BACKGROUND Acute liver failure(ALF)due to diffuse hepatic infiltration by metastatic mela-noma is extremely rare and often misdiagnosed.In the absence of prior malig-nancy,this presentation can mimic other hepatic eme...BACKGROUND Acute liver failure(ALF)due to diffuse hepatic infiltration by metastatic mela-noma is extremely rare and often misdiagnosed.In the absence of prior malig-nancy,this presentation can mimic other hepatic emergencies such as Budd-Chiari syndrome.Early identification is crucial,especially in transplant candidates,to prevent inappropriate management.CASE SUMMARY A 61-year-old male presented with jaundice,abdominal distension,and enceph-alopathy.Liver imaging suggested acute Budd-Chiari syndrome,and liver trans-plantation was considered.However,biopsy revealed extensive hepatic infilt-ration by human melanoma black-positive melanoma cells.There was no known can-cer history,although retrospective symptoms suggested uveal localization as a possi-ble primary site.The patient rapidly deteriorated and died.A review of 12 simi-lar cases revealed shared diagnostic challenges,frequent misdiagnoses,and poor outcomes.CONCLUSION Infiltrative melanoma should be considered in unexplained ALF,even without previously known malignancy.展开更多
文摘BACKGROUND Acute liver failure(ALF)due to diffuse hepatic infiltration by metastatic mela-noma is extremely rare and often misdiagnosed.In the absence of prior malig-nancy,this presentation can mimic other hepatic emergencies such as Budd-Chiari syndrome.Early identification is crucial,especially in transplant candidates,to prevent inappropriate management.CASE SUMMARY A 61-year-old male presented with jaundice,abdominal distension,and enceph-alopathy.Liver imaging suggested acute Budd-Chiari syndrome,and liver trans-plantation was considered.However,biopsy revealed extensive hepatic infilt-ration by human melanoma black-positive melanoma cells.There was no known can-cer history,although retrospective symptoms suggested uveal localization as a possi-ble primary site.The patient rapidly deteriorated and died.A review of 12 simi-lar cases revealed shared diagnostic challenges,frequent misdiagnoses,and poor outcomes.CONCLUSION Infiltrative melanoma should be considered in unexplained ALF,even without previously known malignancy.
