outpatients undergoing maintenance hemodialysis from January 2023 to January 2024 at the Blood Purification Centers of Taizhou Traditional Chinese Medicine Hospital and Taizhou Second People’s Hospital were selected as the study subjects.The patients were randomly divided into two groups:the study group and the control group,with 35 patients in each group.Both groups received maintenance hemodialysis,while the control group received only conventional Western medicine treatment,and the study group was additionally treated with Jianpi Wenshen Granules.The changes in biochemical and inflammatory markers before and after treatment were compared between the two groups.The nutritional status of the patients was assessed using the Controlling Nutritional Status(CONUT)score,and detailed statistics were gathered on anemia and albumin levels in both groups.Results:After treatment,the CONUT score in the study group significantly decreased compared to the control group,showing a significant correlation(P<0.05).Albumin and hemoglobin levels significantly increased,with a notable difference(P<0.05).There were no significant differences in alanine aminotransferase and aspartate aminotransferase levels between the two groups before and after treatment(P>0.05).Conclusion:In elderly patients undergoing maintenance hemodialysis,Jianpi Wenshen Granules improve the CONUT score and enhance nutritional status,demonstrating potential for clinical application and promotion.展开更多
基金Supported by Program for the National Natural Science Foundation of China(No.52071053,U1704253,52103334)the Fundamental Research Funds for the Central Universities(DUT24GF102)the Shandong Province Natural Science Youth Fund(ZR2024QA134)。
文摘Magnetic absorbers with high permeability have significant advantages in lowfrequency and broadband electromagnetic wave(EMW)absorption.However,the insufficient magnetic loss and inherent high conductivity of existing magnetic absorbers limit the further expansion of EMW absorption bandwidth.Herein,the spinel(FeCoNiCrCu)_(3)O_(4) high-entropy oxides(HEO)are successfully constructed on the surface of FeCoNiCr_(0.4)Cu_(0.2) high-entropy alloys(HEA)through low-temperature oxygen bath treatment.On the one hand,HEO and HEA have different magnetocrystalline anisotropies,which is conducive to achieving continuous natural resonance to improve magnetic loss.On the other hand,HEO with low conductivity can serve as an impedance matching layer,achieving magneto-electric co-modulation.When the thickness is 5 mm,the minimum reflection loss(RL)value and absorption bandwidth(RL<−5 dB)of bi-phase high-entropy composites(BPHEC)can reach−12.8 dB and 633 MHz,respectively.The RCS reduction value of multilayer sample with impedance gradient characteristic can reach 18.34 dB m^(2).In addition,the BPHEC also exhibits temperaturestable EMW absorption performance,high Curie temperature,and oxidation resistance.The absorption bandwidth maintains between 593 and 691 MHz from−50 to 150℃.This work offers a new and tunable strategy toward modulating the electromagnetic genes for temperature-stable ultra-broadband megahertz EMW absorption.
基金supported by the National Key R&D Program of China(2022YFD1401005).
文摘Diplodia tip blight,caused by Diplodia sapinea,is a global pine necrotic disease causing heavy economic losses to the pine industry.Chemical control,its main current management,easily induces pathogen resistance and environmental pollution,which biological control avoids.This study investigated juniper essential oil’s efficacy against the disease on Mongolian Scots pine(Pinus sylvestris var.mongolica)and its induced resistance mechanisms via pot experiments,physiological assays(defense enzyme activities,resistant substances)and metabolomic sequencing(secondary metabolites).Results showed varied efficacy:three foliar sprays of 10μL mL^(-1) oil achieved the best control phenylalanine ammonia-lyase(PAL),polyphenol oxidase(82.9%).The 20μL mL^(-1) treatment significantly increased(PPO)activities,and contents of lignin,flavonoids and total phenolics.Metabolomic analysis showed 326 upregulated and 527 downregulated different metabolites in essential oilinduced and pathogen-inoculated pines,compared to 483 upregulated and 277 downregulated metabolites in noninduced but inoculated pines.The differentially expressed metabolites in treated pines were primarily enriched in pathways related to amino acid metabolism and plant secondary metabolite biosynthesis,with notably increased expression levels of ferulic acid,scopoletin,pipecolic acid,D-proline,and DL-arginine.Therefore,juniper essential oil protects against D.sapinea by inducing systemic acquired resistance in Mongolian Scots pine.In conclusion,juniper essential oil controls D.sapinea by inducing systemic acquired resistance(SAR)in Mongolian Scots pine,clarifying the molecular mechanism and supporting biological control of the disease.
