BACKGROUND Functional gastrointestinal disorders(FGIDs)are common gastrointestinal conditions that significantly impair patient quality of life.Current clinical treatment methods are relatively limited,making the sear...BACKGROUND Functional gastrointestinal disorders(FGIDs)are common gastrointestinal conditions that significantly impair patient quality of life.Current clinical treatment methods are relatively limited,making the search for more effective therapeutic strategies critically important.Latent myofascial trigger points(MTrPs)injection,as an emerging minimally invasive treatment method,has shown potential in alleviating muscle pain and improving function,but its application in FGIDs remains insufficiently validated.AIM To assess improvements in gastrointestinal symptom severity,quality of life indices,and treatment-related adverse events between the two therapeutic approaches.METHODS This single-blind randomized controlled study recruited 60 FGIDs patients from Qilu Hospital of Shandong University,randomly divided into an injection group(TI group)and an oral medication group(PO group)at a 1:1 ratio.The TI group received abdominal wall latent MTrPs injection therapy,while the PO group received oral symptomatic medication treatment.Primary outcome measures were gastrointestinal symptom severity scores(Gastrointestinal Symptom Rating Scale,Irritable Bowel Syndrome Severity Scoring System scales)at 2 weeks and 4 weeks after treatment completion.Secondary outcome measures included Gastrointestinal Quality of Life Index scores.Both groups underwent rigorous follow-up and assessment.RESULTS The TI group is anticipated to significantly outperform the PO group in gastrointestinal symptom relief and quality of life improvement.TI group patients are expected to show a notable decrease in symptom scores,increased quality of life index,and higher clinical effectiveness rate.Additionally,the TI group is projected to have a low adverse event rate and good safety profile.CONCLUSION Latent MTrPs injection therapy may represent an effective and safe new method for treating FGIDs.Compared to traditional oral medication treatment,this method demonstrates significant advantages in improving patient symptoms and quality of life.展开更多
With the increasing availability of real-time traffic information, dynamic spatial networks are pervasive nowa- days and path planning in dynamic spatial networks becomes an important issue. In this light, we propose ...With the increasing availability of real-time traffic information, dynamic spatial networks are pervasive nowa- days and path planning in dynamic spatial networks becomes an important issue. In this light, we propose and investigate a novel problem of dynamically monitoring shortest paths in spatial networks （DSPM query）. When a traveler aims to a des- tination, his/her shortest path to the destination may change due to two reasons： 1） the travel costs of some edges have been updated and 2） the traveler deviates from the pre-planned path. Our target is to accelerate the shortest path computing in dynamic spatial networks, and we believe that this study may be useful in many mobile applications, such as route planning and recommendation, car navigation and tracking, and location-based services in general. This problem is challenging due to two reasons： 1） how to maintain and reuse the existing computation results to accelerate the following computations, and 2） how to prune the search space effectively. To overcome these challenges, filter-and-refinement paradigm is adopted. We maintain an expansion tree and define a pair of upper and lower bounds to prune the search space. A series of optimization techniques are developed to accelerate the shortest path computing. The performance of the developed methods is studied in extensive experiments based on real spatial data.展开更多
This special issue on Foundation Models for Information Retrieval and Knowledge Processing highlights the transformative potential of foundation models across a range of applications. The six selected papers explore i...This special issue on Foundation Models for Information Retrieval and Knowledge Processing highlights the transformative potential of foundation models across a range of applications. The six selected papers explore innovative methodologies and practical implementations that enhance the efficiency, accuracy, and scalability of information retrieval systems and knowledge processing frameworks, which are summarized as follow.展开更多
文摘BACKGROUND Functional gastrointestinal disorders(FGIDs)are common gastrointestinal conditions that significantly impair patient quality of life.Current clinical treatment methods are relatively limited,making the search for more effective therapeutic strategies critically important.Latent myofascial trigger points(MTrPs)injection,as an emerging minimally invasive treatment method,has shown potential in alleviating muscle pain and improving function,but its application in FGIDs remains insufficiently validated.AIM To assess improvements in gastrointestinal symptom severity,quality of life indices,and treatment-related adverse events between the two therapeutic approaches.METHODS This single-blind randomized controlled study recruited 60 FGIDs patients from Qilu Hospital of Shandong University,randomly divided into an injection group(TI group)and an oral medication group(PO group)at a 1:1 ratio.The TI group received abdominal wall latent MTrPs injection therapy,while the PO group received oral symptomatic medication treatment.Primary outcome measures were gastrointestinal symptom severity scores(Gastrointestinal Symptom Rating Scale,Irritable Bowel Syndrome Severity Scoring System scales)at 2 weeks and 4 weeks after treatment completion.Secondary outcome measures included Gastrointestinal Quality of Life Index scores.Both groups underwent rigorous follow-up and assessment.RESULTS The TI group is anticipated to significantly outperform the PO group in gastrointestinal symptom relief and quality of life improvement.TI group patients are expected to show a notable decrease in symptom scores,increased quality of life index,and higher clinical effectiveness rate.Additionally,the TI group is projected to have a low adverse event rate and good safety profile.CONCLUSION Latent MTrPs injection therapy may represent an effective and safe new method for treating FGIDs.Compared to traditional oral medication treatment,this method demonstrates significant advantages in improving patient symptoms and quality of life.
基金This work is partially supported by the National Natural Science Foundation of China under Grant Nos. 61402532 and 41371386, the Science Foundation of China University of Petroleum-Beijing under Grant No. 2462013YJRC031, the Excellent Talents of Beijing Program under Grant No. 2013D009051000003, Beijing Nova Program, and the Open Research Fund Program of Shenzhen Key Laboratory of Spatial Smart Sensing and Services （Shenzhen University）.
文摘With the increasing availability of real-time traffic information, dynamic spatial networks are pervasive nowa- days and path planning in dynamic spatial networks becomes an important issue. In this light, we propose and investigate a novel problem of dynamically monitoring shortest paths in spatial networks （DSPM query）. When a traveler aims to a des- tination, his/her shortest path to the destination may change due to two reasons： 1） the travel costs of some edges have been updated and 2） the traveler deviates from the pre-planned path. Our target is to accelerate the shortest path computing in dynamic spatial networks, and we believe that this study may be useful in many mobile applications, such as route planning and recommendation, car navigation and tracking, and location-based services in general. This problem is challenging due to two reasons： 1） how to maintain and reuse the existing computation results to accelerate the following computations, and 2） how to prune the search space effectively. To overcome these challenges, filter-and-refinement paradigm is adopted. We maintain an expansion tree and define a pair of upper and lower bounds to prune the search space. A series of optimization techniques are developed to accelerate the shortest path computing. The performance of the developed methods is studied in extensive experiments based on real spatial data.
文摘This special issue on Foundation Models for Information Retrieval and Knowledge Processing highlights the transformative potential of foundation models across a range of applications. The six selected papers explore innovative methodologies and practical implementations that enhance the efficiency, accuracy, and scalability of information retrieval systems and knowledge processing frameworks, which are summarized as follow.
