BACKGROUND Cholangiocarcinoma(CCA),also known as bile duct cancer,is a devastating malignancy primarily affecting the biliary tract.AIM To assess their performance in clinical diagnosis and monitoring of CCA,plasma me...BACKGROUND Cholangiocarcinoma(CCA),also known as bile duct cancer,is a devastating malignancy primarily affecting the biliary tract.AIM To assess their performance in clinical diagnosis and monitoring of CCA,plasma methylation and circulating tumor cells were detected.METHODS Plasma samples were collected from Hubei Cancer Hospital(n=156).Plasma DNA was tested to detect SHOX2,HOXA9,SEPTIN9,and RASSF1A methylation using TaqMan PCR.Circulating tumor cells(CTCs)were detected in the peripheral blood of patients using the United States Food and Drug Administration-approved cell search system before and after clinical therapy.The CCA diagnostic value was estimated using the area under the curve.The independent prognosis risk factors for patients with CCA were estimated using Cox and logistic regression analyses.RESULTS The sensitivity and specificity of the four DNA plasma methylations exhibited 64.74%sensitivity and 93.88%specificity for detecting CCA.The receiver operating characteristic curve of the combined value for CCA diagnosis in plasma was 0.828±0.032.RASSF1A plasma methylation was related to the prognosis of patients with CCA.We determined the prognostic hazard ratio for CCA using CTC count,tumor stage,methylation,and carbohydrate antigen 19-9 levels as key factors.Our overall survival nomogram achieved a C-index of 0.705(0.605-0.805).CONCLUSION SHOX2,HOXA9,SEPTIN9,and RASSF1A plasma methylation demonstrated increased sensitivity for diagnosing CCA.RASSF1A plasma methylation and CTCs were valuable predictors to assess CCA prognosis and recurrence.展开更多
This study investigates the adsorption mechanism,the film formation process,and the inhibition performance of benzotriazole(BTAH)on carbon steels with different grain sizes(i.e.,24.5,4.3,and 0.6μm)in 3.5 wt.%NaCl sol...This study investigates the adsorption mechanism,the film formation process,and the inhibition performance of benzotriazole(BTAH)on carbon steels with different grain sizes(i.e.,24.5,4.3,and 0.6μm)in 3.5 wt.%NaCl solution.The results demonstrate that grain refinement significantly impacts the adsorption and inhibition performance of BTAH on carbon steels.Ultra-refinement of steel grains to 0.6μm improves the maximum inhibition efficiency of BTAH to 90.0%within 168 h of immersion,which was much higher than that of the steels with 24.5μm(73.6%)and 4.3μm grain sizes(81.7%).Notably,grain sizes of 4.3 and 0.6μm facilitate a combination of physisorption and chemisorption of BTAH after 120 h of immersion,as evidenced by the X-ray photoelectron spectroscopy(XPS)results and Langmuir adsorption isotherms,while BTAH adsorbed on carbon steels with a grain size of 24.5μm through physisorption during the 168 h of immersion.Ultra-refinement of grains has beneficial impacts on promoting the formation of a stable and dense corrosion inhibitor film,leading to improved corrosion resistance and the mitigation of non-uniform corrosion.These advantageous effects can be attributed to the higher adsorption energy at grain boundaries(approximately-3.12 eV)compared to grain interiors(ranging from-0.79 to 2.47 eV),promoting both the physisorption and chemisorption of organic corrosion inhibitors.The investigation comprehensively illustrates,for the first time,the effects of grain size on the adsorption mechanism,film formation process,and inhibition performance of organic corrosion inhibitors on carbon steels.This study demonstrates a promising approach to enhancing corrosion inhibition performance through microstructural design.展开更多
Photo-assisted Li–O_(2)batteries present a promising avenue for reducing overpotential and enhancing the capacity of next-generation energy storage devices.In this study,we introduce a novel photo-assisted Li–O_(2)s...Photo-assisted Li–O_(2)batteries present a promising avenue for reducing overpotential and enhancing the capacity of next-generation energy storage devices.In this study,we introduce a novel photo-assisted Li–O_(2)system featuring a Z-scheme In_(2)S_(3)/MnO_(2)/BiOCl heterojunction as a photocathode.This innovative design significantly boosts visible light absorption and facilitates the spatial separation of photogenerated electron-hole pairs.The Z-scheme charge transfer pathway establishes efficient channels for enhancing electron transfer and charge separation,thereby fostering high photocatalytic efficiency.During illumination,photo-generated electrons traverse within the band structure,participating in the Oxygen Reduction Reaction(ORR)during discharging,while photo-induced holes in the valence band facilitate the oxidation reaction of discharge products during the charging process.Under illumination,the surface electrons of In_(2)S_(3)/MnO_(2)/BiOCl modify the morphology of the discharge product(Li_(2)O_(2)),leading to accelerated decomposition kinetics of Li_(2)O_(2)during charging.Remarkably,the In_(2)S_(3)/MnO_(2)/BiOCl photoelectrode exhibits a high specific capacity of 19330 mAh/g under illumination,surpassing performance in the dark by a significant margin.This results in an ultranarrow discharge/charge overpotential of 0.19/0.16 V,coupled with excellent cyclic stability and a long cycle life of 1500 h at 200 mA/g.Further surface tests on the photoelectrode demonstrate that light energy application promotes the decomposition of Li_(2)O_(2),corroborated by density function theory(DFT)theoretical calculations.This study of Z-scheme heterostructured photocathodes sheds light on the mechanism of photo-generated charge carriers in Li–O_(2)batteries,providing valuable insights into their functionality and potential for future battery technologies.展开更多
Rare-earth based frustrated magnets have attracted great attention as excellent candidates for magnetic refrigeration at sub-Kelvin temperatures,while the experimental identification of systems exhibiting both large v...Rare-earth based frustrated magnets have attracted great attention as excellent candidates for magnetic refrigeration at sub-Kelvin temperatures,while the experimental identification of systems exhibiting both large volumetric cooling capacity and reduced working temperatures far below 1K remains a challenge.Here,through ultra-low temperature magnetism and thermodynamic characterizations,we unveil the large magnetocaloric effect(MCE)realized at sub-Kelvin temperatures in the frustrated Kagome antiferromagnet Gd_(3)BWO_(9) with T_(N)∼1.0 K.The isothermal magnetization curves indicate the existence of field(B)induced anisotropic magnetic phase diagrams,where four distinct magnetic phases for B‖c-axis and five magnetic phases for B‖ab-plane are identified at T<T_(N).The analysis of magnetic entropy S(B,T)data and direct adiabatic demagnetization tests reveal remarkable cooling performance at sub-Kelvin temperatures featured by a large volumetric entropy density of 502.2 mJ/K/cm^(3)and a low attainable minimal temperature T_(min)∼168mK from the initial cooling condition of 2K and 6 T,surpassing most Gd-based refrigerants previously documented in temperature ranges of 0.25–4 K.The realized T_(min)∼168mK far below T_(N)∼1.0K in Gd_(3)BWO_(9) is related to the combined effects of magnetic frustration and criticality-enhanced MCE,which together leave substantial magnetic entropy at reduced temperatures by enhancing spin fluctuations.展开更多
