A 32-channel charge-sensitive amplifier(CSA)is designed for fast timing in the delay-line readout of a parallel plate avalanche counter(PPAC)array.It is realized on a PCB with operational amplifiers and other discrete...A 32-channel charge-sensitive amplifier(CSA)is designed for fast timing in the delay-line readout of a parallel plate avalanche counter(PPAC)array.It is realized on a PCB with operational amplifiers and other discrete components.Each channel consists of an integrator,a pole-zero cancellation net,and a linear amplification stage,which can be adapted to accommodate either positive or negative input signals.The RMS equivalent input noise charges are 3.3 fC,the conversion gains are approximately±2 mV∕fC,and the intrinsic time resolution reaches 32 ps.In the prototype PPAC application,the CSA performs as well as the commercial FTA820A amplifier,providing a position resolution as good as 0.17 mm,and exhibiting reliable stability during several hours of continuous data acquisition.展开更多
Objective:This study aimed to assess the feasibility and safety of the SHURUI single-port robotic surgical system for a range of major urological surgeries.Methods:In this prospective,multicenter clinical trial,we exa...Objective:This study aimed to assess the feasibility and safety of the SHURUI single-port robotic surgical system for a range of major urological surgeries.Methods:In this prospective,multicenter clinical trial,we examined the effectiveness of the SHURUI single-port robotic surgical system in urological interventions.The first 50 patients from four centers in China underwent single-port surgeries including partial nephrectomy,radical prostatectomy,partial adrenalectomy,and pyeloureteroplasty,exclusively by the SHURUI single-port robotic surgical system.The study's primary endpoints focused on the success of surgeries,defined as no deviations from planned procedures,no need for more than one port,and no re-operations within 24 h after surgery.Secondary endpoints encompassed a range of surgical metrics,functional outcomes,and patient demographic data.Clinical assessments were conducted before surgery,before discharge,and 1 month after discharge.Results:The surgical procedures were executed successfully without requiring intraoperative conversions or transfusions.Both estimated blood loss and operation durations were maintained within satisfactory limits.For each type of surgery,the mean console times and estimated blood loss were 179.8(standard deviation[SD]39.4)min and 125.6(SD 126.0)mL for radical prostatectomy,126.7(SD 47.8)min and 39.2(SD 54.4)mL for partial nephrectomy,112.6(SD 37.4)min and 20.0(SD 13.2)mL for partial adrenalectomy,and 148.0(SD 18.2)min and 18.0(SD 17.9)mL for pyeloureteroplasty,respectively.Across the cohort,17 patients experienced a total of 25 adverse events,while 10 postoperative complications,all rated as Clavien-Dindo grade I,were encountered by eight patients.All patients had shown recovery or improvement from these events before the end of this trial.Conclusion:The SHURUI single-port robotic surgical system demonstrated feasibility and safety in the performance of major urological surgeries.These initial findings highlight the system's potential,though further research and longer follow-up are required to assess long-term outcomes.展开更多
Highly oriented pyrolytic graphite (HOPG) is frequently adopted as the reaction target in12C+12C fusion reaction experiments owing to its superior purity.In this study,we investigate the reaction yield dependence on t...Highly oriented pyrolytic graphite (HOPG) is frequently adopted as the reaction target in12C+12C fusion reaction experiments owing to its superior purity.In this study,we investigate the reaction yield dependence on the accumulated beam dose on HOPG target using a novel detection system consisting of a time-projection chamber and silicon array.The reaction yields are significantly reduced under intense beam bombardment owing to radiation damage to the HOPG surface.The α_(0) and p_(0,1) yields decrease by 51.5% and 25%,respectively,when the ^(12)C^(2+) beam dose accumulates at 5 C.Using the novel detection system and HOPG target,the α0yield is determined to be 2.68_(-1.69)^(+4.69)×10^(-17/12) C after correcting for the yield loss due to radiation damage.Our result represents the highest sensitivity achieved to date in direct measurements of ^(12)C(12C,α_(0))^(20)Ne.展开更多
The weak adsorption energy of oxygen-containing intermediates on Co center leads to a considerable performance dis-parity between Co-N-C and costly Pt benchmark in catalyzing oxygen reduction reaction(ORR).In this wor...The weak adsorption energy of oxygen-containing intermediates on Co center leads to a considerable performance dis-parity between Co-N-C and costly Pt benchmark in catalyzing oxygen reduction reaction(ORR).In this work,we strategi-cally engineer the active site structure of Co-N-C via B substitution,which is accomplished by the pyrolysis of ammonium borate.During this process,the in-situ generated NH_(3)gas plays a critical role in creating surface defects and boron atoms substituting nitrogen atoms in the carbon structure.The well-designed CoB_(1)N_(3)active site endows Co with higher charge density and stronger adsorption energy toward oxygen species,potentially accelerating ORR kinetics.As expected,the resulting Co-B/N-C catalyst exhibited superior ORR performance over Co-N-C counterpart,with 40 mV,and fivefold en-hancement in half-wave potential and turnover frequency(TOF).More importantly,the excellent ORR performance could be translated into membrane electrode assembly(MEA)in a fuel cell test,delivering an impressive peak power density of 824 mW·cm^(-2),which is currently the best among Co-based catalysts under the same conditions.This work not only demon-strates an effective method for designing advanced catalysts,but also affords a highly promising non-precious metal ORR electrocatalyst for fuel cell applications.展开更多
In the upcoming 5 G heterogeneous networks, leveraging multiple radio access technologies(RATs) shows to be a crucial issue in achieving RAT multiplexing gain to meet the explosive traffic demand. For always best conn...In the upcoming 5 G heterogeneous networks, leveraging multiple radio access technologies(RATs) shows to be a crucial issue in achieving RAT multiplexing gain to meet the explosive traffic demand. For always best connection(ABC), users tend to activate parallel transmission across all available RATs. However from a system-wide perspective, this might not be optimal given the context of network load, interference and diverse service requirements. To intelligently determine how to use these multi-RAT access resources concurrently, this paper proposes a joint multi-RAT user association and resource allocation strategy with triple decision and integrated context awareness of users and networks. A dynamic game based ant colony algorithm(GACA) is designed to simultaneously maximize the system utility and the fairness of resource allocation. Simulation results show that it's more reasonable to make multi-RAT association decision from a system-wide viewpoint than from an individual one. Compared to max-SNR based and ABC based strategies, the proposed method alleviates network congestion and optimizes resource allocation. It obtains 39%~70% performance improvement.展开更多