基金Supported by A Grant from the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry of China, No. [2008] 101
文摘AIM: To assess the value of ultrasonography (US) in evaluation of proximal gastric accommodation disorder in patients with functional dyspepsia (FD). METHODS: Between April 2011 and March 2012, 45 patients with FD and 27 healthy volunteers were enrolled in this study. Two-dimensional ultrasound (2DUS) and 3-dimensional ultrasound (3DUS) were performed sequentially to measure proximal gastric area (PGA), maximal proximal gastric diameter (MPGD), and proximal gastric volume (PGV). These values were measured separately in the two groups every other 5 min for a duration of 25 min after the beginning of ingestion of a test meal. Air pocket grading was done separately for images of 2DUS and blocks of 3DUS obtained at five scanning time points. RESULTS: Both PGA and PGV of patients were significantly smaller than healthy controls (P = 0.000 and 0.002, respectively). Comparing the two parameters between the groups at each time point, the differences were also statistically significant (P = 0.000-0.013), except at 10 min for the PGV (P = 0.077). However, no overall difference was found between the groups in the MPGD measurements (P = 0.114), though it was statistically significant at a 20-minute examination point (P = 0.026). A total of 360 sets or blocks of images were obtained for both 2DUS and 3DUS. For the images analyzed by 2DUS, none were excluded because of gastric gas, and 50 (13.9%) and 310 (86.1%) sets were determined as air pockets grades 1 and 2, respectively. For the images analyzed by 3DUS, 23 (6.4%) blocks were excluded from the measurement due to presence of a large fundus air pocket (grade 3); fifty (13.9%) and 287 (79.7%) blocks were also graded as 1 and 2, respectively. CONCLUSION: Measurement of both PGA and PGV by 2DUS and 3DUS could be useful for assessment of the proximal gastric accommodation.
基金funded by the “13th Five-Year Plan” National Science and Technology Major Project of China(No.2016ZX05004002)
文摘Karst in interbedded carbonates and evaporites has been reported to have important and complex impacts on reservoir. It is significant for exploration and karst geology. Here, we report such a new case from Middle Triassic Leikoupo Formation of Sichuan Basin, Southwest China. Stratigraphic incompleteness and the occurrence of unconformity provide evidence for the presence of eogenetic karst. Under the impact of this eogenetic karst, residual weathered and solution-collapse breccia, solution pores and silicification and dedolomitization have been observed. Classic stratigraphic zonation of karst is not readily distinguishable, which is ascribed to the stratigraphic collapse of carbonate rocks resulting from the dissolution of evaporites by lateral subsurface fluid flow. In terms of impact on reservoir quality, karst can generally improve the initial physical property of the porous layers in theory. However, subsurface fluid flow dissolved the evarporitic beds and facilitated the collapse of overlying strata. As a consequence, the lateral continuity of the reservoirs would be destroyed, and relatively high-quality reservoirs can only be developed with little collapse of overlying strata, reflecting reservoir heterogeneities. This may be a general feature of reservoir formation under the impact of karst in interbedded carbonates and evaporites.