The layered van der Waals(vdW)ferroelectric CuInP_(2)S_(6) (CIPS)exhibits unique cation-hopping-driven phenomena that bring about unconventional properties with intriguing mechanisms and hold promise for advanced appl...The layered van der Waals(vdW)ferroelectric CuInP_(2)S_(6) (CIPS)exhibits unique cation-hopping-driven phenomena that bring about unconventional properties with intriguing mechanisms and hold promise for advanced applications in nanoelectronics.However,an explicit analysis of its lattice dynamics and vibrational symmetries,pivotal for understanding the material’s peculiar ferroelectric and ferroionic behaviors,remains incomplete.Here,we employ angle-resolved polarized Raman spectroscopy in concert with first-principles calculations to systematically unravel the anisotropic lattice vibrations of CIPS single crystals.By analyzing the polarization-dependent Raman intensities,we determine the symmetry assignments and Raman tensors of all major vibrational modes,revealing good agreement with theoretical predictions.Furthermore,we demonstrate the utility of Raman spectroscopy as a sensitive and non-invasive probe for structural and ferroelectric order evolution by examining temperature-driven phase transitions and thickness-dependent polarization suppression in CIPS.Our findings establish a foundational framework for correlating lattice dynamics with functional properties in CIPS and provide a methodological blueprint for studying other vdW ferroelectrics.展开更多
Parkinson’s disease(PD)is a common neurodegenerative disorder with increasing incidence and disability rates globally,placing a heavy burden on patients and their families.In the prodromal phase of PD,nonmotor sympto...Parkinson’s disease(PD)is a common neurodegenerative disorder with increasing incidence and disability rates globally,placing a heavy burden on patients and their families.In the prodromal phase of PD,nonmotor symptoms,particularly depression and sleep disorders,are frequent,with profound effects on disease progression and patient quality of life.Emerging research highlights the critical role of inflammatory markers-including interleukins and tumor necrosis factor-in the pathogenesis of prodromal PD.These inflammatory mediators participate in neurodegenerative processes and may induce or exacerbate depressive symptoms and sleep disorders by disrupting the function of the hypothala-micpituitary-adrenal axis and affecting neurotransmitter,including serotonin,metabolism.Understanding their correlations with nonmotor symptoms in prodromal PD remains incomplete,limiting our ability to develop targeted interventions.This comprehensive review aims to investigate the specific correlations between inflammatory markers and nonmotor symptoms-particularly depression and sleep disorders-in prodromal PD.The findings could have important practical applications,potentially leading to the development of new diagnostic tools and therapeutic strategies for managing PD.By identifying and understanding these correlations,healthcare providers may better predict disease progression and implement more effective treatments for nonmotor symptoms in PD.展开更多
Organic cathode materials exhibit higher energy storage capacity,their poor cyclability due to dissolution in liquid organic electrolytes remains a challenge.However,recently,the electrochemical behavior of organopoly...Organic cathode materials exhibit higher energy storage capacity,their poor cyclability due to dissolution in liquid organic electrolytes remains a challenge.However,recently,the electrochemical behavior of organopolysulfides incorporating N-heterocycles unveils promising cathode materials with stable cycling performance.Herein,the integration of organosulfides salt as cathodes with solid electrolytes,exemplified by sodium allyl(methyl)carbamodithioate and sodium diethylcarbamodithioate with a polymer solid electrolyte of polyethylene oxide and LiTFSI,addresses the poor electrochemical stability of organic electrodes.Comparative analysis highlights sodium allyl(methyl)carbamodithioate's superior electrochemical performance and stability compared with sodium diethylcarbamodithioate,emphasizing the efficacy of periphery aliphatic modification in enhancing electrode capacity,rate performance,and electrochemical stability for organosulfide materials within all-solid-state lithium organic batteries.We also explore the origin of periphery aliphatic modification in these enhancing electrochemical performances by kinetic analysis and thermodynamic analysis.Furthermore,employing density functional theory calculations and ex situ FTIR experiments elucidates the critical role of the N-C=S structure in the energy storage mechanism.This research advances organic cathode design within organosulfide materials,unlocking the potential of allsolid-state lithium organic batteries with enhanced cyclability,propelling the development of next-generation energy storage systems.展开更多
Background and Objective: Concurrent chemoradiotherapy for cervical carcinoma develops rapidly and has become a common and standard therapy in recent years. Both the local control rate and survival rate of patients we...Background and Objective: Concurrent chemoradiotherapy for cervical carcinoma develops rapidly and has become a common and standard therapy in recent years. Both the local control rate and survival rate of patients were increased and the risk of death fell by 30%-50%. This study aimed to explore the efficacy of concurrent chemoradiotherapy plus adjuvant chemotherapy on and the treatment compliance of the patients with advanced cervical squamous cell carcinoma. Methods: A total of 156 patients with stage IIa-IIIb cervical squamous cell carcinoma were randomly divided into the concurrent chemoradiotherapy group (experimental group) and radiotherapy group (control group). Intracavity and external beam radiation therapy were administered. At point A, 40-48 Gy were given by 10-12 fractions; at point B, 46-50 Gy were given by 23-25 fractions. In the same time, experimental group was treated by cisplatin (DDP, 40 mg) on day 1, repeated every week. Ten days after radiation therapy, TP regimen was administered as adjuvant chemotherapy. Results: For the experimental and control groups, the objective response rates were 88.61% and 75.32%, 1-year survival rates were 88.57% and 70.77%, 1-year local control rates were 81.43% and 64.62%, 3-year survival rates were 82.14% and 57.69%, and 3-year local control rates were 75.00% and 46.15%, with significant differences (P < 0.05). Quality of life of all patients were significantly improved after treatment (P< 0.05). Conclusion: Concurrent chemoradiotherapy plus adjuvant chemotherapy for advanced cervical cancer can improve short-term and long-term survival and local control rates of patients, improve the quality of life, and the toxicity can be tolerated.展开更多
