1.Introduction Planning and managing land resources requires the use of land use and land cover(LULC)maps,which provide vital information on the interactions between humans and the environment(Esfandeh et al.,2022;Pra...1.Introduction Planning and managing land resources requires the use of land use and land cover(LULC)maps,which provide vital information on the interactions between humans and the environment(Esfandeh et al.,2022;Pratic`o et al.,2021;Yao et al.,2022).The precision of LULC monitoring has increased due to developments in Earth observation and remote sensing,allowing for well-informed environmental management decision-making(Qian and Zhang,2022;Viana et al.,2019).展开更多
Groundwater,the world’s largest freshwater supply,is facing increasing strain due to various uses such as agriculture,industry,livestock,and household.This study aims to investigate groundwater prospective zonation i...Groundwater,the world’s largest freshwater supply,is facing increasing strain due to various uses such as agriculture,industry,livestock,and household.This study aims to investigate groundwater prospective zonation in the Bandu Sub-watershed in Purulia,West Bengal,using the AHP model and RS&GIS methodologies.To achieve Goal 6 of the UN-initiated 17 SDGs,it is crucial to determine the spatial distribution of groundwater prospective zones village-by-village,with 1/3 of the regions falling under red alert zones for sustainable development.The 16 most crucial elements affecting groundwater prospective zones(GWPZs)were mapped using AHP,and the final prospective map was obtained through Weighted Overlay analysis.The study identified five different classes within the Sub-watershed as excellent,good,moderate,poor,and very poor.The validation results showed that the approach used to derive GWPZ is reliable,and the results can be applied to future sustainable developments to reduce water shortages through suitable management methods.The research aims to increase the effectiveness of sustainable groundwater zone management,ensuring long-term water management and access.展开更多
OBJECTIVE Platinum compounds such as cisplatin and carboplatin are frequently used as the first-line chemotherapy for the treatment of the head and neck squamous cell carcinoma(HNSCC).In the present study,we investiga...OBJECTIVE Platinum compounds such as cisplatin and carboplatin are frequently used as the first-line chemotherapy for the treatment of the head and neck squamous cell carcinoma(HNSCC).In the present study,we investigated whether garcinol,apolyisoprenylated benzophenone can chemosensitize HNSCC to cisplatin.METHODS The effect of garcinol and cisplatin on HNSCC was assessed by MTT,Western blotting,real time PCR,FACS,immunohistochemistry,DNA binding assay and xenograft mouse model.RESULTS We found that garcinol inhibited the viability of a panel of diverse HNSCC cell lines,enhanced the apoptotic effect of cisplatin,suppressed constitutive as well as cisplatin-induced NF-κB activation,and downregulated the expression of various oncogenic gene products(cyclin D1,Bcl-2,survivin and VEGF).In vivo study showed that administration of garcinol alone(0.5 mg·kg-1,ip five times/week)significantly suppressed the growth of the tumor,and this effect was further increased by cisplatin.Both the markers of proliferation index(Ki-67)and microvessel density(CD31)were downregulated in tumor tissues by the combination of cisplatin and garcinol.The pharmacokinetic results of garcinol indicated that good systemic exposure was achievable after ip administration of garcinol at 0.5and 2mg·kg-1 with mean peak concentration(cmax)of 1825.4 and 6635.7nmol·L-1 in the mouse serum,respectively.CONCLUSION Overall,our results suggest that garcinol can indeed potentiate the effects of cisplatin by negative regulation of various inflammatory and proliferative biomarkers.展开更多
The availability of better economic possibilities and well-connected transportation networks has attracted people to migrate to peri-urban and rural neighbourhoods,changing the landscape of regions outside the city an...The availability of better economic possibilities and well-connected transportation networks has attracted people to migrate to peri-urban and rural neighbourhoods,changing the landscape of regions outside the city and fostering the growth of physical infrastructure.Using multi-temporal satellite images,the dynamics of Land Use/Land Cover(LULC)changes,the impact of urban growth on LULC changes,and regional environmental implications were investigated in the peri-urban and rural neighbourhoods of Durgapur Municipal Corporation in India.The study used different case studies to highlight the study area’s heterogeneity,as the phenomenon of change is not consistent.Landsat TM and OLI-TIRS satellite images in 1991,2001,2011,and 2021 were used to analyse the changes in LULC types.We