In this work,as a new type of oil-based additive,a phosphate mixture of(Sr_(0.9)Ca_(0.1))_(3)(PO_(4))_(2)and Sr_(3)(PO_(4))_(2)(SrP)with a flower-like structure was synthesized.Compared with pure poly-α-olefin-8(PAO8...In this work,as a new type of oil-based additive,a phosphate mixture of(Sr_(0.9)Ca_(0.1))_(3)(PO_(4))_(2)and Sr_(3)(PO_(4))_(2)(SrP)with a flower-like structure was synthesized.Compared with pure poly-α-olefin-8(PAO8),when a titanium alloy is lubricated,the use of 20 wt%SrP for lubrication can reduce the coefficient of friction(COF)by 69.89%and the wear rate(WR)by 99.86%.The extraordinary tribological performance was attributed to the deposition of a layer of SrP on the surface of the titanium alloy.On the one hand,the deposition layer formed by SrP can prevent direct contact between friction pairs,protect the surface of the titanium alloy,and prevent adhesion wear of the titanium alloy.On the other hand,the low-shear interlayer sliding of SrP nanosheets inside the deposition layer was beneficial for friction reduction.X-ray photoelectron spectroscopy(XPS)confirmed that after frictional sliding,the active group phosphate in SrP was activated,and other metals were oxidized to produce a series of oxides.In addition,phosphate can form P‒O‒Ti bonds with titanium at the interface,which is the key to SrP deposition and adsorption on the surface of titanium alloys.The SrP additive not only exhibited excellent performance in lubricating titanium alloy discs but also stainless steel 304,42CrMo,and tin bronze.After lubrication with 20 wt%SrP additive,the wear tracks of stainless steel 304 and 42CrMo were not detected,and WR of tin bronze decreased by 92%.An interface lubrication mechanism has been proposed that may be beneficial for the design and application of new lubricating materials.展开更多
The global spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2019(COVID-19).In this study,we developed...The global spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2019(COVID-19).In this study,we developed an integrative drug repositioning framework,which fully takes advantage of machine learning and statistical analysis approaches to systematically integrate and mine large-scale knowledge graph,literature and transcriptome data to discover the potential drug candidates against SARS-CoV-2.Our in silico screening followed by wet-lab validation indicated that a poly-ADP-ribose polymerase 1(PARP1)inhibitor,CVL218,currently in Phase I clinical trial,may be repurposed to treat COVID-19.Our in vitro assays revealed that CVL218 can exhibit effective inhibitory activity against SARS-CoV-2 replication without obvious cytopathic effect.In addition,we showed that CVL218 can interact with the nucleocapsid(N)protein of SARS-CoV-2 and is able to suppress the LPS-induced production of several inflammatory cytokines that are highly relevant to the prevention of immunopathology induced by SARS-CoV-2 infection.展开更多
基金supported by the Major Program(D)of Hubei Province(2023BAA003)the National Natural Science Foundation of China(52205213)Shanghai Sailing Program(24YF2744900).
文摘In this work,as a new type of oil-based additive,a phosphate mixture of(Sr_(0.9)Ca_(0.1))_(3)(PO_(4))_(2)and Sr_(3)(PO_(4))_(2)(SrP)with a flower-like structure was synthesized.Compared with pure poly-α-olefin-8(PAO8),when a titanium alloy is lubricated,the use of 20 wt%SrP for lubrication can reduce the coefficient of friction(COF)by 69.89%and the wear rate(WR)by 99.86%.The extraordinary tribological performance was attributed to the deposition of a layer of SrP on the surface of the titanium alloy.On the one hand,the deposition layer formed by SrP can prevent direct contact between friction pairs,protect the surface of the titanium alloy,and prevent adhesion wear of the titanium alloy.On the other hand,the low-shear interlayer sliding of SrP nanosheets inside the deposition layer was beneficial for friction reduction.X-ray photoelectron spectroscopy(XPS)confirmed that after frictional sliding,the active group phosphate in SrP was activated,and other metals were oxidized to produce a series of oxides.In addition,phosphate can form P‒O‒Ti bonds with titanium at the interface,which is the key to SrP deposition and adsorption on the surface of titanium alloys.The SrP additive not only exhibited excellent performance in lubricating titanium alloy discs but also stainless steel 304,42CrMo,and tin bronze.After lubrication with 20 wt%SrP additive,the wear tracks of stainless steel 304 and 42CrMo were not detected,and WR of tin bronze decreased by 92%.An interface lubrication mechanism has been proposed that may be beneficial for the design and application of new lubricating materials.
基金This work was supported in part by the National Natural Science Foundation of China(61872216,81630103,31900862,31725014)Jiangsu Provincial Emergency Project on Prevention and Control of COVID-19 Epidemic(BE2020601)+2 种基金the Nation Science and Technology Major Projects for Major New Drugs Innovation and Development(2018ZX09711003-004-002,2019ZX09301010)Pudong New Area Science and Technology Development Foundation(PKX2019-S08)the Turing Al Institute of Nanjing,and the Zhongguancun Haihua Institute for Frontier Information Technology.
文摘The global spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2019(COVID-19).In this study,we developed an integrative drug repositioning framework,which fully takes advantage of machine learning and statistical analysis approaches to systematically integrate and mine large-scale knowledge graph,literature and transcriptome data to discover the potential drug candidates against SARS-CoV-2.Our in silico screening followed by wet-lab validation indicated that a poly-ADP-ribose polymerase 1(PARP1)inhibitor,CVL218,currently in Phase I clinical trial,may be repurposed to treat COVID-19.Our in vitro assays revealed that CVL218 can exhibit effective inhibitory activity against SARS-CoV-2 replication without obvious cytopathic effect.In addition,we showed that CVL218 can interact with the nucleocapsid(N)protein of SARS-CoV-2 and is able to suppress the LPS-induced production of several inflammatory cytokines that are highly relevant to the prevention of immunopathology induced by SARS-CoV-2 infection.