The ability to navigate long distances is essential for many animals to locate shelter,food,and breeding grounds.Magnetic sense has evolved in various migratory and homing species to orient them based on the geomagnet...The ability to navigate long distances is essential for many animals to locate shelter,food,and breeding grounds.Magnetic sense has evolved in various migratory and homing species to orient them based on the geomagnetic field.A highly conserved ironsulfur cluster assembly protein IscA is proposed as an animal magnetoreceptor(MagR).Iron-sulfur cluster binding is also suggested to play an essential role in MagR magnetism and is thus critical in animal magnetoreception.In the current study,we provide evidence for distinct iron binding and iron-sulfur cluster binding in MagR in pigeons,an avian species that relies on the geomagnetic field for navigation and homing.Pigeon MagR showed significantly higher total iron content from both iron-and ironsulfur binding.Y65 in pigeon MagR was shown to directly mediate mononuclear iron binding,and its mutation abolished iron-binding capacity of the protein.Surprisingly,both iron binding and iron-sulfur binding demonstrated synergistic effects,and thus appear to be integral and indispensable to pigeon MagR magnetism.These results not only extend our current understanding of the origin and complexity of MagR magnetism,but also imply a possible molecular explanation for the huge diversity in animal magnetoreception.展开更多
The persistent increase of CO_(2) levels in the atmosphere,already exceeding 400 ppm,urges the exploration of CO_(2) emission reduction and recycling technologies.Ideally,photocatalytic conversion of CO_(2) into valua...The persistent increase of CO_(2) levels in the atmosphere,already exceeding 400 ppm,urges the exploration of CO_(2) emission reduction and recycling technologies.Ideally,photocatalytic conversion of CO_(2) into valuable hydrocarbons realizes solar-to-chemical energy conversion,which is a desirable“kill two birds with one stone”strategy;namely,CO_(2) photoreduction can simultaneously tackle energy shortage and keep global carbon balance.Graphitic carbon nitride(g-C_(3)N_(4))working on CO_(2) reduction reaction deserves a highlight not only for the metal-free feature that endows it with low cost,tunable electronic structure,and easy fabrication properties but also because of its strong reduction ability.The present review concisely summarizes the latest advances of g-C_(3)N_(4)-based photocatalysts toward CO_(2) reduction.It starts with the discussion of thermodynamics and dynamics aspects of the CO_(2) reduction process.Then the modification strategies to promote g-C_(3)N_(4)-based photocatalysts in CO_(2) photoreduction have been discussed in detail,including surface functionalization,molecule structure engineering,crystallization,morphology engineering,loading cocatalyst,and constructing heterojunction.Meanwhile,the intrinsic factors affecting CO_(2) reduction activity and selectivity are analyzed and summarized.In the end,the challenges and prospects for the future development of highly g-C_(3)N_(4)-based photocatalysts in CO_(2) reduction are also presented.展开更多
Birds exhibit extraordinary mobility and remarkable navigational skills,obtaining guidance cues from the Earth’s magnetic field for orientation and long-distance movement.Bird species also show tremendous diversity i...Birds exhibit extraordinary mobility and remarkable navigational skills,obtaining guidance cues from the Earth’s magnetic field for orientation and long-distance movement.Bird species also show tremendous diversity in navigation strategies,with considerable differences even within the same taxa and among individuals from the same population.The highly conserved iron and iron-sulfur cluster binding magnetoreceptor(MagR)protein is suggested to enable animals,including birds,to detect the geomagnetic field and navigate accordingly.Notably,MagR is also implicated in other functions,such as electron transfer and biogenesis of iron-sulfur clusters,raising the question of whether variability exists in its biochemical and biophysical features among species,particularly birds.In the current study,we conducted a comparative analysis of MagR from two different bird species,including the migratory European robin(Erithacus rubecula)and the homing pigeon(Columba livia).Sequence alignment revealed an extremely high degree of similarity between the MagRs of these species,with only three sequence variations.Nevertheless,two of these variations underpinned significant differences in metal binding capacity,oligomeric state,and magnetic properties.These findings offer compelling evidence for the marked differences in MagR between the two avian species,potentially explaining how a highly conserved protein can mediate such diverse functions.展开更多
Hydrogel-based triboelectric nanoge nerator(TENG)has a promising applied prospect in wearable electronic devices.However,its low performance,poor stability,insufficient recyclability and inferior self-healing seriousl...Hydrogel-based triboelectric nanoge nerator(TENG)has a promising applied prospect in wearable electronic devices.However,its low performance,poor stability,insufficient recyclability and inferior self-healing seriously hinder its development.Herein,we report a robust route to a liquid metal(LM)/polyvinyl alcohol(PVA)hydrogel-based TENG(LP-TENG).Owing to the intrinsically liquid feature of conductive LM within the flexible PVA hydrogel,the as-prepared LP-TENG exhibited comprehensiye advantages of adaptability,biocompatibility,outstanding electrical performance,superior stability,recyclability and diverse applications,which were unattainable by traditional systems.Concretely,the LP-TENG delivered appealing open circuit voltage of 250 V,short circuit current of 4μA and transferred charge of 120 nC with high stability,outperforming most advanced TENG systems.The LP-TENG was successfully employed for versatile applications with multifunctionality,including human motion detection,handwriting recognition,energy collection,message transmission and human-machine interaction.This work presents significant prospects for crafting advanced materials and devices in the fields of wearable electronics,flexible skin and smart robots.展开更多
