High content of citric acid in red raspberry juice leads to poor sensory experience. This study developed a feasible method to degrade citric acid in red raspberry juice using a novel characterized Issatchenkia terric...High content of citric acid in red raspberry juice leads to poor sensory experience. This study developed a feasible method to degrade citric acid in red raspberry juice using a novel characterized Issatchenkia terricola WJL-G4 isolated from red raspberry fruits. I. terricola WJL-G4 exhibited a potent capability of reducing the citric acid contents from(22.8 ± 0.08) g/L to(6.2 ± 0.02) g/L within 36 h fermentation, then completely depleted after 48 h. Furthermore, the contents of phenolic compound, including neochlorogenic acid, p-coumaric acid, raspberry ketone, and rutin significantly increased after 36 h fermentation. Fermentation increased total flavonoid contents in red raspberry juice, compared to that in control group. Volatile profiles exhibited to be enriched after fermentation, which contributed to the improvement of the juice taste. Our findings showed that I. terricola WJL-G4 can be applied in deacidification, enrichment of flavonoid compounds and volatile profiles in fermented red raspberry juice..展开更多
Background:A considerable number of muscle development-related genes were differentially expressed in the early stage of avian adipocyte differentiation.However,the functions of them in adipocyte differentiation remai...Background:A considerable number of muscle development-related genes were differentially expressed in the early stage of avian adipocyte differentiation.However,the functions of them in adipocyte differentiation remain largely known.In this study,the myoblast determination protein 1(MYOD1)was selected as a representative of muscle development.We investigated its expression,function,and regulation in avian adipocyte differentiation.Results:The expression of MYOD1 decreased significantly in the early stage of avian adipocyte differentiation.CRIS PR/Cas9-mediated deletion of MYOD1 induced adipocyte differentiation,whereas over-expression of MYOD1 inhibited adipogenesis.The mRNA-seq data showed that MYOD1 could perturb the lipid biosynthetic process during differentiation.Our results showed that MYOD1 directly up-regulates the miR-206 expression by binding the upstream 1200 bp region of miR-206.Then,over-expression of miR-206 can inhibit the adipogenesis.Furthermore,MYOD1 affected the expression of endogenous miR-206 and its target gene Kruppel-like factor 4(KLF4),which is an important activator of adipogenesis.Accordingly,the inhibition of miR-206 or over-expression of KLF4 could counteract the inhibitory effect of MYOD1 on adipocyte differentiation.Conclusions:Our results establish that MYOD1 inhibits adipocyte differentiation by up-regulating miR-206 to suppress the KLF4 expression.These findings identify a novel function of MYOD1 in adipocyte differentiation,suggesting a potential role in body-fat distribution regulation.展开更多
Background:Heterosis is an important biological phenomenon that has been extensively utilized in agricultural breeding.However,negative heterosis is also pervasively observed in nature,which can cause unfavorable impa...Background:Heterosis is an important biological phenomenon that has been extensively utilized in agricultural breeding.However,negative heterosis is also pervasively observed in nature,which can cause unfavorable impacts on production performance.Compared with systematic studies of positive heterosis,the phenomenon of negative heterosis has been largely ignored in genetic studies and breeding programs,and the genetic mechanism of this phenomenon has not been thoroughly elucidated to date.Here,we used chickens,the most common agricultural animals worldwide,to determine the genetic and molecular mechanisms of negative heterosis.Results:We performed reciprocal crossing experiments with two distinct chicken lines and found that the body weight presented widely negative heterosis in the early growth of chickens.Negative heterosis of carcass traits was more common than positive heterosis,especially breast muscle mass,which was over−40%in reciprocal progenies.Genome-wide gene expression pattern analyses of breast muscle tissues revealed that nonadditivity,including dominance and overdominace,was the major gene inheritance pattern.Nonadditive genes,including a substantial number of genes encoding ATPase and NADH dehydrogenase,accounted for more than 68%of differentially expressed genes in reciprocal crosses(4257 of 5587 and 3617 of 5243,respectively).Moreover,nonadditive genes were significantly associated with the biological process of oxidative phosphorylation,which is the major metabolic pathway for energy release and animal growth and development.The detection of ATP content and ATPase activity for purebred and crossbred progenies further confirmed that chickens with lower muscle yield had lower ATP concentrations but higher hydrolysis activity,which supported the important role of oxidative phosphorylation in negative heterosis for growth traits in chickens.Conclusions:These findings revealed that nonadditive genes and their related oxidative phosphorylation were the major genetic and molecular factors in the negative heterosis of growth in chickens,which would be beneficial to future breeding strategies.展开更多
