Main text Synaptic degeneration is a prominent feature of vari-ous neurodegenerative diseases and represents an early pathogenic event in Alzheimer’s disease(AD)[1,2].Multiple synapse-specific proteins involved in di...Main text Synaptic degeneration is a prominent feature of vari-ous neurodegenerative diseases and represents an early pathogenic event in Alzheimer’s disease(AD)[1,2].Multiple synapse-specific proteins involved in distinct synaptic pathways can be measured in the cerebrospi-nal fluid(CSF)and have been implicated as promising biomarkers of synaptic degeneration.Among them,the most extensively studied ones include the presynaptic proteins synaptosomal-associated protein-25(SNAP25),growth-associated protein-43(GAP43)and synaptotag-min-1(SYT1)and postsynaptic protein neurogranin(NRGN)[3,4].展开更多
基金supported by the Canadian Institutes of Health Research(CIHR)[MOP-11–51-31,RFN 152985,159815,162303]Canadian Consortium of Neurodegeneration and Aging(CCNA+4 种基金MOP-11–51-31-team 1)Weston Brain Institute,the Alzheimer’s Association[NIRG-12–92090,NIRP-12–259245]Brain Canada Foundation(CFI Project 34874,33397)the Fonds de Recherche du Québec–Santé(FRQSChercheur Boursier,2020-VICO-279314)。
文摘Main text Synaptic degeneration is a prominent feature of vari-ous neurodegenerative diseases and represents an early pathogenic event in Alzheimer’s disease(AD)[1,2].Multiple synapse-specific proteins involved in distinct synaptic pathways can be measured in the cerebrospi-nal fluid(CSF)and have been implicated as promising biomarkers of synaptic degeneration.Among them,the most extensively studied ones include the presynaptic proteins synaptosomal-associated protein-25(SNAP25),growth-associated protein-43(GAP43)and synaptotag-min-1(SYT1)and postsynaptic protein neurogranin(NRGN)[3,4].
