To improve the thermal stability of nanocrystalline(NC)metals,their interface structure can be modified by applying amorphous intergranular layers.However,traditional amorphous metallic intergranular layers are rarely...To improve the thermal stability of nanocrystalline(NC)metals,their interface structure can be modified by applying amorphous intergranular layers.However,traditional amorphous metallic intergranular layers are rarely formed in most pure metals or alloys.In this study,we demonstrate that amorphous oxide intergranular layers can greatly improve the thermal stability of NC metals by tailoring the grain boundaries(GBs)of NC metals.Using a Au-ZrO_(2) model system,ultra-fine Au nanoparticles(∼3 nm)with exceptional thermal stability at temperatures up to 600℃ were formed after introducing amorphous ZrO_(2) intergranular layers at the GBs of NC Au.Quantitative thermodynamic model calculations revealed that the exceptional thermal stability of the Au nanoparticles originated fundamentally from the formation of low-energy Au|ZrO_(2) interfaces.The kinetic stabilization was further discussed,showing that the Ostwald ripening of Au nanoparticles was suppressed due to the presence of amorphous ZrO_(2) intergranular.This study sheds light on new strategies for enhancing the thermal stability of NC metals by utilizing amorphous oxide intergranular layers,paving the way for the achievement of ultra-stable NC metals through interface modification.展开更多
Xyloglucan represents the primary hemicellulose component in higher plant cell walls,providing mechanical support.The XTH gene family encodes xyloglucan endotransferase/hydrolase,a crucial enzyme in cell wall remodeli...Xyloglucan represents the primary hemicellulose component in higher plant cell walls,providing mechanical support.The XTH gene family encodes xyloglucan endotransferase/hydrolase,a crucial enzyme in cell wall remodeling.Studies examining XTH family-related genes in apples remain limited.This study investigated the Md XTH30 gene,isolated from apple(Malus×domestica),which demonstrated responsiveness to abscisic acid,Na Cl,and polyethylene glycol(PEG)6000,with cytoplasmic localization confirmed through subcellular mapping.To elucidate the role of Md XTH30 in stress response,transgenic Md XTH30 apple calli were generated and the gene was heterologously expressed in Arabidopsis via Agrobacterium-mediated transformation.The findings revealed that Md XTH30 enhanced resistance to drought,salt stress,and pathogens through regulation of relevant genes in both apple calli and Arabidopsis.These results identify potentially significant candidate genes for improving biotic and abiotic stress resistance at the cell wall level.展开更多
Prunella vulgaris,a traditional Chinese medicine(TCM),exerts a significant hypotensive effect,particularly in managing various forms of hypertension.Nonetheless,the precise antihypertensive constituents and their resp...Prunella vulgaris,a traditional Chinese medicine(TCM),exerts a significant hypotensive effect,particularly in managing various forms of hypertension.Nonetheless,the precise antihypertensive constituents and their respective targets remain elusive.This study endeavored to identify the hypotensive components of P.vulgaris and elucidated its mode of action based on hypotensive targets.Utilizing the Systematic Pharmacology of Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),UniProt,GeneCards,STRING,RCSB,and the Human Genome Annotation and Analysis Database(Metascape),we conducted a screening of active ingredients and hypotensive targets.The Network Analyzer software Cytoscape 3.9.0 facilitated a comprehensive analysis of the active ingredients.Molecular docking was executed employing Sybyl-X 2.0 and Discovery Studio 2019.Predictions and analyses of the pharmacokinetics and toxicity of active ingredients were performed using the ADMETlab 2.0 online platform.Eight active compounds(1–8)and 11 hypotensive targets were identified,with IL1B and PPARG exhibiting a high degree of correlation.Dominant biological processes included negative regulation of apoptotic processes,positive regulation of gene expression,response to xenobiotic stimulus,and response to hypoxia.KEGG analysis unveiled core pharmacological mechanisms,notably fluid shear stress and atherosclerosis,lipid and atherosclerosis,P13K-Akt,MAPK,and relaxin signaling pathways.Compounds 5–8 demonstrated robust interactions with multiple targets through hydrogen bonds,van der Waals forces,and pi-alkyl interactions,which serve as primary stabilizers of docking complexes.Notably,compound 7 exhibited promising ADMET prediction results,suggesting its potential for drug molecule development.Our findings underscored the synergistic effects of P.vulgaris on multiple targets and pathways in hypertension treatment,reflecting the characteristic multi-component and multi-target effects of TCM.展开更多
We present the first detailed photometric analysis of ATO J108.6991+27.8306(hereinafter as J108).The shortperiod close binary J108 was observed by the Nanshan 1 m Wide Field Telescope of the Xinjiang Astronomical Obse...We present the first detailed photometric analysis of ATO J108.6991+27.8306(hereinafter as J108).The shortperiod close binary J108 was observed by the Nanshan 1 m Wide Field Telescope of the Xinjiang Astronomical Observatory.The obtained BVRI-band light curves were used to determine the photometric solution by using the 2003 version of the Wilson-Devinney code.J108 is a typical deep(f>50%),low mass ratio(q<0.25)overcontact binary system with a mass ratio of q=0.1501 and a fill-out factor of f=50.1%,suggesting that it is in the late evolutionary stage of contact binary systems.We found the target to be a W-type W UMa binary and provided evidence for the presence of starspots on both components.From the temperature-luminosity diagram,the main component is the evolved main sequence star with an evolutionary age of about 7.94 Gyr.展开更多