The correlation between IgY levels of the serum and the yolk has been well documented in wild and domestic birds. The levels of total yolk IgY can be an index of the general health status of birds and may contribute t...The correlation between IgY levels of the serum and the yolk has been well documented in wild and domestic birds. The levels of total yolk IgY can be an index of the general health status of birds and may contribute to breeding programs when fitness of the offspring is a concern. We measured the levels of total serum IgY and yolk IgY in three different breeds （White Leghorn, Silkie and Dongxiang blue-shell） using indirect ELISA, and found that there was a significantly positive correlation between the levels of total serum IgY and total yolk IgY in all three breeds （White Leghorn： r = 0.404, P 〈 0.001, n = 100; Silkie： r = 0.561, P 〈 0.001, n = 70; Dongxiang blue-shell： r = 0.619, P 〈 0.001, n = 30）. We also measured the total serum IgY levels in the 3-day-old offspring hatched from the Silkie hens and results were significantly correlated for serum IgY levels （r = 0.535, P 〈 0.001, n = 70） and the yolk IgY levels （r = 0.481, P 〈 0.001, n = 70）. The regression analysis showed simple linear regression between IgY levels in hen serum, yolk and offspring serum. Our results suggest that total IgY level could be used as an index for chicken fitness.展开更多
When subjected to external loads from the ground and nearby construction,tunnel segmental lining joints are prone to damaging deformation.This can result in water leakage into tunnels,posing great safety risks.With th...When subjected to external loads from the ground and nearby construction,tunnel segmental lining joints are prone to damaging deformation.This can result in water leakage into tunnels,posing great safety risks.With this issue in mind,we conducted a series of full-scale tests to study the effects of external loads on the waterproofing performance of longitudinal joints.A customized rig for testing segmental joints was developed to assess the effect of loading magnitude,eccentricity,and loading-unloading-reloading cycles on waterproofing performance.Additionally,the relationship between joint force,sealing gasket deformation,and waterproofing pressure was investigated.The results indicate that:(1)the sealing gasket’s compression rapidly decreases as external loads increase,which weakens the waterproofing capacity of the joint;(2)the watertightness limit dramatically decreases as the bending moment increases;(3)a loading-unloading-reloading cycle leads to degradation of the joint’s waterproofing performance.The findings of this study provide a reference for subsequent waterproofing design of segmental tunnel joints,helping ensure the safety of tunnels throughout their operational lifespans.展开更多
Ferroptosis inducers exhibit great potential as anticancer drugs but face two key challenges:(1)non-selective toxicity toward both tumor and immune cells may suppress antitumor immunity;(2)tumor resistance driven by a...Ferroptosis inducers exhibit great potential as anticancer drugs but face two key challenges:(1)non-selective toxicity toward both tumor and immune cells may suppress antitumor immunity;(2)tumor resistance driven by antioxidant defense mechanisms or iron metabolism regulation reduces therapeutic efficacy.To address these issues,herein,a new oxaliplatin(Ⅳ)prodrug FAOP by coupling artesunate(ART)and(3-carboxypropionyl)ferrocene(ferrocene fragments)was rationally designed.FAOP could release oxaliplatin(OP),ART and ferrocene fragments,exerting a synergistic anti-cancer effect.Firstly,ferrocene fragments would induce ferroptosis by catalyzing Fenton reaction to generate hydroxyl radicals(·OH),causing lipid peroxidation.Secondly,ART inhibited GPX4 by reducing glutathione(GSH)levels and generating reactive oxygen species(ROS),thereby disrupting the redox balance and further sensitizing cells to ferroptosis.Lastly,OP could induce apoptosis while synergizing with intracellular ROS,resulting in enhanced immunogenic cell death(ICD)and activating both innate and adaptive immunity.The immune effector-activated CD8^(+)T cells produced IFN-γ,which inhibited the cystine transport by tumor cells,further impaired GPX4 activation and sensitized ferroptosis.The mutual reinforcement strategy of ICD and ferroptosis mediated by FAOP could overcome the limitations of traditional chemotherapy and reverse immunosuppression caused by ferroptosis inducers,offering a novel idea for designing ferroptosis inducers.展开更多