A dissertation is a research report or scientific paper written by an author to obtain a certain degree. It reflects postgraduates’ research achievements and the educational quality of an institute, even a country. T...A dissertation is a research report or scientific paper written by an author to obtain a certain degree. It reflects postgraduates’ research achievements and the educational quality of an institute, even a country. To construct an optimized quality evaluation system for postgraduate dissertation (QESPD), we summarized the influencing factors and invited 10 experienced specialists to rate and prioritize them based on fuzzy analytic hierarchy process. Four primary indicators (innovation, integrity, scientificity and normativity) and 16 sub-indicators were selected to form the evaluation system. The order of primary indicators by weight, was innovation (0.4269), scientificity (0.2807), integrity (0.1728) and normativity (0.1196). The top five sub-dimensions were theoretical originality, scientific value, data reliability, design rationality and evidence credibility. To demonstrate the effectiveness of the proposed system, a case study was performed. In the case study, it was demonstrated that the established two-index-hierarchy QESPD in this study was a more scientific and reasonable evaluation system worthy of promotion and application.展开更多
Hereditary multiple exostoses(HME)is an autosomal dominant bone disorder characterized by abnormal bone development.HME mostly involves the forearm,resulting in forearm deformities,limited functional activities,etc.Cu...Hereditary multiple exostoses(HME)is an autosomal dominant bone disorder characterized by abnormal bone development.HME mostly involves the forearm,resulting in forearm deformities,limited functional activities,etc.Currently,there are multiple surgical methods including tumor resection with or without ulnar osteotomy and lengthening,simple radial head resection and distal radial hemiepiphysiodesis,but the optimal treatment remains controversial.Ulnar lengthening serves as an effective surgical intervention for forearm deformities in HME patients.This review examines its surgical techniques,complications,and timing of the operation to guide clinical decision-making for improving function and cosmetic outcomes.展开更多
Recent advances have deepened our understanding of the evolutionary and developmental origins of feather branching architectures.However,the internal tissue differentiation within these branches has received limited a...Recent advances have deepened our understanding of the evolutionary and developmental origins of feather branching architectures.However,the internal tissue differentiation within these branches has received limited attention.This study examined eight fossilized feathers preserved in early Late Cretaceous Burmese amber,characterized by barb rami composed entirely of cortical tissue with no internal medulla.Based on barb rami morphology,the feathers were categorized into three distinct morphotypes.Comparative analysis with feather development in extant chickens suggested minimal tissue differentiation in these early feathers.Functional simulations further revealed that modern barb rami configurations provide greater aerodynamic stability than medulla-free early feathers under most conditions,highlighting flexural stiffness as a key factor in the evolution of feather branches.The presence of medullafree barb rami suggests that although the three-level hierarchical branching pattern characteristic of modern feathers had emerged by the Jurassic,tissue differentiation within feather branches remained developmentally unstable during the Late Cretaceous.This instability likely contributed to the structural variability of early feathers,enabling morphologies that no longer persist in modern birds.展开更多
This experimental investigation was conducted on the flow boiling performance of refrigerant R134a in two types of parallel microchannels:sintered porous microchannels(PP-MCs)and smooth parallel microchannels(SP-MCs)....This experimental investigation was conducted on the flow boiling performance of refrigerant R134a in two types of parallel microchannels:sintered porous microchannels(PP-MCs)and smooth parallel microchannels(SP-MCs).The tests were performed under controlled conditions including an inlet subcooling of 5±0.2℃,saturation temperature of 33℃,mass fluxes of 346 and 485 kg/m2·s,and a range of heat fluxes.Key findings reveal that the sintered porous microstructure significantly enhances bubble nucleation,reducing the wall superheat required for the onset of nucleate boiling(ONB)to only 0.13℃ compared to 2.2℃ in smooth channels.The porous structure also improves heat transfer coefficients at low and medium heat fluxes(<20–30 W/cm^(2))and low vapor quality(x<0.2–0.4)due to augmented thin-film evaporation and intensified nucleate boiling.However,smooth microchannels exhibit superior performance under high heat flux and high vapor quality conditions,as the porous structure is prone to early dry-out and flow blockage.Notably,the porous microchannels demonstrate lower flow resistance and enhanced stability,with pressure drop fluctuations reduced by up to 46.4%in amplitude and 44.8%in standard deviation,attributed to improved capillary-assisted liquid replenishment and suppressed flow oscillations.The results underscore the potential of PP-MCs as a high-performance cooling solution for high-heat-flux applications.展开更多
Angiosperms experienced one of the most remarkable radiations of land plants and are now the dominant autotrophs in terrestrial ecosystems.Recent phylogenomic studies based on large-scale data from plastid,mitochondri...Angiosperms experienced one of the most remarkable radiations of land plants and are now the dominant autotrophs in terrestrial ecosystems.Recent phylogenomic studies based on large-scale data from plastid,mitochondrial,or nuclear transcriptomes/genomes and increased taxon sampling have provided unprecedent resolution into the phylogeny of flowering plants.However,owing to ancient rapid radiations,the interrelationships among the five lineages of Mesangiospermae,the vast majority of angiosperms,remain contentious.Here we show that,although plastid and mitochondrial genomes lack sufficient phylogenetic signal for resolving deeper phylogeny,the relationships among five mesangiosperm lineages can be confidently resolved under better-fitting models using genome-scale data.According to our Bayesian cross-validation and model test in a maximum likelihood framework,siteheterogeneous models(e.g.,CAT-GTR+G4,LG+C20+F+G)outperform site-homogeneous or partition models often used in previous studies.Under site-heterogeneous models,the approximately unbiased test favored our preferred tree recovered from various datasets:Ceratophyllales(coontails)are robustly recovered as sister to monocots,and they together are sister to the clade comprising magnoliids,Chloranthales,and eudicots.Our phylogenomic analyses resolve the last enigma of the deeper phylogeny of angiosperms and emphasize the efficacy of modeling compositional heterogeneity in resolving rapid radiations of plants.展开更多