基金supported by National Key Research and Development Project of Stem Cell and Transformation Research (2019YFA0112100 , 2019YFA0112102)National Natural Science Foundation of China (81973252, 81620108028)。
文摘Due to the complex pathophysiological mechanism, spinal cord injury (SCI) has become one of the most intractable central nervous system (CNS) diseases to therapy. Stem cell transplantation, mesenchymal stem cells (MSCs) particularly, appeals to more and more attention along with the encouraging therapeutic results for the functional regeneration of SCI. However, traditional cell transplantation strategies have some limitations, including the unsatisfying survival rate of MSCs and their random diffusion from the injection site to ambient tissues. The application of biomaterials in tissue engineering provides a new horizon. Biomaterials can not only confine MSCs in the injured lesions with higher cell viability, but also promote their therapeutic efficacy. This review summarizes the strategies and advantages of biomaterials reinforced MSCs transplantation to treat SCI in recent years,which are clarified in the light of various therapeutic effects in pathophysiological aspects of SCI.
基金supported by grants from the National Natural Science Foundation of China(Grant No.81472323)Top Talent Support Project of Zhengzhou University(Grant No.ZDGD 13001)Innovation Scientists and Technicians Troop Construction Projects of Henan Province(Grant No.3047)
文摘Objective: This study aimed to determine if gastric cardia adenocarcinoma(GCA) risk was associated with the lys(A or *2) allele at the rs671(glu504lys) polymorphism within the aldehyde dehydrogenase 2(ALDH2) gene in a Chinese Han population. We also aimed to investigate ALDH2 genotypic distributions between subjects from high- and low-incidence areas for both GCA and esophageal squamous cell carcinoma(ESCC).Methods: We designed a case-control study including 2,686 patients with GCA and 3,675 control subjects from high- and lowincidence areas for both GCA and ESCC in China. Taq Man allele discrimination assay was used to genotype the rs671 polymorphism. χ~2 test and binary logistic regression analysis were used to estimate the odds ratios for the development of GCA,and multivariate ordinal logistic regression was used to analyze ALDH2 genotypic distributions among different groups.Results: Compared with ALDH2*1/*1 homozygotes, ALDH2*1/*2 and ALDH2*2/*2 carriers did not increase the risk for GCA in the Chinese Han population(P>0.05). Interestingly, the ratio of homozygous or heterozygous ALDH2 *2 carriers in highincidence areas for both GCA and ESCC was lower than that in low-incidence areas(P<0.001).Conclusions: Genotypes of rs671 at ALDH2 may not increase GCA susceptibility in Chinese Han populations. In addition, the ALDH2 genotypic distribution differs between Chinese Han populations from high- and low-incidence areas for both GCA and ESCC. Our findings may shed light on the possible genetic mechanism for the dramatic geographic differences of GCA occurrence in China.
基金Project supported by the Joint Funds of the National Natural Science Foundation of China(U1932160)the National Natural Science Foundation of China(51605272)。
文摘Phosphor-in-glass(PiG)is a potential color convertor for high power WLEDs.A novel glass matrix with advanced performance is still a challenge.Recently,Eu^(3+)doped glass matrix has attracted much consideration mainly due to its red compensation.A new borophosphate matrix to realize Eu^(3+)red light was designed in the Na_(2)O-ZnO-P_(2)O_(5)-B_(2)O_(3)-Eu_(2)O_(3)system.Meanwhile,a series of PiGs composed of different concentrations of Y3Al5O12:Ce phosphor and the matrix were also fabricated by re-sintering.The crystallization of Eu^(3+)based phosphate offers a novel red emission quenching apart from normal concentration quenching in the glass system.No direct energy transfer but only little reabso rption occurs between Eu^(3+)and Ce^(3+)ions.The Ce^(3+)concentration effect is obvious on the electroluminescent color.The optimized color rendering index of 79.7,the CIE coordinates near natural white and the range of CCT from 3943 to 6097 K were obtained for the packaged white light emitting diodes(WLEDs)together with the excellent CCT stability higher than about 97.5%and the quadruple thermal conductivity than that of silicon resin.The work implies borophosphate glass based PiGs with fine transparence and energy conversion efficiency are promising for excellent WLEDs,while the LED by using the PiG sample without any yellow phosphor doped is of high color purity and has a potential use as the 465 nm blue source.