Orthodontic appliances are essential for dentofacial deformity corrections.However,orthodontic appliances inadvertently increase the risk of bacterial colonization and dental calculus formation,which may lead to denta...Orthodontic appliances are essential for dentofacial deformity corrections.However,orthodontic appliances inadvertently increase the risk of bacterial colonization and dental calculus formation,which may lead to dental caries and gingivitis.Herein,this study developed a pH-responsive antifouling coating by integrating a zwitterionic hydrogel(ZH)with pH-responsive microcapsules(PRMs)encapsulating bactericide,displaying excellent synergies of anti-bacteria and anti-calculus for orthodontic appliances.The excellent antifouling properties can be attributed to two following points:ZH provides anti-adhesion properties via electrostatically induced hydration layers,while the PRMs can kill bacteria by on-demand bactericide release under acidic conditions.Results demonstrated that ZH+PRMs coating significantly reduced bacterial adhesion and inhibited calculus formation while maintaining excellent biocompatibility.By optimizing PRMs concentrations(0–15 wt%),compared with ZH,the antibacterial efficiency of ZH+PRMs(optimal concentration 10 wt%)increased from 49.8%±7.3%to 95.2%±1.1%for E.coli and from 85.7%±3.5%to 91.3%±1.4%for S.mutans.Compared with pristine steel(SS),ZH+PRMs coating showed ca.97.0%reduction for calcium carbonate and ca.87.3%reduction for calcium phosphate.In an in vitro model,compared with SS,our coating extended the crystal biofilm inhibition effect from one day to five days.Therefore,this study can provide promising strategies for reducing the risk of dental caries and gingivitis during orthodontic treatment.展开更多
The deployment of mega constellations has had a significant effect on the compounding space debris environment,increasing the number of on-orbit objects in all conditions and damaging the stability of the space debris...The deployment of mega constellations has had a significant effect on the compounding space debris environment,increasing the number of on-orbit objects in all conditions and damaging the stability of the space debris environment.The increased density of space objects is associated with an increased risk of on-orbit collisions.Collision risk exists not only between a mega constellation and the space debris environment but also inside a mega constellation.In this study,we used the Starlink constellation to investigate the self-induced collision risk caused by malfunctioning satellites.First,we analyzed the conjunction condition between malfunctioning and operative satellites based on long-term orbital evolution characteristics.The collision probability was then calculated based on the conjunction analysis results.The results show that malfunctioning satellites in Phase 1 cause an 86.2%self-induced collision probability based on a malfunctioning rate of 1%,which is close to the collision probability caused by objects larger than 6 cm during five years of service.Therefore,self-induced collisions are another important risk factor for the Starlink constellation.展开更多
With the rapid development of flexible interconnection technology in active distribution networks(ADNs),many power electronic devices have been employed to improve system operational performance.As a novel fully-con-t...With the rapid development of flexible interconnection technology in active distribution networks(ADNs),many power electronic devices have been employed to improve system operational performance.As a novel fully-con-trolled power electronic device,energy storage integrated soft open point(ESOP)is gradually replacing traditional switches.This can significantly enhance the controllability of ADNs.To facilitate the utilization of ESOP,device loca-tions and capacities should be configured optimally.Thus,this paper proposes a multi-stage expansion planning method of ESOP with the consideration of tie-line reconstruction.First,based on multi-terminal modular design characteristics,the ESOP planning model is established.A multi-stage planning framework of ESOP is then presented,in which the evolutionary relationship among different planning schemes is analyzed.Based on this framework,a multi-stage planning method of ESOP with consideration of tie-line reconstruction is subsequently proposed.Finally,case studies are conducted on a modified practical distribution network,and the cost-benefit analysis of device and multiple impact factors are given to prove the effectiveness of the proposed method.展开更多