Chlorogenic acid(CGA),as a polyphenol abundant in daily diet,exerted various intestinal functions.However,the material basis of its intestinal bioactivities was still unclear.Our study investigated the gastrointestina...Chlorogenic acid(CGA),as a polyphenol abundant in daily diet,exerted various intestinal functions.However,the material basis of its intestinal bioactivities was still unclear.Our study investigated the gastrointestinal distribution of CGA using ultra high performance liquid chromatography-tandem mass spectrum(UPLC-MS/MS)and explored the main drivers leading to different metabolic fates of the metabolites.After oral administration of 50 mg/kg bw CGA to mice,CGA and sulfated metabolites were mainly determined in small intestine.Protocatechuic acid,catechol,and 3-hydroxyphenylpropionic acid were found in copious amounts in large intestine and feces.Besides,caffeic acid existed in the entire intestine and feces.In the in vitro mice/human fecal fermentation of CGA,the production of metabolites was consistent with that in the colon,indicating that microorganisms might lead to the difference in the gastrointestinal distribution of CGA metabolites.Moreover,CGA,3-hydroxyphenylpropionic acid,protocatechuic acid,catechol,and caffeic acid reduced proinflammatory cytokines(interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α))and increased mucin(Muc2)and tight junction(occludin)mRNA in LPS-induced Caco-2/HT-29 MTX co-culture cells.In conclusion,the biotransformation of CGA in different gastrointestinal tracts varied significantly,and its metabolites could partially support its intestinal bioactivities.展开更多
Inspired by brick-and-mortar architectures and suture interfaces,we propose a design of bioinspired nacre-like materials with interlocking sutures to improve the toughness of brittle materials.Laser-engraved glass int...Inspired by brick-and-mortar architectures and suture interfaces,we propose a design of bioinspired nacre-like materials with interlocking sutures to improve the toughness of brittle materials.Laser-engraved glass interlockers are laminated with soft interlayers in a staggered arrangement,and the fundamental mechanical properties of the structure are investigated through experiments and numerical modeling.It is found that the tensile performance,such as the strength and toughness,is strongly affected by the interlocking angle and suture line spacing.The geometric interlocking originated from suture interfaces as well as tablet sliding arising from the staggered arrangement of interlockers cooperatively contribute to enhancing the strength and toughness of this bioinspired design.Additionally,the finite element modeling shows the interfacial failure and plastic deformation,revealing the interplay of the geometric interlocking mechanism and the sliding mechanism.This novel bioinspired design paves a new path for fabrication of structural materials combining high stiffness,high strength,and enhanced toughness.展开更多
BACKGROUND Older patients often experience thirst after general anesthesia for gastrointestinal surgery,particularly during the post-anesthesia care unit(PACU)phase.Thirst not only compromises patient comfort but also...BACKGROUND Older patients often experience thirst after general anesthesia for gastrointestinal surgery,particularly during the post-anesthesia care unit(PACU)phase.Thirst not only compromises patient comfort but also induces anxiety,which may hinder recovery.Although previous studies have addressed postoperative thirst,research specifically examining thirst experiences and nursing needs in older patients remains limited.AIM To explore thirst experiences and nursing needs of older PACU patients following gastrointestinal surgery,aiming to inform targeted interventions.METHODS This study employed a phenomenological approach within a qualitative research framework.A purposeful sampling method was used to select 12 older patients who underwent gastrointestinal surgery under general anesthesia at a tertiary hospital in Shanghai between November and December 2024.Data were collected through semi-structured interviews and analyzed using Colaizzi’s seven-step method.Themes were extracted from the interview data.RESULTS Analysis of the interview data identified four main themes and eight subthemes:(1)Intense sensations of thirst post-surgery(subjective experience of thirst and duration of thirst);(2)Emotional experiences of thirst-related discomfort(anxiety,irritability,and helplessness);(3)Practical challenges in relieving thirst(limitations of current interventions and nursing response time);and(4)Patient expectations of nursing care(desire for more timely interventions and expectation for more proactive attention from nursing staff).CONCLUSION Older patients frequently experience substantial thirst discomfort after gastrointestinal surgery under general anesthesia.A multidisciplinary perioperative intervention plan is essential to alleviate these symptoms and enhance postoperative comfort.展开更多
Heat processing of food has been well validated as the trigger to generate heat-processing side product of advanced lipoxidation end products(ALEs),which potentially engenders the threat on systemic health or progress...Heat processing of food has been well validated as the trigger to generate heat-processing side product of advanced lipoxidation end products(ALEs),which potentially engenders the threat on systemic health or progression of diseases,especially the accumulated effect after long-term intake.Thus,the study was proposed to evaluate the effect of dietary ALEs on health after long-term ingestion,specifically through simulating the intake of dietary ALE in mice within 9 months to investigate the intervention effect and underlying mechanism.The unexpected observation of renal insufficiency or impairment after long-term intake of dietary ALEs indicated the negative impact on renal health,which has been verified by the pathological analysis.Further studies revealed that a high-ALEs diet disrupted the intestinal barrier,with enhanced impact after disturbing the gut microbiota to potentially lower the abundance of beneficial microbiome through producing nephrotoxic metabolites.Correlation analysis showed that the proliferation of harmful bacteria and the reduction of beneficial bacteria were strongly correlated with intestinal barrier damage and the development of renal insufficiency.Furthermore,the underlying mechanism was unveiled as that ALEs could inhibit AMPK/SIRT1 signaling to fundamentally induce renal inflammation and oxidative stress.Thus,it was revealed that long-term intake of dietary ALE could result in renal impairment,and the results emphasized the control or intervention on dietary ALE to decrease to accumulated impairment on systemic health.展开更多
