Objective This study elucidated the function and role of SUMOylation in type Ⅰ endometrial carcinoma.Methods Fifty type Ⅰ endometrial carcinoma cases and para-cancer tissue samples were collected.The expression leve...Objective This study elucidated the function and role of SUMOylation in type Ⅰ endometrial carcinoma.Methods Fifty type Ⅰ endometrial carcinoma cases and para-cancer tissue samples were collected.The expression levels of ubiquitin-conjugating enzyme E2I(Ube2 i,Ubc9) and small ubiquitin-like modifier 1(SUMO1)/sentrin-specific peptidase 1(SENP1) proteins were examined using immunohistochemistry and the correlation with clinicopathological parameters was analyzed.Results Ubc9 expression in type Ⅰ endometrial carcinoma tissues was significantly higher than that in the para-cancer tissues;in contrast,the expression of the SENP1 protein was markedly lower than that in the para-cancer tissues.Ubc9 and SENP1 expression levels were negatively correlated and were associated with tumor differentiation,but not age,depth of invasion,tumor stage,and lymph node metastasis.Conclusion SUMOylation modification plays a major role in the pathogenesis and development of type Ⅰ endometrial carcinoma.Thus,it could be a potential target for the treatment of endometrial cancer.展开更多
文摘Objective This study elucidated the function and role of SUMOylation in type Ⅰ endometrial carcinoma.Methods Fifty type Ⅰ endometrial carcinoma cases and para-cancer tissue samples were collected.The expression levels of ubiquitin-conjugating enzyme E2I(Ube2 i,Ubc9) and small ubiquitin-like modifier 1(SUMO1)/sentrin-specific peptidase 1(SENP1) proteins were examined using immunohistochemistry and the correlation with clinicopathological parameters was analyzed.Results Ubc9 expression in type Ⅰ endometrial carcinoma tissues was significantly higher than that in the para-cancer tissues;in contrast,the expression of the SENP1 protein was markedly lower than that in the para-cancer tissues.Ubc9 and SENP1 expression levels were negatively correlated and were associated with tumor differentiation,but not age,depth of invasion,tumor stage,and lymph node metastasis.Conclusion SUMOylation modification plays a major role in the pathogenesis and development of type Ⅰ endometrial carcinoma.Thus,it could be a potential target for the treatment of endometrial cancer.