Abuse of amphetamine-based stimulants is a primary public health concern.Recent studies have underscored a troubling escalation in the inappropriate use of prescription amphetamine-based stimulants.However,the neuroph...Abuse of amphetamine-based stimulants is a primary public health concern.Recent studies have underscored a troubling escalation in the inappropriate use of prescription amphetamine-based stimulants.However,the neurophysiological mechanisms underlying the impact of acute methamphetamine exposure(AME)on sleep homeostasis remain to be explored.This study employed non-human primates and electroencephalogram(EEG)sleep staging to evaluate the influence of AME on neural oscillations.The primary focus was on alterations in spindles,delta oscillations,and slow oscillations(SOs)and their interactions as conduits through which AME influences sleep stability.AME predominantly diminishes sleep-spindle waves in the non-rapid eye movement 2(NREM2)stage,and impacts SOs and delta waves differentially.Furthermore,the competitive relationships between SO/delta waves nesting with sleep spindles were selectively strengthened by methamphetamine.Complexity analysis also revealed that the SO-nested spindles had lost their ability to maintain sleep depth and stability.In summary,this finding could be one of the intrinsic electrophysiological mechanisms by which AME disrupted sleep homeostasis.展开更多
The impact of rolling temperature and the crystallographic orientation ofα-colonies on the globularization behavior of lamellarα+βmicrostructure in Ti-6Al-4V alloy was investigated.Firstly,the lamellar structure wa...The impact of rolling temperature and the crystallographic orientation ofα-colonies on the globularization behavior of lamellarα+βmicrostructure in Ti-6Al-4V alloy was investigated.Firstly,the lamellar structure was heavily rolled at 600,700,800 and 900°C,respectively.Heavy rolling from temperatures of 600 to 900°C resulted in an increased volume fraction and thickness ofβlamellae,while the corresponding parameters forαlamellae decreased.Then,these rolledα+βlamellar microstructures were spheroidized into equiaxed grains upon subsequent annealing.The results demonstrate that the globularization fraction of the lamellar structures diminishes as the rolling temperature increases.Additionally,the globularization fraction forα-colonies with hard crystallographic orientations,such as<0001>//ND and<0001>//TD,is considerably lower compared to those with softer orientations,positioned at certain angles to ND,RD,and TD during annealing process.This results in heterogeneous globularization ofαlamellae,leading to the development of pronounced sharp micro-texture.Furthermore,the slipping deformations ofα-colonies with varying crystallographic orientations during rolling were meticulously analyzed.展开更多
An ultra-strong steel with enhanced ductility and ultrafine lamellar structure was produced by heavy warm rolling(HWR)of metastable austenite and subsequent quenching.The HWR steel exhibited an ultrahigh yield strengt...An ultra-strong steel with enhanced ductility and ultrafine lamellar structure was produced by heavy warm rolling(HWR)of metastable austenite and subsequent quenching.The HWR steel exhibited an ultrahigh yield strength of 1.09 GPa and an ultimate tensile strength of 2.6 GPa,with a total elongation of 6.7%at room temperature.The high yield strength was primarily attributed to the synergistic strengthening of high-density dislocations,nanotwins,and ultrafine martensite grains with an average effective grain size of 1.02μm.The enhanced ductility is attributed to the parallel lamellar structure,which increased the work-hardening capacity and resulted in delamination toughening.Compared to the heavy multistage rolling(HMR)process,which starts rolling at higher temperatures,the HWR method employed in this study demonstrates significant enhancements in both strength and ductility.Following a 150℃ low-temperature tempering for 1 h,the yield strength of HWR steel was further increased to 2.2 GPa,and the total elongation improved to 10.1%.展开更多
The long-lasting expectation“the hotter the engine,the better”calls for the development of high-temperature metallic alloys.Although the high specific strengths of titanium alloys are compelling for such application...The long-lasting expectation“the hotter the engine,the better”calls for the development of high-temperature metallic alloys.Although the high specific strengths of titanium alloys are compelling for such applications,their deleterious softening beyond 600℃ imposes serious limitations.Much has been known for decades regarding the phase metallurgy for precipitation strengthening design in titanium alloys,however,the other facile strength promotion mechanism,dispersion strengthening,remains comparatively less-explored and unutilized.The present research concerns the multi-scale dispersion strengthening in titanium alloys,with mechanistic emphases on the critical plasticity micro-events that affect strength preservation.Due to the simultaneous introduction of intragranular dispersoids and intergranular reinforcers,the current titanium alloys present superior engineering tensile strength of 519 MPa at 700℃.Throughout the examined 25-800℃ temperature range,noticeable softening induced by the thermal activation occurs above 600℃,accompanied by evident strength loss.The temperature-dependence transition of dominated softening mechanisms from dynamic recovery to dynamic recrystallization has been clarified by theoretical calculations.Furthermore,the strengthening effect of multi-scale architectures is underpinned as the enhanced dislocation strengthening owing to the introduction of thermally-stable heterointerfaces,which could generically guide the design of similar heat-resistant titanium alloys.展开更多
The subgenus Symplecta(Symplecta)Meigen,1830 is a small group within the genus Symplecta.Eighteen species and subspecies are known worldwide,of which two are known to occur in China.Herein,all known Chinese species in...The subgenus Symplecta(Symplecta)Meigen,1830 is a small group within the genus Symplecta.Eighteen species and subspecies are known worldwide,of which two are known to occur in China.Herein,all known Chinese species in this subgenus are reviewed.In addition,a species from Xizang,China,Symplecta(S.)xizangensis Ma,Wang&Kang sp.nov.,is described and illustrated as new to science.A key to all Chinese species in this subgenus is presented.展开更多
