Objective:Preoperative prediction of microvascular invasion(MVI)in patients with hepatocellular cancer(HCC)is important for developing surgical strategy.We aimed to develop and validate a combined intratumoral and per...Objective:Preoperative prediction of microvascular invasion(MVI)in patients with hepatocellular cancer(HCC)is important for developing surgical strategy.We aimed to develop and validate a combined intratumoral and peritumoral radiomics model based on gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic acid(Gd-EOB-DTPA)-enhanced magnetic resonance imaging(MRI)for preoperative prediction of MVI in primary HCC patients.展开更多
Objective:This study aims to develop prognostic nomograms based on inflammatory markers for hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC)patients.Methods:Between November 2003 and December 2017,1,350HCC...Objective:This study aims to develop prognostic nomograms based on inflammatory markers for hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC)patients.Methods:Between November 2003 and December 2017,1,350HCC patients who were HBV surface antigen(HBsAg)positive and underwent curative hepatectomy were retrospectively collected from two medical centers.展开更多
Objective:Pretreatment prediction of Immunoscore in patients with hepatocellular cancer(HCC)is important for precision immunotherapy.We aimed to develop a radiomics model based on gadolinium-ethoxybenzyl-diethylenetri...Objective:Pretreatment prediction of Immunoscore in patients with hepatocellular cancer(HCC)is important for precision immunotherapy.We aimed to develop a radiomics model based on gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic acid(Gd-EOB-DTPA)-enhanced magnetic resonance imaging(MRI)for pretreatment prediction of Immunoscore(0-2 vs.3-4)in HCC.展开更多
Objective:Tumor size and location may have highly important influence on the treatment choices for hepatocellular carcinoma(HCC).This study aimed to investigate the optimal treatment modality between radiofrequency ab...Objective:Tumor size and location may have highly important influence on the treatment choices for hepatocellular carcinoma(HCC).This study aimed to investigate the optimal treatment modality between radiofrequency ablation(RFA)and repeat hepatectomy according to tumor size and location for solitary small recurrent HCC(rHCC).展开更多
Objective:Treatment strategies for recurrent hepatocellular carcinoma(rHCC)are controversial.We used the status of microvascular invasion(MVI)at primary resection as a marker to choose moderate treatment options for r...Objective:Treatment strategies for recurrent hepatocellular carcinoma(rHCC)are controversial.We used the status of microvascular invasion(MVI)at primary resection as a marker to choose moderate treatment options for rHCC patients with Barcelona Clinic Liver Cancer(BCLC)stage B-C disease.Methods:From June 2009 to June 2017.展开更多
Objective:Microvascular invasion(MVI)is an important risk factor for early recurrence after hepatectomy for hepatocellular carcinoma(HCC).However,it lacks the systemic evidence of the tissue sampling protocol for effi...Objective:Microvascular invasion(MVI)is an important risk factor for early recurrence after hepatectomy for hepatocellular carcinoma(HCC).However,it lacks the systemic evidence of the tissue sampling protocol for efficient MVI detection.This study aims to explore the relationship between the number of sampling sites(NuSS)crossing the tumor interface,the paracancerous parenchyma,and the positive rate of MVI.展开更多
Objective:To develop and validate a radiomics nomogram based on gadolinium-ethoxybenzyl-diethylenetriamine(GdEOB-DTPA)enhanced magnetic resonance imaging(MRI)for pretreatment prediction of Immunoscore(0–2 vs.3–4)in ...Objective:To develop and validate a radiomics nomogram based on gadolinium-ethoxybenzyl-diethylenetriamine(GdEOB-DTPA)enhanced magnetic resonance imaging(MRI)for pretreatment prediction of Immunoscore(0–2 vs.3–4)in hepatocellular carcinoma(HCC)patients.展开更多
Background and Aims:Patients with cirrhosis are at an increased risk of bacterial infection(BI),which is the most common precondition for acute-on-chronic liver fail-ure(ACLF).In this study,we aimed to evaluate the ab...Background and Aims:Patients with cirrhosis are at an increased risk of bacterial infection(BI),which is the most common precondition for acute-on-chronic liver fail-ure(ACLF).In this study,we aimed to evaluate the abil-ity of mitochondria-related indicators(mitochondrial mass and mitochondrial membrane potential(MMP))of T cells in peripheral blood to predict BI and ACLF within 90 days in cirrhotic patients.Methods:We prospectively studied mitochondria-related indicators in various T cells from 235 cirrhotic