Background Studies on the association between oxidative stress and epilepsy have yielded varied results.In this study,we aimed to investigate the causal relationship between oxidative stress markers and epilepsy.Metho...Background Studies on the association between oxidative stress and epilepsy have yielded varied results.In this study,we aimed to investigate the causal relationship between oxidative stress markers and epilepsy.Methods A bidirectional two-sample Mendelian randomization(MR)study was performed based on publicly available statistics from genome-wide association studies.To explore the causal efects,single nucleotide polymorphisms were selected as instrumental variables.Inverse-variance weighted method was performed for primary analysis,supplemented by weighted median,MR-Egger,simple mode,and weighted mode.Furthermore,sensitivity analyses were performed to detect heterogeneity and pleiotropy.Results Our results showed that part of the oxidative stress biomarkers are associated with epilepsy and its subtypes.Zinc is associated with increased risk of epilepsy and generalized epilepsy(odds ratio[OR]=1.064 and 1.125,respectively).Glutathione transferase is associated with increased risk of generalized epilepsy(OR=1.055),while albumin is associated with decreased risk of generalized epilepsy(OR=0.723).Inverse MR analysis revealed that epilepsy is associated with increased levels of uric acid and total bilirubin(beta=1.266 and 0.081,respectively),as well as decreased zinc level(beta=−0.278).Furthermore,generalized epilepsy is associated with decreased ascorbate and retinol levels(beta=−0.029 and−0.038,respectively).Conclusions Our study presented novel evidence of potential causal relationships between oxidative stress and epilepsy,suggesting potential therapeutic targets for epilepsy.展开更多
基金supported by Heilongjiang Tongsheng Food Technology Co.Ltd.+1 种基金“the Fundamental Research Funds for the Central Universities”[grant number 2572018BA07 and 2572018CG02]“Applied Technology Research and Development Project of Harbin Science and Technology Bureau”[grant number 2017RAYXJ012]。
文摘High content of citric acid in red raspberry juice leads to poor sensory experience. This study developed a feasible method to degrade citric acid in red raspberry juice using a novel characterized Issatchenkia terricola WJL-G4 isolated from red raspberry fruits. I. terricola WJL-G4 exhibited a potent capability of reducing the citric acid contents from(22.8 ± 0.08) g/L to(6.2 ± 0.02) g/L within 36 h fermentation, then completely depleted after 48 h. Furthermore, the contents of phenolic compound, including neochlorogenic acid, p-coumaric acid, raspberry ketone, and rutin significantly increased after 36 h fermentation. Fermentation increased total flavonoid contents in red raspberry juice, compared to that in control group. Volatile profiles exhibited to be enriched after fermentation, which contributed to the improvement of the juice taste. Our findings showed that I. terricola WJL-G4 can be applied in deacidification, enrichment of flavonoid compounds and volatile profiles in fermented red raspberry juice..
基金supported by the National Waterfowl-Industry Technology Research System(CARS-42)National Nature Science Foundation of China(31972525,31572388)+1 种基金Beijing Municipal Science&Technology Commission(Z181100002418008)Key-Area Research and Development Program of Guangdong Province(2020B020222003).
文摘Background:A considerable number of muscle development-related genes were differentially expressed in the early stage of avian adipocyte differentiation.However,the functions of them in adipocyte differentiation remain largely known.In this study,the myoblast determination protein 1(MYOD1)was selected as a representative of muscle development.We investigated its expression,function,and regulation in avian adipocyte differentiation.Results:The expression of MYOD1 decreased significantly in the early stage of avian adipocyte differentiation.CRIS PR/Cas9-mediated deletion of MYOD1 induced adipocyte differentiation,whereas over-expression of MYOD1 inhibited adipogenesis.The mRNA-seq data showed that MYOD1 could perturb the lipid biosynthetic process during differentiation.Our results showed that MYOD1 directly up-regulates the miR-206 expression by binding the upstream 1200 bp region of miR-206.Then,over-expression of miR-206 can inhibit the adipogenesis.Furthermore,MYOD1 affected the expression of endogenous miR-206 and its target gene Kruppel-like factor 4(KLF4),which is an important activator of adipogenesis.Accordingly,the inhibition of miR-206 or over-expression of KLF4 could counteract the inhibitory effect of MYOD1 on adipocyte differentiation.Conclusions:Our results establish that MYOD1 inhibits adipocyte differentiation by up-regulating miR-206 to suppress the KLF4 expression.These findings identify a novel function of MYOD1 in adipocyte differentiation,suggesting a potential role in body-fat distribution regulation.
