Elderly individuals disproportionately face heat exposure risk compared to other demographic groups,with projected amplification in the future.The vast disparities between Global North and South countries necessitate ...Elderly individuals disproportionately face heat exposure risk compared to other demographic groups,with projected amplification in the future.The vast disparities between Global North and South countries necessitate a comprehensive understanding of the underlying factors influencing future heat exposure vulnerabilities.Here,we use factor decomposition method to quantify the contribution of climate change,population,and aging to heat exposure risk under four shared socioeconomic pathways(SSP)(SSP126,SSP245,SSP370,SSP585)from 2000 to 2100 at 20-year intervals.Results demonstrate a projected global escalation in heat exposure risk by 16 and 76 times under SSP126 and SSP585,respectively,with the North generally suffering lower risk than the South.Climate change emerges as a pivotal driver of future heat exposure risk in the North while aging notably influences the South.Despite climate change is projected to reduce heat exposure risk by up to 10%in the North under SSP1-2.6 by the end of the 21st century,aging remains a critical risk factor.展开更多
Exhaled ammonia(NH_(3))is an essential noninvasive biomarker for disease diagnosis.In this study,an acetone-modifier positive photoionization ion mobility spectrometry(AM-PIMS)method was developed for accurate qualita...Exhaled ammonia(NH_(3))is an essential noninvasive biomarker for disease diagnosis.In this study,an acetone-modifier positive photoionization ion mobility spectrometry(AM-PIMS)method was developed for accurate qualitative and quantitative analysis of exhaled NH_(3)with high selectivity and sensitivity.Acetone was introduced into the drift tube along with the drift gas as a modifier,and the characteristic NH_(3)product ion peak of(C_(3)H_(6)O)_(4)NH_(4)^(+)(K_(0)=1.45 cm^(2)/V·s)was obtained through the ion-molecule reaction with acetone reactant ions(C_(3)H_(6)O)_(2)H^(+)(K_(0)=1.87 cm^(2)/V·s),which significantly increased the peak-to-peak resolution and improved the accuracy of exhaled NH_(3)qualitative identification.Moreover,the interference of high humidity and the memory effect of NH_(3)molecules were significantly reduced via online dilution and purging sampling,thus realizing breath-by-breath measurement.As a result,a wide quantitative range of 5.87-140.92μmol/L with a response time of 40 ms was achieved,and the exhaled NH_(3)profile could be synchronized with the concentration curve of exhaled CO_(2).Finally,the analytical capacity of AM-PIMS was demonstrated by measuring the exhaled NH_(3)of healthy subjects,demonstrating its great potential for clinical disease diagnosis.展开更多
基金supported by the National Key R&D Program of China(Grant No.2022YFF1303101)the open fund project of the State Key Laboratory of Regional and Urban Ecology(Grant No.SKLURE2023-2-4).
文摘Elderly individuals disproportionately face heat exposure risk compared to other demographic groups,with projected amplification in the future.The vast disparities between Global North and South countries necessitate a comprehensive understanding of the underlying factors influencing future heat exposure vulnerabilities.Here,we use factor decomposition method to quantify the contribution of climate change,population,and aging to heat exposure risk under four shared socioeconomic pathways(SSP)(SSP126,SSP245,SSP370,SSP585)from 2000 to 2100 at 20-year intervals.Results demonstrate a projected global escalation in heat exposure risk by 16 and 76 times under SSP126 and SSP585,respectively,with the North generally suffering lower risk than the South.Climate change emerges as a pivotal driver of future heat exposure risk in the North while aging notably influences the South.Despite climate change is projected to reduce heat exposure risk by up to 10%in the North under SSP1-2.6 by the end of the 21st century,aging remains a critical risk factor.
基金supported by the National Natural Science Foundation of China(Grant Nos.:22027804,21974141,and 21904125)Natural Science Foundation of Liaoning Province(Grant Nos.:2022-MS-019 and 2022-MS-016)+2 种基金Science and Technology Innovation Foundation of Dalian(Grant No.:2022JJ13SN096)Dalian Institute of Chemical Physics(Grant Nos.:DICP I202141 and DICP I202144)1+X Program for Large Cohort Study-Clinical Research Incubation Project,The Second Hospital of Dalian Medical University(Project No.:2022DXDL01).
文摘Exhaled ammonia(NH_(3))is an essential noninvasive biomarker for disease diagnosis.In this study,an acetone-modifier positive photoionization ion mobility spectrometry(AM-PIMS)method was developed for accurate qualitative and quantitative analysis of exhaled NH_(3)with high selectivity and sensitivity.Acetone was introduced into the drift tube along with the drift gas as a modifier,and the characteristic NH_(3)product ion peak of(C_(3)H_(6)O)_(4)NH_(4)^(+)(K_(0)=1.45 cm^(2)/V·s)was obtained through the ion-molecule reaction with acetone reactant ions(C_(3)H_(6)O)_(2)H^(+)(K_(0)=1.87 cm^(2)/V·s),which significantly increased the peak-to-peak resolution and improved the accuracy of exhaled NH_(3)qualitative identification.Moreover,the interference of high humidity and the memory effect of NH_(3)molecules were significantly reduced via online dilution and purging sampling,thus realizing breath-by-breath measurement.As a result,a wide quantitative range of 5.87-140.92μmol/L with a response time of 40 ms was achieved,and the exhaled NH_(3)profile could be synchronized with the concentration curve of exhaled CO_(2).Finally,the analytical capacity of AM-PIMS was demonstrated by measuring the exhaled NH_(3)of healthy subjects,demonstrating its great potential for clinical disease diagnosis.