Bats are critical viral reservoirs that harbor viromes with high cross-species transmission risks,yet their virome diversity in the mainland Southeast Asia and adjacent regions remains underexplored.Here,we characteri...Bats are critical viral reservoirs that harbor viromes with high cross-species transmission risks,yet their virome diversity in the mainland Southeast Asia and adjacent regions remains underexplored.Here,we characterized the bat viromes from 659 samples(197 individuals,16 species)from Yunnan province and Guangxi Zhuang autonomous region,China,as well as from Cambodia,using next-generation sequencing(NGS).RNA sequencing,viral classification,phylogenetic analyses,and deep learning-based host adaptability analysis were performed to reveal the viral composition and cross-species transmission risks.We identified 137 viral strains,including 40 novel species spanning 18 families.Viral richness was highest in Vespertilionidae bats(12 viral families found)along China's southwestern border,where Middle Eastern respiratory syndrome(MERS)-like coronavirus(Co V)was found.Cambodian bat viruses were evolutionarily more distant from those of known viruses.A porcine epidemic diarrhea virus(PEDV)-related Co V was found in Cambodia,showing 90.36%genome homology with PEDV CV777 and exhibiting recombinant features between Suidae-adapted ORF1ab and Chiroptera-adapted Spike genes,suggesting that bats are the evolutionary source of PEDV.These findings illuminate the undercharacterized bat viral diversity in biogeographic transition zones and highlight the mainland Southeast Asia and adjacent regions as a hotspot for Co V recombination.We advocate for enhanced One Health-aligned surveillance targeting viral recombination hotspots and human±bat interfaces in this ecologically critical region.展开更多
An electroencephalographic(EEG)signature of auditory hallucinations(AHs)is important for facilitating the diagnosis and treatment of AHs in schizophrenia.We recorded EEG from 25 schizophrenia patients with recurrent A...An electroencephalographic(EEG)signature of auditory hallucinations(AHs)is important for facilitating the diagnosis and treatment of AHs in schizophrenia.We recorded EEG from 25 schizophrenia patients with recurrent AHs.During the period of AHs,EEG recordings exhibited significantly elevated beta2-band power in the temporal region,as compared to those recorded in the absence of AHs or during stimulation with verbal sounds.We further generated methamphetamine-treated rhesus monkeys exhibiting psychosis-like behaviors,including repetitive sudden searching actions in the absence of external intrusion,suggesting the occurrence of AHs.Epidural EEG beta2-band power in the temporal region of these monkeys was enhanced immediately after methamphetamine treatment and positively correlated with the frequency of sudden searching actions.Thus,the enhancement of temporal beta2-band oscillations represents a signature for AHs in both patients and a monkey model of psychosis,and this monkey model can be used for developing closed-loop neuromodulation approaches for the treatment of refractory AHs in schizophrenia.展开更多
Human disturbances are considered to break reproduction barriers among species.Significant increases in hybridization events have been reported among a large number of taxonomic groups in anthropogenic environments,pr...Human disturbances are considered to break reproduction barriers among species.Significant increases in hybridization events have been reported among a large number of taxonomic groups in anthropogenic environments,providing novel insights into species evolution mechanisms and conservation management in the Anthropocene.The Eastern Golden Frog(Pelophylax plancyi)and BlackSpotted Frog(P.nigromaculatus)are two sympatric anuran species with a long history of mitochondrial genome introgression in highly urbanized continental East Asia.However,there is only limited understanding of the pattern of their contemporary hybridization and factors influencing their interspecific relationship under anthropogenic disturbances.Here,interspecific hybridization between P.plancyi and P.nigromaculatus at the population level was investigated in Shanghai.All except two haplotypes obtained from both species in Shanghai were mixed together,and located in the introgression clade,implying multiple ancient mitochondrial introgression events occurred in the populations of our study area.Asymmetric genetic introgression was detected by microsatellite markers,with 0.7%of P.plancyi and 14.6%of P.nigromaculatus identified as contemporary admixed individuals.Consistent with the trend of population density,higher genetic diversity of neutral microsatellite loci was found in the more abundant P.plancyi;however,variation in mitochondrial(Cyt-b)and nuclear(POMC)genes was higher in relatively rare P.nigromaculatus.The population density of P.plancyi and number of water patches within local habitats were significantly positively correlated with both occurrences and proportions of admixed individuals in the populations of P.plancyi and P.nigromaculatus.Considering the prevalent transformation of habitats in urbanized areas,these results imply that a high population density in isolated artificially altered habitats is likely to increase interspecific hybridization.Thus,population monitoring and improvement of landscape connectivity between habitats would be needed to control the intensity of interspecific hybridization between P.plancyi and P.nigromaculatus in anthropogenic-disturbed environments.展开更多
Cloud base height(CBH) is a crucial parameter for cloud radiative effect estimates, climate change simulations, and aviation guidance. However, due to the limited information on cloud vertical structures included in p...Cloud base height(CBH) is a crucial parameter for cloud radiative effect estimates, climate change simulations, and aviation guidance. However, due to the limited information on cloud vertical structures included in passive satellite radiometer observations, few operational satellite CBH products are currently available. This study presents a new method for retrieving CBH from satellite radiometers. The method first uses the combined measurements of satellite radiometers and ground-based cloud radars to develop a lookup table(LUT) of effective cloud water content(ECWC), representing the vertically varying cloud water content. This LUT allows for the conversion of cloud water path to cloud geometric thickness(CGT), enabling the estimation of CBH as the difference between cloud top height and CGT. Detailed comparative analysis of CBH estimates from the state-of-the-art ECWC LUT are conducted against four ground-based millimeter-wave cloud radar(MMCR) measurements, and results show that the mean bias(correlation coefficient) is0.18±1.79 km(0.73), which is lower(higher) than 0.23±2.11 km(0.67) as derived from the combined measurements of satellite radiometers and satellite radar-lidar(i.e., Cloud Sat and CALIPSO). Furthermore, the percentages of the CBH biases within 250 m increase by 5% to 10%, which varies by location. This indicates that the CBH estimates from our algorithm are more consistent with ground-based MMCR measurements. Therefore, this algorithm shows great potential for further improvement of the CBH retrievals as ground-based MMCR are being increasingly included in global surface meteorological observing networks, and the improved CBH retrievals will contribute to better cloud radiative effect estimates.展开更多
