Objectives Dominant strains of SARS-CoV-2 have been replaced by SARS-CoV-2 JN.1 lineage variants,which have spread widely in a short period of time.However,an accurate detection method and the reason for rapid spread ...Objectives Dominant strains of SARS-CoV-2 have been replaced by SARS-CoV-2 JN.1 lineage variants,which have spread widely in a short period of time.However,an accurate detection method and the reason for rapid spread have not been clarified.Methods Ion Torrent,Illumina,and Nanopore platforms were used to sequence the whole genome of SARSCoV-2 from samples collected from positive cases in the Dalian Center for Disease Control from December 2023 to January 2024.Results The Ion Torrent and Illumina platforms failed to detect some of the variation sites,whereas the optimized Ion Torrent and Nanopore platforms detected all the sites.The Ion Torrent platform had higher sensitivity than the other two platforms and was more suitable for short-read length sequencing;however,the amplicon primers had to be optimized.The Illumina platform was also suitable for short-read length but prone to miss some variation sites.The Nanopore platform was more suitable for long-read length sequencing and had high compatibility for more variation sites.By comparing JN.1 lineage variants with BA.2.86,multiple specific variation sites were detected for the first time in the non-S protein region.Conclusions Timely optimized primers and supplement variation sites provide a more effective means for monitoring and controlling the prevalence of JN.1 lineage variants in advance.The discovery of specific variation sites may indicate the reasons for immune escape and rapid transmission.展开更多
The rapid advancement of flexible electronic technology has enabled the creation of diverse innovative flexible devices,greatly facilitating the development of next-generation intelligent robots.Specifically,the integ...The rapid advancement of flexible electronic technology has enabled the creation of diverse innovative flexible devices,greatly facilitating the development of next-generation intelligent robots.Specifically,the integration of such advanced flexible electronics into robotic systems has significantly enhanced human-robot interaction,improved the level of intelligence of robots,and refined their operational performance.These breakthroughs span various aspects of robotics and reveal substantial application potential.In this review,we categorize flexible electronic devices based on their functional roles and systematically summarize the latest progress in the development of novel flexible electronic components.Furthermore,we conduct in-depth analyses of innovative applications of flexible electronic devices in robotic command input,intelligent decision-making,and the enhancement of manipulation performance.The review comprehensively demonstrates the considerable improvements that flexible electronics bring to intelligent robotic systems.It is hoped that the review can offer valuable insights and inspiration for the future development of flexible electronic devices and novel applications in intelligent robotics.展开更多
Flexible pressure sensors are a key component of electronic skins(e-skins),converting mechanical stimuli into easily analyzed electrical signals.These sensors need to be highly sensitive to respond to small changes in...Flexible pressure sensors are a key component of electronic skins(e-skins),converting mechanical stimuli into easily analyzed electrical signals.These sensors need to be highly sensitive to respond to small changes in external stimuli.However,balancing the trade-off between sensitivity and pressure monitoring range remains a significant challenge.Here,we fabricated a capacitive tunable pressure sensor(TPS),based on the synergistic effect within a composite material,composed of a sponge-like porous structure and thermoplastic expandable microspheres(TEMs).By adjusting the temperature to drive the expansion of the TEMs,mode switching between low and high compression modulus was achieved.This enables high sensitivity(2.39 kPa^(-1))in low compression modulus mode and a wide pressure monitoring range(up to 953.96 kPa)in high compression modulus mode.TPSs are applicable in diverse fields,from detecting subtle pressures like human pulse and respiration to measuring larger pressures based on touch,and even vehicle loads.These sensors can also be integrated with machine learning algorithms for object recognition.The success of TPS is expected to provide new ideas in solving the trade-off between sensitivity and pressure monitoring range of flexible pressure sensors.展开更多
基金supported by grants from the Dalian Science and Technology Innovation Fund(Grant No.2023JJ13SN040)the Dalian Medical Science Research Project(Grant No.2111033).
