OBJECTIVE:To assess the effectiveness and safety of traditional Chinese medical therapy for cancer-related fatigue.METHODS:We systematically searched eight electronic databases up to June 2017 for randomized clinical ...OBJECTIVE:To assess the effectiveness and safety of traditional Chinese medical therapy for cancer-related fatigue.METHODS:We systematically searched eight electronic databases up to June 2017 for randomized clinical trials of traditional Chinese medical therapy for cancer-related fatigue.Two authors independently extracted data and assessed the risk bias of the included trials using the Cochrane Handbook.Data were analyzed by Rev Man 5.2 software.RESULTS:A total of 23 trials involving 1832 participants identified with cancer-related fatigue were included.Twenty trials reported a beneficial effect of traditional Chinese medical therapy on cancer-related fatigue.On pooling the data from Chinese herbal medicine therapy and acupuncture or moxibustion therapy,respectively,significant differences were found between experimental groups and control groups.Fatigue improvement rates showed significant differences between traditional Chinese medical therapy and control groups[odds ratio(OR),7.62;95%confidence interval(CI),3.75-15.49;P<0.00001;and OR,3.78;95%CI,2.29-6.23;P<0.00001).Fatigue change scores also showed significant differences between the two groups(mean difference,-0.91;95%CI,-1.16 to-0.65;P<0.00001).Eleven trials demonstrated that traditional Chinese medical therapy improved the quality of life of cancer patients.No severe adverse effects occurred in traditional Chinese medical therapy groups.CONCLUSION:Meta-analysis showed that Chinese medical therapy seems to be effective and safe in the treatment of cancer-related fatigue.展开更多
基金Supported by Grants from the Natural Science Foundation of China(No.81903991,No.81974543)the Natural Science Foundation of Guangdong Province(No.2017A030310326,No.2019A1515011362)+3 种基金the Guangzhou science and technology plan project(No.201804010149,No.202002030155)the Chinese medicine science and technology research project of Guangdong Provincial Hospital of Chinese Medicine(No.YN2019MJ09)the Major Research Projects in First-class Disciplines of Guangzhou University of Chinese Medicine(No.A1260619111001)the Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome(No.ZH2020KF03)
文摘OBJECTIVE:To assess the effectiveness and safety of traditional Chinese medical therapy for cancer-related fatigue.METHODS:We systematically searched eight electronic databases up to June 2017 for randomized clinical trials of traditional Chinese medical therapy for cancer-related fatigue.Two authors independently extracted data and assessed the risk bias of the included trials using the Cochrane Handbook.Data were analyzed by Rev Man 5.2 software.RESULTS:A total of 23 trials involving 1832 participants identified with cancer-related fatigue were included.Twenty trials reported a beneficial effect of traditional Chinese medical therapy on cancer-related fatigue.On pooling the data from Chinese herbal medicine therapy and acupuncture or moxibustion therapy,respectively,significant differences were found between experimental groups and control groups.Fatigue improvement rates showed significant differences between traditional Chinese medical therapy and control groups[odds ratio(OR),7.62;95%confidence interval(CI),3.75-15.49;P<0.00001;and OR,3.78;95%CI,2.29-6.23;P<0.00001).Fatigue change scores also showed significant differences between the two groups(mean difference,-0.91;95%CI,-1.16 to-0.65;P<0.00001).Eleven trials demonstrated that traditional Chinese medical therapy improved the quality of life of cancer patients.No severe adverse effects occurred in traditional Chinese medical therapy groups.CONCLUSION:Meta-analysis showed that Chinese medical therapy seems to be effective and safe in the treatment of cancer-related fatigue.