With the rapid development of wind power, the large-scale wind power integration brings a new range of issues in dispatching operation. In order to gain a better grasp of the influence caused by wind power combined to...With the rapid development of wind power, the large-scale wind power integration brings a new range of issues in dispatching operation. In order to gain a better grasp of the influence caused by wind power combined to the grid, the paper first establishes the impact characteristic indexes, and then analyzes the regularity of wind power time series in different spatial and temporal scales. At last, according to the analysis results, this paper assesses the impact of time-series characteristics of wind power on power grid, such as the frequency regulation, peak load regulation, which can provide the reference for wind power optimal dispatching of Jilin Power Grid.展开更多
We performed new photometric observations for two contact binaries(i.e., CRTS J025408.1+265957 and CRTS J012111.1+272933), which were observed by the 1.0 m telescope at Xingjiang Astronomical Observatory. From our lig...We performed new photometric observations for two contact binaries(i.e., CRTS J025408.1+265957 and CRTS J012111.1+272933), which were observed by the 1.0 m telescope at Xingjiang Astronomical Observatory. From our light curves and several survey data, we derived several sets of photometric solutions. We found that CRTS J025408.1+265957 and CRTS J012111.1+272933 were A-and W-type W UMa, respectively. The results imply that the spot migrates or disappears in the two contact binaries, which were identified by chromospheric activity emissions(e.g., Hαemission) from LAMOST spectra. From the O-C curves, the orbital periods of the two contact binaries may be increasing, which is interpreted by the mass transfer from the less massive component to the more massive one. With mass transferring, the two contact binaries may evolve from the contact configurations to semi-detached ones as predicted by the theory of thermal relaxation oscillation.展开更多
Solid-state polymer electrolytes(SPEs) capable of withstanding high voltage are considered to be key for next-generation energy storage devices with inherent safety as well as high energy density.This study involves t...Solid-state polymer electrolytes(SPEs) capable of withstanding high voltage are considered to be key for next-generation energy storage devices with inherent safety as well as high energy density.This study involves the rational design of solid-state-C≡N functionalized P(VEC_1-CEA_(0.3))/LiTFSI@CE SPEs and its synthesis by in-situ free radical polymerization of vinyl ethylene carbonate(VEC) and 2-cyanoethyl acrylate(CEA).In situ polymerization yields electrode/electrolyte interfaces with low interfacial resistance,forming a stable SEI layer enriched with LiF,Li_(3)N,and RCOOLi,ensuring stable Li plating/stripping for over 1400 h.The-C≡N moiety renders the αH on the adjacent αC positively charged,thereby endowing it with the capability to anchor TFSI^(-).Simultaneously,the incorporation of-C≡N moiety diminishes the electron-donating ability of the C=O,C-O-C,and-C≡N functional groups,facilitating not only the ion conductivity enhancement but also a more rapid Li^(+)migration proved by DFT theoretical calculations and Raman spectroscopy.At room temperature,t_(Li+) of 0.60 for P(VEC_1-CEA_(0.3))/LiTFSI@CE SPEs is achieved when the ionic conductivity σ_(Li+)is 2.63×10^(-4) S cm^(-1) and the electrochemical window is expanded to5.0 V.Both coin cells with high-areal-loading cathodes and the 6.5-mAh pouch cell,exhibit stable charge/discharge cycling.At 25℃,the 4.45-V Li|P(VEC_1-CEA_(0.3))/LiTFSI@CE|LiCoO_(2) battery performs stable cycling over 200 cycles at 0.2 C,with a capacity retention of 82.1%.展开更多
Compared with traditional real aperture microwave radiometers,one-dimensional synthetic aperture microwave radiometers have higher spatial resolution.In this paper,we proposed to retrieve sea surface temperature using...Compared with traditional real aperture microwave radiometers,one-dimensional synthetic aperture microwave radiometers have higher spatial resolution.In this paper,we proposed to retrieve sea surface temperature using a one-dimensional synthetic aperture microwave radiometer that operates at frequencies of 6.9 GHz,10.65 GHz,18.7 GHz and 23.8 GHz at multiple incidence angles.We used the ERA5 reanalysis data provided by the European Centre for Medium-Range Weather Forecasts and a radiation transmission forward model to calculate the model brightness temperature.The brightness temperature measured by the spaceborne one-dimensional synthetic aperture microwave radiometer was simulated by adding Gaussian noise to the model brightness temperature.Then,a backpropagation(BP)neural network algorithm,a random forest(RF)algorithm and two multiple linear regression algorithms(RE1 and RE2)were developed to retrieve sea surface temperature from the measured brightness temperature within the incidence angle range of 0°-65°.The results show that the retrieval errors of the four algorithms increase with the increasing Gaussian noise.The BP achieves the lowest retrieval errors at all incidence angles.The retrieval error of the RE1 and RE2 decrease first and then increase with the incidence angle and the retrieval error of the RF is contrary to that of RE1 and RE2.展开更多
Specimens of the crane fly genus Helius Lepeletier&Serville,1828 from Sichuan,China are examined and studied.Three Helius species all belonging to the nominotypical subgenus are recognized,of which H.(H.)pallidiss...Specimens of the crane fly genus Helius Lepeletier&Serville,1828 from Sichuan,China are examined and studied.Three Helius species all belonging to the nominotypical subgenus are recognized,of which H.(H.)pallidissimoides Xu,Ma&Zhang,sp.nov.is described and illustrated as new to science,and H.(H.)pallidissimus Alexander,1930 and H.(H.)franckianus Alexander,1940 are redescribed and illustrated.For the first time,descriptions and illustrations are provided for the male of H.(H.)pallidissimus and the female of H.(H.)franckianus.展开更多
基金financially supported by the National Natural Science Foundation of China(No.51971153).