文摘Objectives Dominant strains of SARS-CoV-2 have been replaced by SARS-CoV-2 JN.1 lineage variants,which have spread widely in a short period of time.However,an accurate detection method and the reason for rapid spread have not been clarified.Methods Ion Torrent,Illumina,and Nanopore platforms were used to sequence the whole genome of SARSCoV-2 from samples collected from positive cases in the Dalian Center for Disease Control from December 2023 to January 2024.Results The Ion Torrent and Illumina platforms failed to detect some of the variation sites,whereas the optimized Ion Torrent and Nanopore platforms detected all the sites.The Ion Torrent platform had higher sensitivity than the other two platforms and was more suitable for short-read length sequencing;however,the amplicon primers had to be optimized.The Illumina platform was also suitable for short-read length but prone to miss some variation sites.The Nanopore platform was more suitable for long-read length sequencing and had high compatibility for more variation sites.By comparing JN.1 lineage variants with BA.2.86,multiple specific variation sites were detected for the first time in the non-S protein region.Conclusions Timely optimized primers and supplement variation sites provide a more effective means for monitoring and controlling the prevalence of JN.1 lineage variants in advance.The discovery of specific variation sites may indicate the reasons for immune escape and rapid transmission.
基金supported by the National Key Research and Development Program of China(2022YFB3204700)the National Natural Science Foundation of China(52575654)+3 种基金the Natural Science Foundation of Chongqing(2023NSCQ-MSX2286)the Key Research and Development Program of Heilongjiang Province(2024ZX01B03)the China Postdoctoral Science Foundation(2025M774298)Postdoctoral Fellowship Program of CPSF(GZC20252733).
文摘The rapid advancement of flexible electronic technology has enabled the creation of diverse innovative flexible devices,greatly facilitating the development of next-generation intelligent robots.Specifically,the integration of such advanced flexible electronics into robotic systems has significantly enhanced human-robot interaction,improved the level of intelligence of robots,and refined their operational performance.These breakthroughs span various aspects of robotics and reveal substantial application potential.In this review,we categorize flexible electronic devices based on their functional roles and systematically summarize the latest progress in the development of novel flexible electronic components.Furthermore,we conduct in-depth analyses of innovative applications of flexible electronic devices in robotic command input,intelligent decision-making,and the enhancement of manipulation performance.The review comprehensively demonstrates the considerable improvements that flexible electronics bring to intelligent robotic systems.It is hoped that the review can offer valuable insights and inspiration for the future development of flexible electronic devices and novel applications in intelligent robotics.
基金National Key Research and Development Program of China,Grant/Award Number:2024YFA0920100National Natural Science Foundation of China,Grant/Award Numbers:52473255,52173237Postdoctoral Fellowship Program of CPSF,Grant/Award Number:GZC20233469。
文摘Flexible pressure sensors are a key component of electronic skins(e-skins),converting mechanical stimuli into easily analyzed electrical signals.These sensors need to be highly sensitive to respond to small changes in external stimuli.However,balancing the trade-off between sensitivity and pressure monitoring range remains a significant challenge.Here,we fabricated a capacitive tunable pressure sensor(TPS),based on the synergistic effect within a composite material,composed of a sponge-like porous structure and thermoplastic expandable microspheres(TEMs).By adjusting the temperature to drive the expansion of the TEMs,mode switching between low and high compression modulus was achieved.This enables high sensitivity(2.39 kPa^(-1))in low compression modulus mode and a wide pressure monitoring range(up to 953.96 kPa)in high compression modulus mode.TPSs are applicable in diverse fields,from detecting subtle pressures like human pulse and respiration to measuring larger pressures based on touch,and even vehicle loads.These sensors can also be integrated with machine learning algorithms for object recognition.The success of TPS is expected to provide new ideas in solving the trade-off between sensitivity and pressure monitoring range of flexible pressure sensors.
