This study aims to identify the highly non-specific toxic by-products during ozonation of three cresols in wastewater.In ozonated effluents,biotoxicity increased along with increasing reaction time,followed by a gradu...This study aims to identify the highly non-specific toxic by-products during ozonation of three cresols in wastewater.In ozonated effluents,biotoxicity increased along with increasing reaction time,followed by a gradual decrease.The peak biotoxicity for ozonated o-cresol(o-C),m-cresol(m-C),and p-cresol(p-C)was estimated to be 17.4,14.8 and 5.5 times higher than that of untreated wastewater,respectively.A redox-directed approach with high-resolution mass spectrometry detection and toxicity prediction revealed that monomeric para-benzoquinones(p-BQs),hydroxylated p-BQs,and dimeric p-BQs in ozonated cresols were the primary contributors to the increased toxicity.Calculations based on density functional theory indicated formation pathways of p-BQs byproducts,e.g.,the formation of 2-methyl-p-benzoquinone was likely induced by ozone molecules rather than hydroxyl radicals in ozonated o-C and m-C,and the formation of p-BQs during ozonation of p-C was attributed to the oxidation of methyl group to carboxyl group and subsequent decarboxylation initiated by hydroxyl radicals.Electron paramagnetic resonance and spin density calculation showed that the presence of carbon-centered cresoxyl radicals was responsible for dimeric p-BQs formation.Collectively,these results underscore significant contribution of non-halogenated p-BQs to non-specific toxicity increase in ozonated effluents.展开更多
Advancing aqueous zinc-ion batteries(AZIBs)are significantly challenged by the need to find cathode materials that can provide both high capacity and fast reaction kinetics.Tellurium telluride,a topological insulator,...Advancing aqueous zinc-ion batteries(AZIBs)are significantly challenged by the need to find cathode materials that can provide both high capacity and fast reaction kinetics.Tellurium telluride,a topological insulator,has emerged as a promising cathode candidate for AZIBs,garnering increasing attention.However,the complete understanding of its electrochemical reaction mechanism and its unsatisfactory energy storage performance are major obstacles to the practical use.In this work,we synthesize a bimetallic bismuth-nickel telluride with Te vacancies,defined as Bi_(2)Te_(3-x)/NiTe_(2),which forms a topological insulator/topological Dirac semimetal heterostructure through a hydrothermal approach.The electrochemical reaction mechanism of Bi_(2)Te_(3-x)/NiTe_(2),along with its phase and structural changes are elucidated by using in-situ X-ray diffraction,various electrochemical techniques,and ex-situ characterizations.The influences of Bi_(2)Te_(3-x)/NiTe_(2)on the electronic structure,interracial electron transfer,migration barrier,and ion adsorption energy are investigated by using density functional theory calculations.Our findings reveal that Bi_(2)Te_(3-x)/NiTe_(2)exhibits excellent specific capacity,stable cycling,and superior rate capability as a cathode material for AZIBs.Moreover,further studies demonstrate that Bi_(2)Te_(3-x)/NiTe_(2)maintains exceptional performance at low temperatures of-15 and-5℃,and also retains stability and flexibility when integrated into flexible battery packs.展开更多
Due to the high-order B-spline basis functions utilized in isogeometric analysis(IGA)and the repeatedly updating global stiffness matrix of topology optimization,Isogeometric topology optimization(ITO)intrinsically su...Due to the high-order B-spline basis functions utilized in isogeometric analysis(IGA)and the repeatedly updating global stiffness matrix of topology optimization,Isogeometric topology optimization(ITO)intrinsically suffers from the computationally demanding process.In this work,we address the efficiency problem existing in the assembling stiffness matrix and sensitivity analysis using B˙ezier element stiffness mapping.The Element-wise and Interaction-wise parallel computing frameworks for updating the global stiffness matrix are proposed for ITO with B˙ezier element stiffness mapping,which differs from these ones with the traditional Gaussian integrals utilized.Since the explicit stiffness computation formula derived from B˙ezier element stiffness mapping possesses a typical parallel structure,the presented GPU-enabled ITO method can greatly accelerate the computation speed while maintaining its high memory efficiency unaltered.Numerical examples demonstrate threefold speedup:1)the assembling stiffness matrix is accelerated by 10×maximumly with the proposed GPU strategy;2)the solution efficiency of a sparse linear system is enhanced by up to 30×with Eigen replaced by AMGCL;3)the efficiency of sensitivity analysis is promoted by 100×with GPU applied.Therefore,the proposed method is a promising way to enhance the numerical efficiency of ITO for both single-patch and multiple-patch design problems.展开更多
