In this letter,we have commented on the study by Zhang et al,which utilized bioinformatics and immunohistochemistry to assess the value of fatty acidbinding protein 4(FABP4)as a biomarker for colon adenocarcinoma(COAD...In this letter,we have commented on the study by Zhang et al,which utilized bioinformatics and immunohistochemistry to assess the value of fatty acidbinding protein 4(FABP4)as a biomarker for colon adenocarcinoma(COAD).Their findings improve our understanding of FABP4 in cancer cell adhesion and immune cell infiltration.However,differential expression analysis was insufficient to demonstrate a direct association between FABP4 expression and the occurrence and progression of COAD.Using Mendelian randomization for causal inferences can provide a solid biological foundation for model construction.Furthermore,integrating machine and deep learning approaches may yield more robust and precise prognostic outcomes than using a single Cox regression model.In addition,integrating genome-wide association study data to identify additional pathogenic genes involved in the regulation of fatty acid metabolism may facilitate the development of a multi-target strategy.This approach could potentially mitigate the compensatory effects associated with targeting FABP4 alone,and enhance therapeutic efficacy.Enhancing experimental validation would further improve the reliability of the results.With the continuous advancement of machine learning,multi-omics technologies,and experimental techniques,future studies may systematically integrate diverse sequencing datasets to offer novel insights into the early diagnosis,individualized treatment,and prognostic evaluation of COAD.展开更多
目的比较3种不同出血速率在不同管电压条件下,多层螺旋CT(MDCT)显示消化道活动性出血的敏感性。方法复制消化道出血模型,以测得的30例消化道出血患者(均经病理证实)出血点CT平均值(212.13±64.54)HU为参考值,将浓度为320 mg I/ml碘...目的比较3种不同出血速率在不同管电压条件下,多层螺旋CT(MDCT)显示消化道活动性出血的敏感性。方法复制消化道出血模型,以测得的30例消化道出血患者(均经病理证实)出血点CT平均值(212.13±64.54)HU为参考值,将浓度为320 mg I/ml碘佛醇与0.9%生理盐水配比成浓度为6.4 mg I/ml的碘溶液,120 k V对应CT值(214.73±1.63)HU,在相同对比剂浓度下(6.4 mg I/ml),通过微量注射泵模拟出血速率,分别以0.3、0.4和0.5 ml/min的注射速率注射,并对消化道出血模型行MDCT扫描。对照组:120 kV,300 mAs;实验A组:100 k V,300 m As;实验B组:100 k V,400 m As;实验C组:80 k V,465 m As。由2位放射医师采用双盲法读片,比较4组辐射剂量、客观噪声值、信噪比,记录每组MDCT对模型出血的检出情况,并测量出血点CT值。结果对照组、实验A、B、C组CT容积剂量指数(CTDIvol)、有效剂量(ED)比较,差异有统计学意义(P <0.05);实验B组图像噪声、信噪比、图像质量主观评分与对照组比较,差异无统计学意义(P>0.05);对照组和实验各组在出血速率为0.5和0.4 ml/min时对模型出血的检出率为100%;对照组、实验A、B组未能检出出血速率为0.3 mgI/min的出血;实验C组在出血率为0.3 ml/min时对模型出血检出率为28.6%(2/7),但检出率与对照组(-0.5 ml/min)比较差异有统计学意义(P<0.05)。结论常规扫描条件下,MDCT能够显示出血速率>0.4 ml/min的出血点;降低管电压能够有效增加出血点CT值。展开更多
文摘In this letter,we have commented on the study by Zhang et al,which utilized bioinformatics and immunohistochemistry to assess the value of fatty acidbinding protein 4(FABP4)as a biomarker for colon adenocarcinoma(COAD).Their findings improve our understanding of FABP4 in cancer cell adhesion and immune cell infiltration.However,differential expression analysis was insufficient to demonstrate a direct association between FABP4 expression and the occurrence and progression of COAD.Using Mendelian randomization for causal inferences can provide a solid biological foundation for model construction.Furthermore,integrating machine and deep learning approaches may yield more robust and precise prognostic outcomes than using a single Cox regression model.In addition,integrating genome-wide association study data to identify additional pathogenic genes involved in the regulation of fatty acid metabolism may facilitate the development of a multi-target strategy.This approach could potentially mitigate the compensatory effects associated with targeting FABP4 alone,and enhance therapeutic efficacy.Enhancing experimental validation would further improve the reliability of the results.With the continuous advancement of machine learning,multi-omics technologies,and experimental techniques,future studies may systematically integrate diverse sequencing datasets to offer novel insights into the early diagnosis,individualized treatment,and prognostic evaluation of COAD.
文摘目的比较3种不同出血速率在不同管电压条件下,多层螺旋CT(MDCT)显示消化道活动性出血的敏感性。方法复制消化道出血模型,以测得的30例消化道出血患者(均经病理证实)出血点CT平均值(212.13±64.54)HU为参考值,将浓度为320 mg I/ml碘佛醇与0.9%生理盐水配比成浓度为6.4 mg I/ml的碘溶液,120 k V对应CT值(214.73±1.63)HU,在相同对比剂浓度下(6.4 mg I/ml),通过微量注射泵模拟出血速率,分别以0.3、0.4和0.5 ml/min的注射速率注射,并对消化道出血模型行MDCT扫描。对照组:120 kV,300 mAs;实验A组:100 k V,300 m As;实验B组:100 k V,400 m As;实验C组:80 k V,465 m As。由2位放射医师采用双盲法读片,比较4组辐射剂量、客观噪声值、信噪比,记录每组MDCT对模型出血的检出情况,并测量出血点CT值。结果对照组、实验A、B、C组CT容积剂量指数(CTDIvol)、有效剂量(ED)比较,差异有统计学意义(P <0.05);实验B组图像噪声、信噪比、图像质量主观评分与对照组比较,差异无统计学意义(P>0.05);对照组和实验各组在出血速率为0.5和0.4 ml/min时对模型出血的检出率为100%;对照组、实验A、B组未能检出出血速率为0.3 mgI/min的出血;实验C组在出血率为0.3 ml/min时对模型出血检出率为28.6%(2/7),但检出率与对照组(-0.5 ml/min)比较差异有统计学意义(P<0.05)。结论常规扫描条件下,MDCT能够显示出血速率>0.4 ml/min的出血点;降低管电压能够有效增加出血点CT值。
