Bone mesenchymal stem cells(BMSCs)are stem cells located in the bone marrow matrix that have a variety of differentiation potentials and biological functions.They play an important role in bone regenerative medicine.T...Bone mesenchymal stem cells(BMSCs)are stem cells located in the bone marrow matrix that have a variety of differentiation potentials and biological functions.They play an important role in bone regenerative medicine.The senescence of BMsCs might cause accelerated degeneration of bone tissue.Autophagy is a process in which cellular homeostasis is maintained by autophagosomes and lysosomes.It could control the function and senescence of BMSCs during bone aging and might be a therapeutic target for treating diseases during aging.1 Ferroptosis is a regulated cell death process.2 The inhibition of ferroptosis in mesenchymal stem cells could reduce cell injury and might have great therapeutic value.3-5.展开更多
基金supported by the National Natural Science Foundation of China(No.82072425)the Natural Science Foundation of Jiangsu Province,China(No.BK20220059)the Jiangsu Medical Research Project(China)(No.ZD2022021)。
文摘Bone mesenchymal stem cells(BMSCs)are stem cells located in the bone marrow matrix that have a variety of differentiation potentials and biological functions.They play an important role in bone regenerative medicine.The senescence of BMsCs might cause accelerated degeneration of bone tissue.Autophagy is a process in which cellular homeostasis is maintained by autophagosomes and lysosomes.It could control the function and senescence of BMSCs during bone aging and might be a therapeutic target for treating diseases during aging.1 Ferroptosis is a regulated cell death process.2 The inhibition of ferroptosis in mesenchymal stem cells could reduce cell injury and might have great therapeutic value.3-5.