Sodium titanium phosphate(NaTi_(2)(PO_(4))_(3),NTP)has emerged as a promising electrode material due to its three-dimensional open framework.This study investigates the use of NTP in aqueous dilute Li^(+)/Na^(+)electr...Sodium titanium phosphate(NaTi_(2)(PO_(4))_(3),NTP)has emerged as a promising electrode material due to its three-dimensional open framework.This study investigates the use of NTP in aqueous dilute Li^(+)/Na^(+)electrolytes and extends its application to high-concentration K+electrolytes.X-ray photoelectron spectroscopy,X-ray absorption near-edge structure analysis,and density functional theory calculations revealed that highly electronegative fluorine partially substitutes for oxygen in the NTP lattice,resulting in the formation of Ti-F bonds.The substitution effectively modulates the electronic structure of Ti^(4+),alters the local coordination environment,and influences the redox dynamics.Enhanced long-term cycling stability and rate performance were demonstrated across aqueous sodium-ion,lithium-ion,and potassium-ion half-cells.Among the investigated systems,the aqueous sodium-ion system exhibited the best electrochemical performance,characterized by a single,well-defined charge–discharge plateau,stable cycling behavior with 88.7%capacity retention after 500 cycles at 1 A g^(−1),and an initial specific discharge capacity of 121.7 mAh g^(−1) at 0.2 A g^(−1).The results establish F-doped NTP as a promising candidate for advanced energy storage applications in aqueous alkali metal-ion batteries.展开更多
Mountains are rich in biodiversity,and butterflies are species-rich and have a good ecological and evolutionary research foundation.This review addresses the potential and progress of studying mountain biodiversity us...Mountains are rich in biodiversity,and butterflies are species-rich and have a good ecological and evolutionary research foundation.This review addresses the potential and progress of studying mountain biodiversity using butterflies as a model.We discuss the uniqueness of mountain ecosystems,factors influencing the distribution of mountain butterflies,representative genetic and evolutionary models in butterfly research,and evolutionary studies of mountain biodiversity involving butterfly genetics and genomics.Finally,we demonstrate the necessity of studying mountain butterflies and propose future perspectives.This review provides insights for studying the biodiversity of mountain butterflies as well as a summary of research methods for reference.展开更多
Understanding the immunological characteristics of monocytes-including the characteristics associated with fibrosis-in severe coronavirus disease 2019(COVID-19)is crucial for understanding the pathogenic mechanism of ...Understanding the immunological characteristics of monocytes-including the characteristics associated with fibrosis-in severe coronavirus disease 2019(COVID-19)is crucial for understanding the pathogenic mechanism of the disease and preventing disease severity.In this study,we performed single-cell transcriptomic sequencing of peripheral blood samples collected from six healthy controls and 14 COVID-19samples including severe,moderate,and convalescent samples from three severely/critically ill and four moderately ill patients.We found that the monocytes were strongly remodeled in the severely/critically ill patients with COVID-19,with an increased proportion of monocytes and seriously reduced diversity.In addition,we discovered two novel severe-disease-specific monocyte subsets:Mono 0 and Mono 5.These subsets expressed amphiregulin(AREG),epiregulin(EREG),and cytokine interleukin-18(IL-18)gene,exhibited an enriched erythroblastic leukemia viral oncogene homolog(ErbB)signaling pathway,and appeared to exhibit pro-fibrogenic and pro-inflammation characteristics.We also found metabolic changes in Mono 0 and Mono 5,including increased glycolysis/gluconeogenesis and an increased hypoxia inducible factor-1(HIF-1)signaling pathway.Notably,one pre-severe sample displayed a monocyte atlas similar to that of the severe/critical samples.In conclusion,our study discovered two novel severedisease-specific monocyte subsets as potential predictors and therapeutic targets for severe COVID-19.Overall,this study provides potential predictors for severe disease and therapeutic targets for COVID-19 and thus provides a resource for further studies on COVID-19.展开更多
This work puts forward an explicit isogeometric topology optimization(ITO)method using moving morphable components(MMC),which takes the suitably graded truncated hierarchical B-Spline based isogeometric analysis as th...This work puts forward an explicit isogeometric topology optimization(ITO)method using moving morphable components(MMC),which takes the suitably graded truncated hierarchical B-Spline based isogeometric analysis as the solver of physical unknown(SGTHB-ITO-MMC).By applying properly basis graded constraints to the hierarchical mesh of truncated hierarchical B-splines(THB),the convergence and robustness of the SGTHB-ITOMMC are simultaneously improved and the tiny holes occurred in optimized structure are eliminated,due to the improved accuracy around the explicit structural boundaries.Moreover,an efficient computational method is developed for the topological description functions(TDF)ofMMC under the admissible hierarchicalmesh,which consists of reducing the dimensionality strategy for design space and the locally computing strategy for hierarchical mesh.We apply the above SGTHB-ITO-MMC with improved efficiency to a series of 2D and 3Dcompliance design problems.The numerical results show that the proposed SGTHB-ITO-MMC method outperforms the traditional THB-ITO-MMCmethod in terms of convergence rate and efficiency.Therefore,the proposed SGTHB-ITO-MMC is an effective way of solving topology optimization(TO)problems.展开更多