基金supported by the National Key Research and Development Project of Stem Cell and Transformation Research(2019YFA0112100,2019YFA0112102)National Natural Science Foundation of China(81973252,81803451 and 81620108028)。
文摘Traumatic spinal cord injury is a fatal acute event without effective clinical therapies.Following the trauma,immediate neural protection and microenvironment mitigation are vitally important for nerve tissue repair,where stem cell-based therapies could be eclipsed by the deficiency of cells due to the hostile microenvironment as well as the transport and preservation processes.Effective emergency strategies are required to be convenient,biocompatible,and stable.Herein,we assess an emergency cell-free treatment using mesenchymal stem cell-derived exosomes,which have proven capable of comprehensive mitigation of the inhibitory lesion microenvironment.The clinically validated fibrin glue is utilized to encapsulate the exosomes and in-situ gelates in transected rat spinal cords to provide a substrate for exosome delivery as well as nerve tissue growth.The emergency treatment alleviates the inflammatory and oxidative microenvironment,inducing effective nerve tissue repair and functional recovery.The therapy presents a promising strategy for effective emergency treatment of central nervous system trauma。
基金supported by the Wuhan Bureau of Science and Technology(No.202002020101010022)China Geological Survey(No.DD20190282)the support team from the National Biosafety Laboratory in Wuhan,China,for the support they extended to us。
文摘Wastewater-based epidemiology(WBE)has emerged as an effective environmental surveillance tool in monitoring fecal-oral pathogen infections within a community.Congruently,SARS-Co V-2,the etiologic agent of COVID-19,has been demonstrated to infect the gastrointestinal tissues,and be shed in feces.In the present study,SARS-Co V-2 RNA was concentrated from wastewater,sludge,surface water,ground water,sediment,and soil samples of municipal and hospital wastewater systems and related environments in Wuhan during the COVID-19 middle and low risk periods,and the viral RNA copies quantified using reverse transcription quantitative polymerase chain reaction(RT-q PCR).From the findings of this study,during the middle risk period,one influent sample and three secondary effluents collected from waste water treatment plant 2,as well as two samples from Jinyintan Hospital wastewater system influent were SARS-Co V-2 RNA positive.One sludge sample collected from Guanggu Branch of Tongji Hospital,which was obtained during the low risk period,was also positive for SARS-Co V-2 RNA.These study findings demonstrate the significance of WBE in continuous surveillance of SARS-Co V-2 at the community level,even when the COVID-19 prevalence is low.Overall,this study can be used as an important reference for contingency management of wastewater treatment plants and COVID-19 prevention and control departments of Wuhan.
基金support from the National Natural Science Foundation of China(No.11872160).
文摘Owing to the unique advantages in flight altitude,dwelling time and wide coverage area,stratospheric airships provide permanent monitoring and surveillance for both civil and military applications.Here we propose a semi-rigid stratosphere airship design with circumferential high-pressure inflatable rings and a longitudinal carbon fiber skeleton supported inside.We perform numerical simulations to analyze the deformation characteristics during the whole ascending and descending process.An equivalent internal gradient pressure model of helium is established based on the capsule shape and buoyancy-weight equilibrium conditions.The implicit dynamic method is used to deal with the large deformation of the airship capsule under a low negative pressure condition.Deformation and load-bearing performance of the airship capsule,inflatable ring,skeleton,and suspension line are obtained under different working conditions.The results show that the airship,supported with the inflatable rings and the suspension lines,effectively maintains the shape and ensures the stiffness during the ascending,dwelling,and descending stages,especially suffering from negative pressure.
基金supported by the National Natural Science Foundation of China Young Scientists Fund(No.81801216,No.81802143,No.81901966)the China Postdoctoral Foundation(No.2018M633748).