used the relative deviation(RD),annual change intensity(ACI),uniform intensity(UI)to show the dynamicity of LULC types(agriculture land;built-up land;fallow land;vegetated land;mining area;and water bodies)during 1991-2021.This study also applied the Decision-Making Trial and Evaluation Laboratory(DEMATEL)to measure environmental sensitivity zones and find out the causes of LULC changes.According to LULC statistics,agriculture land,built-up land,and mining area increased by 51.7,95.46,and 24.79 km^(2),respectively,from 1991 to 2021.The results also suggested that built-up land and mining area had the greatest land surface temperature(LST),whereas water bodies and vegetated land showed the lowest LST.Moreover,this study looked at the relationships among LST,spectral indices(Normalized Differenced Built-up Index(NDBI),Normalized Difference Vegetation Index(NDVI),and Normalized Difference Water Index(NDWI)),and environmental sensitivity.The results showed that all of the spectral indices have the strongest association with LST,indicating that built-up land had a far stronger influence on the LST.The spectral indices indicated that the decreasing trends of vegetated land and water bodies were 4.26 and 0.43 km^(2)/a,respectively,during 1991-2021.In summary,this study can help the policy-makers to predict the increasing rate of temperature and the causes for the temperature increase with the rapid expansion of built-up land,thus making effective peri-urban planning decisions.展开更多
Present research is an endeavour to scrutinise the spatio-temporal climatic characteristics of tropical cyclones(TCs)bustle in the Bay of Bengal basin,found in RSMC-IMD data all through 1971–2020.A large number of TC...Present research is an endeavour to scrutinise the spatio-temporal climatic characteristics of tropical cyclones(TCs)bustle in the Bay of Bengal basin,found in RSMC-IMD data all through 1971–2020.A large number of TCs,i.e.121 with a decadal average of 35.2 TCs has been examined for the last 50 years where depression(D)and deep depression(DD)have not been taken into account as these are less violent in nature.During the study periods,inter-annual and inter-decadal variation in cyclogenesis,landfall,length,speed,track shape and sinuosity,energy metrics and damage profile have been perceived.The study is clearly showing TCs took the northward track during the pre-monsoon season and made their landfall across the coasts of Bangladesh and Myanmar,while post-monsoon TCs made their landfall directly on the coasts of Orissa and West Bengal.In the post-monsoon phase,VF,ACE and PDI are significantly higher than in the monsoon season in the case of TCs and higher in the pre-monsoon season than in the monsoon season in the case of TCs comparing the energy metrics in different seasons.TC activity is comparatively pronounced during La Niña and El Niño regimes respectively and the genesis position in the BoB is moves to the east(west)of 87°E.During the cold regime,the number of extreme TC above the VSCS category,increased intensely.It is believed that the research findings will help stakeholders of the nation to take accurate strides to combat such violent events with persistent intensification.展开更多
文摘1.Introduction Planning and managing land resources requires the use of land use and land cover(LULC)maps,which provide vital information on the interactions between humans and the environment(Esfandeh et al.,2022;Pratic`o et al.,2021;Yao et al.,2022).The precision of LULC monitoring has increased due to developments in Earth observation and remote sensing,allowing for well-informed environmental management decision-making(Qian and Zhang,2022;Viana et al.,2019).
文摘Groundwater,the world’s largest freshwater supply,is facing increasing strain due to various uses such as agriculture,industry,livestock,and household.This study aims to investigate groundwater prospective zonation in the Bandu Sub-watershed in Purulia,West Bengal,using the AHP model and RS&GIS methodologies.To achieve Goal 6 of the UN-initiated 17 SDGs,it is crucial to determine the spatial distribution of groundwater prospective zones village-by-village,with 1/3 of the regions falling under red alert zones for sustainable development.The 16 most crucial elements affecting groundwater prospective zones(GWPZs)were mapped using AHP,and the final prospective map was obtained through Weighted Overlay analysis.The study identified five different classes within the Sub-watershed as excellent,good,moderate,poor,and very poor.The validation results showed that the approach used to derive GWPZ is reliable,and the results can be applied to future sustainable developments to reduce water shortages through suitable management methods.The research aims to increase the effectiveness of sustainable groundwater zone management,ensuring long-term water management and access.