We propose a new approach to reuse the basis function evaluations in the numerical integration of isogeometric analysis.The concept of reusability of the basis functions is introduced according to their symmetrical,tr...We propose a new approach to reuse the basis function evaluations in the numerical integration of isogeometric analysis.The concept of reusability of the basis functions is introduced according to their symmetrical,translational and proportional features on both the coarse and refined levels.Based on these features and the parametric domain regularity of each basis,we classify the bases on the original level and then reuse them on the refined level,which can reduce the time for basis calculations at integration nodes.By using the sum factorization method and the mean value theorem for the integrals,a new integration method with high integral efficiency is proposed.We validate the proposed method by some structural analysis problems in domains with different dimensionality.Comparing the numerical result accuracy and the time cost of the proposed integration method with the full Gauss integration quadrature,it turns out to be very promising.展开更多
In a study of DNA methylation changes in melatonin-deficient rice mutants,mutant plants showed premature leaf senescence during grain-filling and reduced grain yield.Melatonin deficiency led to transcriptional reprogr...In a study of DNA methylation changes in melatonin-deficient rice mutants,mutant plants showed premature leaf senescence during grain-filling and reduced grain yield.Melatonin deficiency led to transcriptional reprogramming,especially of genes involved in chlorophyll and carbon metabolism,redox regulation,and transcriptional regulation,during dark-induced leaf senescence.Hypomethylation of mCG and mCHG in the melatonin-deficient rice mutants was associated with the expression change of both protein-coding genes and transposable element-related genes.Changes in gene expression and DNA methylation in the melatonin-deficient mutants were compensated by exogenous application of melatonin.A decreased S-adenosyl-L-methionine level may have contributed to the DNA methylation variations in rice mutants of melatonin deficiency under dark conditions.展开更多
The transport and thermoelectric properties together with annealing of the new layered Bi-chalcogenide LaOBiHgS_(3)are studied.On the transport part,the insulating behavior of the as-grown sample is evidently depresse...The transport and thermoelectric properties together with annealing of the new layered Bi-chalcogenide LaOBiHgS_(3)are studied.On the transport part,the insulating behavior of the as-grown sample is evidently depressed by post annealing.A hump-like abnormality appears around 170 K.The thermoelectric performance of the sample is observably improved by the annealing,mainly because of the enhanced electrical conductance.The present results suggest that the physical properties of LaOBiHgS_(3)are sensitive to post annealing and the possible micro adjustments that follow,indicating the layered Bi-chalcogenide family to be an ideal platform for designing novel functional materials.展开更多
This paper aims to solve large-scale and complex isogeometric topology optimization problems that consumesignificant computational resources. A novel isogeometric topology optimization method with a hybrid parallelstr...This paper aims to solve large-scale and complex isogeometric topology optimization problems that consumesignificant computational resources. A novel isogeometric topology optimization method with a hybrid parallelstrategy of CPU/GPU is proposed, while the hybrid parallel strategies for stiffness matrix assembly, equationsolving, sensitivity analysis, and design variable update are discussed in detail. To ensure the high efficiency ofCPU/GPU computing, a workload balancing strategy is presented for optimally distributing the workload betweenCPU and GPU. To illustrate the advantages of the proposedmethod, three benchmark examples are tested to verifythe hybrid parallel strategy in this paper. The results show that the efficiency of the hybrid method is faster thanserial CPU and parallel GPU, while the speedups can be up to two orders of magnitude.展开更多
Isogeometric analysis(IGA),which aims at integrating CAD and CAE models,is one of the most active research topics in both computational mechanics and computer-aided geometric design.The rapidly growing interests in IG...Isogeometric analysis(IGA),which aims at integrating CAD and CAE models,is one of the most active research topics in both computational mechanics and computer-aided geometric design.The rapidly growing interests in IGA has led to profound developments of relevant theories and applications,one of which being structural optimization.With the rapid growth of researches in IGA,this special issue contributes to highlight recent developments,challenges and opportunities of IGA and IGA-based structural design optimization,with focuses on theory development,numerical implementations and potential applications.展开更多