文摘Objective:This study aims to investigate the effects of hydralazine on inflammation induced by spinal cord injury(SCI)in the central nervous system(CNS)and its mechanism in promoting the structural and functional recovery of the injured CNS.Methods:A compressive SCI mouse model was utilized for this investigation.Immunofluorescence and quantitative real-time polymerase chain reaction were employed to examine the levels of acrolein,acrolein-induced inflammation-related factors,and macrophages at the injury site and within the CNS.Western blotting was used to evaluate the activity of the phosphoinositide 3-kinase(PI3K)/AKT pathway to study macrophage regulation.The neuropathic pain and motor function recovery were evaluated by glutamic acid decarboxylase 65/67(GAD65/67),vesicular glutamate transporter 1(VGLUT1),paw withdrawal response,and Basso Mouse Scale score.Nissl staining and Luxol Fast Blue(LFB)staining were performed to investigate the structural recovery of the injured CNS.Results:Hydralazine downregulated the levels of acrolein,IL-1β,and TNF-αin the spinal cord.The downregulation of acrolein induced by hydralazine promoted the activation of the PI3K/AKT pathway,leading to M2 macrophage polarization,which protected neurons against SCI-induced inflammation.Additionally,hydralazine promoted the structural recovery of the injured spinal cord area.Mitigating inflammation and oxidative stress by hydralazine in the animal model alleviated neuropathic pain and altered neurotransmitter expression.Furthermore,hydralazine facilitated motor function recovery following SCI.Nissl staining and LFB staining indicated that hydralazine promoted the structural recovery of the injured CNS.Conclusion:Hydralazine,an acrolein scavenger,significantly mitigated SCI-induced inflammation and oxidative stress in vivo,modulated macrophage activation,and consequently promoted the structural and functional recovery of the injured CNS.
文摘AIM:To investigate the short-term efficacy and safety of inebilizumab for neuromyelitis optica spectrum disorders(NMOSD).METHODS:A total of 33 patients with NMOSD treated with inebilizumab(Group INB,n=15)or rituximab(Group RTX,n=18)in addition to high-dose glucocorticoids were included.Both groups underwent hormone shock therapy during the acute phase.Subsequently,Group INB received inebilizumab injections during the remission phase,while Group RTX received rituximab injections.A comparison of aquaporins 4(AQP4)titer values,peripheral blood B lymphocyte counts,and visual function recovery was conducted before and 8wk after treatment.Additionally,adverse reactions and patient tolerability were analyzed after using inebilizumab treatment regimes.RESULTS:Following inebilizumab treatment,there was a significantly improvement in the visual acuity of NMOSD patients(P<0.05),accompanied by a notable decrease in AQP4 titer values and B lymphocyte ratio(P<0.05).Moreover,inebilizumab treatment showed a partial effect in preventing optic nerve atrophy(P<0.05).However,there were no significant differences in other therapeutic effects compared to rituximab,which has previously demonstrated substantial therapeutic efficacy(P>0.05).Furthermore,inebilizumab exhibited higher safety levels than that of rituximab injections.CONCLUSION:The combination of inebilizumab and high-dose glucocorticoids proves to be effective.In comparison to rituximab injections,inebilizumab displays better tolerance and safety.Moreover,it demonstrates a partial effect in preventing optic nerve atrophy.Thus,it stands as an effective method to reduce the disability rates and improve the daily living ability of patients with NMOSD.
基金Supported by National Natural Science Foundation of Xinjiang Autonomous Region, China (No.81460089)
文摘AIM: To explore an improved procedure involving incomplete fluid-air exchange for idiopathic macular hole(IMH), and the closure rate, visual function, and the visual field of macular holes(MHs) were evaluated.METHODS: This prospective randomized controlled study, included 40 eyes of 40 patients with IMH who were treated with pars plana vitrectomy and peeling of the internal limiting membrane. They were grouped by random digital table. Twenty-one eyes underwent incomplete fluidair exchange(IFA) and 19 eyes underwent traditional complete fluid-air exchange(CFA) as the control group. Outcomes included best-corrected visual acuity(BCVA), intraocular pressure, and optical coherence tomography, light adaptive electroretinography, and visual field evaluations.RESULTS: All MHs <400 μm were successfully closed. BCVAs before and 6 mo after surgery were 0.82±0.41 logMAR and 0.28±0.17 logMAR in IFA group and 0.86±0.34 logMAR and 0.34±0.23 logMAR in CFA group, respectively. The electroretinogram analysis of patients in IFA group revealed increases in b-wave amplitudes at 1, 3, and 6 mo after surgery. Additionally, patients in IFA group showed an amplitude increase of 28.6% from baseline at 6 mo(P<0.05), while no obvious improvements were noted in CFA group. Although there were no statistically significant improvements in either group, the IFA group showed a slight increase in mean sensitivity(P>0.05).CONCLUSION: IFA is a reliable method that offers comparable closure rate to CFA and facilitates improvements in visual function.