基金The project supported by National Medical Research Council of Singapore and NUS Academic Research fund
文摘OBJECTIVE Platinum compounds such as cisplatin and carboplatin are frequently used as the first-line chemotherapy for the treatment of the head and neck squamous cell carcinoma(HNSCC).In the present study,we investigated whether garcinol,apolyisoprenylated benzophenone can chemosensitize HNSCC to cisplatin.METHODS The effect of garcinol and cisplatin on HNSCC was assessed by MTT,Western blotting,real time PCR,FACS,immunohistochemistry,DNA binding assay and xenograft mouse model.RESULTS We found that garcinol inhibited the viability of a panel of diverse HNSCC cell lines,enhanced the apoptotic effect of cisplatin,suppressed constitutive as well as cisplatin-induced NF-κB activation,and downregulated the expression of various oncogenic gene products(cyclin D1,Bcl-2,survivin and VEGF).In vivo study showed that administration of garcinol alone(0.5 mg·kg-1,ip five times/week)significantly suppressed the growth of the tumor,and this effect was further increased by cisplatin.Both the markers of proliferation index(Ki-67)and microvessel density(CD31)were downregulated in tumor tissues by the combination of cisplatin and garcinol.The pharmacokinetic results of garcinol indicated that good systemic exposure was achievable after ip administration of garcinol at 0.5and 2mg·kg-1 with mean peak concentration(cmax)of 1825.4 and 6635.7nmol·L-1 in the mouse serum,respectively.CONCLUSION Overall,our results suggest that garcinol can indeed potentiate the effects of cisplatin by negative regulation of various inflammatory and proliferative biomarkers.
文摘The availability of better economic possibilities and well-connected transportation networks has attracted people to migrate to peri-urban and rural neighbourhoods,changing the landscape of regions outside the city and fostering the growth of physical infrastructure.Using multi-temporal satellite images,the dynamics of Land Use/Land Cover(LULC)changes,the impact of urban growth on LULC changes,and regional environmental implications were investigated in the peri-urban and rural neighbourhoods of Durgapur Municipal Corporation in India.The study used different case studies to highlight the study area’s heterogeneity,as the phenomenon of change is not consistent.Landsat TM and OLI-TIRS satellite images in 1991,2001,2011,and 2021 were used to analyse the changes in LULC types.We used the relative deviation(RD),annual change intensity(ACI),uniform intensity(UI)to show the dynamicity of LULC types(agriculture land;built-up land;fallow land;vegetated land;mining area;and water bodies)during 1991-2021.This study also applied the Decision-Making Trial and Evaluation Laboratory(DEMATEL)to measure environmental sensitivity zones and find out the causes of LULC changes.According to LULC statistics,agriculture land,built-up land,and mining area increased by 51.7,95.46,and 24.79 km^(2),respectively,from 1991 to 2021.The results also suggested that built-up land and mining area had the greatest land surface temperature(LST),whereas water bodies and vegetated land showed the lowest LST.Moreover,this study looked at the relationships among LST,spectral indices(Normalized Differenced Built-up Index(NDBI),Normalized Difference Vegetation Index(NDVI),and Normalized Difference Water Index(NDWI)),and environmental sensitivity.The results showed that all of the spectral indices have the strongest association with LST,indicating that built-up land had a far stronger influence on the LST.The spectral indices indicated that the decreasing trends of vegetated land and water bodies were 4.26 and 0.43 km^(2)/a,respectively,during 1991-2021.In summary,this study can help the policy-makers to predict the increasing rate of temperature and the causes for the temperature increase with the rapid expansion of built-up land,thus making effective peri-urban planning decisions.
基金Ministry of Science and Technology&Biotechnology(WBDSTBT)。
文摘Present research is an endeavour to scrutinise the spatio-temporal climatic characteristics of tropical cyclones(TCs)bustle in the Bay of Bengal basin,found in RSMC-IMD data all through 1971–2020.A large number of TCs,i.e.121 with a decadal average of 35.2 TCs has been examined for the last 50 years where depression(D)and deep depression(DD)have not been taken into account as these are less violent in nature.During the study periods,inter-annual and inter-decadal variation in cyclogenesis,landfall,length,speed,track shape and sinuosity,energy metrics and damage profile have been perceived.The study is clearly showing TCs took the northward track during the pre-monsoon season and made their landfall across the coasts of Bangladesh and Myanmar,while post-monsoon TCs made their landfall directly on the coasts of Orissa and West Bengal.In the post-monsoon phase,VF,ACE and PDI are significantly higher than in the monsoon season in the case of TCs and higher in the pre-monsoon season than in the monsoon season in the case of TCs comparing the energy metrics in different seasons.TC activity is comparatively pronounced during La Niña and El Niño regimes respectively and the genesis position in the BoB is moves to the east(west)of 87°E.During the cold regime,the number of extreme TC above the VSCS category,increased intensely.It is believed that the research findings will help stakeholders of the nation to take accurate strides to combat such violent events with persistent intensification.
