Objective:To evaluate the efficacy and safety of acupoint application for post-stroke depression(PSD)by regulating gastrointestinal function.A secondary objective is to explore the potential mechanism underlying this ...Objective:To evaluate the efficacy and safety of acupoint application for post-stroke depression(PSD)by regulating gastrointestinal function.A secondary objective is to explore the potential mechanism underlying this approach from the perspective of gut microbiota.Methods:This multicenter,randomized,double-blind(patients and assessors),placebo-controlled trial will enroll 80 patients with PSD,and include a 1-week run-in period,a 4-week treatment phase,and a 12-week follow-up.Eligible participants will randomly be assigned in a 1:1 ratio to either the acupoint application or placebo(non-acupoint)groups.Treatments will be administered thrice weekly for 4 weeks.The primary outcome is change in the Hamilton Rating Scale for Depression(HAMD)score.Secondary outcomes include the Beck Depression Inventory(BDI),36-Item Short-Form Health Survey(SF-36),Barthel Index of Activities of Daily Living,Social Adaptation Self-Evaluation Scale(SASS),and gut microbiota profiling.All outcomes will be assessed at baseline(prior to treatment),during treatment(weeks 2 and 4),and during follow-up(weeks 8,12,and 16).The Treatment Emergent Symptom Scale(TESS)will be used for evaluation throughout the 4-week treatment phase.Discussion:The results of this study will provide important evidence supporting a novel treatment strategy for PSD that targets gastrointestinal regulation,potentially informing future clinical practice.展开更多
Efficient collection of water from fog provides a potential solution to solve the global freshwater shortage problem, particularly in the desert or arid regions. In this work, a flexible and highly efficient fog colle...Efficient collection of water from fog provides a potential solution to solve the global freshwater shortage problem, particularly in the desert or arid regions. In this work, a flexible and highly efficient fog collector was prepared by mimicking the back exoskeleton structure of the Namib desert beetle. The improved fog collector was constructed by a superhydrophobic-superhydrophilic patterned fabric via a simple weaving method, followed by in-situ deposition of copper particles. Compared with the conventional fog collector with a plane structure, the fabric has shown a higher water-harvesting rate at 1432.7 mg/h/cm2,owing to the biomimetic three-dimensional structure, its enhanced condensation performance enabled by the copper coating and the rational distribution of wetting units. The device construction makes use of the widely available textile materials through mature manufacturing technology, which makes it highly suitable for large-scale industrial production.展开更多
Air-borne pollutants in particulate matter(PM)form,produced either physically during industrial processes or certain biological routes,have posed a great threat to human health.Particularly during the current COVID-19...Air-borne pollutants in particulate matter(PM)form,produced either physically during industrial processes or certain biological routes,have posed a great threat to human health.Particularly during the current COVID-19 pandemic,effective filtration of the virus is an urgent matter worldwide.In this review,we first introduce some fundamentals about PM,including its source and classification,filtration mechanisms,and evaluation parameters.Advanced filtration materials and their functions are then summarized,among which polymers and MOFs are discussed in detail together with their antibacterial performance.The discussion on the application is divided into end-of-pipe treatment and source control.Finally,we conclude this review with our prospective view on future research in this area.展开更多
The objectives of this study are to employ the meshless local Petrov-Galerkin method （MLPGM） to solve three-dimensional shell problems. The computational accuracy of MLPGM for shell problems is affected by many fact...The objectives of this study are to employ the meshless local Petrov-Galerkin method （MLPGM） to solve three-dimensional shell problems. The computational accuracy of MLPGM for shell problems is affected by many factors, including the dimension of compact support domain, the dimension of quadrture domain, the number of integral cells and the number of Gauss points. These factors＇ sensitivity analysis is to adopt the Taguchi experimental design technology and point out the dimension of the quadrature domain with the largest influence on the computational accuracy of the present MLPGM for shells and give out the optimum combination of these factors. A few examples are given to verify the reliability and good convergence of MLPGM for shell problems compared to the theoretical or the finite element results.展开更多
