Deep brain stimulation(DBS)is an established therapeutic intervention for people with Parkinson’s disease(PwPD)and is increasingly being utilized for other neurological disorders.Although effective in alleviating mot...Deep brain stimulation(DBS)is an established therapeutic intervention for people with Parkinson’s disease(PwPD)and is increasingly being utilized for other neurological disorders.Although effective in alleviating motor symptoms and reducing medication requirements,DBS has undergone minimal conceptual evolution and still relies on continuous high-frequency electrical stimulation.In Parkinson’s disease(PD),this persistent stimulation may cause adverse effects,including dysarthria,stimulation-induced dyskinesia,impulsivity,and mood alterations.Additionally,the continuous energy demand of current DBS systems accelerates battery depletion,necessitating more frequent battery charging or battery replacement surgeries,increasing risks,burden,and costs.Basic neuroscience research has long demonstrated that exogenous electrical stimulation can induce persistent changes to synaptic connections,known as long-term plasticity.展开更多
文摘Deep brain stimulation(DBS)is an established therapeutic intervention for people with Parkinson’s disease(PwPD)and is increasingly being utilized for other neurological disorders.Although effective in alleviating motor symptoms and reducing medication requirements,DBS has undergone minimal conceptual evolution and still relies on continuous high-frequency electrical stimulation.In Parkinson’s disease(PD),this persistent stimulation may cause adverse effects,including dysarthria,stimulation-induced dyskinesia,impulsivity,and mood alterations.Additionally,the continuous energy demand of current DBS systems accelerates battery depletion,necessitating more frequent battery charging or battery replacement surgeries,increasing risks,burden,and costs.Basic neuroscience research has long demonstrated that exogenous electrical stimulation can induce persistent changes to synaptic connections,known as long-term plasticity.