The conversion of biomass into lactic acid is essential for meeting industrial demand sustainably,alleviating resource shortages and environmental issues with benefits such as controllable conditions,lower costs,and r...The conversion of biomass into lactic acid is essential for meeting industrial demand sustainably,alleviating resource shortages and environmental issues with benefits such as controllable conditions,lower costs,and recyclable catalysts over traditional methods.The one-pot conversion of biomass(e.g.,microalgae,lignocellulose)and platform compounds(e.g.,glucose,fructose,erythritol,glycerol)to lactic acid involves multiple reaction steps to generate precursors such as dihydroxyacetone and pyruvaldehyde.Mismatched reaction rates often cause significant side reactions,resulting in low lactic acid selectivity and massive byproducts such as formic acid,acetic acid,and acetolactate.Achieving high selectivity to lactic acid requires precise catalytic control to synchronize reaction rates,promoting the targeted formation of lactic acid.In this review,we describe the reaction pathways for lactic acid production from biomass and its platform compounds,summarizing the advancements in the selective synthesis of lactic acid using alkali/alkaline earth catalysts and Lewis acid catalysts which involve post-transition metal(Al,Ga,Sn,Pb,etc.),transition metal(Zr,Nb,Mo,etc.)and lanthanide catalysts,as well as redox catalysts(such as perovskite-type and photocatalytic catalysts).The methods for regulating the selectivity to biomass-derived lactic acid are also summarized.By reviewing the progress and challenges in catalyst development for biomass-based lactic acid,we provide an outlook on catalyst design and characterization,reaction mechanism studies,and practical applications.展开更多
Herein,a novel label-free electrochemical immunosensor was fabricated via immobilizing specific anti-β-lactoglobulin(β-LG)antibodies(Abs)onto an integrated electrode of gold nanoparticles(AuNPs)/Prussian blue(PB)/cu...Herein,a novel label-free electrochemical immunosensor was fabricated via immobilizing specific anti-β-lactoglobulin(β-LG)antibodies(Abs)onto an integrated electrode of gold nanoparticles(AuNPs)/Prussian blue(PB)/cubic Ia3d structured mesoporous carbon(CMK-8).This immunosensor allowed for the quantitative detection of the major milk allergenβ-LG.CMK-8 with excellent electrical conductivity and uniformly adjustable pore structure was modified on the glassy carbon electrode(GCE)and served as the sensitive substrate for the electro-polymerization of PB,forming the redox-active layer.AuNPs were subsequently electrochemically deposited on PB/CMK-8/GCE to improve the electrical conductivity and utilized as the connector for Abs immobilization.Duringβ-LG detection,the Abs-modified AuNPs/PB/CMK-8/GCE exhibited a significant reduction in differential pulse voltammetry current signal when exposed toβ-LG,displaying an inverse dose-dependent relationship.The developed electrochemical immunosensor demonstrated good detection performance forβ-LG,with a wider linear range of 0.01-100 ng/mL and a lower detection limit of 4.72 pg/mL.Meanwhile,the sensor exhibited remarkable repeatability,reproducibility,stability and anti-interference capabilities,which was further applied to detectβ-LG in dairy food,achieving satisfactory recoveries(89.2%-98.8%)and lower relative standard deviation(£3.1%).Therefore,this innovative electrochemical method for food allergen detection holds great potential application in food safety determination and evaluation.展开更多
Community-acquired pneumonia(CAP)in adults(≥18 years old)is the most common infectious disease encountered in emergency departments.Its clinical complexity and the need for prompt treatment decisions pose significant...Community-acquired pneumonia(CAP)in adults(≥18 years old)is the most common infectious disease encountered in emergency departments.Its clinical complexity and the need for prompt treatment decisions pose significant challenges for patient management.The physician-pharmacist collaborative management(PPCM)model,which optimizes drug therapy regimens through collaboration between physicians and clinical pharmacists,has demonstrated strong clinical value in practice.However,the lack of standardized national guidelines for the application of the PPCM model in emergency departments in China has hampered its widespread adoption.This guideline is developed based on evidence-based medicine and clinical practice experience,with a focus on the application of the PPCM model in the management of CAP in emergency settings.It outlines the significance of the PPCM model,its applicable scenarios,the respective roles of emergency physicians and clinical pharmacists,and its practical implementation in the antimicrobial treatment of CAP patients.In addition,the guideline proposes standardized implementation processes and clinical pathways.By promoting the PPCM model,the expert panel aims to standardize the use of antimicrobial agents in the emergency treatment of CAP,reduce the risk of antimicrobial resistance,and improve patient outcomes.展开更多
In this work,through performing microstructural characterization,tensile testing and failure analysis,the influence of electrochemical hydrogen charging on the microstructure and mechanical behavior of an as-cast Mg-8...In this work,through performing microstructural characterization,tensile testing and failure analysis,the influence of electrochemical hydrogen charging on the microstructure and mechanical behavior of an as-cast Mg-8wt.%Li alloy was investigated.It revealed that after being hydrogen charged at 50 mA/cm2 for respectively 3 h,6 h and 18 h in 0.1 M NaCl solution,obvious HID occurred and the damage degree was gradually increased with the hydrogen charging time.For the sample being hydrogen charged for 3 h,micro pores with the diameter ranging from 10~30µm were formed and preferentially present inα-Mg phase.Moreover,micro cracks with the length ranging from 10~50µm mainly initiated inα-Mg phase,atα-Mg/β-Li interfaces and the peripheries of pores.With the increase of hydrogen charging time,the numbers of pores and cracks were obviously increased.Tensile results revealed that the hydrogen charging can simultaneously decrease the tensile strength and ductility of the alloy.Compared with the uncharged sample,the tensile yield strength,ultimate tensile strength and the elongation ratio to failure were respectively reduced by 5.7%,7.3%,31.7%for the 3h-charged sample and 24.6%,24.8%,67.0%for the 18h-charged sample.Failure analysis indicated that hydrogen charging can induce the brittle cracking of the alloy and the size of brittle cracking region being composed of quasi-cleavage facets and interfacial cracks on the fracture surfaces was increased with the hydrogen charging time.展开更多
基金supported by the National Natural Science Foundation of China(Nos.U2167202,12225504,12005276)the Natural Science Foundation of Shandong Province(No.ZR2024QA172)the Fundamental Research Funds of Shandong University.