Magnesium hydride(MgH2) is one of the most promising hydrogen storage materials for practical application due to its favorable reversibility, low cost and environmental benign;however, it suffers from high dehydrogena...Magnesium hydride(MgH2) is one of the most promising hydrogen storage materials for practical application due to its favorable reversibility, low cost and environmental benign;however, it suffers from high dehydrogenation temperature and slow sorption kinetics.Exploring proper catalysts with high and sustainable activity is extremely desired for substantially improving the hydrogen storage properties of MgH2. In this work, a composite catalyst with high-loading of ultrafine Ni nanoparticles(NPs) uniformly dispersed on porous hollow carbon nanospheres is developed, which shows superior catalytic activity towards the de-/hydrogenation of MgH2. With an addition of 5wt% of the composite, which contains 90 wt% Ni NPs, the onset and peak dehydrogenation temperatures of MgH2are lowered to 190 and 242 ℃, respectively. 6.2 wt% H2is rapidly released within 30 min at 250 ℃. The amount of H2that the dehydrogenation product can absorb at a low temperature of 150 ℃ in only 250 s is very close to the initial dehydrogenation value. A dehydrogenation capacity of 6.4wt% remains after 50 cycles at a moderate cyclic regime, corresponding to a capacity retention of 94.1%. The Ni NPs are highly active,reacting with MgH2and forming nanosized Mg2Ni/Mg2NiH4. They act as catalysts during hydrogen sorption cycling, and maintain a high dispersibility with the help of the dispersive role of the carbon substrate, leading to sustainably catalytic activity. The present work provides new insight into designing stable and highly active catalysts for promoting the(de)hydrogenation kinetics of MgH2.展开更多
A simple method was proposed to activate alkaline Cu(OH)_(2)with an acidic ionomer,Nafion,to regulate its surface microenvironment,including hydrophobicity and local basicity.In particular,the direct complete neutrali...A simple method was proposed to activate alkaline Cu(OH)_(2)with an acidic ionomer,Nafion,to regulate its surface microenvironment,including hydrophobicity and local basicity.In particular,the direct complete neutralization reaction between Cu(OH)_(2)and Nafion in aqueous solution induces the exposing of vast anions which can exclude the in-situ-formed hydroxides and raise the local basicity.Remarkably,the optimal Nafionactivated Cu(OH)_(2)-derived Cu can efficiently suppress the hydrogen evolution reaction(HER)and improve the selectivity for multi-carbon products in the CO_(2)electroreduction reaction(eCO_(2)RR).The H2 Faradaic efficiency(FE)decreased to 11%at a current density of 300 mA/cm2(−0.76 V vs.RHE)in a flow cell,while the bare one with H2 had an FE of 40%.The total eCO_(2)RR FE reaches as high as 83%,along with an evidently increased C2H4 FE of 44%as compared with the bare one(24%),and good stability(8000 s),surpassing that of most of the reported Cu(OH)_(2)-derived Cu.The experimental and theoretical results both show that the strong hydrophobicity and high local basicity jointly boosted the eCO_(2)RR as acquired by felicitously introducing ionomer on the Cu(OH)_(2)-derived Cu surface.展开更多
Polyimide(PI)synthesized from aromatic diamine and dianhydrides via two-step poly-condensation method was highly soluble in TGDDM(MY-720)and DGEBA(E-51)at desirable temperature.TGDDM-PI(M-PI)and DGEBA-PI(E-PI)composit...Polyimide(PI)synthesized from aromatic diamine and dianhydrides via two-step poly-condensation method was highly soluble in TGDDM(MY-720)and DGEBA(E-51)at desirable temperature.TGDDM-PI(M-PI)and DGEBA-PI(E-PI)composites within 0.5%-3%PI loading could be prepared without organic solvent.On the cryogenically fractured surfaces of M-PI and E-PI composites,no obvious heterogeneous phase was observed by SEM.The mechanical properties were promoted significantly by PI,especially for impact strength.Adding 2%PI-2W into MY-720 and E-51 composites,the impact strength increased to 21 and 51 kJ/m2,the tensile strength increased by 62%and 19%,and the flexural strength by 18%and 13%,respectively,with slight increases in tensile modulus.These results were related to the promotion in plasticity of composites and changes in fragile→ductile fracture mode.Moreover,Tg and thermal stability of M-PI and E-PI were increased effectively.展开更多
The shuttle effect of polysulfides is a major challenge for the commercialization of lithium-sulfur battery.The systematic modification of separators has the potential to solve these problems by enhancing the adsorpti...The shuttle effect of polysulfides is a major challenge for the commercialization of lithium-sulfur battery.The systematic modification of separators has the potential to solve these problems by enhancing the adsorption and catalytic conversion of polysulfides.Herein,strong internal electric field bismuth oxycarbonate(Bi_(2)O_(2)CO_(3))nanoflowers decorated conductive carbon(DC+BOC)is proposed to be systematically modified on separator.This intermediate layer not only possesses a strong affinity for polysulfides,but also promotes the conversion of polysulfides and induces the formation of a stable solid electrolyte interphase(SEI)layer,thereby improving the rate performance and cycling stability of the battery.As expected,the modified membrane achieved a high specific capacity of 713 mA h g^(-1) at 5 C.At 1 C,high reversibility of 719 mA h g^(-1) was achieved after 550 cycles with only 0.044%decay per cycle.More importantly,under the sulfur loading of 5.1 mg cm^(-2),the area specific capacity remained at4.1 mA h cm^(-2) after 200 cycles,and the attenuation rate per cycle was only 0,056%.This work provides a new strategy to overcome the shuttle effect of polysulfide,and shows great potential in the application of high-performance lithium-sulfur batteries.展开更多
The water-lubricated bearings are usually the state of turbulent cavitating flow under high-speed conditions. And the distribution of cavitation bubbles and the interface effect between the two phases have not been in...The water-lubricated bearings are usually the state of turbulent cavitating flow under high-speed conditions. And the distribution of cavitation bubbles and the interface effect between the two phases have not been included in previous studies on high-speed water-lubricated bearings. In order to study the influence of interface effect and cavitation bubble distribution on the dynamic characteristics of high-speed water-lubricated spiral groove thrust bearings(SGTB).A turbulent cavitating flow lubrication model based on two-phase fluid and population balance equation of bubbles was established in this paper. Stiffness and the damping coefficients of the SGTB were calculated using the perturbation pressure equations. An experimental apparatus was developed to verify the theoretical model. Simulating and experimental results show that the small-sized bubbles tend to generate in the turbulent cavitating flow when at a high rotary speed, and the bubbles mainly locate at the edges of the spiral groove. The simulating results also show that the direct stiffness coefficients are increased due to cavitation effect, and cross stiffness coefficients and damping coefficients are hardly affected by the cavitation effect. Turbulent effect on the dynamic characteristics of SGTB is much stronger than the cavitating effect.展开更多
基金Supported by the Medical Talents of Wuhan Health and Family Planning Commission,No.2017[51](to Yu J)the Medical Talents of Wuhan Hospital of Traditional Chinese and Western Medicine(to Yu J)+1 种基金the Hubei Natural Science Foundation,No.2023AFB1091Wuhan Medical Research Project,No.WX23A36(to Yu J).
