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钯催化3-(2-氨基嘧啶-4-基)吲哚2位C—H键芳基化反应的研究 被引量:3
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作者 孙美娇 谭晶 +2 位作者 谭玉 彭进松 陈春霞 《有机化学》 SCIE CAS CSCD 北大核心 2023年第11期3945-3959,共15页
以N-甲基-3-(2-氨基嘧啶-4-基)吲哚衍生物和碘代芳烃为起始原料,详细探讨了钯催化吲哚2位选择性C—H键活化/芳基化反应过程.以醋酸钯为催化剂,三苯基膦为配体,碳酸银为添加剂,碳酸钠为碱,在120℃下于1,4-二氧六环中反应24 h,可获得较高... 以N-甲基-3-(2-氨基嘧啶-4-基)吲哚衍生物和碘代芳烃为起始原料,详细探讨了钯催化吲哚2位选择性C—H键活化/芳基化反应过程.以醋酸钯为催化剂,三苯基膦为配体,碳酸银为添加剂,碳酸钠为碱,在120℃下于1,4-二氧六环中反应24 h,可获得较高产率的2-芳基化吲哚衍生物.在此标准条件下,通过改变两种反应底物的结构,探究了该合成方法的适用范围与局限性,合成得到的系列吲哚衍生物经1H NMR、13C NMR和HRMS结构表征. 展开更多
关键词 钯催化 碳氢键活化 芳基化 嘧啶导向基团 吲哚衍生物
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Observation of the Effect of Pain Grading Nursing Strategy in Patients with Pelvic Fracture
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作者 tanyu 《外文科技期刊数据库(文摘版)医药卫生》 2022年第7期161-165,共5页
Objective: to explore the application effect of pain grading nursing strategy in patients with pelvic fracture. Methods: from February 1, 2020 to January 31, 2022, 76 patients with pelvic fracture were selected and in... Objective: to explore the application effect of pain grading nursing strategy in patients with pelvic fracture. Methods: from February 1, 2020 to January 31, 2022, 76 patients with pelvic fracture were selected and included in this study. Taking the method of rolling dice as the grouping standard, they were divided into two groups, namely the reference group (38 cases) and the research group (38 cases). Patients in the reference group were given the conventional nursing mode, and patients in the research group were given the pain grading nursing strategy on this basis. Record the nursing effects of the two groups of patients, and analyze and discuss them. Results: compared with before nursing, the pain scores of the two groups of patients after nursing were lower, and the score of the experimental group was more ideal: (4.57 ± 0.40). Compared with before nursing, the indexes of pain stress in the two groups changed obviously after nursing. Seven days after nursing, the indexes in the experimental group were lower than those in the reference group, namely, substance P (SP) (6.51 ± 0.19) μ g/ml, prostaglandin E2 (PGE2) (130.25 ± 15.21) pg/ml and neuropeptide Y (NPY). After nursing, compared with the reference group, the scores of various functional disorders in the experimental group were lower, and complications were less. Conclusion: the application of pain grading nursing strategy for patients with pelvic fracture is effective, which can not only quickly relieve the pain and discomfort of patients, but also reduce the occurrence of complications and promote the early recovery of related functions. 展开更多
关键词 graded nursing strategy for pain pelvic fracture PAIN COMPLICATIONS DYSFUNCTION
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Discussion on the Effect of Comprehensive Nursing Intervention in Preventing Delirium of ICU Patients
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作者 LONGYaman tanyu WANGMaojun 《外文科技期刊数据库(文摘版)医药卫生》 2022年第7期104-107,共4页
Objective: to analyze the effect of comprehensive nursing intervention in preventing delirium of ICU patients. Methods: 100 patients with TCU from September 2020 to October 2021 were selected as the research object, a... Objective: to analyze the effect of comprehensive nursing intervention in preventing delirium of ICU patients. Methods: 100 patients with TCU from September 2020 to October 2021 were selected as the research object, and randomly divided into comprehensive group and routine group, with 50 patients in each group. The nursing outcomes of the two groups were evaluated. Results: the delirium scores of the two groups before and after nursing were recorded. The delirium scores of the two groups before nursing were similar (P > 0.05). After nursing, the delirium scores of the comprehensive group were (27.12 ± 2.69) and those of the control group were (20.35 ± 1.35). After nursing, the delirium scores of the comprehensive group were significant. The incidence of comprehensive delirium in group A was significantly lower (P < 0.05). The stay time in ICU of comprehensive group was (3.02 ± 0.31) d, that of control group was (4.71 ± 0.83) d, that of comprehensive group was (0.60 ± 0.21) d, and that of control group was (1.33) d. Conclusion: in the process of preventing patients delirium in ICU, comprehensive nursing can be integrated, which can not only significantly reduce the incidence of patients delirium, but also significantly shorten the duration of patients delirium and stay in ICU. It is highly favored by patients and has the value of vigorous publicity and promotion. 展开更多
关键词 comprehensive nursing ICU DELIRIUM EFFECT
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