文摘A 32-channel charge-sensitive amplifier(CSA)is designed for fast timing in the delay-line readout of a parallel plate avalanche counter(PPAC)array.It is realized on a PCB with operational amplifiers and other discrete components.Each channel consists of an integrator,a pole-zero cancellation net,and a linear amplification stage,which can be adapted to accommodate either positive or negative input signals.The RMS equivalent input noise charges are 3.3 fC,the conversion gains are approximately±2 mV∕fC,and the intrinsic time resolution reaches 32 ps.In the prototype PPAC application,the CSA performs as well as the commercial FTA820A amplifier,providing a position resolution as good as 0.17 mm,and exhibiting reliable stability during several hours of continuous data acquisition.
基金funded by the National Key Research and Development Program of China(Grant No.2022YFB4700904 to Wang L)the Shanghai Shenkang Hospital Development Center's project for the Promotion of Clinical Skills and Clinical Innovation Three-Year Action Plan(Project No.SHDC2022CRT006 to Wang L and SHDC2022CRS010B to Tang S).
文摘Objective:This study aimed to assess the feasibility and safety of the SHURUI single-port robotic surgical system for a range of major urological surgeries.Methods:In this prospective,multicenter clinical trial,we examined the effectiveness of the SHURUI single-port robotic surgical system in urological interventions.The first 50 patients from four centers in China underwent single-port surgeries including partial nephrectomy,radical prostatectomy,partial adrenalectomy,and pyeloureteroplasty,exclusively by the SHURUI single-port robotic surgical system.The study's primary endpoints focused on the success of surgeries,defined as no deviations from planned procedures,no need for more than one port,and no re-operations within 24 h after surgery.Secondary endpoints encompassed a range of surgical metrics,functional outcomes,and patient demographic data.Clinical assessments were conducted before surgery,before discharge,and 1 month after discharge.Results:The surgical procedures were executed successfully without requiring intraoperative conversions or transfusions.Both estimated blood loss and operation durations were maintained within satisfactory limits.For each type of surgery,the mean console times and estimated blood loss were 179.8(standard deviation[SD]39.4)min and 125.6(SD 126.0)mL for radical prostatectomy,126.7(SD 47.8)min and 39.2(SD 54.4)mL for partial nephrectomy,112.6(SD 37.4)min and 20.0(SD 13.2)mL for partial adrenalectomy,and 148.0(SD 18.2)min and 18.0(SD 17.9)mL for pyeloureteroplasty,respectively.Across the cohort,17 patients experienced a total of 25 adverse events,while 10 postoperative complications,all rated as Clavien-Dindo grade I,were encountered by eight patients.All patients had shown recovery or improvement from these events before the end of this trial.Conclusion:The SHURUI single-port robotic surgical system demonstrated feasibility and safety in the performance of major urological surgeries.These initial findings highlight the system's potential,though further research and longer follow-up are required to assess long-term outcomes.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB34020200)National Key Research and Development Program(MOST 2022YFA1602304)+1 种基金Scientific Research Instrument and Equipment Development Program of the Chinese Academy of Sciences(No.GJJSTD20210007)National Natural Science Foundation of China(Nos.12175156,U1632142).
文摘Highly oriented pyrolytic graphite (HOPG) is frequently adopted as the reaction target in12C+12C fusion reaction experiments owing to its superior purity.In this study,we investigate the reaction yield dependence on the accumulated beam dose on HOPG target using a novel detection system consisting of a time-projection chamber and silicon array.The reaction yields are significantly reduced under intense beam bombardment owing to radiation damage to the HOPG surface.The α_(0) and p_(0,1) yields decrease by 51.5% and 25%,respectively,when the ^(12)C^(2+) beam dose accumulates at 5 C.Using the novel detection system and HOPG target,the α0yield is determined to be 2.68_(-1.69)^(+4.69)×10^(-17/12) C after correcting for the yield loss due to radiation damage.Our result represents the highest sensitivity achieved to date in direct measurements of ^(12)C(12C,α_(0))^(20)Ne.
基金the National Key Research and Development Program of China(2022YFB4004100)National Natural Science Foundation of China(22272161,22179126)+1 种基金the Jilin Province Science and Technology Development Program(YDZJ202202CXJD011,20240101019JC)Jilin Province major science and technology project(222648GX0105103875)for financial supports.
文摘The weak adsorption energy of oxygen-containing intermediates on Co center leads to a considerable performance dis-parity between Co-N-C and costly Pt benchmark in catalyzing oxygen reduction reaction(ORR).In this work,we strategi-cally engineer the active site structure of Co-N-C via B substitution,which is accomplished by the pyrolysis of ammonium borate.During this process,the in-situ generated NH_(3)gas plays a critical role in creating surface defects and boron atoms substituting nitrogen atoms in the carbon structure.The well-designed CoB_(1)N_(3)active site endows Co with higher charge density and stronger adsorption energy toward oxygen species,potentially accelerating ORR kinetics.As expected,the resulting Co-B/N-C catalyst exhibited superior ORR performance over Co-N-C counterpart,with 40 mV,and fivefold en-hancement in half-wave potential and turnover frequency(TOF).More importantly,the excellent ORR performance could be translated into membrane electrode assembly(MEA)in a fuel cell test,delivering an impressive peak power density of 824 mW·cm^(-2),which is currently the best among Co-based catalysts under the same conditions.This work not only demon-strates an effective method for designing advanced catalysts,but also affords a highly promising non-precious metal ORR electrocatalyst for fuel cell applications.
基金supported by the National Natural Science Fund of China(Grant NO.61771065,Grant NO.61571054 and Grant NO.61631005)Beijing Nova Program(NO.Z151100000315077)
文摘In the upcoming 5 G heterogeneous networks, leveraging multiple radio access technologies(RATs) shows to be a crucial issue in achieving RAT multiplexing gain to meet the explosive traffic demand. For always best connection(ABC), users tend to activate parallel transmission across all available RATs. However from a system-wide perspective, this might not be optimal given the context of network load, interference and diverse service requirements. To intelligently determine how to use these multi-RAT access resources concurrently, this paper proposes a joint multi-RAT user association and resource allocation strategy with triple decision and integrated context awareness of users and networks. A dynamic game based ant colony algorithm(GACA) is designed to simultaneously maximize the system utility and the fairness of resource allocation. Simulation results show that it's more reasonable to make multi-RAT association decision from a system-wide viewpoint than from an individual one. Compared to max-SNR based and ABC based strategies, the proposed method alleviates network congestion and optimizes resource allocation. It obtains 39%~70% performance improvement.