Geographical indication right and new plant variety right are important agricultural intellectual property.This article researches the current situation on protection of geographical indication right of green Chinese ...Geographical indication right and new plant variety right are important agricultural intellectual property.This article researches the current situation on protection of geographical indication right of green Chinese onion resources and new plant variety right.And it puts forward the following measures for improvement:(i)Promoting the implementation of geographical indication product protection based on the national quality system;(ii)Establishing the national quality standards of geographical indication green Chinese onion,in order to improve quality standardization;(iii)Encouraging more enterprises within the scope of protection of geographical indication to use special signs of geographical indication;(iv)Unifying the green Chinese onion brands within the scope of protection of geographical indication;(v)Achieving the dual protection of geographical indication right and new variety right of green Chinese onion;(vi)Developing the tourism resources on geographical indication green Chinese onion,to develop tourism agriculture.展开更多
Kallima butterflies are famous for their leaf-mimicking wing patterns.Yet the characterization of Kallima species is still under debate owing to their high phenotypic similarity.With the release of the K.inachus refer...Kallima butterflies are famous for their leaf-mimicking wing patterns.Yet the characterization of Kallima species is still under debate owing to their high phenotypic similarity.With the release of the K.inachus reference genome,phylogenetic studies based on genome-wide data have been carried out,thus improving the understanding of the evolutionary relationships of the genus Kallima.However,we noticed that there is some conflict between genome-based phylogenies and morphological classifications in butterflies.We further examined the cause of this conflict by conducting an in-depth study of the relationships among Kallima butterflies to test possible reticulate phylogenetic topologies.We constructed phylogenies based on various datasets(including SNPs in single-copy genes,coding sequences,neutral regions and all remaining sites across the genome)to compare the topologies,revealing the complex evolutionary history of Kallima butterflies.Our results suggest that the reticulate species topology may constitute a pervasive pattern present not only in species with adaptive radiations but also in gradually evolving species,with Kallima butterflies as an example.展开更多
The protection of intangible cultural heritage and geographical indications of the specialty in Shiyan City was analyzed,and then related suggestions were proposed,for example,to collect and organize the intangible cu...The protection of intangible cultural heritage and geographical indications of the specialty in Shiyan City was analyzed,and then related suggestions were proposed,for example,to collect and organize the intangible cultural heritage related to traditional specialty;to enhance the application of those intangible cultural heritage projects related to traditional industry and agriculture;to establish some demonstration bases for the productive protection of intangible cultural heritages;to strengthen the application of geographical indications of traditional specialty;to build national quality standards for various specialty with geographical indications;to integrate and cultivate the famous specialty brands with geographical indication;to implement the double protection of the geographical indications and intangible cultural heritages;to improve the poverty alleviation through developing the specialty industry with geographical indications.展开更多
Current protection of geographical indications of specialty resources in Anqing area was introduced,development strategies for intellectual property right protection of geographical indications in the city were explor...Current protection of geographical indications of specialty resources in Anqing area was introduced,development strategies for intellectual property right protection of geographical indications in the city were explored from the perspectives of protection of intangible cultural heritage,cultivation of high-quality specialties,technical specifications and quality control,poverty alleviation through industrial development.展开更多
基金supported by the National Natural Science Foundation of China(Nos.52270073 and 51708292)。
文摘This study aims to identify the highly non-specific toxic by-products during ozonation of three cresols in wastewater.In ozonated effluents,biotoxicity increased along with increasing reaction time,followed by a gradual decrease.The peak biotoxicity for ozonated o-cresol(o-C),m-cresol(m-C),and p-cresol(p-C)was estimated to be 17.4,14.8 and 5.5 times higher than that of untreated wastewater,respectively.A redox-directed approach with high-resolution mass spectrometry detection and toxicity prediction revealed that monomeric para-benzoquinones(p-BQs),hydroxylated p-BQs,and dimeric p-BQs in ozonated cresols were the primary contributors to the increased toxicity.Calculations based on density functional theory indicated formation pathways of p-BQs byproducts,e.g.,the formation of 2-methyl-p-benzoquinone was likely induced by ozone molecules rather than hydroxyl radicals in ozonated o-C and m-C,and the formation of p-BQs during ozonation of p-C was attributed to the oxidation of methyl group to carboxyl group and subsequent decarboxylation initiated by hydroxyl radicals.Electron paramagnetic resonance and spin density calculation showed that the presence of carbon-centered cresoxyl radicals was responsible for dimeric p-BQs formation.Collectively,these results underscore significant contribution of non-halogenated p-BQs to non-specific toxicity increase in ozonated effluents.
