Hybrid drug delivery systems(DDS) have been prepared by grafting poly(NIPAM-co-MPS) chains on multimodal porous silica nanoparticles having an inner mesoporous structure and an outer thin layer of micropores. The hybr...Hybrid drug delivery systems(DDS) have been prepared by grafting poly(NIPAM-co-MPS) chains on multimodal porous silica nanoparticles having an inner mesoporous structure and an outer thin layer of micropores. The hybrid thermoresponsive DDS were fully characterized and loaded with a model drug. The in vitro drug release tests are carried out at below and above the lower critical solution temperature(LCST) of the copolymer. The results have revealed that due to the presence of small diameter(~1.3 nm) micropores at the periphery of the particles, the collapsed globules of the thermoresponsive copolymer above its LCST hinders the complete release of the drug which resulted in a reverse thermoresponsive drug release profile by the hybrid DDS.展开更多
Mesoporous silica nanoparticles and related research has noticed a huge growth in the last few years.Some interesting statistics about reports on mesoporous silica are presented in this highlight.After their arrival o...Mesoporous silica nanoparticles and related research has noticed a huge growth in the last few years.Some interesting statistics about reports on mesoporous silica are presented in this highlight.After their arrival on the world stage of research these materials have captured several fields of applications including catalyst supports,drug delivery,water purification and their use in bio-materials.Hydrothermal stability,porous structure stability against hydrolysis and suitable organic or bio-functionalization of them for improved biocompatibility are the main issues to be addressed in the near future.Some recent achievements in the synthesis and surface modification of these materials are discussed briefly.展开更多
文摘Hybrid drug delivery systems(DDS) have been prepared by grafting poly(NIPAM-co-MPS) chains on multimodal porous silica nanoparticles having an inner mesoporous structure and an outer thin layer of micropores. The hybrid thermoresponsive DDS were fully characterized and loaded with a model drug. The in vitro drug release tests are carried out at below and above the lower critical solution temperature(LCST) of the copolymer. The results have revealed that due to the presence of small diameter(~1.3 nm) micropores at the periphery of the particles, the collapsed globules of the thermoresponsive copolymer above its LCST hinders the complete release of the drug which resulted in a reverse thermoresponsive drug release profile by the hybrid DDS.
基金Compagnia di San Paolo and University of Turin,Italy for the on-going research project in our laboratory“Bando per il finaziamento di progetti di ricerca di Ateneoanno 2011”project code ORTO114XNH is acknowledged.
文摘Mesoporous silica nanoparticles and related research has noticed a huge growth in the last few years.Some interesting statistics about reports on mesoporous silica are presented in this highlight.After their arrival on the world stage of research these materials have captured several fields of applications including catalyst supports,drug delivery,water purification and their use in bio-materials.Hydrothermal stability,porous structure stability against hydrolysis and suitable organic or bio-functionalization of them for improved biocompatibility are the main issues to be addressed in the near future.Some recent achievements in the synthesis and surface modification of these materials are discussed briefly.