文摘A dissertation is a research report or scientific paper written by an author to obtain a certain degree. It reflects postgraduates’ research achievements and the educational quality of an institute, even a country. To construct an optimized quality evaluation system for postgraduate dissertation (QESPD), we summarized the influencing factors and invited 10 experienced specialists to rate and prioritize them based on fuzzy analytic hierarchy process. Four primary indicators (innovation, integrity, scientificity and normativity) and 16 sub-indicators were selected to form the evaluation system. The order of primary indicators by weight, was innovation (0.4269), scientificity (0.2807), integrity (0.1728) and normativity (0.1196). The top five sub-dimensions were theoretical originality, scientific value, data reliability, design rationality and evidence credibility. To demonstrate the effectiveness of the proposed system, a case study was performed. In the case study, it was demonstrated that the established two-index-hierarchy QESPD in this study was a more scientific and reasonable evaluation system worthy of promotion and application.
文摘Hereditary multiple exostoses(HME)is an autosomal dominant bone disorder characterized by abnormal bone development.HME mostly involves the forearm,resulting in forearm deformities,limited functional activities,etc.Currently,there are multiple surgical methods including tumor resection with or without ulnar osteotomy and lengthening,simple radial head resection and distal radial hemiepiphysiodesis,but the optimal treatment remains controversial.Ulnar lengthening serves as an effective surgical intervention for forearm deformities in HME patients.This review examines its surgical techniques,complications,and timing of the operation to guide clinical decision-making for improving function and cosmetic outcomes.
基金supported by the Human Frontier Science Program (LT000728/2018)Zijiang Program for Talented Scholars at East China Normal UniversityShanghai Pujiang Program (23PJ1402300)
文摘Recent advances have deepened our understanding of the evolutionary and developmental origins of feather branching architectures.However,the internal tissue differentiation within these branches has received limited attention.This study examined eight fossilized feathers preserved in early Late Cretaceous Burmese amber,characterized by barb rami composed entirely of cortical tissue with no internal medulla.Based on barb rami morphology,the feathers were categorized into three distinct morphotypes.Comparative analysis with feather development in extant chickens suggested minimal tissue differentiation in these early feathers.Functional simulations further revealed that modern barb rami configurations provide greater aerodynamic stability than medulla-free early feathers under most conditions,highlighting flexural stiffness as a key factor in the evolution of feather branches.The presence of medullafree barb rami suggests that although the three-level hierarchical branching pattern characteristic of modern feathers had emerged by the Jurassic,tissue differentiation within feather branches remained developmentally unstable during the Late Cretaceous.This instability likely contributed to the structural variability of early feathers,enabling morphologies that no longer persist in modern birds.
基金ported by the Beijing Municipal Science&Technology Commission(Z231100006123010)Guizhou Provincial Major Scientific and Technological Program(XKBF(2025)031)a grant from Tianjin Key Laboratory of Refrigeration Technology(2025TKLRT002).
文摘This experimental investigation was conducted on the flow boiling performance of refrigerant R134a in two types of parallel microchannels:sintered porous microchannels(PP-MCs)and smooth parallel microchannels(SP-MCs).The tests were performed under controlled conditions including an inlet subcooling of 5±0.2℃,saturation temperature of 33℃,mass fluxes of 346 and 485 kg/m2·s,and a range of heat fluxes.Key findings reveal that the sintered porous microstructure significantly enhances bubble nucleation,reducing the wall superheat required for the onset of nucleate boiling(ONB)to only 0.13℃ compared to 2.2℃ in smooth channels.The porous structure also improves heat transfer coefficients at low and medium heat fluxes(<20–30 W/cm^(2))and low vapor quality(x<0.2–0.4)due to augmented thin-film evaporation and intensified nucleate boiling.However,smooth microchannels exhibit superior performance under high heat flux and high vapor quality conditions,as the porous structure is prone to early dry-out and flow blockage.Notably,the porous microchannels demonstrate lower flow resistance and enhanced stability,with pressure drop fluctuations reduced by up to 46.4%in amplitude and 44.8%in standard deviation,attributed to improved capillary-assisted liquid replenishment and suppressed flow oscillations.The results underscore the potential of PP-MCs as a high-performance cooling solution for high-heat-flux applications.
基金supported by the National Natural Science Foundation of China(42222201,42288201)。
文摘Angiosperms experienced one of the most remarkable radiations of land plants and are now the dominant autotrophs in terrestrial ecosystems.Recent phylogenomic studies based on large-scale data from plastid,mitochondrial,or nuclear transcriptomes/genomes and increased taxon sampling have provided unprecedent resolution into the phylogeny of flowering plants.However,owing to ancient rapid radiations,the interrelationships among the five lineages of Mesangiospermae,the vast majority of angiosperms,remain contentious.Here we show that,although plastid and mitochondrial genomes lack sufficient phylogenetic signal for resolving deeper phylogeny,the relationships among five mesangiosperm lineages can be confidently resolved under better-fitting models using genome-scale data.According to our Bayesian cross-validation and model test in a maximum likelihood framework,siteheterogeneous models(e.g.,CAT-GTR+G4,LG+C20+F+G)outperform site-homogeneous or partition models often used in previous studies.Under site-heterogeneous models,the approximately unbiased test favored our preferred tree recovered from various datasets:Ceratophyllales(coontails)are robustly recovered as sister to monocots,and they together are sister to the clade comprising magnoliids,Chloranthales,and eudicots.Our phylogenomic analyses resolve the last enigma of the deeper phylogeny of angiosperms and emphasize the efficacy of modeling compositional heterogeneity in resolving rapid radiations of plants.