基金supported by the National Natural Science Foundation of China(No.52372223)the Science Foundation of Shaanxi Province(No.2023-JC-ZD-03 and 2022GD-TSLD-15)Shaanxi Fundamental Science Research Project for Mathematics and Physics(No.23JSQ005)。
文摘Advancing aqueous zinc-ion batteries(AZIBs)are significantly challenged by the need to find cathode materials that can provide both high capacity and fast reaction kinetics.Tellurium telluride,a topological insulator,has emerged as a promising cathode candidate for AZIBs,garnering increasing attention.However,the complete understanding of its electrochemical reaction mechanism and its unsatisfactory energy storage performance are major obstacles to the practical use.In this work,we synthesize a bimetallic bismuth-nickel telluride with Te vacancies,defined as Bi_(2)Te_(3-x)/NiTe_(2),which forms a topological insulator/topological Dirac semimetal heterostructure through a hydrothermal approach.The electrochemical reaction mechanism of Bi_(2)Te_(3-x)/NiTe_(2),along with its phase and structural changes are elucidated by using in-situ X-ray diffraction,various electrochemical techniques,and ex-situ characterizations.The influences of Bi_(2)Te_(3-x)/NiTe_(2)on the electronic structure,interracial electron transfer,migration barrier,and ion adsorption energy are investigated by using density functional theory calculations.Our findings reveal that Bi_(2)Te_(3-x)/NiTe_(2)exhibits excellent specific capacity,stable cycling,and superior rate capability as a cathode material for AZIBs.Moreover,further studies demonstrate that Bi_(2)Te_(3-x)/NiTe_(2)maintains exceptional performance at low temperatures of-15 and-5℃,and also retains stability and flexibility when integrated into flexible battery packs.
基金supported by the National Key R&D Program of China(2023YFB2504601)National Natural Science Foundation of China(52205267).
文摘Due to the high-order B-spline basis functions utilized in isogeometric analysis(IGA)and the repeatedly updating global stiffness matrix of topology optimization,Isogeometric topology optimization(ITO)intrinsically suffers from the computationally demanding process.In this work,we address the efficiency problem existing in the assembling stiffness matrix and sensitivity analysis using B˙ezier element stiffness mapping.The Element-wise and Interaction-wise parallel computing frameworks for updating the global stiffness matrix are proposed for ITO with B˙ezier element stiffness mapping,which differs from these ones with the traditional Gaussian integrals utilized.Since the explicit stiffness computation formula derived from B˙ezier element stiffness mapping possesses a typical parallel structure,the presented GPU-enabled ITO method can greatly accelerate the computation speed while maintaining its high memory efficiency unaltered.Numerical examples demonstrate threefold speedup:1)the assembling stiffness matrix is accelerated by 10×maximumly with the proposed GPU strategy;2)the solution efficiency of a sparse linear system is enhanced by up to 30×with Eigen replaced by AMGCL;3)the efficiency of sensitivity analysis is promoted by 100×with GPU applied.Therefore,the proposed method is a promising way to enhance the numerical efficiency of ITO for both single-patch and multiple-patch design problems.
基金supported by the National Natural Science Foundation of China(52072298,51802261,11675129)the Natural Science Basic Research Plan in Shaanxi Province of China(2025JC-YBQN-758)+1 种基金Scientific Research Program Funded by Shaanxi Provincial Education Department(Program No.23JK0662)the Youth Innovation Team of Shaanxi Universities.
