Alzheimer's disease(AD) is a progressive neurodegenerative disease histologically characterized by the presence of extraneuronal plaques,mainly formed by the 42-aminoacid isoform of amyloid-(Aβ_(1-42)),and by int...Alzheimer's disease(AD) is a progressive neurodegenerative disease histologically characterized by the presence of extraneuronal plaques,mainly formed by the 42-aminoacid isoform of amyloid-(Aβ_(1-42)),and by intraneuronal neurofibrillary to ngles,mainly formed by the tau protein and its hyperphosphorylated isoforms(p-tau).AD is the most common cause of dementia,with an estimated lifetime risk of about 1 in 10 for men and 1 in 5 for women.展开更多
1.The complex spectrum of neurodegenerative diseases Epidemiologic data indicate that neurodegenerative diseases(NDDs)show high prevalence with a trend of a progressively growing incidence,especially in aging societie...1.The complex spectrum of neurodegenerative diseases Epidemiologic data indicate that neurodegenerative diseases(NDDs)show high prevalence with a trend of a progressively growing incidence,especially in aging societies.This presents an increasing social and economic burden.展开更多
文摘Alzheimer's disease(AD) is a progressive neurodegenerative disease histologically characterized by the presence of extraneuronal plaques,mainly formed by the 42-aminoacid isoform of amyloid-(Aβ_(1-42)),and by intraneuronal neurofibrillary to ngles,mainly formed by the tau protein and its hyperphosphorylated isoforms(p-tau).AD is the most common cause of dementia,with an estimated lifetime risk of about 1 in 10 for men and 1 in 5 for women.
基金funding from the program Investissements d'avenir ANR-10-IAIHU-06
文摘1.The complex spectrum of neurodegenerative diseases Epidemiologic data indicate that neurodegenerative diseases(NDDs)show high prevalence with a trend of a progressively growing incidence,especially in aging societies.This presents an increasing social and economic burden.
