Dear Editor,The human SWI/SNF chromatin remodeling complexes are essential for modulating genomic architecture and increasing DNA accessibility,thereby regulating gene transcription(Clapier et al.,2017).These complexe...Dear Editor,The human SWI/SNF chromatin remodeling complexes are essential for modulating genomic architecture and increasing DNA accessibility,thereby regulating gene transcription(Clapier et al.,2017).These complexes exhibit a high frequency of mutations across all tumors,with a mutation rate of 20%observed in the coding genes of 29 subunits(Kadoch et al.,2013).展开更多
Endometrial cancer,one of the most prevalent gynecological malignancies,has been steadily increasing in incidence,with 417,000 new cases and 97,000 deaths reported worldwide in 2020.1 Its classification is crucial for...Endometrial cancer,one of the most prevalent gynecological malignancies,has been steadily increasing in incidence,with 417,000 new cases and 97,000 deaths reported worldwide in 2020.1 Its classification is crucial for effective management.展开更多
基金supported by the National Key R&D Program of China(2021YFA1300100 to B.L.)the National Natural Science Foundation of China(32030019,31872817 to B.L.,82072892 to J.W.,81901284 to YH.Y.,32000413 to J.S.,31970587,32170609 to X.S.)+1 种基金the Natural Science Foundation of Guangxi(No.2023GXNSFAA026276 to J.W.)the Fundamental Research Funds for the Central Universities.
文摘Dear Editor,The human SWI/SNF chromatin remodeling complexes are essential for modulating genomic architecture and increasing DNA accessibility,thereby regulating gene transcription(Clapier et al.,2017).These complexes exhibit a high frequency of mutations across all tumors,with a mutation rate of 20%observed in the coding genes of 29 subunits(Kadoch et al.,2013).
基金sponsored in part by the Natural Science Foundation of Guangxi,China(No.2023GXNSFAA026276)the National Natural Science Foundation of China(No.82072892)+1 种基金the Key Discipline Construction Project of Jiading District Health System(Shanghai,China)(No.XK202405)the Research Innovation Project of Jiading Branch of Shanghai General Hospital,China(No.2025-KJPD-01).
文摘Endometrial cancer,one of the most prevalent gynecological malignancies,has been steadily increasing in incidence,with 417,000 new cases and 97,000 deaths reported worldwide in 2020.1 Its classification is crucial for effective management.