文摘Sodium titanium phosphate(NaTi_(2)(PO_(4))_(3),NTP)has emerged as a promising electrode material due to its three-dimensional open framework.This study investigates the use of NTP in aqueous dilute Li^(+)/Na^(+)electrolytes and extends its application to high-concentration K+electrolytes.X-ray photoelectron spectroscopy,X-ray absorption near-edge structure analysis,and density functional theory calculations revealed that highly electronegative fluorine partially substitutes for oxygen in the NTP lattice,resulting in the formation of Ti-F bonds.The substitution effectively modulates the electronic structure of Ti^(4+),alters the local coordination environment,and influences the redox dynamics.Enhanced long-term cycling stability and rate performance were demonstrated across aqueous sodium-ion,lithium-ion,and potassium-ion half-cells.Among the investigated systems,the aqueous sodium-ion system exhibited the best electrochemical performance,characterized by a single,well-defined charge–discharge plateau,stable cycling behavior with 88.7%capacity retention after 500 cycles at 1 A g^(−1),and an initial specific discharge capacity of 121.7 mAh g^(−1) at 0.2 A g^(−1).The results establish F-doped NTP as a promising candidate for advanced energy storage applications in aqueous alkali metal-ion batteries.
基金the National Natural Science Foundation of China(32170420 and 31871271)the Beijing Natural Science Foundation(JQ19021)the Peking-Tsinghua Center for Life Science,the State Key Laboratory of Protein and Plant Gene Research,the Qidong-SLS Innovation Fund,Benyuan Charity Young Investigator Exploration Fellowship in Life Science to W.Z.,and grants from the China Postdoctoral Science Foundation(2023M730082 and BX20230026)to S.W.
文摘Mountains are rich in biodiversity,and butterflies are species-rich and have a good ecological and evolutionary research foundation.This review addresses the potential and progress of studying mountain biodiversity using butterflies as a model.We discuss the uniqueness of mountain ecosystems,factors influencing the distribution of mountain butterflies,representative genetic and evolutionary models in butterfly research,and evolutionary studies of mountain biodiversity involving butterfly genetics and genomics.Finally,we demonstrate the necessity of studying mountain butterflies and propose future perspectives.This review provides insights for studying the biodiversity of mountain butterflies as well as a summary of research methods for reference.
基金supported by the National Science and Technology Major Project(2017ZX10204401001002)the National Key Research and Development Project of China(2017ZX10204401001002008)+1 种基金the Key Research and Development Project of Zhejiang Province(2020C03123)Zhejiang Provincial Nature Science Foundation of China(LED20H19001)。
文摘Understanding the immunological characteristics of monocytes-including the characteristics associated with fibrosis-in severe coronavirus disease 2019(COVID-19)is crucial for understanding the pathogenic mechanism of the disease and preventing disease severity.In this study,we performed single-cell transcriptomic sequencing of peripheral blood samples collected from six healthy controls and 14 COVID-19samples including severe,moderate,and convalescent samples from three severely/critically ill and four moderately ill patients.We found that the monocytes were strongly remodeled in the severely/critically ill patients with COVID-19,with an increased proportion of monocytes and seriously reduced diversity.In addition,we discovered two novel severe-disease-specific monocyte subsets:Mono 0 and Mono 5.These subsets expressed amphiregulin(AREG),epiregulin(EREG),and cytokine interleukin-18(IL-18)gene,exhibited an enriched erythroblastic leukemia viral oncogene homolog(ErbB)signaling pathway,and appeared to exhibit pro-fibrogenic and pro-inflammation characteristics.We also found metabolic changes in Mono 0 and Mono 5,including increased glycolysis/gluconeogenesis and an increased hypoxia inducible factor-1(HIF-1)signaling pathway.Notably,one pre-severe sample displayed a monocyte atlas similar to that of the severe/critical samples.In conclusion,our study discovered two novel severedisease-specific monocyte subsets as potential predictors and therapeutic targets for severe COVID-19.Overall,this study provides potential predictors for severe disease and therapeutic targets for COVID-19 and thus provides a resource for further studies on COVID-19.
基金supported by the National Key R&D Program of China (2020YFB1708300)the Project funded by the China Postdoctoral Science Foundation (2021M701310).
