We have yet to develop a fundamental understanding of the molecular complexities of human spermatozoa.This encompasses the unique packaging and structure of the sperm genome along with their paternally derived RNAs in...We have yet to develop a fundamental understanding of the molecular complexities of human spermatozoa.This encompasses the unique packaging and structure of the sperm genome along with their paternally derived RNAs in preparation for their delivery to the egg.The diversity of these transcripts is vast,including several anti-sense mol- ecules resembling known regulatory micro-RNAs.The field is still grasping with its delivery to the oocyte at fertiliza- tion and possible significance.It remains tempting to analogize them to maternally-derived transcripts active in early embryo patterning.Irrespective of their role in the embryo,their use as a means to assess male factor infertility is promising.展开更多
文摘We have yet to develop a fundamental understanding of the molecular complexities of human spermatozoa.This encompasses the unique packaging and structure of the sperm genome along with their paternally derived RNAs in preparation for their delivery to the egg.The diversity of these transcripts is vast,including several anti-sense mol- ecules resembling known regulatory micro-RNAs.The field is still grasping with its delivery to the oocyte at fertiliza- tion and possible significance.It remains tempting to analogize them to maternally-derived transcripts active in early embryo patterning.Irrespective of their role in the embryo,their use as a means to assess male factor infertility is promising.
