Rational design of catalytic interfaces at the atomic level is crucial for enhancing electrocatalytic CO_(2)reduction.In this study,a Zeolite imidazolate frameworks-8 derived catalyst is developed,featuring atomically...Rational design of catalytic interfaces at the atomic level is crucial for enhancing electrocatalytic CO_(2)reduction.In this study,a Zeolite imidazolate frameworks-8 derived catalyst is developed,featuring atomically dispersed Ni–Zn dual-atom sites(NiZnN_(6))coexisting with Ni_(3)ZnC_(0.7) nanoparticles on nitrogen-doped carbon nanotubes.Strong interaction between the NiZnN_(6) moieties and Ni_(3)ZnC_(0.7) nanoparticle induces charge redistribution,enhancing the electron-donating ability of Ni active sites.Simultaneously,the dual-atom configuration creates an asymmetric electronic environment,where interfacial electronic coupling facilitates partial electron transfer from Zn to Ni,leading to electron enrichment at the Ni center.Consequently,Ni sites preferentially donate electrons to active CO_(2)molecules,lowering the ^(*)COOH formation energy,while Zn sites promote ^(*)CO desorption,thus achieving high CO selectivity(99.6%@-0.7V vs.Reversible Hydrogen Electrode(RHE)).The in-depth investigation in this work provides guidance for establishing the relationship between structure and electrocatalytic activity,holding significant implications for fundamental research on the CO_(2)reduction mechanism.展开更多
Objective:To use fetal heart quantification(fetal HQ)technology to compare the coarctation of the aorta(CoA)and normal fetal heart structure and systolic function and to assess whether there are abnormalities in the f...Objective:To use fetal heart quantification(fetal HQ)technology to compare the coarctation of the aorta(CoA)and normal fetal heart structure and systolic function and to assess whether there are abnormalities in the fetal heart structure and systolic function associated with CoA.Methods:This prospective cohort study was conducted from May 2020 to December 2022 and involved 18–40-week-old singleton pregnancies and 30 fetuses diagnosed with CoA using fetal echocardiography at the General Hospital of Ningxia Medical University and Peking University First Hospital Ningxia Women’s andChildren’s Hospital,China.The control group contained 60 normal fetuses.The following parameters were recorded and analyzed statistically:four-chamber view(4CV)end-diastolic long diameter,4CV epicardial–contralateral epicardial transverse maximum diameter,4CV global sphericity index(GSI),left ventricular(LV)and right ventricular(RV)24-segment end-diastolic diameter(EDD),24-segment sphericity index(SI),LV-fractional area change(LV-FAC),LV-longitudinal strain(LV-LS),RV-fractional area change(RV-FAC),RV-longitudinal strain(RV-LS),and LV and RV 24-segment transverse fractional shortening(FS).Measurement data were compared between the two groups using an independent sample t test,with P<0.05 indicating statistically significant differences.Moreover,the correlation between gestational age and GSI,LV-FAC,LV-LS,RV-FAC,and RV-LS was assessed.Results:Within and between observer comparisons of the parameters associated with major cardiac function revealed an intragroup correlation coefficient of>0.9,indicating high consistency,and a coefficient of variable of<1%,indicating low variability.Correlation analysis revealed no obvious correlation between gestational age and GSI,LV-FAC,LV-LS,RV-FAC,and RV-LS.A comparison of the fourchamber morphological structural parameters of the hearts in the two groups revealed that when compared with the control group,the 4CV end-diastolic long diameter was shortened in fetuses in the CoA group and the epicardial–contralateral epicardial transverse maximum diameter was wider,while the GSI was lower(P<0.05).A comparison of the LV and RV morphological structure parameters between the two groups revealed that when compared with the control group,the LV’s 24-segment EDD was smaller in the CoA group,the RV’s 24-segment EDD was greater in the control group,the SI of the LV’s segments 16–24 was greater than in the control group,and the SI of the RV’s segments 7–24 was less than in the control group(all P<0.05).When comparedwith fetuses in the control group,the LV’s segments16–24 were greater in the CoA group,whereas the RV’s segment 6–24 was smaller(P<0.05).When comparedwith the control group,LV-FAC,RV-FAC,and LS were lower in the CoA group(P<0.05).The FS of the LV segments 1–24 and the FS of the RV segments 1–16 were smaller in the CoA group than in the normal group(P<0.05).Conclusion:Fetal HQ,a new simple technique that offers rapid analysis and high repeatability,can quantitatively evaluate structural and systolic function changes in fetuses with CoA.展开更多