[Objectives]This paper aimed to study the chemical composition of Rubus pirifolius Smith[Methods]A preliminary experiment was carried out using the qualitative reactions of various chemical constituents,in order to ro...[Objectives]This paper aimed to study the chemical composition of Rubus pirifolius Smith[Methods]A preliminary experiment was carried out using the qualitative reactions of various chemical constituents,in order to roughly detect the types of chemical constituents that may be contained in R.pirifolius Smith The ethanol extract of R.pirifolius Smith were separated and purified using silica gel column chromatography,silica gel thin-layer chromatography and recrystallization,and the chemicals obtained were identified using mass spectrometry,nuclear magnetic resonance and literature reference.[Results]The main constituents of R.pirifolius Smith are saponins,tannins,flavonoids,phytosterols,triterpenes and anthraquinones.A total of five compounds were isolated from the ethanol extract of R.pirifolius Smith,and they were identified asβ-sitosterol(1),arjunolic acid(2),stigmasterol-3-O-β-D-glucopyranoside(3),euscaphic acid(4)and 3,3′,4-trimethyle llegic acid(5).[Conclusions]Compounds 1,2,3,4 and 5 were isolated from R.pirifolius Smith for the first time.展开更多
Due to increasingly serious environmental problems,many researchers are investigating green cleanenergy to solve the world’s energy supply issues.So the strategy that Au nanoparticles(Au NPs)and bismuth sulfide(Bi2S3...Due to increasingly serious environmental problems,many researchers are investigating green cleanenergy to solve the world’s energy supply issues.So the strategy that Au nanoparticles(Au NPs)and bismuth sulfide(Bi2S3)NPs are used to evenly decorate TiO2 nanotube arrays(TiO2 NTAs)was carried out.Composite materials demonstrated enhanced solar light absorption ability and excellent photoelectrochemical performance.This was attributed to the presence of Bi2S3 NPs with a narrow band gap and the decoration with noble metallic Au NPs which resulted in local surface plasmon resonance(LSPR)effects.The Au/Bi2S3@TiO2 NTAs composites exhibit improved photocatalytic activity for the degradation of methylene blue(MB)under irradiation of UV and visible light.Moreover,the Au/Bi2S3@TiO2 NTAs exhibits high fluorescence emission at 822 nm.Due to the better binding affinity between Bi2S3,TiO2 and Fe3+ions,the synthesized nanocomposites exhibit high selectivity to Fe3+ions.The number of binding sites for Au/Bi2S3@TiO2 NTAs was estimated to be 1.41 according to the double logarithmic regression method.The calculated value of"K"was 1862 M-1.Fluorescence emission intensity decreases with increasing concentration(30μM–5000μM).The detection limit of the synthesized sensor is 0.221μM.展开更多
Multifunctional flexible devices for human motion detection and thermal management raised great at-tention as the problem of the aging population is becoming more and more serious.However,it is still a challenge to en...Multifunctional flexible devices for human motion detection and thermal management raised great at-tention as the problem of the aging population is becoming more and more serious.However,it is still a challenge to endow the devices with excellent stability and wide application scope.Here we prepared a hydrophobic and conductive fabric-based strain sensor for smart fabric via successively coating with poly-dopamine(PDA),polyaniline(PANI),polypyrrole(PPy),and polydimethylsiloxane(PDMS)through in-situ polymerization and dip-coating,which could be used for strain sensor and wearable heater both in air and underwater.The obtained sample exhibited a fast electrical response in 500 ms and could withstand 10,000 times stretching-releasing cycles,additionally,the sample exhibited satisfactory electro-thermal and photo-thermal performances.As a whole,the multifunctional fabric-based devices with excellent performances show great potential to be applied in medical monitoring and personal care,especially for aged and disabled persons.展开更多
Highly sensitive pressure sensors are often deployed in human-machine interaction area,touch screen and human motion detection.However,there are still great challenges to fabricating with high sensitivity pressure sen...Highly sensitive pressure sensors are often deployed in human-machine interaction area,touch screen and human motion detection.However,there are still great challenges to fabricating with high sensitivity pressure sensor with wide-range detection.Herein,we developed a new strategy to fabricate a highly sensitive pressure sensor using sandpaper and improve its detection range using a sacrificial template.It was the fthatirst time to combine microstructure processing with the sacrificial template method to fabricate pressure sensor.The microstructure of sandpaper endowed the sensor with high sensitivity,and the elastic substrate enhanced the sensor ability to resist high pressure without being damaged.The fabricated sensor device exhibits a superior sensitivity of 39.077 kPa-1in the range from 50 kPa to 110 kPa with a broad linear response.Remarkably,high pressure ceiling(<160 kPa) ensures that the sponge could be applied in different practical conditions to monitor a range of subtle human motions including finger,wrist bending,and pulse.For applications,the sensor device can not only detect the foot stepping behavior(0.7 MPa) but also produce an obvious response to an extremely slight paper(9 mg,~0.9 Pa).The successful preparation of this micro-structured elastic sponge material provided new ideas for exploring its potential applications in pressure sensors and flexible wearable electronic devices.展开更多