文摘BACKGROUND Cholangiocarcinoma(CCA),also known as bile duct cancer,is a devastating malignancy primarily affecting the biliary tract.AIM To assess their performance in clinical diagnosis and monitoring of CCA,plasma methylation and circulating tumor cells were detected.METHODS Plasma samples were collected from Hubei Cancer Hospital(n=156).Plasma DNA was tested to detect SHOX2,HOXA9,SEPTIN9,and RASSF1A methylation using TaqMan PCR.Circulating tumor cells(CTCs)were detected in the peripheral blood of patients using the United States Food and Drug Administration-approved cell search system before and after clinical therapy.The CCA diagnostic value was estimated using the area under the curve.The independent prognosis risk factors for patients with CCA were estimated using Cox and logistic regression analyses.RESULTS The sensitivity and specificity of the four DNA plasma methylations exhibited 64.74%sensitivity and 93.88%specificity for detecting CCA.The receiver operating characteristic curve of the combined value for CCA diagnosis in plasma was 0.828±0.032.RASSF1A plasma methylation was related to the prognosis of patients with CCA.We determined the prognostic hazard ratio for CCA using CTC count,tumor stage,methylation,and carbohydrate antigen 19-9 levels as key factors.Our overall survival nomogram achieved a C-index of 0.705(0.605-0.805).CONCLUSION SHOX2,HOXA9,SEPTIN9,and RASSF1A plasma methylation demonstrated increased sensitivity for diagnosing CCA.RASSF1A plasma methylation and CTCs were valuable predictors to assess CCA prognosis and recurrence.
基金support of the National Natural Science Foundation of China(Nos.52171063,52274362,and 52371049)the Key R&D projects of Henan Province(No.221111230800)+1 种基金the Doctoral Fund of Henan University of Technology(No.2023BS047)the Natural science Project of Zhengzhou Science and Technology Bureau(No.22ZZRDZX04)。
文摘This study investigates the adsorption mechanism,the film formation process,and the inhibition performance of benzotriazole(BTAH)on carbon steels with different grain sizes(i.e.,24.5,4.3,and 0.6μm)in 3.5 wt.%NaCl solution.The results demonstrate that grain refinement significantly impacts the adsorption and inhibition performance of BTAH on carbon steels.Ultra-refinement of steel grains to 0.6μm improves the maximum inhibition efficiency of BTAH to 90.0%within 168 h of immersion,which was much higher than that of the steels with 24.5μm(73.6%)and 4.3μm grain sizes(81.7%).Notably,grain sizes of 4.3 and 0.6μm facilitate a combination of physisorption and chemisorption of BTAH after 120 h of immersion,as evidenced by the X-ray photoelectron spectroscopy(XPS)results and Langmuir adsorption isotherms,while BTAH adsorbed on carbon steels with a grain size of 24.5μm through physisorption during the 168 h of immersion.Ultra-refinement of grains has beneficial impacts on promoting the formation of a stable and dense corrosion inhibitor film,leading to improved corrosion resistance and the mitigation of non-uniform corrosion.These advantageous effects can be attributed to the higher adsorption energy at grain boundaries(approximately-3.12 eV)compared to grain interiors(ranging from-0.79 to 2.47 eV),promoting both the physisorption and chemisorption of organic corrosion inhibitors.The investigation comprehensively illustrates,for the first time,the effects of grain size on the adsorption mechanism,film formation process,and inhibition performance of organic corrosion inhibitors on carbon steels.This study demonstrates a promising approach to enhancing corrosion inhibition performance through microstructural design.
基金funded by the Natural Science Project of the Zhengzhou Science and Technology Bureau(No.22ZZRDZX04).
文摘Photo-assisted Li–O_(2)batteries present a promising avenue for reducing overpotential and enhancing the capacity of next-generation energy storage devices.In this study,we introduce a novel photo-assisted Li–O_(2)system featuring a Z-scheme In_(2)S_(3)/MnO_(2)/BiOCl heterojunction as a photocathode.This innovative design significantly boosts visible light absorption and facilitates the spatial separation of photogenerated electron-hole pairs.The Z-scheme charge transfer pathway establishes efficient channels for enhancing electron transfer and charge separation,thereby fostering high photocatalytic efficiency.During illumination,photo-generated electrons traverse within the band structure,participating in the Oxygen Reduction Reaction(ORR)during discharging,while photo-induced holes in the valence band facilitate the oxidation reaction of discharge products during the charging process.Under illumination,the surface electrons of In_(2)S_(3)/MnO_(2)/BiOCl modify the morphology of the discharge product(Li_(2)O_(2)),leading to accelerated decomposition kinetics of Li_(2)O_(2)during charging.Remarkably,the In_(2)S_(3)/MnO_(2)/BiOCl photoelectrode exhibits a high specific capacity of 19330 mAh/g under illumination,surpassing performance in the dark by a significant margin.This results in an ultranarrow discharge/charge overpotential of 0.19/0.16 V,coupled with excellent cyclic stability and a long cycle life of 1500 h at 200 mA/g.Further surface tests on the photoelectrode demonstrate that light energy application promotes the decomposition of Li_(2)O_(2),corroborated by density function theory(DFT)theoretical calculations.This study of Z-scheme heterostructured photocathodes sheds light on the mechanism of photo-generated charge carriers in Li–O_(2)batteries,providing valuable insights into their functionality and potential for future battery technologies.
基金supported by the National Key Research and Development Program(Grant Nos.2024YFA1611200 and 2023YFA1406500)the National Natural Science Foundation of China(Grant Nos.12141002 and 52088101)the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB1270000)。
文摘Rare-earth based frustrated magnets have attracted great attention as excellent candidates for magnetic refrigeration at sub-Kelvin temperatures,while the experimental identification of systems exhibiting both large volumetric cooling capacity and reduced working temperatures far below 1K remains a challenge.Here,through ultra-low temperature magnetism and thermodynamic characterizations,we unveil the large magnetocaloric effect(MCE)realized at sub-Kelvin temperatures in the frustrated Kagome antiferromagnet Gd_(3)BWO_(9) with T_(N)∼1.0 K.The isothermal magnetization curves indicate the existence of field(B)induced anisotropic magnetic phase diagrams,where four distinct magnetic phases for B‖c-axis and five magnetic phases for B‖ab-plane are identified at T<T_(N).The analysis of magnetic entropy S(B,T)data and direct adiabatic demagnetization tests reveal remarkable cooling performance at sub-Kelvin temperatures featured by a large volumetric entropy density of 502.2 mJ/K/cm^(3)and a low attainable minimal temperature T_(min)∼168mK from the initial cooling condition of 2K and 6 T,surpassing most Gd-based refrigerants previously documented in temperature ranges of 0.25–4 K.The realized T_(min)∼168mK far below T_(N)∼1.0K in Gd_(3)BWO_(9) is related to the combined effects of magnetic frustration and criticality-enhanced MCE,which together leave substantial magnetic entropy at reduced temperatures by enhancing spin fluctuations.
