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在实验性鼠结核病中利福喷丁及FCE22807两种长效利福霉素的活性
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作者 J.Dhillon J.M.Dickinson +3 位作者 J.A.Guy t.k.ng D.A.Mitchison 王撷秀 《国际结核病与肺部疾病杂志》 1995年第2期81-87,共7页
在实验性鼠结核病中,通过脾脏的活菌计数对长效利福霉素,利福喷丁(RPE)和FCE22807(FCE)的有效性进行了研究。用结核分支杆菌H37R_v株感染两周后,采用异烟肼25mg/kg、利福平10mg/kg和吡嗪酰胺150mg/kg,每日给药进行治疗持续6周。此后将... 在实验性鼠结核病中,通过脾脏的活菌计数对长效利福霉素,利福喷丁(RPE)和FCE22807(FCE)的有效性进行了研究。用结核分支杆菌H37R_v株感染两周后,采用异烟肼25mg/kg、利福平10mg/kg和吡嗪酰胺150mg/kg,每日给药进行治疗持续6周。此后将小鼠分组,给RPE或FCE间隔分别为1周、2周或3周,化疗18周和24周后进行脾脏活菌计数。实验1显示RPE的剂量很有效,在每周给药1次的方案中,16mg/kg的剂量迅速灭菌,10mg/kg灭菌作用不十分迅速,6.25mg/kg作用不完全。RPE每2周或3周给药作用小,每2周给药16mg/kg其作用尽管与6mg/kg每周给药相同。第二个实验比较了RPE和FCE每次给药12mg/kg或8mg/kg。8mg/kg每2周或3周给药结果相似,尽管FCE较RPE作用稍强。血清分析表明8mg/kg及12mg/kgFCE的血清水平甚至低于6.25mg/kgRPE所产生的水平。这提示如果FCE的生物利用度可以提高,该药可能是较RPE更好的药物,并且服用16mg/kgRPE后的血清水平与人服用8mg/kg同时摄入富有脂肪的食物后的水平相似,提示在人类治疗中有效的2周给药1次的良好前景,对长效利福霉素在肺结核治疗管理中可能发挥的作用进行了讨论。 展开更多
关键词 利福霉素 利福喷丁 利福平 藤黄八迭球菌 金黄色葡萄球菌 3周给药 小鼠 TUBERCULOSIS 活菌计数 实验性
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Correction:Topological superconductivity in multifold fermion metals
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作者 Zhe Shen Gao Xue-Jian Gao +3 位作者 Wen-Yu He Xiao Yan Xu t.k.ng K.T.Law 《Quantum Frontiers》 2023年第1期57-57,共1页
Following publication of the original article[1],the following information has been delete from the Acknowledgments section:KTL acknowledges the support of the Croucher Foundation,the Dr.Tai-chin Lo Foundation and the... Following publication of the original article[1],the following information has been delete from the Acknowledgments section:KTL acknowledges the support of the Croucher Foundation,the Dr.Tai-chin Lo Foundation and the HKRGC through grants C6026-16W,C6025-19G,16310219 and 16309718.The following information has been added to the Funding section:K.T.L.acknowledges the support of the Ministry of Science and Technology,China,and Hong Kong Research Grant Council throughGrantsNo.2020YFA0309600,No.RFS2021-6S03,No.C6025-19G,No.AoE/P-701/20,No.16310520,No.16310219,No.16307622,and No.16309718. 展开更多
关键词 multifold fermion metals topological superconductivity research grant council research grants Hong Kong Research Grants Council funding acknowledgments Ministry Science Technology China
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Topological superconductivity in multifold fermion metals
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作者 Zhe Shen Gao Xue-Jian Gao +3 位作者 Wen-Yu He Xiao Yan Xu t.k.ng K.T.Law 《Quantum Frontiers》 2022年第1期14-19,共6页
Recently,multifold fermions characterized by band crossings with multifold degeneracy and Fermi surfaces with higher Chern numbers have been discovered experimentally in AlPt(Schroter et al.in Nat Phys 15:759-765,2019... Recently,multifold fermions characterized by band crossings with multifold degeneracy and Fermi surfaces with higher Chern numbers have been discovered experimentally in AlPt(Schroter et al.in Nat Phys 15:759-765,2019)and XSi(X=Rh,Co)(Sanchez et al.in Nature 567:500-505,2019;Rao et al.in Nature 567:496-499,2019;Takane et al.in Phys Rev Lett 122:076402,2019).In this work,we largely expand the family of multifold fermion materials by pointing out that several well-studied noncentrosymmetric superconductors are indeed multifold fermion metals.Importantly,their normal state topological properties,which have been ignored in previous studies,play an important role in the superconducting properties.Taking Li_(2)Pd_(3)B and Li_(2)Pt_(3)B as examples,we found a large number of unconventional degenerate points,such as double spin-1,spin-3/2,Weyl and double Weyl topological band crossing points near the Fermi energy,which result in finite Chern numbers on Fermi surfaces.Long Fermi arc states in Li_(2)Pd_(3)B,originating from the nontrivial band topology were found.Importantly,it has been shown experimentally that Li_(2)Pd_(3)B and Li_(2)Pt_(3)B are fully gapped and gapless superconductors,respectively.By analyzing the possible pairing symmetries,we suggest that Li_(2)Pd_(3)B is a conventional s-wave superconductor or DIII class topological superconductor with Majorana surface states.Li_(2)Pt_(3)B,being gapless,is likely to be a nodal topological superconductor with dispersionless surface Majorana modes.We further identified that several noncentrosymmetric superconductors,such as Mo_(3)Al_(2)C,PdBiSe,Y_(2)C_(3)and La2C_(3),are multifold fermion superconductors.This work calls for a revisit for the study of noncentrosymmtric superconductors which provide platforms for investigating the interplay between superconductivity and topologically nontrivial Fermi surfaces. 展开更多
关键词 Li_(2)(Pd Pt)_(3)B Multifold fermion Topological superconductivity
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