For lifetime non-smokers, lung cancer risk is mainly associated with inhalation exposure to air pollution. For the Chinese population, indoor air pollution due to solid fuel combustion has been the primary source of i...For lifetime non-smokers, lung cancer risk is mainly associated with inhalation exposure to air pollution. For the Chinese population, indoor air pollution due to solid fuel combustion has been the primary source of inhalation exposure for decades. Polycyclic aromatic hydrocarbons （PAHs） are the by-products of incomplete combustion.展开更多
BACKGROUND Rumination is a critical psychological factor contributing to the relapse of major depressive episodes(MDEs)and a core residual symptom in remitted MDEs.Investigating its neural correlations is essential fo...BACKGROUND Rumination is a critical psychological factor contributing to the relapse of major depressive episodes(MDEs)and a core residual symptom in remitted MDEs.Investigating its neural correlations is essential for developing strategies to prevent MDE relapse.Despite its clinical importance,the brain network mechanisms underlying rumination in remitted MDE patients have yet to be fully elucidated.AIM To investigate the brain network mechanism underlying rumination in patients with remitted MDEs using functional magnetic resonance imaging(fMRI).METHODS We conducted an fMRI-based rumination-distraction task to induce rumination and distraction states in 51 patients with remitted MDEs.Functional connectivity(FC)was analyzed using the network-based statistic(NBS)approach,and eight topological metrics were calculated to compare the network topological properties between the two states.Correlation analyses were further performed to identify the relationships between individual rumination levels and the significantly altered brain network metrics.RESULTS The NBS analysis revealed that the altered FCs between the rumination and distraction states were located primarily in the frontoparietal,default mode,and cerebellar networks.No significant correlation was detected between these altered FCs and individual rumination levels.Among the eight topological metrics,the clustering coefficient,shortest path length,and local efficiency were significantly lower during rumination and positively correlated with individual rumination levels.In contrast,global efficiency was greater in the rumination state than in the distraction state and was negatively correlated with individual rumination levels.CONCLUSION Our work revealed the altered FC and topological properties during rumination in remitted MDE patients,offering valuable insights into the neural mechanisms of rumination from a brain network perspective.展开更多
利用TCMSP数据库检索乌药有效作用成分与分子靶点,采用Genecards数据库筛选抗氧化和抑菌相关靶点与交集靶点,将STRING数据库构建的交集靶点PPI网络导入Cytoscape 3.8.0中,筛选出乌药抗氧化和抗菌作用的核心靶点,利用Auto Dock Vina对共...利用TCMSP数据库检索乌药有效作用成分与分子靶点,采用Genecards数据库筛选抗氧化和抑菌相关靶点与交集靶点,将STRING数据库构建的交集靶点PPI网络导入Cytoscape 3.8.0中,筛选出乌药抗氧化和抗菌作用的核心靶点,利用Auto Dock Vina对共同核心靶点与乌药活性成分中重要物质进行分子对接。结果筛选出乌药中9个有效作用成分、179个相关作用靶点,得到抗氧化相关靶点551个、抗菌相关靶点441个;通过交集筛选并得到乌药与抗氧化的交集靶点为99个、与抑菌的交集靶点为40个;以Betweenness、Degree和Closeness算法依次取前50%筛选出乌药抑菌和抗氧化作用的核心靶点,取交集得到共同核心靶点4个,分别为TNF、CASP3、IL6和AKT1。分子对接结果显示乌药功能性成分与核心靶点均可形成具有较高亲和力的复合物。同时结合乌药蜜饮体外抗氧化与抑菌能力实验结果表明,乌药的活性成分具备联合抗氧化和抑菌能力,本研究为乌药在药膳食疗联合抗氧化与抑菌方面的作用机制探讨提供了新思路。展开更多
相比电动汽车(electricvehicle,EV)慢充用户,大规模、随机快充负荷的接入将会带来更加严重的电网安全运行问题。从整体社会经济效益最大化的角度出发,仅单纯从电网侧增加基础设施建设并非最佳解决之道,有必要从用户角度研究有效的调度...相比电动汽车(electricvehicle,EV)慢充用户,大规模、随机快充负荷的接入将会带来更加严重的电网安全运行问题。从整体社会经济效益最大化的角度出发,仅单纯从电网侧增加基础设施建设并非最佳解决之道,有必要从用户角度研究有效的调度策略对电动汽车的快充行为进行引导。为此,基于未来智慧城市的场景下,提出了基于节点关键度的配网供电电压偏差指标(voltage deviation index based on node importance,VDINI)的概念,指出动态调整快充站充电服务费的手段,分析电动汽车用户对于快充站选择行为的影响因素,建立电动汽车用户基于自身效益的充电位置决策模型,从而说明通过调整各充电服务费的来对快充行为进行引导的可行性。在此基础上,根据需要满足的各种约束条件,制定各快充站快充服务费的求解流程,在保证充电站效益不变的同时,将电动汽车合理地引导至各个快充站,均衡区域内的充电负荷,实现空间上的有序快充,改善了配网的电能质量。算例仿真验证了所提充电服务费制定方法的合理性以及快充负荷引导策略的优越性。展开更多
基金funded by the National Natural Science Foundation of China(41390240 and 41571130010)the 111 Project(B14001)
文摘For lifetime non-smokers, lung cancer risk is mainly associated with inhalation exposure to air pollution. For the Chinese population, indoor air pollution due to solid fuel combustion has been the primary source of inhalation exposure for decades. Polycyclic aromatic hydrocarbons （PAHs） are the by-products of incomplete combustion.