文摘To improve the thermal stability of nanocrystalline(NC)metals,their interface structure can be modified by applying amorphous intergranular layers.However,traditional amorphous metallic intergranular layers are rarely formed in most pure metals or alloys.In this study,we demonstrate that amorphous oxide intergranular layers can greatly improve the thermal stability of NC metals by tailoring the grain boundaries(GBs)of NC metals.Using a Au-ZrO_(2) model system,ultra-fine Au nanoparticles(∼3 nm)with exceptional thermal stability at temperatures up to 600℃ were formed after introducing amorphous ZrO_(2) intergranular layers at the GBs of NC Au.Quantitative thermodynamic model calculations revealed that the exceptional thermal stability of the Au nanoparticles originated fundamentally from the formation of low-energy Au|ZrO_(2) interfaces.The kinetic stabilization was further discussed,showing that the Ostwald ripening of Au nanoparticles was suppressed due to the presence of amorphous ZrO_(2) intergranular.This study sheds light on new strategies for enhancing the thermal stability of NC metals by utilizing amorphous oxide intergranular layers,paving the way for the achievement of ultra-stable NC metals through interface modification.
基金supported by the National Key R&D Plan Project(2023YFD2301000)the National Key Research and Development Program of Shandong Province,China(2024CXGC0109032023CXPT013)+2 种基金the National Natural Science Foundation of China(32472705,32302513)the Young Talent of Lifting Engineering for Science and Technology in Shandong,China(SDAST2024QTA083)the Natural Science Foundation of Shandong Province,China(ZR2022JQ14,ZR2022QC112)。
文摘Xyloglucan represents the primary hemicellulose component in higher plant cell walls,providing mechanical support.The XTH gene family encodes xyloglucan endotransferase/hydrolase,a crucial enzyme in cell wall remodeling.Studies examining XTH family-related genes in apples remain limited.This study investigated the Md XTH30 gene,isolated from apple(Malus×domestica),which demonstrated responsiveness to abscisic acid,Na Cl,and polyethylene glycol(PEG)6000,with cytoplasmic localization confirmed through subcellular mapping.To elucidate the role of Md XTH30 in stress response,transgenic Md XTH30 apple calli were generated and the gene was heterologously expressed in Arabidopsis via Agrobacterium-mediated transformation.The findings revealed that Md XTH30 enhanced resistance to drought,salt stress,and pathogens through regulation of relevant genes in both apple calli and Arabidopsis.These results identify potentially significant candidate genes for improving biotic and abiotic stress resistance at the cell wall level.
基金National Natural Science Foundation of China(Grant No.21702178)Training Plan of Young Backbone Teachers in Universities of Henan Province(Grant No.2021GGJS144)+5 种基金Key Scientific Research Program in Universities of Henan Province(Grant No.22A350009 and 23A350012)National Undergraduate Training Program for Innovation and Entrepreneurship(Grant No.202410480007 and 202310480020)Undergraduate Training Program for Innovation and Entrepreneurship of Henan Province(Grant No.202210480020 and 202210480021)Scientific Research Innovation Team of Xuchang University(Grant No.2022CXTD007)Horizontal Cooperation Project(Grant No.2023HX181)Undergraduate Training Program for Innovation and Entrepreneurship of Xuchang University(Grant No.X202210480016)。
文摘Prunella vulgaris,a traditional Chinese medicine(TCM),exerts a significant hypotensive effect,particularly in managing various forms of hypertension.Nonetheless,the precise antihypertensive constituents and their respective targets remain elusive.This study endeavored to identify the hypotensive components of P.vulgaris and elucidated its mode of action based on hypotensive targets.Utilizing the Systematic Pharmacology of Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),UniProt,GeneCards,STRING,RCSB,and the Human Genome Annotation and Analysis Database(Metascape),we conducted a screening of active ingredients and hypotensive targets.The Network Analyzer software Cytoscape 3.9.0 facilitated a comprehensive analysis of the active ingredients.Molecular docking was executed employing Sybyl-X 2.0 and Discovery Studio 2019.Predictions and analyses of the pharmacokinetics and toxicity of active ingredients were performed using the ADMETlab 2.0 online platform.Eight active compounds(1–8)and 11 hypotensive targets were identified,with IL1B and PPARG exhibiting a high degree of correlation.Dominant biological processes included negative regulation of apoptotic processes,positive regulation of gene expression,response to xenobiotic stimulus,and response to hypoxia.KEGG analysis unveiled core pharmacological mechanisms,notably fluid shear stress and atherosclerosis,lipid and atherosclerosis,P13K-Akt,MAPK,and relaxin signaling pathways.Compounds 5–8 demonstrated robust interactions with multiple targets through hydrogen bonds,van der Waals forces,and pi-alkyl interactions,which serve as primary stabilizers of docking complexes.Notably,compound 7 exhibited promising ADMET prediction results,suggesting its potential for drug molecule development.Our findings underscored the synergistic effects of P.vulgaris on multiple targets and pathways in hypertension treatment,reflecting the characteristic multi-component and multi-target effects of TCM.
基金supported by the National Key R&D program of China for Intergovernmental Scientific and Technological Innovation Cooperation Project under No.2022YFE0126200the Chinese Academy of Sciences(CAS)"Light of West China"Program,No.2022-XBQNXZ-013+2 种基金the Natural Science Foundation of Xinjiang Uygur Autonomous Region,No.2022D01E86the National Natural Science Foundation of China under grant U2031204the science research grants from the China Manned Space Project with No.CMS-CSST2021-A08。
文摘We present the first detailed photometric analysis of ATO J108.6991+27.8306(hereinafter as J108).The shortperiod close binary J108 was observed by the Nanshan 1 m Wide Field Telescope of the Xinjiang Astronomical Observatory.The obtained BVRI-band light curves were used to determine the photometric solution by using the 2003 version of the Wilson-Devinney code.J108 is a typical deep(f>50%),low mass ratio(q<0.25)overcontact binary system with a mass ratio of q=0.1501 and a fill-out factor of f=50.1%,suggesting that it is in the late evolutionary stage of contact binary systems.We found the target to be a W-type W UMa binary and provided evidence for the presence of starspots on both components.From the temperature-luminosity diagram,the main component is the evolved main sequence star with an evolutionary age of about 7.94 Gyr.
