Advancements in visualization methods have brought the meningeal lymphatic system(MLS)into the spotlight.The meningeal lymphatic vessels(mLVs)play a vital role in draining cerebrospinal fluid and immune cells,acting a...Advancements in visualization methods have brought the meningeal lymphatic system(MLS)into the spotlight.The meningeal lymphatic vessels(mLVs)play a vital role in draining cerebrospinal fluid and immune cells,acting as a central hub for immune surveillance in the brain.Age-related morphological and functional declines of mLVs suggest their involvement in the pathogenesis of neurodegenerative disorders(NDDs).In this article,we summarize key discoveries about the MLS over the past decade,highlight the neuro-immune crosstalk in the meninges,and discuss the role of mLVs in both brain homeostasis and neurodegeneration.As a critical regulator of brain function and a potential therapeutic target,the MLS offers a promising avenue for the diagnosis and treatment of NDDs,particularly Alzheimer’s Disease.展开更多
基金supported by the grants from the National Natural Science Foundation of China(82293642 and 82230043)Department of Science and Technology of Zhejiang Province(2023ZY1018+1 种基金2024SSYS0054)Oujiang Laboratory(OJQDJQ202202)to WS.
文摘Advancements in visualization methods have brought the meningeal lymphatic system(MLS)into the spotlight.The meningeal lymphatic vessels(mLVs)play a vital role in draining cerebrospinal fluid and immune cells,acting as a central hub for immune surveillance in the brain.Age-related morphological and functional declines of mLVs suggest their involvement in the pathogenesis of neurodegenerative disorders(NDDs).In this article,we summarize key discoveries about the MLS over the past decade,highlight the neuro-immune crosstalk in the meninges,and discuss the role of mLVs in both brain homeostasis and neurodegeneration.As a critical regulator of brain function and a potential therapeutic target,the MLS offers a promising avenue for the diagnosis and treatment of NDDs,particularly Alzheimer’s Disease.