基金the National Key Research and Development Program of China,No.2021ZD0202000the National Natural Science Foundation of China,No.82101612 and No.82471570+1 种基金the Natural Science Foundation of Hunan Province,China,No.2022JJ40692the Science and Technology Innovation Program of Hunan Province,No.2021RC2040 and No.2024RC3056.
文摘BACKGROUND Rumination is a critical psychological factor contributing to the relapse of major depressive episodes(MDEs)and a core residual symptom in remitted MDEs.Investigating its neural correlations is essential for developing strategies to prevent MDE relapse.Despite its clinical importance,the brain network mechanisms underlying rumination in remitted MDE patients have yet to be fully elucidated.AIM To investigate the brain network mechanism underlying rumination in patients with remitted MDEs using functional magnetic resonance imaging(fMRI).METHODS We conducted an fMRI-based rumination-distraction task to induce rumination and distraction states in 51 patients with remitted MDEs.Functional connectivity(FC)was analyzed using the network-based statistic(NBS)approach,and eight topological metrics were calculated to compare the network topological properties between the two states.Correlation analyses were further performed to identify the relationships between individual rumination levels and the significantly altered brain network metrics.RESULTS The NBS analysis revealed that the altered FCs between the rumination and distraction states were located primarily in the frontoparietal,default mode,and cerebellar networks.No significant correlation was detected between these altered FCs and individual rumination levels.Among the eight topological metrics,the clustering coefficient,shortest path length,and local efficiency were significantly lower during rumination and positively correlated with individual rumination levels.In contrast,global efficiency was greater in the rumination state than in the distraction state and was negatively correlated with individual rumination levels.CONCLUSION Our work revealed the altered FC and topological properties during rumination in remitted MDE patients,offering valuable insights into the neural mechanisms of rumination from a brain network perspective.
文摘利用TCMSP数据库检索乌药有效作用成分与分子靶点,采用Genecards数据库筛选抗氧化和抑菌相关靶点与交集靶点,将STRING数据库构建的交集靶点PPI网络导入Cytoscape 3.8.0中,筛选出乌药抗氧化和抗菌作用的核心靶点,利用Auto Dock Vina对共同核心靶点与乌药活性成分中重要物质进行分子对接。结果筛选出乌药中9个有效作用成分、179个相关作用靶点,得到抗氧化相关靶点551个、抗菌相关靶点441个;通过交集筛选并得到乌药与抗氧化的交集靶点为99个、与抑菌的交集靶点为40个;以Betweenness、Degree和Closeness算法依次取前50%筛选出乌药抑菌和抗氧化作用的核心靶点,取交集得到共同核心靶点4个,分别为TNF、CASP3、IL6和AKT1。分子对接结果显示乌药功能性成分与核心靶点均可形成具有较高亲和力的复合物。同时结合乌药蜜饮体外抗氧化与抑菌能力实验结果表明,乌药的活性成分具备联合抗氧化和抑菌能力,本研究为乌药在药膳食疗联合抗氧化与抑菌方面的作用机制探讨提供了新思路。
文摘相比电动汽车(electricvehicle,EV)慢充用户,大规模、随机快充负荷的接入将会带来更加严重的电网安全运行问题。从整体社会经济效益最大化的角度出发,仅单纯从电网侧增加基础设施建设并非最佳解决之道,有必要从用户角度研究有效的调度策略对电动汽车的快充行为进行引导。为此,基于未来智慧城市的场景下,提出了基于节点关键度的配网供电电压偏差指标(voltage deviation index based on node importance,VDINI)的概念,指出动态调整快充站充电服务费的手段,分析电动汽车用户对于快充站选择行为的影响因素,建立电动汽车用户基于自身效益的充电位置决策模型,从而说明通过调整各充电服务费的来对快充行为进行引导的可行性。在此基础上,根据需要满足的各种约束条件,制定各快充站快充服务费的求解流程,在保证充电站效益不变的同时,将电动汽车合理地引导至各个快充站,均衡区域内的充电负荷,实现空间上的有序快充,改善了配网的电能质量。算例仿真验证了所提充电服务费制定方法的合理性以及快充负荷引导策略的优越性。
