Dyslipidemia is a significant risk factor for cardiovascular disease.While cross-sectional studies suggest lower odds of dyslipidemia in greener environments,longitudinal research is limited.This prospective cohort st...Dyslipidemia is a significant risk factor for cardiovascular disease.While cross-sectional studies suggest lower odds of dyslipidemia in greener environments,longitudinal research is limited.This prospective cohort study analyzed data from 3,454,623 adults from January 2017 to December 2021,focusing on dyslipidemia and its subtypes.Residential greenness was assessed using vegetation indices and greenspace percentages.Cox regressions and generalized estimating equation models were used to analyze associations between greenness and dyslipidemia outcomes.Over a median follow-up period of 3.21 years,744,732 cases of dyslipidemia were observed.Greener environments were associated with a reduced risk of dyslipidemia,hypercholesterolemia,hypertriglyceridemia,and hyperbetalipo-proteinemia(hazard ratios ranged from 0.82 to 0.96)and an increased risk of hypoalphalipoproteinemia(hazard ratios were 1.12 to 1.15).Higher greenness levels were linked to lower serum lipids.These associations were stronger among older adults and those with higher education.Mediation analyses showed that lower air pollution,temperature,and higher physical activity accounted for 2.08−33.72%of the associations between greenness and dyslipidemia.Our findings suggest that greenspace exposure can be incorporated into dyslipidemia etiology and prevention strategies.Nature therapies like forest bathing can be supplementary strategies.展开更多
Hyperglycemia is a key risk factor for death and disability worldwide.To better inform prevention strategies,we aimed to delineate and predict the temporal,spatial,and demographic patterns in mean fasting plasma gluco...Hyperglycemia is a key risk factor for death and disability worldwide.To better inform prevention strategies,we aimed to delineate and predict the temporal,spatial,and demographic patterns in mean fasting plasma glucose(FPG)levels and their related disease burden globally.Based on the Global Burden of Disease Study 2019,we estimated the distributions of mean FPG levels and high FPG-related disease burden by age,sex,year,socioeconomic status(SES),and geographical region from 1990 to 2050.展开更多
The invasion and metastasis of breast cancer are supposed to involve several stages in which epithelial-mesenchymal transition(EMT)is regarded as the mechan-istic basis for the behavior of cancer cells.A series of fac...The invasion and metastasis of breast cancer are supposed to involve several stages in which epithelial-mesenchymal transition(EMT)is regarded as the mechan-istic basis for the behavior of cancer cells.A series of factors related to EMT are apparently involved in such process.The current study aimed to investigate the contributions of EMT and related factors in lymph node metastasis of breast cancer.The expressions of E-cadherin(E-Cad),N-cadherin(N-Cad),vascular endothelial cell growth factor(VEGF),matrix metalloproteinase-9(MMP-9),cyclooxygenase-2(COX-2),and CD34 were examined in 74 cases of breast cancer,including 39 cases with lymph node metastasis and 35 cases without lymph node metastasis by immunohistochemistry.Multivariable Cox proportional hazards model was used to analyze the patients’prognosis.The expressions of N-Cad,VEGF,MMP-9,and COX-2 in cases with lymph node metastasis were significantly higher than those without lymph node metastasis(P<0.05),while the E-Cad level was inversely related to status of lymph node metastasis(P<0.05).The metastasis rate of lymph node in the cases with EMT(lower E-Cad expression and higher N-Cad expression)was 78.3%,while that without EMT(higher E-Cad expression and lower N-Cad expression)was 11.1%.There was a statistical difference in the expression of COX-2 protein between histological grade I and grade II or III,respectively(P<0.05).In the cases with higher grade,the expression of E-Cad was decreased,while that of N-Cad was increased.Higher microvascular density(MVD)was also found to be significantly associated with lymphatic metastasis(P<0.05),and the cases with higher MVD had shorter survival time.This study indicates that EMT and expressions of VEGF,MMP-9 and COX-2,and MVD value are strongly correlated with lymph node metastasis in breast cancer.展开更多
基金supported by the Key Research and Development Program of Xinjiang Uyghur Autonomous Region(2022B03032,2022B03032-1)the National Natural Science Foundation of China(No.81972992)Guangzhou Science and Technology Plan Project(202201011616).