文摘This work puts forward an explicit isogeometric topology optimization(ITO)method using moving morphable components(MMC),which takes the suitably graded truncated hierarchical B-Spline based isogeometric analysis as the solver of physical unknown(SGTHB-ITO-MMC).By applying properly basis graded constraints to the hierarchical mesh of truncated hierarchical B-splines(THB),the convergence and robustness of the SGTHB-ITOMMC are simultaneously improved and the tiny holes occurred in optimized structure are eliminated,due to the improved accuracy around the explicit structural boundaries.Moreover,an efficient computational method is developed for the topological description functions(TDF)ofMMC under the admissible hierarchicalmesh,which consists of reducing the dimensionality strategy for design space and the locally computing strategy for hierarchical mesh.We apply the above SGTHB-ITO-MMC with improved efficiency to a series of 2D and 3Dcompliance design problems.The numerical results show that the proposed SGTHB-ITO-MMC method outperforms the traditional THB-ITO-MMCmethod in terms of convergence rate and efficiency.Therefore,the proposed SGTHB-ITO-MMC is an effective way of solving topology optimization(TO)problems.
基金National Natural Science Foundation of China(Grant Nos.#51675197,#51805190).
文摘We propose a new approach to reuse the basis function evaluations in the numerical integration of isogeometric analysis.The concept of reusability of the basis functions is introduced according to their symmetrical,translational and proportional features on both the coarse and refined levels.Based on these features and the parametric domain regularity of each basis,we classify the bases on the original level and then reuse them on the refined level,which can reduce the time for basis calculations at integration nodes.By using the sum factorization method and the mean value theorem for the integrals,a new integration method with high integral efficiency is proposed.We validate the proposed method by some structural analysis problems in domains with different dimensionality.Comparing the numerical result accuracy and the time cost of the proposed integration method with the full Gauss integration quadrature,it turns out to be very promising.
基金supported by the National Natural Science Foundation of China(32100448,32070558,32061143030,32170636)Natural Science Foundation of Jiangsu Province(BK20210799)+2 种基金Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),the Seed Industry Revitalization Project of Jiangsu Province(JBGS[2021]009)the Shanghai Science and Technology Agriculture Project([2022]No.1–6)the Project of Zhongshan Biological Breeding Laboratory(BM2022008-029)。
文摘In a study of DNA methylation changes in melatonin-deficient rice mutants,mutant plants showed premature leaf senescence during grain-filling and reduced grain yield.Melatonin deficiency led to transcriptional reprogramming,especially of genes involved in chlorophyll and carbon metabolism,redox regulation,and transcriptional regulation,during dark-induced leaf senescence.Hypomethylation of mCG and mCHG in the melatonin-deficient rice mutants was associated with the expression change of both protein-coding genes and transposable element-related genes.Changes in gene expression and DNA methylation in the melatonin-deficient mutants were compensated by exogenous application of melatonin.A decreased S-adenosyl-L-methionine level may have contributed to the DNA methylation variations in rice mutants of melatonin deficiency under dark conditions.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.51572001,11404002,and 11404003)the ‘211 Project’ of Anhui University,China(Grant No.J01001319J10113190007)
文摘The transport and thermoelectric properties together with annealing of the new layered Bi-chalcogenide LaOBiHgS_(3)are studied.On the transport part,the insulating behavior of the as-grown sample is evidently depressed by post annealing.A hump-like abnormality appears around 170 K.The thermoelectric performance of the sample is observably improved by the annealing,mainly because of the enhanced electrical conductance.The present results suggest that the physical properties of LaOBiHgS_(3)are sensitive to post annealing and the possible micro adjustments that follow,indicating the layered Bi-chalcogenide family to be an ideal platform for designing novel functional materials.
基金the National Key R&D Program of China(2020YFB1708300)the National Natural Science Foundation of China(52005192)the Project of Ministry of Industry and Information Technology(TC210804R-3).
文摘This paper aims to solve large-scale and complex isogeometric topology optimization problems that consumesignificant computational resources. A novel isogeometric topology optimization method with a hybrid parallelstrategy of CPU/GPU is proposed, while the hybrid parallel strategies for stiffness matrix assembly, equationsolving, sensitivity analysis, and design variable update are discussed in detail. To ensure the high efficiency ofCPU/GPU computing, a workload balancing strategy is presented for optimally distributing the workload betweenCPU and GPU. To illustrate the advantages of the proposedmethod, three benchmark examples are tested to verifythe hybrid parallel strategy in this paper. The results show that the efficiency of the hybrid method is faster thanserial CPU and parallel GPU, while the speedups can be up to two orders of magnitude.