基金supported by the National Natural Science Foundation of China(Grant Nos.12474089,12574102 for L.Y.and L.F.,and 12404102 for J.Z.)the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions(for L.Y.and L.F.)+2 种基金the Natural Science Foundation of the Jiangsu Province(Grant No.BK20230806 for J.Z.)Southeast University Interdisciplinary Research Program for Young Scholars(Grant No.2024FGC1008 for J.Z.)the support by the State Key Laboratory of Solid State Microstructures(Nanjing University)(No.M37067)。
文摘The layered van der Waals(vdW)ferroelectric CuInP_(2)S_(6) (CIPS)exhibits unique cation-hopping-driven phenomena that bring about unconventional properties with intriguing mechanisms and hold promise for advanced applications in nanoelectronics.However,an explicit analysis of its lattice dynamics and vibrational symmetries,pivotal for understanding the material’s peculiar ferroelectric and ferroionic behaviors,remains incomplete.Here,we employ angle-resolved polarized Raman spectroscopy in concert with first-principles calculations to systematically unravel the anisotropic lattice vibrations of CIPS single crystals.By analyzing the polarization-dependent Raman intensities,we determine the symmetry assignments and Raman tensors of all major vibrational modes,revealing good agreement with theoretical predictions.Furthermore,we demonstrate the utility of Raman spectroscopy as a sensitive and non-invasive probe for structural and ferroelectric order evolution by examining temperature-driven phase transitions and thickness-dependent polarization suppression in CIPS.Our findings establish a foundational framework for correlating lattice dynamics with functional properties in CIPS and provide a methodological blueprint for studying other vdW ferroelectrics.
文摘Parkinson’s disease(PD)is a common neurodegenerative disorder with increasing incidence and disability rates globally,placing a heavy burden on patients and their families.In the prodromal phase of PD,nonmotor symptoms,particularly depression and sleep disorders,are frequent,with profound effects on disease progression and patient quality of life.Emerging research highlights the critical role of inflammatory markers-including interleukins and tumor necrosis factor-in the pathogenesis of prodromal PD.These inflammatory mediators participate in neurodegenerative processes and may induce or exacerbate depressive symptoms and sleep disorders by disrupting the function of the hypothala-micpituitary-adrenal axis and affecting neurotransmitter,including serotonin,metabolism.Understanding their correlations with nonmotor symptoms in prodromal PD remains incomplete,limiting our ability to develop targeted interventions.This comprehensive review aims to investigate the specific correlations between inflammatory markers and nonmotor symptoms-particularly depression and sleep disorders-in prodromal PD.The findings could have important practical applications,potentially leading to the development of new diagnostic tools and therapeutic strategies for managing PD.By identifying and understanding these correlations,healthcare providers may better predict disease progression and implement more effective treatments for nonmotor symptoms in PD.
基金supported by the National Natural Science Foundation of China(52272088,52072273 and 51972239)the Zhejiang Provincial Natural Science Foundation of China(LZ21E020001)the Key Lab of Advanced Energy Storage and Conversion(2021HZSY0051)。
文摘Organic cathode materials exhibit higher energy storage capacity,their poor cyclability due to dissolution in liquid organic electrolytes remains a challenge.However,recently,the electrochemical behavior of organopolysulfides incorporating N-heterocycles unveils promising cathode materials with stable cycling performance.Herein,the integration of organosulfides salt as cathodes with solid electrolytes,exemplified by sodium allyl(methyl)carbamodithioate and sodium diethylcarbamodithioate with a polymer solid electrolyte of polyethylene oxide and LiTFSI,addresses the poor electrochemical stability of organic electrodes.Comparative analysis highlights sodium allyl(methyl)carbamodithioate's superior electrochemical performance and stability compared with sodium diethylcarbamodithioate,emphasizing the efficacy of periphery aliphatic modification in enhancing electrode capacity,rate performance,and electrochemical stability for organosulfide materials within all-solid-state lithium organic batteries.We also explore the origin of periphery aliphatic modification in these enhancing electrochemical performances by kinetic analysis and thermodynamic analysis.Furthermore,employing density functional theory calculations and ex situ FTIR experiments elucidates the critical role of the N-C=S structure in the energy storage mechanism.This research advances organic cathode design within organosulfide materials,unlocking the potential of allsolid-state lithium organic batteries with enhanced cyclability,propelling the development of next-generation energy storage systems.
文摘Background and Objective: Concurrent chemoradiotherapy for cervical carcinoma develops rapidly and has become a common and standard therapy in recent years. Both the local control rate and survival rate of patients were increased and the risk of death fell by 30%-50%. This study aimed to explore the efficacy of concurrent chemoradiotherapy plus adjuvant chemotherapy on and the treatment compliance of the patients with advanced cervical squamous cell carcinoma. Methods: A total of 156 patients with stage IIa-IIIb cervical squamous cell carcinoma were randomly divided into the concurrent chemoradiotherapy group (experimental group) and radiotherapy group (control group). Intracavity and external beam radiation therapy were administered. At point A, 40-48 Gy were given by 10-12 fractions; at point B, 46-50 Gy were given by 23-25 fractions. In the same time, experimental group was treated by cisplatin (DDP, 40 mg) on day 1, repeated every week. Ten days after radiation therapy, TP regimen was administered as adjuvant chemotherapy. Results: For the experimental and control groups, the objective response rates were 88.61% and 75.32%, 1-year survival rates were 88.57% and 70.77%, 1-year local control rates were 81.43% and 64.62%, 3-year survival rates were 82.14% and 57.69%, and 3-year local control rates were 75.00% and 46.15%, with significant differences (P < 0.05). Quality of life of all patients were significantly improved after treatment (P< 0.05). Conclusion: Concurrent chemoradiotherapy plus adjuvant chemotherapy for advanced cervical cancer can improve short-term and long-term survival and local control rates of patients, improve the quality of life, and the toxicity can be tolerated.