patients at the Second Hospital of Nanjing.The outcomes of interest were BI and ACLF.Results:The re-stricted cubic spline analysis showed that the MMP of CD8^(+)T cells had a linear relationship with the risk of BI and ACLF(both P<0.001).Multivariable Cox regression analysis demonstrated that the MMP of CD8^(+)T cells was an inde-pendent risk factor for both BI and ACLF(BI:hazard ra-tio 0.96,95%confidence interval 0.94–0.98;P<0.001;ACLF:hazard ratio 0.94,95%confidence interval 0.90–0.97;P<0.001).The MMP of CD8^(+)T cells exhibited better diagnostic efficacy than traditional indices in predicting BI(C index:0.75).The MMP of CD8^(+)T cells,when combined with traditional models(Child-Turcotte-Pugh and model for end-stage liver disease score),improved their diagnostic efficiency in predicting both BI and ACLF.Additionally,the MMP of CD8^(+)T cells showed a significant negative correla-tion with inflammation-related markers(P<0.05).Mito-chondrial damage and abnormally activated mitochondrial autophagy were observed in CD8^(+)T cells from cirrhotic patients with low MMP.Conclusions:The MMP of CD8^(+)T cells could serve as a valuable predictor of BI and ACLF within 90 days in cirrhotic patients.展开更多
Here we presented a novel technology to achieve a Super-hydrophobic coating with microscopic roughness on copper surface. First, make a layer of verdigris grow on the fresh pure copper surface. Gain it by exposing the...Here we presented a novel technology to achieve a Super-hydrophobic coating with microscopic roughness on copper surface. First, make a layer of verdigris grow on the fresh pure copper surface. Gain it by exposing the copper to air and the mist of acetic acid solution. The green coating is a mixture of basic copper（II） carbonate and copper（II） acetate. Second heat the coating and make it decompose to CuO. Lastly, form an n-octadecanethiol self-assembled monolayers coating on the outermost surface. Contact angle test, scanning electron microscope analysis and electrochemical testing were carded out to characterize the surface, and a heat transfer experiment for dropwise condensation of steam was performed also. Results show that the modified surface bears a few Super-hydrophobic features, the static contact angle is higher than that in literatures, reaching 153.1±1.7°. The microscopic roughness can be seen in SEM images, differing much from H2O2 etched surface and bare copper surface. The condensation of steam on the surface is a typical form of dropwise condensation, in the measured range of temperature difference, under 0.1 MPa, the average convection heat transfer coefficients of the vertical surface are 1.7-2.1 times for those of film condensation. At the same time, the inhibition efficiency of surface is improved to some extent comparing with the same kind of SAMs, which suggests that the lifetime of maintenance dropwise condensation would have the possibility to surpass the existing record.展开更多
文摘Objective:Preoperative prediction of microvascular invasion(MVI)in patients with hepatocellular cancer(HCC)is important for developing surgical strategy.We aimed to develop and validate a combined intratumoral and peritumoral radiomics model based on gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic acid(Gd-EOB-DTPA)-enhanced magnetic resonance imaging(MRI)for preoperative prediction of MVI in primary HCC patients.
文摘Objective:This study aims to develop prognostic nomograms based on inflammatory markers for hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC)patients.Methods:Between November 2003 and December 2017,1,350HCC patients who were HBV surface antigen(HBsAg)positive and underwent curative hepatectomy were retrospectively collected from two medical centers.
文摘Objective:Pretreatment prediction of Immunoscore in patients with hepatocellular cancer(HCC)is important for precision immunotherapy.We aimed to develop a radiomics model based on gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic acid(Gd-EOB-DTPA)-enhanced magnetic resonance imaging(MRI)for pretreatment prediction of Immunoscore(0-2 vs.3-4)in HCC.
文摘Objective:Tumor size and location may have highly important influence on the treatment choices for hepatocellular carcinoma(HCC).This study aimed to investigate the optimal treatment modality between radiofrequency ablation(RFA)and repeat hepatectomy according to tumor size and location for solitary small recurrent HCC(rHCC).
文摘Objective:Treatment strategies for recurrent hepatocellular carcinoma(rHCC)are controversial.We used the status of microvascular invasion(MVI)at primary resection as a marker to choose moderate treatment options for rHCC patients with Barcelona Clinic Liver Cancer(BCLC)stage B-C disease.Methods:From June 2009 to June 2017.