基金supported by the National Natural Science Foundation of China(No.82271515)the SJTU Trans-Med Awards Research(No.2019015)+4 种基金the Scientific and Technological Innovation Action Plan of Shanghai(No.KY20211478)the Shanghai Municipal Science and Technology Major Project(No.2021SHZDZX)the Nursing Development Program of Shanghai Jiao Tong University School of Medicine(No.SJTUHLXK2022)the 2024 Shanghai Ruijin Hospital Nursing Research Fund(No.RJHK-2024-001)the Shanghai Nursing Association Funding(No.2024MS-B13),China。
文摘Abuse of amphetamine-based stimulants is a primary public health concern.Recent studies have underscored a troubling escalation in the inappropriate use of prescription amphetamine-based stimulants.However,the neurophysiological mechanisms underlying the impact of acute methamphetamine exposure(AME)on sleep homeostasis remain to be explored.This study employed non-human primates and electroencephalogram(EEG)sleep staging to evaluate the influence of AME on neural oscillations.The primary focus was on alterations in spindles,delta oscillations,and slow oscillations(SOs)and their interactions as conduits through which AME influences sleep stability.AME predominantly diminishes sleep-spindle waves in the non-rapid eye movement 2(NREM2)stage,and impacts SOs and delta waves differentially.Furthermore,the competitive relationships between SO/delta waves nesting with sleep spindles were selectively strengthened by methamphetamine.Complexity analysis also revealed that the SO-nested spindles had lost their ability to maintain sleep depth and stability.In summary,this finding could be one of the intrinsic electrophysiological mechanisms by which AME disrupted sleep homeostasis.
文摘The impact of rolling temperature and the crystallographic orientation ofα-colonies on the globularization behavior of lamellarα+βmicrostructure in Ti-6Al-4V alloy was investigated.Firstly,the lamellar structure was heavily rolled at 600,700,800 and 900°C,respectively.Heavy rolling from temperatures of 600 to 900°C resulted in an increased volume fraction and thickness ofβlamellae,while the corresponding parameters forαlamellae decreased.Then,these rolledα+βlamellar microstructures were spheroidized into equiaxed grains upon subsequent annealing.The results demonstrate that the globularization fraction of the lamellar structures diminishes as the rolling temperature increases.Additionally,the globularization fraction forα-colonies with hard crystallographic orientations,such as<0001>//ND and<0001>//TD,is considerably lower compared to those with softer orientations,positioned at certain angles to ND,RD,and TD during annealing process.This results in heterogeneous globularization ofαlamellae,leading to the development of pronounced sharp micro-texture.Furthermore,the slipping deformations ofα-colonies with varying crystallographic orientations during rolling were meticulously analyzed.
基金supported by the National Natural Science Foundation of China(No.52071212).
文摘An ultra-strong steel with enhanced ductility and ultrafine lamellar structure was produced by heavy warm rolling(HWR)of metastable austenite and subsequent quenching.The HWR steel exhibited an ultrahigh yield strength of 1.09 GPa and an ultimate tensile strength of 2.6 GPa,with a total elongation of 6.7%at room temperature.The high yield strength was primarily attributed to the synergistic strengthening of high-density dislocations,nanotwins,and ultrafine martensite grains with an average effective grain size of 1.02μm.The enhanced ductility is attributed to the parallel lamellar structure,which increased the work-hardening capacity and resulted in delamination toughening.Compared to the heavy multistage rolling(HMR)process,which starts rolling at higher temperatures,the HWR method employed in this study demonstrates significant enhancements in both strength and ductility.Following a 150℃ low-temperature tempering for 1 h,the yield strength of HWR steel was further increased to 2.2 GPa,and the total elongation improved to 10.1%.
基金financially supported by the National Key R&D Program of China(No.2021YFB3701203)the National Natural Science Foundation of China(Nos.U22A20113,52261135543,52171137 and 52071116)the Heilongjiang Touyan Team Program,Heilongjiang Provincial Natural Science Foundation of China(No.TD2020E001).
文摘The long-lasting expectation“the hotter the engine,the better”calls for the development of high-temperature metallic alloys.Although the high specific strengths of titanium alloys are compelling for such applications,their deleterious softening beyond 600℃ imposes serious limitations.Much has been known for decades regarding the phase metallurgy for precipitation strengthening design in titanium alloys,however,the other facile strength promotion mechanism,dispersion strengthening,remains comparatively less-explored and unutilized.The present research concerns the multi-scale dispersion strengthening in titanium alloys,with mechanistic emphases on the critical plasticity micro-events that affect strength preservation.Due to the simultaneous introduction of intragranular dispersoids and intergranular reinforcers,the current titanium alloys present superior engineering tensile strength of 519 MPa at 700℃.Throughout the examined 25-800℃ temperature range,noticeable softening induced by the thermal activation occurs above 600℃,accompanied by evident strength loss.The temperature-dependence transition of dominated softening mechanisms from dynamic recovery to dynamic recrystallization has been clarified by theoretical calculations.Furthermore,the strengthening effect of multi-scale architectures is underpinned as the enhanced dislocation strengthening owing to the introduction of thermally-stable heterointerfaces,which could generically guide the design of similar heat-resistant titanium alloys.
基金supported by the Shandong Provincial Natural Science Foundation,China(ZR2018LC006)the High-level Talents Funds of Qingdao Agricultural University,China(663-1119008 and 663-1118015)+1 种基金the National Natural Science Foundation of China(32100356,32470481)the National Animal Collection Resource Center,China.
文摘The subgenus Symplecta(Symplecta)Meigen,1830 is a small group within the genus Symplecta.Eighteen species and subspecies are known worldwide,of which two are known to occur in China.Herein,all known Chinese species in this subgenus are reviewed.In addition,a species from Xizang,China,Symplecta(S.)xizangensis Ma,Wang&Kang sp.nov.,is described and illustrated as new to science.A key to all Chinese species in this subgenus is presented.