We demonstrate in-plane field-free-switching spin-orbit torque(SOT)magnetic tunnel junction(MTJ)devices that are capable of low switching current density,fast speed,high reliability,and,most importantly,manufactured u...We demonstrate in-plane field-free-switching spin-orbit torque(SOT)magnetic tunnel junction(MTJ)devices that are capable of low switching current density,fast speed,high reliability,and,most importantly,manufactured uniformly by the 200-mm-wafer platform.The performance of the devices is systematically studied,including their magnetic properties,switch-ing behaviors,endurance and data retention.The successful integration of SOT devices within the 200-mm-wafer manufactur-ing platform provides a feasible way to industrialize SOT MRAMs.It is expected to obtain excellent performance of the devices by further optimizing the MTJ film stacks and the corresponding fabrication processes in the future.展开更多
Stochastic system state estimation subject to the unknown interference input widely exists in many fields,such as the control,communication,signal processing,and fault diagnosis.However,the research results are mostly...Stochastic system state estimation subject to the unknown interference input widely exists in many fields,such as the control,communication,signal processing,and fault diagnosis.However,the research results are mostly limited to the stochastic system in which only the dynamic state model or the measurement model concerns the individual unknown interference input,and the state model and the measurement model are both with the same unknown interference input.State estimate of the stochastic systems where the state model and the measurement model contain dual Unknown Interference inputs(dual-UI)with different physical meanings and mathematical definitions is concerned here.Firstly,the decoupling condition with the Unknown Interference input in the State model(S-UI)is shown,which introduces the decoupled system with the adjacent Measurement concerned Unknown Interference inputs(M-UI)appearing in the state model and the measurement model.Then,through defining the Differential term of the adjacent M-UI(M-UID),the equivalent system with only M-UID in the state model is obtained.Finally,considering the design freedom of the equivalent system,the decoupling filter in the minimum mean square error sense and the adaptive minimum upper filter with different applicable conditions are represented to obtain the optimal and sub-optimal state estimate,respectively.Two simulation cases verify the effectiveness and superiority compared with the traditional methods.展开更多
Orbital angular momentum(OAM),described by an azimuthal phase term expej lθT,has unbound orthogonal states with different topological charges l.Therefore,with the explosive growth of global communication capacity,esp...Orbital angular momentum(OAM),described by an azimuthal phase term expej lθT,has unbound orthogonal states with different topological charges l.Therefore,with the explosive growth of global communication capacity,especially for short-distance optical interconnects,light-carrying OAM has proved its great potential to improve transmission capacity and spectral efficiency in the space-division multiplexing system due to its orthogonality,security,and compatibility with other techniques.Meanwhile,100-m freespace optical interconnects become an alternative solution for the“last mile”problem and provide interbuilding communication.We experimentally demonstrate a 260-m secure optical interconnect using OAM multiplexing and 16-ary quadrature amplitude modulation(16-QAM)signals.We study the beam wandering,power fluctuation,channel cross talk,bit-error-rate performance,and link security.Additionally,we also investigate the link performance for 1-to-9 multicasting at the range of 260 m.Considering that the power distribution may be affected by atmospheric turbulence,we introduce an offline feedback process to make it flexibly controllable.展开更多
