Microorganisms play a vital role in human health through their interactions with the body.Studies of host-microbe mechanisms and interactions are crucial for advancing health management.Recently,the organoid-based mod...Microorganisms play a vital role in human health through their interactions with the body.Studies of host-microbe mechanisms and interactions are crucial for advancing health management.Recently,the organoid-based models have provided new platforms in this field.Derived from human tissues,these models offer several advantages over traditional systems and,when combined with advanced analytical techniques,they enable deeper insights into host-microbe interactions.In this review,we summarize the different models and techniques used,with a particular focus on the newly developed organoid models.We discuss how these models can be effectively utilized in microorganism-host interaction studies and address their associated limitations.展开更多
基金supported by the National Key Research and Development Program of China(2022YFC2304400 and 2022YFC2304401)the Shenzhen Medical Research Fund(D2401023)+4 种基金the National Natural Science Foundation of China(Grant No.82200034)the Natural Science Foundation of Shenzhen(JCYJ20240813115821029)the Sanming Project of Medicine in Shenzhen(SZSM202211035)the Shenzhen Key Medical Discipline(SZXK078)the SUSTech Starting-up Research Grant(Y01416133).
文摘Microorganisms play a vital role in human health through their interactions with the body.Studies of host-microbe mechanisms and interactions are crucial for advancing health management.Recently,the organoid-based models have provided new platforms in this field.Derived from human tissues,these models offer several advantages over traditional systems and,when combined with advanced analytical techniques,they enable deeper insights into host-microbe interactions.In this review,we summarize the different models and techniques used,with a particular focus on the newly developed organoid models.We discuss how these models can be effectively utilized in microorganism-host interaction studies and address their associated limitations.