基金supported by the National Natural Science Foundation of China(31640001 to C.X.,U21A20148 to X.Z.and C.X.)the Presidential Foundation of Hefei Institutes of Physical Science,Chinese Academy of Sciences(Y96XC11131,E26CCG27,and E26CCD15 to C.X.)。
文摘The ability to navigate long distances is essential for many animals to locate shelter,food,and breeding grounds.Magnetic sense has evolved in various migratory and homing species to orient them based on the geomagnetic field.A highly conserved ironsulfur cluster assembly protein IscA is proposed as an animal magnetoreceptor(MagR).Iron-sulfur cluster binding is also suggested to play an essential role in MagR magnetism and is thus critical in animal magnetoreception.In the current study,we provide evidence for distinct iron binding and iron-sulfur cluster binding in MagR in pigeons,an avian species that relies on the geomagnetic field for navigation and homing.Pigeon MagR showed significantly higher total iron content from both iron-and ironsulfur binding.Y65 in pigeon MagR was shown to directly mediate mononuclear iron binding,and its mutation abolished iron-binding capacity of the protein.Surprisingly,both iron binding and iron-sulfur binding demonstrated synergistic effects,and thus appear to be integral and indispensable to pigeon MagR magnetism.These results not only extend our current understanding of the origin and complexity of MagR magnetism,but also imply a possible molecular explanation for the huge diversity in animal magnetoreception.
基金Natural Science Foundation of Xinjiang Province,Grant/Award Numbers:2019D01C064,2020D01A49,2020D01B25,2021D01B40National Natural Science Foundation of China,Grant/Award Numbers:21905209,52072273Tianshan innovation team project of Xinjiang Uygur Autonomous Region,Grant/Award Number:2021D14013。
文摘The persistent increase of CO_(2) levels in the atmosphere,already exceeding 400 ppm,urges the exploration of CO_(2) emission reduction and recycling technologies.Ideally,photocatalytic conversion of CO_(2) into valuable hydrocarbons realizes solar-to-chemical energy conversion,which is a desirable“kill two birds with one stone”strategy;namely,CO_(2) photoreduction can simultaneously tackle energy shortage and keep global carbon balance.Graphitic carbon nitride(g-C_(3)N_(4))working on CO_(2) reduction reaction deserves a highlight not only for the metal-free feature that endows it with low cost,tunable electronic structure,and easy fabrication properties but also because of its strong reduction ability.The present review concisely summarizes the latest advances of g-C_(3)N_(4)-based photocatalysts toward CO_(2) reduction.It starts with the discussion of thermodynamics and dynamics aspects of the CO_(2) reduction process.Then the modification strategies to promote g-C_(3)N_(4)-based photocatalysts in CO_(2) photoreduction have been discussed in detail,including surface functionalization,molecule structure engineering,crystallization,morphology engineering,loading cocatalyst,and constructing heterojunction.Meanwhile,the intrinsic factors affecting CO_(2) reduction activity and selectivity are analyzed and summarized.In the end,the challenges and prospects for the future development of highly g-C_(3)N_(4)-based photocatalysts in CO_(2) reduction are also presented.
基金supported by the National Natural Science Foundation of China(31640001 and T2350005 to C.X.,U21A20148 to X.Z.and C.X.)Ministry of Science and Technology of China(2021ZD0140300 to C.X.)Presidential Foundation of Hefei Institutes of Physical Science,Chinese Academy of Sciences(Y96XC11131,E26CCG27,and E26CCD15 to C.X.,E36CWGBR24B and E36CZG14132 to T.C.)。
文摘Birds exhibit extraordinary mobility and remarkable navigational skills,obtaining guidance cues from the Earth’s magnetic field for orientation and long-distance movement.Bird species also show tremendous diversity in navigation strategies,with considerable differences even within the same taxa and among individuals from the same population.The highly conserved iron and iron-sulfur cluster binding magnetoreceptor(MagR)protein is suggested to enable animals,including birds,to detect the geomagnetic field and navigate accordingly.Notably,MagR is also implicated in other functions,such as electron transfer and biogenesis of iron-sulfur clusters,raising the question of whether variability exists in its biochemical and biophysical features among species,particularly birds.In the current study,we conducted a comparative analysis of MagR from two different bird species,including the migratory European robin(Erithacus rubecula)and the homing pigeon(Columba livia).Sequence alignment revealed an extremely high degree of similarity between the MagRs of these species,with only three sequence variations.Nevertheless,two of these variations underpinned significant differences in metal binding capacity,oligomeric state,and magnetic properties.These findings offer compelling evidence for the marked differences in MagR between the two avian species,potentially explaining how a highly conserved protein can mediate such diverse functions.
基金financially supported by the Natural Science Foundation of China(Nos.22109120,62104170 and 82202757)Zhejiang Provincial Natural Science Foundation of China(Nos.LQ21B030002 and LY23F040001)。
文摘Hydrogel-based triboelectric nanoge nerator(TENG)has a promising applied prospect in wearable electronic devices.However,its low performance,poor stability,insufficient recyclability and inferior self-healing seriously hinder its development.Herein,we report a robust route to a liquid metal(LM)/polyvinyl alcohol(PVA)hydrogel-based TENG(LP-TENG).Owing to the intrinsically liquid feature of conductive LM within the flexible PVA hydrogel,the as-prepared LP-TENG exhibited comprehensiye advantages of adaptability,biocompatibility,outstanding electrical performance,superior stability,recyclability and diverse applications,which were unattainable by traditional systems.Concretely,the LP-TENG delivered appealing open circuit voltage of 250 V,short circuit current of 4μA and transferred charge of 120 nC with high stability,outperforming most advanced TENG systems.The LP-TENG was successfully employed for versatile applications with multifunctionality,including human motion detection,handwriting recognition,energy collection,message transmission and human-machine interaction.This work presents significant prospects for crafting advanced materials and devices in the fields of wearable electronics,flexible skin and smart robots.
