The environment surrounding a tumor,known as the tumor microenvironment(TME),plays a role in how cancer progresses and responds to treatment.It poses both challenges and opportunities for improving cancer therapy.Rece...The environment surrounding a tumor,known as the tumor microenvironment(TME),plays a role in how cancer progresses and responds to treatment.It poses both challenges and opportunities for improving cancer therapy.Recent progress in understanding the TME complexity and diversity has led to approaches for treating cancer.This perspective discusses the strategies for targeting the TME,such as adjusting networks using extracellular vesicles to deliver drugs and enhancing immune checkpoint inhibitors(ICIS)through combined treatments.Furthermore,it highlights adoptive cell transfer(ACT)therapies as an option for tumors.By studying how components of the TME interact and utilizing technologies like single-cell RNA sequencing and spatial transcriptomics,we can develop more precise and efficient treatments for cancer.This article emphasizes the need to reshape the TME to boost antitumor immunity and overcome resistance to therapy,providing guidance for research and clinical practices in precision oncology.展开更多
Prurigo nodularis(PN)is a chronic pruritic inflammatory skin disease characterized by hyperkeratotic papules and nodules symmetrically distributed on the back and extensor surfaces of the extremities,accompanied by se...Prurigo nodularis(PN)is a chronic pruritic inflammatory skin disease characterized by hyperkeratotic papules and nodules symmetrically distributed on the back and extensor surfaces of the extremities,accompanied by severe pruritus.PN has a serious impact on quality of life.[1–3]PN is a complex and difficult-to-treat condition.There is a lack of unified understanding of its diagnosis and treatment specifications,and the means approved for treating PN are limited;thus,clinicians mostly use empirical therapies.展开更多
基金supported by a grant from the Public Welfare Projects of Ningbo,China(2020S065)the Health Major Science and Technology Planning Project of Zhejiang,China(WKJ-ZJ-2411),and a grant from the Project of Ningbo Leading Medical&Health Discipline(2022-F23).
文摘The environment surrounding a tumor,known as the tumor microenvironment(TME),plays a role in how cancer progresses and responds to treatment.It poses both challenges and opportunities for improving cancer therapy.Recent progress in understanding the TME complexity and diversity has led to approaches for treating cancer.This perspective discusses the strategies for targeting the TME,such as adjusting networks using extracellular vesicles to deliver drugs and enhancing immune checkpoint inhibitors(ICIS)through combined treatments.Furthermore,it highlights adoptive cell transfer(ACT)therapies as an option for tumors.By studying how components of the TME interact and utilizing technologies like single-cell RNA sequencing and spatial transcriptomics,we can develop more precise and efficient treatments for cancer.This article emphasizes the need to reshape the TME to boost antitumor immunity and overcome resistance to therapy,providing guidance for research and clinical practices in precision oncology.
基金supported by a grant from the National Key Research and Development Programme of China(No.2023YFC2508200)
文摘Prurigo nodularis(PN)is a chronic pruritic inflammatory skin disease characterized by hyperkeratotic papules and nodules symmetrically distributed on the back and extensor surfaces of the extremities,accompanied by severe pruritus.PN has a serious impact on quality of life.[1–3]PN is a complex and difficult-to-treat condition.There is a lack of unified understanding of its diagnosis and treatment specifications,and the means approved for treating PN are limited;thus,clinicians mostly use empirical therapies.