基金supported by the Capital’s Funds for Health Improvement and Research(grant number 2024-1G4421 to Y.T.)the National Key Research and Development Program of China(grant numbers 2024YFC2607500 and 2019YFC1200500 to J.J.)the National Natural Science Foundation of China(grant number U2002219 to J.J.).
文摘Bats are critical viral reservoirs that harbor viromes with high cross-species transmission risks,yet their virome diversity in the mainland Southeast Asia and adjacent regions remains underexplored.Here,we characterized the bat viromes from 659 samples(197 individuals,16 species)from Yunnan province and Guangxi Zhuang autonomous region,China,as well as from Cambodia,using next-generation sequencing(NGS).RNA sequencing,viral classification,phylogenetic analyses,and deep learning-based host adaptability analysis were performed to reveal the viral composition and cross-species transmission risks.We identified 137 viral strains,including 40 novel species spanning 18 families.Viral richness was highest in Vespertilionidae bats(12 viral families found)along China's southwestern border,where Middle Eastern respiratory syndrome(MERS)-like coronavirus(Co V)was found.Cambodian bat viruses were evolutionarily more distant from those of known viruses.A porcine epidemic diarrhea virus(PEDV)-related Co V was found in Cambodia,showing 90.36%genome homology with PEDV CV777 and exhibiting recombinant features between Suidae-adapted ORF1ab and Chiroptera-adapted Spike genes,suggesting that bats are the evolutionary source of PEDV.These findings illuminate the undercharacterized bat viral diversity in biogeographic transition zones and highlight the mainland Southeast Asia and adjacent regions as a hotspot for Co V recombination.We advocate for enhanced One Health-aligned surveillance targeting viral recombination hotspots and human±bat interfaces in this ecologically critical region.
基金supported by a Shanghai Municipal Science and Technology Major Project(2021SHZDZX,E154N41011)the Lingang Lab Program(LG2021050202 and LG2021060301)+1 种基金the National Nature Science Foundation(82130041)the Shanghai Rising-star Cultivation Program(22YF1439200).
文摘An electroencephalographic(EEG)signature of auditory hallucinations(AHs)is important for facilitating the diagnosis and treatment of AHs in schizophrenia.We recorded EEG from 25 schizophrenia patients with recurrent AHs.During the period of AHs,EEG recordings exhibited significantly elevated beta2-band power in the temporal region,as compared to those recorded in the absence of AHs or during stimulation with verbal sounds.We further generated methamphetamine-treated rhesus monkeys exhibiting psychosis-like behaviors,including repetitive sudden searching actions in the absence of external intrusion,suggesting the occurrence of AHs.Epidural EEG beta2-band power in the temporal region of these monkeys was enhanced immediately after methamphetamine treatment and positively correlated with the frequency of sudden searching actions.Thus,the enhancement of temporal beta2-band oscillations represents a signature for AHs in both patients and a monkey model of psychosis,and this monkey model can be used for developing closed-loop neuromodulation approaches for the treatment of refractory AHs in schizophrenia.
基金supported by the National Natural Science Foundation of China(32071529)the Yangtze Delta Estuarine Wetland Ecosystem Observation and Research Station(Z202204)+1 种基金Shanghai Key Lab for Urban Ecological Processes and EcoRestoration(SHUES2020B06,SHUES2021C04)the Fundamental Research Funds for the Central Universities.
文摘Human disturbances are considered to break reproduction barriers among species.Significant increases in hybridization events have been reported among a large number of taxonomic groups in anthropogenic environments,providing novel insights into species evolution mechanisms and conservation management in the Anthropocene.The Eastern Golden Frog(Pelophylax plancyi)and BlackSpotted Frog(P.nigromaculatus)are two sympatric anuran species with a long history of mitochondrial genome introgression in highly urbanized continental East Asia.However,there is only limited understanding of the pattern of their contemporary hybridization and factors influencing their interspecific relationship under anthropogenic disturbances.Here,interspecific hybridization between P.plancyi and P.nigromaculatus at the population level was investigated in Shanghai.All except two haplotypes obtained from both species in Shanghai were mixed together,and located in the introgression clade,implying multiple ancient mitochondrial introgression events occurred in the populations of our study area.Asymmetric genetic introgression was detected by microsatellite markers,with 0.7%of P.plancyi and 14.6%of P.nigromaculatus identified as contemporary admixed individuals.Consistent with the trend of population density,higher genetic diversity of neutral microsatellite loci was found in the more abundant P.plancyi;however,variation in mitochondrial(Cyt-b)and nuclear(POMC)genes was higher in relatively rare P.nigromaculatus.The population density of P.plancyi and number of water patches within local habitats were significantly positively correlated with both occurrences and proportions of admixed individuals in the populations of P.plancyi and P.nigromaculatus.Considering the prevalent transformation of habitats in urbanized areas,these results imply that a high population density in isolated artificially altered habitats is likely to increase interspecific hybridization.Thus,population monitoring and improvement of landscape connectivity between habitats would be needed to control the intensity of interspecific hybridization between P.plancyi and P.nigromaculatus in anthropogenic-disturbed environments.
基金funded by the National Natural Science Foundation of China (Grant Nos. 42305150 and 42325501)the China Postdoctoral Science Foundation (Grant No. 2023M741774)。
文摘Cloud base height(CBH) is a crucial parameter for cloud radiative effect estimates, climate change simulations, and aviation guidance. However, due to the limited information on cloud vertical structures included in passive satellite radiometer observations, few operational satellite CBH products are currently available. This study presents a new method for retrieving CBH from satellite radiometers. The method first uses the combined measurements of satellite radiometers and ground-based cloud radars to develop a lookup table(LUT) of effective cloud water content(ECWC), representing the vertically varying cloud water content. This LUT allows for the conversion of cloud water path to cloud geometric thickness(CGT), enabling the estimation of CBH as the difference between cloud top height and CGT. Detailed comparative analysis of CBH estimates from the state-of-the-art ECWC LUT are conducted against four ground-based millimeter-wave cloud radar(MMCR) measurements, and results show that the mean bias(correlation coefficient) is0.18±1.79 km(0.73), which is lower(higher) than 0.23±2.11 km(0.67) as derived from the combined measurements of satellite radiometers and satellite radar-lidar(i.e., Cloud Sat and CALIPSO). Furthermore, the percentages of the CBH biases within 250 m increase by 5% to 10%, which varies by location. This indicates that the CBH estimates from our algorithm are more consistent with ground-based MMCR measurements. Therefore, this algorithm shows great potential for further improvement of the CBH retrievals as ground-based MMCR are being increasingly included in global surface meteorological observing networks, and the improved CBH retrievals will contribute to better cloud radiative effect estimates.