基金the financial support from the Natural Science Foundation of Shanghai(24ZR1453900)Project for AI-Driven Reform of Research Paradigms to Empower Advancement of Disciplines(Z-2024-369-036)。
文摘Rational design of catalytic interfaces at the atomic level is crucial for enhancing electrocatalytic CO_(2)reduction.In this study,a Zeolite imidazolate frameworks-8 derived catalyst is developed,featuring atomically dispersed Ni–Zn dual-atom sites(NiZnN_(6))coexisting with Ni_(3)ZnC_(0.7) nanoparticles on nitrogen-doped carbon nanotubes.Strong interaction between the NiZnN_(6) moieties and Ni_(3)ZnC_(0.7) nanoparticle induces charge redistribution,enhancing the electron-donating ability of Ni active sites.Simultaneously,the dual-atom configuration creates an asymmetric electronic environment,where interfacial electronic coupling facilitates partial electron transfer from Zn to Ni,leading to electron enrichment at the Ni center.Consequently,Ni sites preferentially donate electrons to active CO_(2)molecules,lowering the ^(*)COOH formation energy,while Zn sites promote ^(*)CO desorption,thus achieving high CO selectivity(99.6%@-0.7V vs.Reversible Hydrogen Electrode(RHE)).The in-depth investigation in this work provides guidance for establishing the relationship between structure and electrocatalytic activity,holding significant implications for fundamental research on the CO_(2)reduction mechanism.
基金funded by the Ningxia Natural Science Foundation(grant ID.2022A1467).
文摘Objective:To use fetal heart quantification(fetal HQ)technology to compare the coarctation of the aorta(CoA)and normal fetal heart structure and systolic function and to assess whether there are abnormalities in the fetal heart structure and systolic function associated with CoA.Methods:This prospective cohort study was conducted from May 2020 to December 2022 and involved 18–40-week-old singleton pregnancies and 30 fetuses diagnosed with CoA using fetal echocardiography at the General Hospital of Ningxia Medical University and Peking University First Hospital Ningxia Women’s andChildren’s Hospital,China.The control group contained 60 normal fetuses.The following parameters were recorded and analyzed statistically:four-chamber view(4CV)end-diastolic long diameter,4CV epicardial–contralateral epicardial transverse maximum diameter,4CV global sphericity index(GSI),left ventricular(LV)and right ventricular(RV)24-segment end-diastolic diameter(EDD),24-segment sphericity index(SI),LV-fractional area change(LV-FAC),LV-longitudinal strain(LV-LS),RV-fractional area change(RV-FAC),RV-longitudinal strain(RV-LS),and LV and RV 24-segment transverse fractional shortening(FS).Measurement data were compared between the two groups using an independent sample t test,with P<0.05 indicating statistically significant differences.Moreover,the correlation between gestational age and GSI,LV-FAC,LV-LS,RV-FAC,and RV-LS was assessed.Results:Within and between observer comparisons of the parameters associated with major cardiac function revealed an intragroup correlation coefficient of>0.9,indicating high consistency,and a coefficient of variable of<1%,indicating low variability.Correlation analysis revealed no obvious correlation between gestational age and GSI,LV-FAC,LV-LS,RV-FAC,and RV-LS.A comparison of the fourchamber morphological structural parameters of the hearts in the two groups revealed that when compared with the control group,the 4CV end-diastolic long diameter was shortened in fetuses in the CoA group and the epicardial–contralateral epicardial transverse maximum diameter was wider,while the GSI was lower(P<0.05).A comparison of the LV and RV morphological structure parameters between the two groups revealed that when compared with the control group,the LV’s 24-segment EDD was smaller in the CoA group,the RV’s 24-segment EDD was greater in the control group,the SI of the LV’s segments 16–24 was greater than in the control group,and the SI of the RV’s segments 7–24 was less than in the control group(all P<0.05).When comparedwith fetuses in the control group,the LV’s segments16–24 were greater in the CoA group,whereas the RV’s segment 6–24 was smaller(P<0.05).When comparedwith the control group,LV-FAC,RV-FAC,and LS were lower in the CoA group(P<0.05).The FS of the LV segments 1–24 and the FS of the RV segments 1–16 were smaller in the CoA group than in the normal group(P<0.05).Conclusion:Fetal HQ,a new simple technique that offers rapid analysis and high repeatability,can quantitatively evaluate structural and systolic function changes in fetuses with CoA.