基金funded by National Natural Science Foundation of China(32101962)the Science and Technology Program of Tianjin,China(Grant number 22JCQNJC01200)+1 种基金the Natural Science Foundation of Zhejiang Province,China(LY21B060007)the Horizontal Project(KYY-HX-20210848).
文摘Chlorogenic acid(CGA),as a polyphenol abundant in daily diet,exerted various intestinal functions.However,the material basis of its intestinal bioactivities was still unclear.Our study investigated the gastrointestinal distribution of CGA using ultra high performance liquid chromatography-tandem mass spectrum(UPLC-MS/MS)and explored the main drivers leading to different metabolic fates of the metabolites.After oral administration of 50 mg/kg bw CGA to mice,CGA and sulfated metabolites were mainly determined in small intestine.Protocatechuic acid,catechol,and 3-hydroxyphenylpropionic acid were found in copious amounts in large intestine and feces.Besides,caffeic acid existed in the entire intestine and feces.In the in vitro mice/human fecal fermentation of CGA,the production of metabolites was consistent with that in the colon,indicating that microorganisms might lead to the difference in the gastrointestinal distribution of CGA metabolites.Moreover,CGA,3-hydroxyphenylpropionic acid,protocatechuic acid,catechol,and caffeic acid reduced proinflammatory cytokines(interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α))and increased mucin(Muc2)and tight junction(occludin)mRNA in LPS-induced Caco-2/HT-29 MTX co-culture cells.In conclusion,the biotransformation of CGA in different gastrointestinal tracts varied significantly,and its metabolites could partially support its intestinal bioactivities.
基金Project supported by the National Natural Science Foundation of China(Nos.12202257,12072184,12002197)。
文摘Inspired by brick-and-mortar architectures and suture interfaces,we propose a design of bioinspired nacre-like materials with interlocking sutures to improve the toughness of brittle materials.Laser-engraved glass interlockers are laminated with soft interlayers in a staggered arrangement,and the fundamental mechanical properties of the structure are investigated through experiments and numerical modeling.It is found that the tensile performance,such as the strength and toughness,is strongly affected by the interlocking angle and suture line spacing.The geometric interlocking originated from suture interfaces as well as tablet sliding arising from the staggered arrangement of interlockers cooperatively contribute to enhancing the strength and toughness of this bioinspired design.Additionally,the finite element modeling shows the interfacial failure and plastic deformation,revealing the interplay of the geometric interlocking mechanism and the sliding mechanism.This novel bioinspired design paves a new path for fabrication of structural materials combining high stiffness,high strength,and enhanced toughness.
文摘BACKGROUND Older patients often experience thirst after general anesthesia for gastrointestinal surgery,particularly during the post-anesthesia care unit(PACU)phase.Thirst not only compromises patient comfort but also induces anxiety,which may hinder recovery.Although previous studies have addressed postoperative thirst,research specifically examining thirst experiences and nursing needs in older patients remains limited.AIM To explore thirst experiences and nursing needs of older PACU patients following gastrointestinal surgery,aiming to inform targeted interventions.METHODS This study employed a phenomenological approach within a qualitative research framework.A purposeful sampling method was used to select 12 older patients who underwent gastrointestinal surgery under general anesthesia at a tertiary hospital in Shanghai between November and December 2024.Data were collected through semi-structured interviews and analyzed using Colaizzi’s seven-step method.Themes were extracted from the interview data.RESULTS Analysis of the interview data identified four main themes and eight subthemes:(1)Intense sensations of thirst post-surgery(subjective experience of thirst and duration of thirst);(2)Emotional experiences of thirst-related discomfort(anxiety,irritability,and helplessness);(3)Practical challenges in relieving thirst(limitations of current interventions and nursing response time);and(4)Patient expectations of nursing care(desire for more timely interventions and expectation for more proactive attention from nursing staff).CONCLUSION Older patients frequently experience substantial thirst discomfort after gastrointestinal surgery under general anesthesia.A multidisciplinary perioperative intervention plan is essential to alleviate these symptoms and enhance postoperative comfort.
基金supported by grants from the National Natural Science Foundation of China(32030083)。
文摘Heat processing of food has been well validated as the trigger to generate heat-processing side product of advanced lipoxidation end products(ALEs),which potentially engenders the threat on systemic health or progression of diseases,especially the accumulated effect after long-term intake.Thus,the study was proposed to evaluate the effect of dietary ALEs on health after long-term ingestion,specifically through simulating the intake of dietary ALE in mice within 9 months to investigate the intervention effect and underlying mechanism.The unexpected observation of renal insufficiency or impairment after long-term intake of dietary ALEs indicated the negative impact on renal health,which has been verified by the pathological analysis.Further studies revealed that a high-ALEs diet disrupted the intestinal barrier,with enhanced impact after disturbing the gut microbiota to potentially lower the abundance of beneficial microbiome through producing nephrotoxic metabolites.Correlation analysis showed that the proliferation of harmful bacteria and the reduction of beneficial bacteria were strongly correlated with intestinal barrier damage and the development of renal insufficiency.Furthermore,the underlying mechanism was unveiled as that ALEs could inhibit AMPK/SIRT1 signaling to fundamentally induce renal inflammation and oxidative stress.Thus,it was revealed that long-term intake of dietary ALE could result in renal impairment,and the results emphasized the control or intervention on dietary ALE to decrease to accumulated impairment on systemic health.
基金supported by the National Key Research and Development Program of China(2022YFB1105100)the National Natural Science Foundation of China(U2330105)the funding from Science Foundation of China University of Petroleum,Beijing(24620188JC005).