基金This work has been supported by National Natural Science Foundation of China(51705158),Guangdong Basic and Applied Basic Research Foundation(2019A1515011783)Guangdong Regular Institutions of Characteristic Innovation Project(2017KTSCX176)KEY Laboratory of Robotics and Intelligent Equipment of Guangdong Regular Institutions of Higher Education(2017KSYS009).These supports are gratefully acknowledged.
文摘Isogeometric analysis(IGA),which aims at integrating CAD and CAE models,is one of the most active research topics in both computational mechanics and computer-aided geometric design.The rapidly growing interests in IGA has led to profound developments of relevant theories and applications,one of which being structural optimization.With the rapid growth of researches in IGA,this special issue contributes to highlight recent developments,challenges and opportunities of IGA and IGA-based structural design optimization,with focuses on theory development,numerical implementations and potential applications.
基金Supported by Humanities and Social Sciences Planning Fund Project(11YJA850019)Scientific and Technological Innovation Project,the Ministry of Culture(2011021)Hubei Social Science Fund Project(2010274)
文摘Geographical indication right and new plant variety right are important agricultural intellectual property.This article researches the current situation on protection of geographical indication right of green Chinese onion resources and new plant variety right.And it puts forward the following measures for improvement:(i)Promoting the implementation of geographical indication product protection based on the national quality system;(ii)Establishing the national quality standards of geographical indication green Chinese onion,in order to improve quality standardization;(iii)Encouraging more enterprises within the scope of protection of geographical indication to use special signs of geographical indication;(iv)Unifying the green Chinese onion brands within the scope of protection of geographical indication;(v)Achieving the dual protection of geographical indication right and new variety right of green Chinese onion;(vi)Developing the tourism resources on geographical indication green Chinese onion,to develop tourism agriculture.
基金supported by grants from the National Natural Science Foundation of China(32325009,32170420)the Peking-Tsinghua Center for Life Sciences,and the State Key Laboratory of Protein and Plant Gene Research to WZ and grants from the China Postdoctoral Science Foundation(2023M730082,BX20230026)to SW.
文摘Kallima butterflies are famous for their leaf-mimicking wing patterns.Yet the characterization of Kallima species is still under debate owing to their high phenotypic similarity.With the release of the K.inachus reference genome,phylogenetic studies based on genome-wide data have been carried out,thus improving the understanding of the evolutionary relationships of the genus Kallima.However,we noticed that there is some conflict between genome-based phylogenies and morphological classifications in butterflies.We further examined the cause of this conflict by conducting an in-depth study of the relationships among Kallima butterflies to test possible reticulate phylogenetic topologies.We constructed phylogenies based on various datasets(including SNPs in single-copy genes,coding sequences,neutral regions and all remaining sites across the genome)to compare the topologies,revealing the complex evolutionary history of Kallima butterflies.Our results suggest that the reticulate species topology may constitute a pervasive pattern present not only in species with adaptive radiations but also in gradually evolving species,with Kallima butterflies as an example.
基金Supported by Humanities and Social Sciences Planning Fund Project(11YJA850019)Scientific and Technological Innovation Project,the Ministry of Culture(2011021)Hubei Social Science Fund Project(2010274)
文摘The protection of intangible cultural heritage and geographical indications of the specialty in Shiyan City was analyzed,and then related suggestions were proposed,for example,to collect and organize the intangible cultural heritage related to traditional specialty;to enhance the application of those intangible cultural heritage projects related to traditional industry and agriculture;to establish some demonstration bases for the productive protection of intangible cultural heritages;to strengthen the application of geographical indications of traditional specialty;to build national quality standards for various specialty with geographical indications;to integrate and cultivate the famous specialty brands with geographical indication;to implement the double protection of the geographical indications and intangible cultural heritages;to improve the poverty alleviation through developing the specialty industry with geographical indications.
基金Supported by Humanities and Social Sciences Research Foundation of the Ministry of Education(11YJA850019)Scientific and Technological Innovation Program of the Ministry of Culture(2011021)"Eleventh Five-year Plan"of Hubei Provincial Social Sciences Program(2010274)
文摘Current protection of geographical indications of specialty resources in Anqing area was introduced,development strategies for intellectual property right protection of geographical indications in the city were explored from the perspectives of protection of intangible cultural heritage,cultivation of high-quality specialties,technical specifications and quality control,poverty alleviation through industrial development.