文摘Objective:Microvascular invasion(MVI)is an important risk factor for early recurrence after hepatectomy for hepatocellular carcinoma(HCC).However,it lacks the systemic evidence of the tissue sampling protocol for efficient MVI detection.This study aims to explore the relationship between the number of sampling sites(NuSS)crossing the tumor interface,the paracancerous parenchyma,and the positive rate of MVI.
文摘Objective:To develop and validate a radiomics nomogram based on gadolinium-ethoxybenzyl-diethylenetriamine(GdEOB-DTPA)enhanced magnetic resonance imaging(MRI)for pretreatment prediction of Immunoscore(0–2 vs.3–4)in hepatocellular carcinoma(HCC)patients.
基金supported by the Innovation Center for Infectious Disease of Jiangsu Province(No.CXZX202232)Key Projects of Jiangsu Provincial Health Commission(ZD2021061)the SEU Innovation Capability Enhancement Plan for Doctoral Students(CXJH_SEU 24230).
文摘Background and Aims:Patients with cirrhosis are at an increased risk of bacterial infection(BI),which is the most common precondition for acute-on-chronic liver fail-ure(ACLF).In this study,we aimed to evaluate the abil-ity of mitochondria-related indicators(mitochondrial mass and mitochondrial membrane potential(MMP))of T cells in peripheral blood to predict BI and ACLF within 90 days in cirrhotic patients.Methods:We prospectively studied mitochondria-related indicators in various T cells from 235 cirrhotic patients at the Second Hospital of Nanjing.The outcomes of interest were BI and ACLF.Results:The re-stricted cubic spline analysis showed that the MMP of CD8^(+)T cells had a linear relationship with the risk of BI and ACLF(both P<0.001).Multivariable Cox regression analysis demonstrated that the MMP of CD8^(+)T cells was an inde-pendent risk factor for both BI and ACLF(BI:hazard ra-tio 0.96,95%confidence interval 0.94–0.98;P<0.001;ACLF:hazard ratio 0.94,95%confidence interval 0.90–0.97;P<0.001).The MMP of CD8^(+)T cells exhibited better diagnostic efficacy than traditional indices in predicting BI(C index:0.75).The MMP of CD8^(+)T cells,when combined with traditional models(Child-Turcotte-Pugh and model for end-stage liver disease score),improved their diagnostic efficiency in predicting both BI and ACLF.Additionally,the MMP of CD8^(+)T cells showed a significant negative correla-tion with inflammation-related markers(P<0.05).Mito-chondrial damage and abnormally activated mitochondrial autophagy were observed in CD8^(+)T cells from cirrhotic patients with low MMP.Conclusions:The MMP of CD8^(+)T cells could serve as a valuable predictor of BI and ACLF within 90 days in cirrhotic patients.
基金supports of the National Natural Seience Foundation of China (Grant No.50706053)the National High Teelmology Research and Development Program of China(863 Prograrn,Grant No.2007AA052259) are gratefully acknowledged.
文摘Here we presented a novel technology to achieve a Super-hydrophobic coating with microscopic roughness on copper surface. First, make a layer of verdigris grow on the fresh pure copper surface. Gain it by exposing the copper to air and the mist of acetic acid solution. The green coating is a mixture of basic copper（II） carbonate and copper（II） acetate. Second heat the coating and make it decompose to CuO. Lastly, form an n-octadecanethiol self-assembled monolayers coating on the outermost surface. Contact angle test, scanning electron microscope analysis and electrochemical testing were carded out to characterize the surface, and a heat transfer experiment for dropwise condensation of steam was performed also. Results show that the modified surface bears a few Super-hydrophobic features, the static contact angle is higher than that in literatures, reaching 153.1±1.7°. The microscopic roughness can be seen in SEM images, differing much from H2O2 etched surface and bare copper surface. The condensation of steam on the surface is a typical form of dropwise condensation, in the measured range of temperature difference, under 0.1 MPa, the average convection heat transfer coefficients of the vertical surface are 1.7-2.1 times for those of film condensation. At the same time, the inhibition efficiency of surface is improved to some extent comparing with the same kind of SAMs, which suggests that the lifetime of maintenance dropwise condensation would have the possibility to surpass the existing record.