基金supported by the National Key Research and Development Program of the Ministry of Science and Technology of PR China (No. 2018YFB1502103)National Natural Science Foundation of PR China (Nos. 52071287, 51571175, U1601212, 51831009)。
文摘Magnesium hydride(MgH2) is one of the most promising hydrogen storage materials for practical application due to its favorable reversibility, low cost and environmental benign;however, it suffers from high dehydrogenation temperature and slow sorption kinetics.Exploring proper catalysts with high and sustainable activity is extremely desired for substantially improving the hydrogen storage properties of MgH2. In this work, a composite catalyst with high-loading of ultrafine Ni nanoparticles(NPs) uniformly dispersed on porous hollow carbon nanospheres is developed, which shows superior catalytic activity towards the de-/hydrogenation of MgH2. With an addition of 5wt% of the composite, which contains 90 wt% Ni NPs, the onset and peak dehydrogenation temperatures of MgH2are lowered to 190 and 242 ℃, respectively. 6.2 wt% H2is rapidly released within 30 min at 250 ℃. The amount of H2that the dehydrogenation product can absorb at a low temperature of 150 ℃ in only 250 s is very close to the initial dehydrogenation value. A dehydrogenation capacity of 6.4wt% remains after 50 cycles at a moderate cyclic regime, corresponding to a capacity retention of 94.1%. The Ni NPs are highly active,reacting with MgH2and forming nanosized Mg2Ni/Mg2NiH4. They act as catalysts during hydrogen sorption cycling, and maintain a high dispersibility with the help of the dispersive role of the carbon substrate, leading to sustainably catalytic activity. The present work provides new insight into designing stable and highly active catalysts for promoting the(de)hydrogenation kinetics of MgH2.
基金National Natural Science Foundation of China,Grant/Award Numbers:52201227,21972126,51872209,52072273Zhejiang Provincial Special Support Program for High-level Talents,Grant/Award Number:2019R52042Key Project of Zhejiang Provincial Natural Science Foundation,Grant/Award Number:LZ20B030001。
文摘A simple method was proposed to activate alkaline Cu(OH)_(2)with an acidic ionomer,Nafion,to regulate its surface microenvironment,including hydrophobicity and local basicity.In particular,the direct complete neutralization reaction between Cu(OH)_(2)and Nafion in aqueous solution induces the exposing of vast anions which can exclude the in-situ-formed hydroxides and raise the local basicity.Remarkably,the optimal Nafionactivated Cu(OH)_(2)-derived Cu can efficiently suppress the hydrogen evolution reaction(HER)and improve the selectivity for multi-carbon products in the CO_(2)electroreduction reaction(eCO_(2)RR).The H2 Faradaic efficiency(FE)decreased to 11%at a current density of 300 mA/cm2(−0.76 V vs.RHE)in a flow cell,while the bare one with H2 had an FE of 40%.The total eCO_(2)RR FE reaches as high as 83%,along with an evidently increased C2H4 FE of 44%as compared with the bare one(24%),and good stability(8000 s),surpassing that of most of the reported Cu(OH)_(2)-derived Cu.The experimental and theoretical results both show that the strong hydrophobicity and high local basicity jointly boosted the eCO_(2)RR as acquired by felicitously introducing ionomer on the Cu(OH)_(2)-derived Cu surface.
基金This work was financially supported by the National Key Research and Development Program of China(No.2016YFC0204300)the National Natural Science Foundation of China(Nos.21777043,21976056).
文摘Polyimide(PI)synthesized from aromatic diamine and dianhydrides via two-step poly-condensation method was highly soluble in TGDDM(MY-720)and DGEBA(E-51)at desirable temperature.TGDDM-PI(M-PI)and DGEBA-PI(E-PI)composites within 0.5%-3%PI loading could be prepared without organic solvent.On the cryogenically fractured surfaces of M-PI and E-PI composites,no obvious heterogeneous phase was observed by SEM.The mechanical properties were promoted significantly by PI,especially for impact strength.Adding 2%PI-2W into MY-720 and E-51 composites,the impact strength increased to 21 and 51 kJ/m2,the tensile strength increased by 62%and 19%,and the flexural strength by 18%and 13%,respectively,with slight increases in tensile modulus.These results were related to the promotion in plasticity of composites and changes in fragile→ductile fracture mode.Moreover,Tg and thermal stability of M-PI and E-PI were increased effectively.
基金financially sponsored by the National Natural Science Foundation of China(51872208 and 52072273)the Zhejiang Provincial Special Support Program for High-level Talents(2019R52042)。
文摘The shuttle effect of polysulfides is a major challenge for the commercialization of lithium-sulfur battery.The systematic modification of separators has the potential to solve these problems by enhancing the adsorption and catalytic conversion of polysulfides.Herein,strong internal electric field bismuth oxycarbonate(Bi_(2)O_(2)CO_(3))nanoflowers decorated conductive carbon(DC+BOC)is proposed to be systematically modified on separator.This intermediate layer not only possesses a strong affinity for polysulfides,but also promotes the conversion of polysulfides and induces the formation of a stable solid electrolyte interphase(SEI)layer,thereby improving the rate performance and cycling stability of the battery.As expected,the modified membrane achieved a high specific capacity of 713 mA h g^(-1) at 5 C.At 1 C,high reversibility of 719 mA h g^(-1) was achieved after 550 cycles with only 0.044%decay per cycle.More importantly,under the sulfur loading of 5.1 mg cm^(-2),the area specific capacity remained at4.1 mA h cm^(-2) after 200 cycles,and the attenuation rate per cycle was only 0,056%.This work provides a new strategy to overcome the shuttle effect of polysulfide,and shows great potential in the application of high-performance lithium-sulfur batteries.
基金Supported by National Natural Science Foundation of China (Grant Nos. 51635004, 11472078)。
文摘The water-lubricated bearings are usually the state of turbulent cavitating flow under high-speed conditions. And the distribution of cavitation bubbles and the interface effect between the two phases have not been included in previous studies on high-speed water-lubricated bearings. In order to study the influence of interface effect and cavitation bubble distribution on the dynamic characteristics of high-speed water-lubricated spiral groove thrust bearings(SGTB).A turbulent cavitating flow lubrication model based on two-phase fluid and population balance equation of bubbles was established in this paper. Stiffness and the damping coefficients of the SGTB were calculated using the perturbation pressure equations. An experimental apparatus was developed to verify the theoretical model. Simulating and experimental results show that the small-sized bubbles tend to generate in the turbulent cavitating flow when at a high rotary speed, and the bubbles mainly locate at the edges of the spiral groove. The simulating results also show that the direct stiffness coefficients are increased due to cavitation effect, and cross stiffness coefficients and damping coefficients are hardly affected by the cavitation effect. Turbulent effect on the dynamic characteristics of SGTB is much stronger than the cavitating effect.
