The stability and evolution of human genetics depend on chromosomes and chromosome-chromosome interactions.We wish to understand the spatial location of chromosomes in dividing cells in order to understand the relatio...The stability and evolution of human genetics depend on chromosomes and chromosome-chromosome interactions.We wish to understand the spatial location of chromosomes in dividing cells in order to understand the relationship between chromosome-chromosome interactions and to further investigate the role of chromosomes and their impact on cell biological behavior.In this study,we explored the relative spatial positional relationships of chromosomes[t(9;22)and t(15;17)]in B-ALL cells by using the three-dimensional DNA fluorescent in situ hybridization(3D-FISH)method.The results showed that chromosomes[t(9;22)and t(15;17)]showed relatively stable spatial relationships.The relative stability of the spatial location of chromosomes in dividing cells may be relevant to disease.展开更多
1.INTRODUCTION Hematological malignancies with NUP98 rearrangement(NUP98r)were included as recurrent genetic abnormali-ties due to their distinctive clinicopathologic characteristics in the 2022 European LeukmiaNet(EL...1.INTRODUCTION Hematological malignancies with NUP98 rearrangement(NUP98r)were included as recurrent genetic abnormali-ties due to their distinctive clinicopathologic characteristics in the 2022 European LeukmiaNet(ELN)classification,the 2022 World Health Organization(WHO)classification,and the International Consensus Classification.展开更多
The CACA Guidelines was summarized by Hematology Oncology Committee of China Anti-Cancer Association.This portion of the CACA Guidelines for adult acute myeloid leukemia(AML)not only focuses on diagnosis,the treat-men...The CACA Guidelines was summarized by Hematology Oncology Committee of China Anti-Cancer Association.This portion of the CACA Guidelines for adult acute myeloid leukemia(AML)not only focuses on diagnosis,the treat-ment options for younger(age<60 years)and older(age≥60 years)patients(including non-APL,APL,R/R AML),but also pay attention to the treatment of AML complications,including central nervous system leukemia(CNSL),cardiotoxicity,agranulocytosis and fever,hepatitis B virus reactivation,uric acid nephropathy,bleeding and coagula-tion disorders,and nursing for patients with AML from the perspective of holistic integrative medicine to enhance the quality of life and treatment effects.展开更多
With the advances in allogeneic hematopoietic cell transplantation(allo-HCT)and supportive care,the number of allo-HCT for elderly patients has been increasing in recent years.However,the advanced donor age limits the...With the advances in allogeneic hematopoietic cell transplantation(allo-HCT)and supportive care,the number of allo-HCT for elderly patients has been increasing in recent years.However,the advanced donor age limits the availability of human leukocyte antigen(HLA)-matched sibling donors(MSD)for elderly individuals.展开更多
Oral drugs such as ibrutinib play an important role in the treatment of mature B-cell lymphoma(BCL)due to their reliable efficacy,manageable safety,high accessibility,and convenience for use.Still,no guidelines or con...Oral drugs such as ibrutinib play an important role in the treatment of mature B-cell lymphoma(BCL)due to their reliable efficacy,manageable safety,high accessibility,and convenience for use.Still,no guidelines or consensus focusing on oral drug therapies for BCL is available.To provide a reference of oral agent-based treatment for mature BCL,a panel of experts from the Lymphocyte Disease Group,Chinese Society of Hematology,Chinese Medical Association conducted an extensive discussion and reached a consensus on oral drugs for Chinese BCL patients on the basis of the current application status of oral drugs in China,combined with the latest authoritative guidelines in the world and current research reports.This consensus reviewed the application of oral drugs in the treatment of BCL and the latest research and provided appropriate recommendations on the use of oral drugs for indolent or aggressive BCL patients.With the deepening of research and the development of standardized clinical applications,oral medications will bring better treatment to BCL patients,enabling more patients to benefit from them.展开更多
文摘The stability and evolution of human genetics depend on chromosomes and chromosome-chromosome interactions.We wish to understand the spatial location of chromosomes in dividing cells in order to understand the relationship between chromosome-chromosome interactions and to further investigate the role of chromosomes and their impact on cell biological behavior.In this study,we explored the relative spatial positional relationships of chromosomes[t(9;22)and t(15;17)]in B-ALL cells by using the three-dimensional DNA fluorescent in situ hybridization(3D-FISH)method.The results showed that chromosomes[t(9;22)and t(15;17)]showed relatively stable spatial relationships.The relative stability of the spatial location of chromosomes in dividing cells may be relevant to disease.
基金supported by grant from the National Key R&D Program of China(2019YFA0111000,2022YFC2502700)the National Natural Science Foundation of China(82170158,82470166,82200149,82100175,82200149,82100170)+1 种基金the priority academic program development of Jiangsu Higher Education Institution,the Natural Science Foundation of Jiangsu Province(BK20231195,BK20210087)the Open Project of Jiangsu Biobank of Clinical Resources(SBK202003001,SBK202003003).
文摘1.INTRODUCTION Hematological malignancies with NUP98 rearrangement(NUP98r)were included as recurrent genetic abnormali-ties due to their distinctive clinicopathologic characteristics in the 2022 European LeukmiaNet(ELN)classification,the 2022 World Health Organization(WHO)classification,and the International Consensus Classification.
基金provided by the National Key Research and Development Program of China(2021YFC2500300)CAMS Innovation Fund for Medical Sciences(2021-I2M-1–041).
文摘The CACA Guidelines was summarized by Hematology Oncology Committee of China Anti-Cancer Association.This portion of the CACA Guidelines for adult acute myeloid leukemia(AML)not only focuses on diagnosis,the treat-ment options for younger(age<60 years)and older(age≥60 years)patients(including non-APL,APL,R/R AML),but also pay attention to the treatment of AML complications,including central nervous system leukemia(CNSL),cardiotoxicity,agranulocytosis and fever,hepatitis B virus reactivation,uric acid nephropathy,bleeding and coagula-tion disorders,and nursing for patients with AML from the perspective of holistic integrative medicine to enhance the quality of life and treatment effects.
基金supported by National Natural Science Foundation of China(No.82370215,82020108003,and 82330008)Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),Jiangsu Provincial Medical Innovation Center(No.CXZX202201)Science and Technology Program of Suzhou(No.SKY2023047)。
文摘With the advances in allogeneic hematopoietic cell transplantation(allo-HCT)and supportive care,the number of allo-HCT for elderly patients has been increasing in recent years.However,the advanced donor age limits the availability of human leukocyte antigen(HLA)-matched sibling donors(MSD)for elderly individuals.
文摘Oral drugs such as ibrutinib play an important role in the treatment of mature B-cell lymphoma(BCL)due to their reliable efficacy,manageable safety,high accessibility,and convenience for use.Still,no guidelines or consensus focusing on oral drug therapies for BCL is available.To provide a reference of oral agent-based treatment for mature BCL,a panel of experts from the Lymphocyte Disease Group,Chinese Society of Hematology,Chinese Medical Association conducted an extensive discussion and reached a consensus on oral drugs for Chinese BCL patients on the basis of the current application status of oral drugs in China,combined with the latest authoritative guidelines in the world and current research reports.This consensus reviewed the application of oral drugs in the treatment of BCL and the latest research and provided appropriate recommendations on the use of oral drugs for indolent or aggressive BCL patients.With the deepening of research and the development of standardized clinical applications,oral medications will bring better treatment to BCL patients,enabling more patients to benefit from them.