文摘The conversion of biomass into lactic acid is essential for meeting industrial demand sustainably,alleviating resource shortages and environmental issues with benefits such as controllable conditions,lower costs,and recyclable catalysts over traditional methods.The one-pot conversion of biomass(e.g.,microalgae,lignocellulose)and platform compounds(e.g.,glucose,fructose,erythritol,glycerol)to lactic acid involves multiple reaction steps to generate precursors such as dihydroxyacetone and pyruvaldehyde.Mismatched reaction rates often cause significant side reactions,resulting in low lactic acid selectivity and massive byproducts such as formic acid,acetic acid,and acetolactate.Achieving high selectivity to lactic acid requires precise catalytic control to synchronize reaction rates,promoting the targeted formation of lactic acid.In this review,we describe the reaction pathways for lactic acid production from biomass and its platform compounds,summarizing the advancements in the selective synthesis of lactic acid using alkali/alkaline earth catalysts and Lewis acid catalysts which involve post-transition metal(Al,Ga,Sn,Pb,etc.),transition metal(Zr,Nb,Mo,etc.)and lanthanide catalysts,as well as redox catalysts(such as perovskite-type and photocatalytic catalysts).The methods for regulating the selectivity to biomass-derived lactic acid are also summarized.By reviewing the progress and challenges in catalyst development for biomass-based lactic acid,we provide an outlook on catalyst design and characterization,reaction mechanism studies,and practical applications.
基金supported by the National Natural Science Foundation of China(32272416,31972147)Project of Tianjin Science and Technology Plan(22ZYJDSS00030).
文摘Herein,a novel label-free electrochemical immunosensor was fabricated via immobilizing specific anti-β-lactoglobulin(β-LG)antibodies(Abs)onto an integrated electrode of gold nanoparticles(AuNPs)/Prussian blue(PB)/cubic Ia3d structured mesoporous carbon(CMK-8).This immunosensor allowed for the quantitative detection of the major milk allergenβ-LG.CMK-8 with excellent electrical conductivity and uniformly adjustable pore structure was modified on the glassy carbon electrode(GCE)and served as the sensitive substrate for the electro-polymerization of PB,forming the redox-active layer.AuNPs were subsequently electrochemically deposited on PB/CMK-8/GCE to improve the electrical conductivity and utilized as the connector for Abs immobilization.Duringβ-LG detection,the Abs-modified AuNPs/PB/CMK-8/GCE exhibited a significant reduction in differential pulse voltammetry current signal when exposed toβ-LG,displaying an inverse dose-dependent relationship.The developed electrochemical immunosensor demonstrated good detection performance forβ-LG,with a wider linear range of 0.01-100 ng/mL and a lower detection limit of 4.72 pg/mL.Meanwhile,the sensor exhibited remarkable repeatability,reproducibility,stability and anti-interference capabilities,which was further applied to detectβ-LG in dairy food,achieving satisfactory recoveries(89.2%-98.8%)and lower relative standard deviation(£3.1%).Therefore,this innovative electrochemical method for food allergen detection holds great potential application in food safety determination and evaluation.
基金supported by Sanming Project of Medicine in Shenzhen(No.SZZYSM202411012)Beijing Clinical Key Specialty Project(2023).
文摘Community-acquired pneumonia(CAP)in adults(≥18 years old)is the most common infectious disease encountered in emergency departments.Its clinical complexity and the need for prompt treatment decisions pose significant challenges for patient management.The physician-pharmacist collaborative management(PPCM)model,which optimizes drug therapy regimens through collaboration between physicians and clinical pharmacists,has demonstrated strong clinical value in practice.However,the lack of standardized national guidelines for the application of the PPCM model in emergency departments in China has hampered its widespread adoption.This guideline is developed based on evidence-based medicine and clinical practice experience,with a focus on the application of the PPCM model in the management of CAP in emergency settings.It outlines the significance of the PPCM model,its applicable scenarios,the respective roles of emergency physicians and clinical pharmacists,and its practical implementation in the antimicrobial treatment of CAP patients.In addition,the guideline proposes standardized implementation processes and clinical pathways.By promoting the PPCM model,the expert panel aims to standardize the use of antimicrobial agents in the emergency treatment of CAP,reduce the risk of antimicrobial resistance,and improve patient outcomes.
基金supported by the National Natural Science Foundation of China Projects under grant[nos.U21A2049,52071220,51871211,51701129 and 51971054]Liaoning Province's project of“Revitalizing Liaoning Talents”(XLYC1907062)+6 种基金the Doctor Startup Fund of Natural Science Foundation Program of Liaoning Province(no.2019-BS-200)the Strategic New Industry Development Special Foundation of Shenzhen(JCYJ20170306141749970)the funds of International Joint Laboratory for Light Alloys,Liaoning BaiQianWan Talents Program,the Domain Foundation of Equipment Advance Research of 13th Five-year Plan(61409220118)National Key Research and Development Program of China under grant[nos.2017YFB0702001 and 2016YFB0301105]the Innovation Fund of Institute of Metal Research(IMR),Chinese Academy of Sciences(CAS),the National Basic Research Program of China(973 Program)project under grant no.2013CB632205the Fundamental Research Fund for the Central Universities under grant[no.N2009006]Bintech-IMR R&D Program[no.GYY-JSBU-2022-009].
文摘In this work,through performing microstructural characterization,tensile testing and failure analysis,the influence of electrochemical hydrogen charging on the microstructure and mechanical behavior of an as-cast Mg-8wt.%Li alloy was investigated.It revealed that after being hydrogen charged at 50 mA/cm2 for respectively 3 h,6 h and 18 h in 0.1 M NaCl solution,obvious HID occurred and the damage degree was gradually increased with the hydrogen charging time.For the sample being hydrogen charged for 3 h,micro pores with the diameter ranging from 10~30µm were formed and preferentially present inα-Mg phase.Moreover,micro cracks with the length ranging from 10~50µm mainly initiated inα-Mg phase,atα-Mg/β-Li interfaces and the peripheries of pores.With the increase of hydrogen charging time,the numbers of pores and cracks were obviously increased.Tensile results revealed that the hydrogen charging can simultaneously decrease the tensile strength and ductility of the alloy.Compared with the uncharged sample,the tensile yield strength,ultimate tensile strength and the elongation ratio to failure were respectively reduced by 5.7%,7.3%,31.7%for the 3h-charged sample and 24.6%,24.8%,67.0%for the 18h-charged sample.Failure analysis indicated that hydrogen charging can induce the brittle cracking of the alloy and the size of brittle cracking region being composed of quasi-cleavage facets and interfacial cracks on the fracture surfaces was increased with the hydrogen charging time.