基金supported by the National Natural Science Foundation of China(No.31930105)China Agriculture Research Systems(CARS-40)China Postdoctoral Science Foundation(No.2020 M680028).
文摘Background:Heterosis is an important biological phenomenon that has been extensively utilized in agricultural breeding.However,negative heterosis is also pervasively observed in nature,which can cause unfavorable impacts on production performance.Compared with systematic studies of positive heterosis,the phenomenon of negative heterosis has been largely ignored in genetic studies and breeding programs,and the genetic mechanism of this phenomenon has not been thoroughly elucidated to date.Here,we used chickens,the most common agricultural animals worldwide,to determine the genetic and molecular mechanisms of negative heterosis.Results:We performed reciprocal crossing experiments with two distinct chicken lines and found that the body weight presented widely negative heterosis in the early growth of chickens.Negative heterosis of carcass traits was more common than positive heterosis,especially breast muscle mass,which was over−40%in reciprocal progenies.Genome-wide gene expression pattern analyses of breast muscle tissues revealed that nonadditivity,including dominance and overdominace,was the major gene inheritance pattern.Nonadditive genes,including a substantial number of genes encoding ATPase and NADH dehydrogenase,accounted for more than 68%of differentially expressed genes in reciprocal crosses(4257 of 5587 and 3617 of 5243,respectively).Moreover,nonadditive genes were significantly associated with the biological process of oxidative phosphorylation,which is the major metabolic pathway for energy release and animal growth and development.The detection of ATP content and ATPase activity for purebred and crossbred progenies further confirmed that chickens with lower muscle yield had lower ATP concentrations but higher hydrolysis activity,which supported the important role of oxidative phosphorylation in negative heterosis for growth traits in chickens.Conclusions:These findings revealed that nonadditive genes and their related oxidative phosphorylation were the major genetic and molecular factors in the negative heterosis of growth in chickens,which would be beneficial to future breeding strategies.
基金supported in part by special funds from the China Agriculture Research System(CARS-41)the Yangtze River Scholar and Innovation Research Team Development Program(IRT0945)the Beijing Poultry Research System
文摘The correlation between IgY levels of the serum and the yolk has been well documented in wild and domestic birds. The levels of total yolk IgY can be an index of the general health status of birds and may contribute to breeding programs when fitness of the offspring is a concern. We measured the levels of total serum IgY and yolk IgY in three different breeds （White Leghorn, Silkie and Dongxiang blue-shell） using indirect ELISA, and found that there was a significantly positive correlation between the levels of total serum IgY and total yolk IgY in all three breeds （White Leghorn： r = 0.404, P 〈 0.001, n = 100; Silkie： r = 0.561, P 〈 0.001, n = 70; Dongxiang blue-shell： r = 0.619, P 〈 0.001, n = 30）. We also measured the total serum IgY levels in the 3-day-old offspring hatched from the Silkie hens and results were significantly correlated for serum IgY levels （r = 0.535, P 〈 0.001, n = 70） and the yolk IgY levels （r = 0.481, P 〈 0.001, n = 70）. The regression analysis showed simple linear regression between IgY levels in hen serum, yolk and offspring serum. Our results suggest that total IgY level could be used as an index for chicken fitness.
基金supported by the National Key Research and Development Program of China(No.2022YFC3800905)the National Natural Science Foundation of China(Nos.52238010,52090082,and 52108381)+2 种基金the Shanghai Science and Technology Committee Program(Nos.22XD1430200,23DZ1202806,and 21DZ1200601)the Young Elite Scientists Sponsorship Program by the China Association for Science and Technology(No.2023QNRC001)the Fundamental Research Funds for the Central Universities,China.