Objective:Primary tumor treatment through surgical resection and adjuvant therapy has been extensively studied,but there is a lack of effective strategies and drugs for the treatment of tumor metastases.Here,we descri...Objective:Primary tumor treatment through surgical resection and adjuvant therapy has been extensively studied,but there is a lack of effective strategies and drugs for the treatment of tumor metastases.Here,we describe a functional product based on a combination of compounds,which can be used as an adjuvant therapy and has well-known mechanisms for inhibiting cancer metastases,improving anti-cancer treatment,and enhancing immunity and antioxidant capacity.Our designed combination,named MVBL,consists of four inexpensive compounds:L-selenium-methylselenocysteine(MSC),D-α-tocopheryl succinic acid(VES),β-carotene(β-Ca),and L-lysine(Lys).Methods:The effects of MVBL on cell viability,cell cycle,cell apoptosis,cell migration,cell invasion,reactive oxygen species(ROS),and paclitaxel(PTX)-combined treatment were studied in vitro.The inhibition of tumor metastasis,antioxidation,and immune enhancement capacity of MVBL were determined in vivo.Results:MVBL exhibited higher toxicity to tumor cells than to normal cells.It did not significantly affect the cell cycle of cancer cells,but increased their apoptosis.Wound healing,adhesion,and transwell assays showed that MVBL significantly inhibited tumor cell migration,adhesion,and invasion.MVBL sensitized MDA-MB-231 breast cancer cells to PTX,indicating that it can be used as an adjuvant to enhance the therapeutic effect of chemotherapy drugs.In mice,experimental data showed that MVBL inhibited tumor metastasis,prolonged their survival time,and enhanced their antioxidant capacity and immune function.Conclusions:This study revealed the roles of MVBL in improving immunity and antioxidation,preventing tumor growth,and inhibiting metastasis in vitro and in vivo.MVBL may be used as an adjuvant drug in cancer therapy for improving the survival and quality of life of cancer patients.展开更多
Due to the pulse interference, measurement outliers and artificial modeling errors, the multivariate skew t noise widely exists in the real environment. However, to date, little attention has been paid to the state es...Due to the pulse interference, measurement outliers and artificial modeling errors, the multivariate skew t noise widely exists in the real environment. However, to date, little attention has been paid to the state estimation for systems in which the process noise and the measurement noise are both modeled as the heavy-tailed and skew non-Gaussian noise. In this paper, the multivariate skew t distribution is utilized to model the heavy-tailed and skew non-Gaussian noise. Then a probabilistic graphical form of the multivariate skew t distribution is given and proved. Based on the probabilistic graphical form, a hierarchical Gaussian state space model for stochastic uncertain systems is proposed, which transforms the estimation problem for systems with the heavy-tailed and skew non-Gaussian noises into the one with a hierarchical Gaussian state space model. Next, given the designed Gaussian state space model, the robust Bayesian filter and smoother based on the variational Bayesian inference are proposed to approximately estimate the system state and the unknown noise parameters. Furthermore, the complexity analysis together with the controllability and observability for stochastic uncertain systems with multivariate skew t noises is given. Finally,the simulation results of the target tracking scenario verify the validity of the proposed algorithms.展开更多
基金supported by the Chinese Medicine Development Fund,Hong Kong SAR,China(23B2/027A_R1)the National Natural Science Foundation of China(81704198).
文摘Objective:To evaluate the efficacy and safety of acupoint application for post-stroke depression(PSD)by regulating gastrointestinal function.A secondary objective is to explore the potential mechanism underlying this approach from the perspective of gut microbiota.Methods:This multicenter,randomized,double-blind(patients and assessors),placebo-controlled trial will enroll 80 patients with PSD,and include a 1-week run-in period,a 4-week treatment phase,and a 12-week follow-up.Eligible participants will randomly be assigned in a 1:1 ratio to either the acupoint application or placebo(non-acupoint)groups.Treatments will be administered thrice weekly for 4 weeks.The primary outcome is change in the Hamilton Rating Scale for Depression(HAMD)score.Secondary outcomes include the Beck Depression Inventory(BDI),36-Item Short-Form Health Survey(SF-36),Barthel Index of Activities of Daily Living,Social Adaptation Self-Evaluation Scale(SASS),and gut microbiota profiling.All outcomes will be assessed at baseline(prior to treatment),during treatment(weeks 2 and 4),and during follow-up(weeks 8,12,and 16).The Treatment Emergent Symptom Scale(TESS)will be used for evaluation throughout the 4-week treatment phase.Discussion:The results of this study will provide important evidence supporting a novel treatment strategy for PSD that targets gastrointestinal regulation,potentially informing future clinical practice.
