Tertiary lymphoid structures(TLS),also referred to as tertiary lymphoid organs or ectopic lymphoid structures,are organized aggregates of immune cells that develop in non-lymphoid tissues in response to certain diseas...Tertiary lymphoid structures(TLS),also referred to as tertiary lymphoid organs or ectopic lymphoid structures,are organized aggregates of immune cells that develop in non-lymphoid tissues in response to certain disease processes^(1).They are typically observed in chronically inflamed tissues that are persistently exposed to antigens,such as in autoimmune diseases,chronic infections,and cancers^(2).In many tumor types,the presence and higher density of TLS are strongly correlated with improved pa-tient prognosis^(3).展开更多
基金supported by the National Key Research and Development Plan(2022YFC3500202,China)the National Natural Science Foundation of China(No.U24A20794).
文摘Tertiary lymphoid structures(TLS),also referred to as tertiary lymphoid organs or ectopic lymphoid structures,are organized aggregates of immune cells that develop in non-lymphoid tissues in response to certain disease processes^(1).They are typically observed in chronically inflamed tissues that are persistently exposed to antigens,such as in autoimmune diseases,chronic infections,and cancers^(2).In many tumor types,the presence and higher density of TLS are strongly correlated with improved pa-tient prognosis^(3).