文摘When subjected to external loads from the ground and nearby construction,tunnel segmental lining joints are prone to damaging deformation.This can result in water leakage into tunnels,posing great safety risks.With this issue in mind,we conducted a series of full-scale tests to study the effects of external loads on the waterproofing performance of longitudinal joints.A customized rig for testing segmental joints was developed to assess the effect of loading magnitude,eccentricity,and loading-unloading-reloading cycles on waterproofing performance.Additionally,the relationship between joint force,sealing gasket deformation,and waterproofing pressure was investigated.The results indicate that:(1)the sealing gasket’s compression rapidly decreases as external loads increase,which weakens the waterproofing capacity of the joint;(2)the watertightness limit dramatically decreases as the bending moment increases;(3)a loading-unloading-reloading cycle leads to degradation of the joint’s waterproofing performance.The findings of this study provide a reference for subsequent waterproofing design of segmental tunnel joints,helping ensure the safety of tunnels throughout their operational lifespans.
基金supported by the National Natural Science Foundation of China(22277090,82202601)the Natural Science Foundation of Shanghai(23ZR1466700)the Shanghai Sailing Program(22YF1433800)。
文摘Ferroptosis inducers exhibit great potential as anticancer drugs but face two key challenges:(1)non-selective toxicity toward both tumor and immune cells may suppress antitumor immunity;(2)tumor resistance driven by antioxidant defense mechanisms or iron metabolism regulation reduces therapeutic efficacy.To address these issues,herein,a new oxaliplatin(Ⅳ)prodrug FAOP by coupling artesunate(ART)and(3-carboxypropionyl)ferrocene(ferrocene fragments)was rationally designed.FAOP could release oxaliplatin(OP),ART and ferrocene fragments,exerting a synergistic anti-cancer effect.Firstly,ferrocene fragments would induce ferroptosis by catalyzing Fenton reaction to generate hydroxyl radicals(·OH),causing lipid peroxidation.Secondly,ART inhibited GPX4 by reducing glutathione(GSH)levels and generating reactive oxygen species(ROS),thereby disrupting the redox balance and further sensitizing cells to ferroptosis.Lastly,OP could induce apoptosis while synergizing with intracellular ROS,resulting in enhanced immunogenic cell death(ICD)and activating both innate and adaptive immunity.The immune effector-activated CD8^(+)T cells produced IFN-γ,which inhibited the cystine transport by tumor cells,further impaired GPX4 activation and sensitized ferroptosis.The mutual reinforcement strategy of ICD and ferroptosis mediated by FAOP could overcome the limitations of traditional chemotherapy and reverse immunosuppression caused by ferroptosis inducers,offering a novel idea for designing ferroptosis inducers.
基金supported by the National Natural Science Foundation of China(Nos.51973003 and 22275203)the Beijing Natural Science Foundation(No.JQ23008)。
文摘Orthodontic appliances are essential for dentofacial deformity corrections.However,orthodontic appliances inadvertently increase the risk of bacterial colonization and dental calculus formation,which may lead to dental caries and gingivitis.Herein,this study developed a pH-responsive antifouling coating by integrating a zwitterionic hydrogel(ZH)with pH-responsive microcapsules(PRMs)encapsulating bactericide,displaying excellent synergies of anti-bacteria and anti-calculus for orthodontic appliances.The excellent antifouling properties can be attributed to two following points:ZH provides anti-adhesion properties via electrostatically induced hydration layers,while the PRMs can kill bacteria by on-demand bactericide release under acidic conditions.Results demonstrated that ZH+PRMs coating significantly reduced bacterial adhesion and inhibited calculus formation while maintaining excellent biocompatibility.By optimizing PRMs concentrations(0–15 wt%),compared with ZH,the antibacterial efficiency of ZH+PRMs(optimal concentration 10 wt%)increased from 49.8%±7.3%to 95.2%±1.1%for E.coli and from 85.7%±3.5%to 91.3%±1.4%for S.mutans.Compared with pristine steel(SS),ZH+PRMs coating showed ca.97.0%reduction for calcium carbonate and ca.87.3%reduction for calcium phosphate.In an in vitro model,compared with SS,our coating extended the crystal biofilm inhibition effect from one day to five days.Therefore,this study can provide promising strategies for reducing the risk of dental caries and gingivitis during orthodontic treatment.