文摘Industrial revolutions have a profound impact on energy and metal demand.Based on technological improvement,industrial transformation,and changes of energy and metal consumption in the United States,this paper identified the evolution characteristics of energy and metal demand driven by industrial revolutions,and analyzed the trends of energy and metal demand driven by the fourth industrial revolution which is happening currently.Results indicated that fossil fuels were the major energy sources which boosted up the past three industrial revolutions,whereas their consumption increased at a slowing pace as the economy was growing continually;after the third industrial revolution,the consumption of fossil fuels decoupled gradually with the economic growth.As the industrial structure transformed as the industrial revolutions went on,more and more metals were used in the industries,and the consumption of different metals showed different trends.In recent years,a new technological revolution has surged mainly driven by the overall application of new information technologies.The technological advance in information,new energies,new materials,etc.,will speed up the industrial transformation and exert a deep effect on the demand of energy and metals.It can be inferred that the ratio of clean,non-polluting,renewable energy will rise while the ratio of fossil fuels will drop in the energy demand,and the demand of rare metals will perhaps enter a fast-growing period,while the demand of traditional bulk metals will fluctuate at mid-high levels.Following the new industrial revolution,China should adopt an energy transition strategy of developing low-carbon and free-carbon technologies simultaneously,reinforce the domestic and international metal supply system with the aim of enhancing global governance capability,strengthen the deep development of rich rare metals and broaden the overseas supply channels of scare rare metals.
基金supported by the National Key R&D Program of China(2018YFC0910602)the National Natural Science Foundation of China(Grant Nos.31771584/61775145/61605121,61620106016/61525503/61835009/81727804)+2 种基金Guangdong Natural Science Foundation Innovation Team(2014A030312008)Shenzhen Basic Research Project(JCYJ20170818100153423/JCYJ20170412110212234/JCYJ20160328144746940/JCYJ20170412105003520/JCYJ20170302142902581)Science Foundation of SZU(Grant No.000193).
文摘Recently,photothermal therapy(PTT)has been proved to have great potential in tumor therapy.In the last several years,MoS_(2),as one novel member of nanomaterials,has been applied into PTT due to its excellent photothermal conversion efficacy.In this work,we applied fuorescence lifetime imaging microscopy(FLIM)techniques into monitoring the PPT-triggered cell death under MoS_(2) nanosheet treatment.Two types of MoS_(2) nanosheets(single layer nanosheets and few layer nanosheets)were obtained,both of which exhibited presentable photothermal conversion fficacy,leading to high cell death rates of 4T1 cells(mouse breast cancer cells)under PTT.Next,live cell images of 4T1 cells were obtained via directly labeling the mitochondria with Rodamine123,which were then continuously observed with FLIM technique.FLIM data showed that the fuorescence lifetimes of mitochondria targeting dye in cells treated with each type of MoS_(2) nanosheets significantly increased during PTT treatment.By contrast,the fuorescence lifetime of the same dye in control cells(without nanomaterials)remained constant after laser irradiation.These findings suggest that FLIM can be of great value in monitoring cell death process during PTT of cancer cells,which could provide dynamic data of the cellular microenvironment at single cell level in multiple biomedical applications.