基金National Natural Science Foundation of China(5197206321501127+3 种基金51502185)Natural Science Foundation of Fujian Province(2019J01256)Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX191916)the funds from China postdoctoral science foundation grant(2019TQ0061)。
文摘Efficient collection of water from fog provides a potential solution to solve the global freshwater shortage problem, particularly in the desert or arid regions. In this work, a flexible and highly efficient fog collector was prepared by mimicking the back exoskeleton structure of the Namib desert beetle. The improved fog collector was constructed by a superhydrophobic-superhydrophilic patterned fabric via a simple weaving method, followed by in-situ deposition of copper particles. Compared with the conventional fog collector with a plane structure, the fabric has shown a higher water-harvesting rate at 1432.7 mg/h/cm2,owing to the biomimetic three-dimensional structure, its enhanced condensation performance enabled by the copper coating and the rational distribution of wetting units. The device construction makes use of the widely available textile materials through mature manufacturing technology, which makes it highly suitable for large-scale industrial production.
基金National Natural Science Foundation of China (22075046,51972063)Natural Science Funds for Distinguished Young Scholar of Fujian Province (2020J06038)+2 种基金Natural Science Foundation of Fujian Province (2020J01514,2019J01652,2019J01256)China Postdoctoral Science Foundation (Pre-station) (Project No.2019TQ0061)111 Project (No.D17005).
文摘Air-borne pollutants in particulate matter(PM)form,produced either physically during industrial processes or certain biological routes,have posed a great threat to human health.Particularly during the current COVID-19 pandemic,effective filtration of the virus is an urgent matter worldwide.In this review,we first introduce some fundamentals about PM,including its source and classification,filtration mechanisms,and evaluation parameters.Advanced filtration materials and their functions are then summarized,among which polymers and MOFs are discussed in detail together with their antibacterial performance.The discussion on the application is divided into end-of-pipe treatment and source control.Finally,we conclude this review with our prospective view on future research in this area.
基金the Scientific Foundation of National Outstanding Youth of China(No.50225520)the Science Foundation of Shandong University of Technology of China(No.2006KJM33).
文摘The objectives of this study are to employ the meshless local Petrov-Galerkin method （MLPGM） to solve three-dimensional shell problems. The computational accuracy of MLPGM for shell problems is affected by many factors, including the dimension of compact support domain, the dimension of quadrture domain, the number of integral cells and the number of Gauss points. These factors＇ sensitivity analysis is to adopt the Taguchi experimental design technology and point out the dimension of the quadrature domain with the largest influence on the computational accuracy of the present MLPGM for shells and give out the optimum combination of these factors. A few examples are given to verify the reliability and good convergence of MLPGM for shell problems compared to the theoretical or the finite element results.
基金Supported by Backbone Student Project of Professor Yang Shilin’s Team of Guangxi University of Chinese Medicine(YSL17016).
文摘[Objectives]This paper aimed to study the chemical composition of Rubus pirifolius Smith[Methods]A preliminary experiment was carried out using the qualitative reactions of various chemical constituents,in order to roughly detect the types of chemical constituents that may be contained in R.pirifolius Smith The ethanol extract of R.pirifolius Smith were separated and purified using silica gel column chromatography,silica gel thin-layer chromatography and recrystallization,and the chemicals obtained were identified using mass spectrometry,nuclear magnetic resonance and literature reference.[Results]The main constituents of R.pirifolius Smith are saponins,tannins,flavonoids,phytosterols,triterpenes and anthraquinones.A total of five compounds were isolated from the ethanol extract of R.pirifolius Smith,and they were identified asβ-sitosterol(1),arjunolic acid(2),stigmasterol-3-O-β-D-glucopyranoside(3),euscaphic acid(4)and 3,3′,4-trimethyle llegic acid(5).[Conclusions]Compounds 1,2,3,4 and 5 were isolated from R.pirifolius Smith for the first time.
基金supported by the National Natural Science Foundation of China(Nos.51972063 and 21501127)the 111 Project(No.D17005)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
文摘Due to increasingly serious environmental problems,many researchers are investigating green cleanenergy to solve the world’s energy supply issues.So the strategy that Au nanoparticles(Au NPs)and bismuth sulfide(Bi2S3)NPs are used to evenly decorate TiO2 nanotube arrays(TiO2 NTAs)was carried out.Composite materials demonstrated enhanced solar light absorption ability and excellent photoelectrochemical performance.This was attributed to the presence of Bi2S3 NPs with a narrow band gap and the decoration with noble metallic Au NPs which resulted in local surface plasmon resonance(LSPR)effects.The Au/Bi2S3@TiO2 NTAs composites exhibit improved photocatalytic activity for the degradation of methylene blue(MB)under irradiation of UV and visible light.Moreover,the Au/Bi2S3@TiO2 NTAs exhibits high fluorescence emission at 822 nm.Due to the better binding affinity between Bi2S3,TiO2 and Fe3+ions,the synthesized nanocomposites exhibit high selectivity to Fe3+ions.The number of binding sites for Au/Bi2S3@TiO2 NTAs was estimated to be 1.41 according to the double logarithmic regression method.The calculated value of"K"was 1862 M-1.Fluorescence emission intensity decreases with increasing concentration(30μM–5000μM).The detection limit of the synthesized sensor is 0.221μM.