文摘The deployment of mega constellations has had a significant effect on the compounding space debris environment,increasing the number of on-orbit objects in all conditions and damaging the stability of the space debris environment.The increased density of space objects is associated with an increased risk of on-orbit collisions.Collision risk exists not only between a mega constellation and the space debris environment but also inside a mega constellation.In this study,we used the Starlink constellation to investigate the self-induced collision risk caused by malfunctioning satellites.First,we analyzed the conjunction condition between malfunctioning and operative satellites based on long-term orbital evolution characteristics.The collision probability was then calculated based on the conjunction analysis results.The results show that malfunctioning satellites in Phase 1 cause an 86.2%self-induced collision probability based on a malfunctioning rate of 1%,which is close to the collision probability caused by objects larger than 6 cm during five years of service.Therefore,self-induced collisions are another important risk factor for the Starlink constellation.
基金supported by the National Natural Science Foundation of China (51977139,52061635103)Tianjin Science Foundation for Youths (21JCQNJC00430)Science and Technology Project of State Grid Tianjin Electric Power Co. (KJ21-1-36).
文摘With the rapid development of flexible interconnection technology in active distribution networks(ADNs),many power electronic devices have been employed to improve system operational performance.As a novel fully-con-trolled power electronic device,energy storage integrated soft open point(ESOP)is gradually replacing traditional switches.This can significantly enhance the controllability of ADNs.To facilitate the utilization of ESOP,device loca-tions and capacities should be configured optimally.Thus,this paper proposes a multi-stage expansion planning method of ESOP with the consideration of tie-line reconstruction.First,based on multi-terminal modular design characteristics,the ESOP planning model is established.A multi-stage planning framework of ESOP is then presented,in which the evolutionary relationship among different planning schemes is analyzed.Based on this framework,a multi-stage planning method of ESOP with consideration of tie-line reconstruction is subsequently proposed.Finally,case studies are conducted on a modified practical distribution network,and the cost-benefit analysis of device and multiple impact factors are given to prove the effectiveness of the proposed method.
基金supported by the grants from 2023 Provincial Key Talent Project,Construction of Innovative Research Platform for Multimodal Imaging and Neuromodulation in Epilepsy in Gansu Province,2023.05-2024.05,funding 400,000,under research,presided over,Second Hospital of Lanzhou UniversityGansu Province Joint Research Fund General Project,Research on Brain Network Mechanisms of Epilepsy and its Co-morbidities Based on Crossmodal Functional Imaging,2024.01-2026.12,funding 200,000,under research,presided over,the Second Hospital of Lanzhou UniversityThe Second Hospital of Lanzhou University,"Cuiying Science and Technology Innovation"project,based on rTMS,tDCS stimulation state of adolescent myoclonic epilepsy brain network and neural loop mechanism research,CY2023-MS-B03,2024.01-2026.12,funding 100,000,in research,presided over,the Second Hospital of Lanzhou University.Hospital of Lanzhou University。
文摘Background Studies on the association between oxidative stress and epilepsy have yielded varied results.In this study,we aimed to investigate the causal relationship between oxidative stress markers and epilepsy.Methods A bidirectional two-sample Mendelian randomization(MR)study was performed based on publicly available statistics from genome-wide association studies.To explore the causal efects,single nucleotide polymorphisms were selected as instrumental variables.Inverse-variance weighted method was performed for primary analysis,supplemented by weighted median,MR-Egger,simple mode,and weighted mode.Furthermore,sensitivity analyses were performed to detect heterogeneity and pleiotropy.Results Our results showed that part of the oxidative stress biomarkers are associated with epilepsy and its subtypes.Zinc is associated with increased risk of epilepsy and generalized epilepsy(odds ratio[OR]=1.064 and 1.125,respectively).Glutathione transferase is associated with increased risk of generalized epilepsy(OR=1.055),while albumin is associated with decreased risk of generalized epilepsy(OR=0.723).Inverse MR analysis revealed that epilepsy is associated with increased levels of uric acid and total bilirubin(beta=1.266 and 0.081,respectively),as well as decreased zinc level(beta=−0.278).Furthermore,generalized epilepsy is associated with decreased ascorbate and retinol levels(beta=−0.029 and−0.038,respectively).Conclusions Our study presented novel evidence of potential causal relationships between oxidative stress and epilepsy,suggesting potential therapeutic targets for epilepsy.