文摘With the rapid development of wind power, the large-scale wind power integration brings a new range of issues in dispatching operation. In order to gain a better grasp of the influence caused by wind power combined to the grid, the paper first establishes the impact characteristic indexes, and then analyzes the regularity of wind power time series in different spatial and temporal scales. At last, according to the analysis results, this paper assesses the impact of time-series characteristics of wind power on power grid, such as the frequency regulation, peak load regulation, which can provide the reference for wind power optimal dispatching of Jilin Power Grid.
基金the generous support of the National Natural Science Foundation of China under Grant No.U2031204the science research grants from the China Manned Space Project with No.CMSCSST-2021-A08。
文摘We performed new photometric observations for two contact binaries(i.e., CRTS J025408.1+265957 and CRTS J012111.1+272933), which were observed by the 1.0 m telescope at Xingjiang Astronomical Observatory. From our light curves and several survey data, we derived several sets of photometric solutions. We found that CRTS J025408.1+265957 and CRTS J012111.1+272933 were A-and W-type W UMa, respectively. The results imply that the spot migrates or disappears in the two contact binaries, which were identified by chromospheric activity emissions(e.g., Hαemission) from LAMOST spectra. From the O-C curves, the orbital periods of the two contact binaries may be increasing, which is interpreted by the mass transfer from the less massive component to the more massive one. With mass transferring, the two contact binaries may evolve from the contact configurations to semi-detached ones as predicted by the theory of thermal relaxation oscillation.
基金National Natural Science Foundation of China (22078228)。
文摘Solid-state polymer electrolytes(SPEs) capable of withstanding high voltage are considered to be key for next-generation energy storage devices with inherent safety as well as high energy density.This study involves the rational design of solid-state-C≡N functionalized P(VEC_1-CEA_(0.3))/LiTFSI@CE SPEs and its synthesis by in-situ free radical polymerization of vinyl ethylene carbonate(VEC) and 2-cyanoethyl acrylate(CEA).In situ polymerization yields electrode/electrolyte interfaces with low interfacial resistance,forming a stable SEI layer enriched with LiF,Li_(3)N,and RCOOLi,ensuring stable Li plating/stripping for over 1400 h.The-C≡N moiety renders the αH on the adjacent αC positively charged,thereby endowing it with the capability to anchor TFSI^(-).Simultaneously,the incorporation of-C≡N moiety diminishes the electron-donating ability of the C=O,C-O-C,and-C≡N functional groups,facilitating not only the ion conductivity enhancement but also a more rapid Li^(+)migration proved by DFT theoretical calculations and Raman spectroscopy.At room temperature,t_(Li+) of 0.60 for P(VEC_1-CEA_(0.3))/LiTFSI@CE SPEs is achieved when the ionic conductivity σ_(Li+)is 2.63×10^(-4) S cm^(-1) and the electrochemical window is expanded to5.0 V.Both coin cells with high-areal-loading cathodes and the 6.5-mAh pouch cell,exhibit stable charge/discharge cycling.At 25℃,the 4.45-V Li|P(VEC_1-CEA_(0.3))/LiTFSI@CE|LiCoO_(2) battery performs stable cycling over 200 cycles at 0.2 C,with a capacity retention of 82.1%.
基金The National Natural Science Foundation of China under contract Nos 41475019 and 41705007.
文摘Compared with traditional real aperture microwave radiometers,one-dimensional synthetic aperture microwave radiometers have higher spatial resolution.In this paper,we proposed to retrieve sea surface temperature using a one-dimensional synthetic aperture microwave radiometer that operates at frequencies of 6.9 GHz,10.65 GHz,18.7 GHz and 23.8 GHz at multiple incidence angles.We used the ERA5 reanalysis data provided by the European Centre for Medium-Range Weather Forecasts and a radiation transmission forward model to calculate the model brightness temperature.The brightness temperature measured by the spaceborne one-dimensional synthetic aperture microwave radiometer was simulated by adding Gaussian noise to the model brightness temperature.Then,a backpropagation(BP)neural network algorithm,a random forest(RF)algorithm and two multiple linear regression algorithms(RE1 and RE2)were developed to retrieve sea surface temperature from the measured brightness temperature within the incidence angle range of 0°-65°.The results show that the retrieval errors of the four algorithms increase with the increasing Gaussian noise.The BP achieves the lowest retrieval errors at all incidence angles.The retrieval error of the RE1 and RE2 decrease first and then increase with the incidence angle and the retrieval error of the RF is contrary to that of RE1 and RE2.
基金supported by the National Natural Science Foundation of China (32100356)the National Animal Collection Resource Center,China
文摘Specimens of the crane fly genus Helius Lepeletier&Serville,1828 from Sichuan,China are examined and studied.Three Helius species all belonging to the nominotypical subgenus are recognized,of which H.(H.)pallidissimoides Xu,Ma&Zhang,sp.nov.is described and illustrated as new to science,and H.(H.)pallidissimus Alexander,1930 and H.(H.)franckianus Alexander,1940 are redescribed and illustrated.For the first time,descriptions and illustrations are provided for the male of H.(H.)pallidissimus and the female of H.(H.)franckianus.