文摘Human mesenchymal stem cells(hMSCs) have tremendous promise for use in a variety of clinical applications.The ability of these cells to self-renew and differentiate into multiple tissues makes them an attractive cell source for a new generation of cell-based regenerative therapies.Encouraging results from clinical trials have also generated growing enthusiasm regarding MSC therapy and related treatment,but gaps remain in understanding MSC tissue repair mechanisms and in clinical strategies for efficient cell delivery and consistent therapeutic outcomes.For these reasons,discoveries from basic research and their implementation in clinical trials are essential to advance MSC therapy from the laboratory bench to the patient’s bedside.
基金supported by the Research Program for Geological Processes,Resources and Environment in the Yangtze River Basin(No.CUGCJ1702)the National Natural Science Foundation of China(Nos.41630318 and 41521001)。
文摘0 INTRODUCTION To relieve the short supply of suitable land for residing,cultivating,and commerce,it is accepted to reclaim land from lakes,river estuaries,and coastal regions in many countries(Mancini et al.,2020).The large-scale reclamation activities have an irreversible effect on the mico-geomorphology and hydrodynamic system of seasonally flooded areas(Zhang et al.,2019;Yu et al.,2018).For example,coastal regions reclaimed extended the groundwater flow paths,as well as created groundwater level rise,resulting in water-logging in the reclaimed area(Hu et al.,2008).Similar changes in groundwater flow systems may alter groundwater-lake water interactions,and it can ultimately affect the water cycle in the lake areas.However,such detailed studies are presently lacking.In addition,natural exchanges between the lake and groundwater systems can be strongly affected by physical hydrological processes(Javadzadeh et al.,2020),chemical properties(Kamtchueng et al.,2015),and bioto behavior(Hancock et al.,2005).
文摘The Editor-in-Chief has retracted this article on the corresponding authors'request.The corresponding authors on behalf of all the authors stated that the data presented in this article does not belong to the named authors,but belongs to Prof.Sheng-xi Wu and Prof.Wang Xi of the Department of Neurobiology of the Fourth Military Medical University,Xi'an,China.
文摘Ectopic breast tissue is reported to occur in 0.4% - 6% of women. Breast neoplasms may develop in ectopic breast tissue, as in eutopic breast tissue. The most frequent condition in ectopic breast is breast cancer. Fibroadenomas of ectopic breast tissue have been reported, but are rare. We report two cases of fibroadenomas of ectopic axillary breast tissues. The sonographic appearance of the nodules was spherical and hypoechoic. We found the component of breast tissue near the nodule. It is important to diagnose fibroadenomas of ectopic breast tissue before a histologic examination.
基金Taizhou Traditional Chinese Medicine Science and Technology Development Project(Project No.TZ202207)。
文摘Objective:To explore the effect of Jianpi Wenshen Granules on the Controlling Nutritional Status(CONUT)score in elderly patients undergoing maintenance hemodialysis.Methods:Seventy elderly outpatients undergoing maintenance hemodialysis from January 2023 to January 2024 at the Blood Purification Centers of Taizhou Traditional Chinese Medicine Hospital and Taizhou Second People’s Hospital were selected as the study subjects.The patients were randomly divided into two groups:the study group and the control group,with 35 patients in each group.Both groups received maintenance hemodialysis,while the control group received only conventional Western medicine treatment,and the study group was additionally treated with Jianpi Wenshen Granules.The changes in biochemical and inflammatory markers before and after treatment were compared between the two groups.The nutritional status of the patients was assessed using the Controlling Nutritional Status(CONUT)score,and detailed statistics were gathered on anemia and albumin levels in both groups.Results:After treatment,the CONUT score in the study group significantly decreased compared to the control group,showing a significant correlation(P<0.05).Albumin and hemoglobin levels significantly increased,with a notable difference(P<0.05).There were no significant differences in alanine aminotransferase and aspartate aminotransferase levels between the two groups before and after treatment(P>0.05).Conclusion:In elderly patients undergoing maintenance hemodialysis,Jianpi Wenshen Granules improve the CONUT score and enhance nutritional status,demonstrating potential for clinical application and promotion.