文摘Dyslipidemia is a significant risk factor for cardiovascular disease.While cross-sectional studies suggest lower odds of dyslipidemia in greener environments,longitudinal research is limited.This prospective cohort study analyzed data from 3,454,623 adults from January 2017 to December 2021,focusing on dyslipidemia and its subtypes.Residential greenness was assessed using vegetation indices and greenspace percentages.Cox regressions and generalized estimating equation models were used to analyze associations between greenness and dyslipidemia outcomes.Over a median follow-up period of 3.21 years,744,732 cases of dyslipidemia were observed.Greener environments were associated with a reduced risk of dyslipidemia,hypercholesterolemia,hypertriglyceridemia,and hyperbetalipo-proteinemia(hazard ratios ranged from 0.82 to 0.96)and an increased risk of hypoalphalipoproteinemia(hazard ratios were 1.12 to 1.15).Higher greenness levels were linked to lower serum lipids.These associations were stronger among older adults and those with higher education.Mediation analyses showed that lower air pollution,temperature,and higher physical activity accounted for 2.08−33.72%of the associations between greenness and dyslipidemia.Our findings suggest that greenspace exposure can be incorporated into dyslipidemia etiology and prevention strategies.Nature therapies like forest bathing can be supplementary strategies.
基金funded by the National Key Research and Development Program of China(No.2018YFC10043002018YFC1004301)+1 种基金the National Natural Science Foundation of China(No.81972992)the Central Public-interest Scientific Institution Basal Research Fund of South China Institute of Environmental Sciences,and MEE(PM-zx703-202204-124).
文摘Hyperglycemia is a key risk factor for death and disability worldwide.To better inform prevention strategies,we aimed to delineate and predict the temporal,spatial,and demographic patterns in mean fasting plasma glucose(FPG)levels and their related disease burden globally.Based on the Global Burden of Disease Study 2019,we estimated the distributions of mean FPG levels and high FPG-related disease burden by age,sex,year,socioeconomic status(SES),and geographical region from 1990 to 2050.
文摘The invasion and metastasis of breast cancer are supposed to involve several stages in which epithelial-mesenchymal transition(EMT)is regarded as the mechan-istic basis for the behavior of cancer cells.A series of factors related to EMT are apparently involved in such process.The current study aimed to investigate the contributions of EMT and related factors in lymph node metastasis of breast cancer.The expressions of E-cadherin(E-Cad),N-cadherin(N-Cad),vascular endothelial cell growth factor(VEGF),matrix metalloproteinase-9(MMP-9),cyclooxygenase-2(COX-2),and CD34 were examined in 74 cases of breast cancer,including 39 cases with lymph node metastasis and 35 cases without lymph node metastasis by immunohistochemistry.Multivariable Cox proportional hazards model was used to analyze the patients’prognosis.The expressions of N-Cad,VEGF,MMP-9,and COX-2 in cases with lymph node metastasis were significantly higher than those without lymph node metastasis(P<0.05),while the E-Cad level was inversely related to status of lymph node metastasis(P<0.05).The metastasis rate of lymph node in the cases with EMT(lower E-Cad expression and higher N-Cad expression)was 78.3%,while that without EMT(higher E-Cad expression and lower N-Cad expression)was 11.1%.There was a statistical difference in the expression of COX-2 protein between histological grade I and grade II or III,respectively(P<0.05).In the cases with higher grade,the expression of E-Cad was decreased,while that of N-Cad was increased.Higher microvascular density(MVD)was also found to be significantly associated with lymphatic metastasis(P<0.05),and the cases with higher MVD had shorter survival time.This study indicates that EMT and expressions of VEGF,MMP-9 and COX-2,and MVD value are strongly correlated with lymph node metastasis in breast cancer.