基金The authors thank the Natural Science Funds for Distin-guished Young Scholar of Fujian Province(No.2020J06038)the National Natural Science Foundation of China(Nos.22075046 and 51972063),the Natural Science Foundation of Fujian Province(2019J01256)+1 种基金the start-up funding from Wenzhou Insti-tute,University of Chinese Academy of Sciences(No.WIU-CASQD2019002)Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province(No.WIBEK181005).
文摘Multifunctional flexible devices for human motion detection and thermal management raised great at-tention as the problem of the aging population is becoming more and more serious.However,it is still a challenge to endow the devices with excellent stability and wide application scope.Here we prepared a hydrophobic and conductive fabric-based strain sensor for smart fabric via successively coating with poly-dopamine(PDA),polyaniline(PANI),polypyrrole(PPy),and polydimethylsiloxane(PDMS)through in-situ polymerization and dip-coating,which could be used for strain sensor and wearable heater both in air and underwater.The obtained sample exhibited a fast electrical response in 500 ms and could withstand 10,000 times stretching-releasing cycles,additionally,the sample exhibited satisfactory electro-thermal and photo-thermal performances.As a whole,the multifunctional fabric-based devices with excellent performances show great potential to be applied in medical monitoring and personal care,especially for aged and disabled persons.
基金financially supported by the National Natural Science Foundation of China (Nos.22075046,51972063,2150112751502185)+2 种基金Natural Science Funds for Distinguished Young Scholar of Fujian Province (No.2020J06038)Natural Science Foundation of Fujian Province (Nos.2020J01514,2019J01652,and2019J01256)111 Project (No.D17005)。
文摘Highly sensitive pressure sensors are often deployed in human-machine interaction area,touch screen and human motion detection.However,there are still great challenges to fabricating with high sensitivity pressure sensor with wide-range detection.Herein,we developed a new strategy to fabricate a highly sensitive pressure sensor using sandpaper and improve its detection range using a sacrificial template.It was the fthatirst time to combine microstructure processing with the sacrificial template method to fabricate pressure sensor.The microstructure of sandpaper endowed the sensor with high sensitivity,and the elastic substrate enhanced the sensor ability to resist high pressure without being damaged.The fabricated sensor device exhibits a superior sensitivity of 39.077 kPa-1in the range from 50 kPa to 110 kPa with a broad linear response.Remarkably,high pressure ceiling(<160 kPa) ensures that the sponge could be applied in different practical conditions to monitor a range of subtle human motions including finger,wrist bending,and pulse.For applications,the sensor device can not only detect the foot stepping behavior(0.7 MPa) but also produce an obvious response to an extremely slight paper(9 mg,~0.9 Pa).The successful preparation of this micro-structured elastic sponge material provided new ideas for exploring its potential applications in pressure sensors and flexible wearable electronic devices.
基金supported by the National Key Research and Development Program of China(Grant Nos.2021YFB3601303,2021YFB3601304,2021YFB3601300)National Natural Science Foundation of China(Nos.62001014 and 62171013)。
文摘We demonstrate in-plane field-free-switching spin-orbit torque(SOT)magnetic tunnel junction(MTJ)devices that are capable of low switching current density,fast speed,high reliability,and,most importantly,manufactured uniformly by the 200-mm-wafer platform.The performance of the devices is systematically studied,including their magnetic properties,switch-ing behaviors,endurance and data retention.The successful integration of SOT devices within the 200-mm-wafer manufactur-ing platform provides a feasible way to industrialize SOT MRAMs.It is expected to obtain excellent performance of the devices by further optimizing the MTJ film stacks and the corresponding fabrication processes in the future.
基金supported by the National Natural Science Foundation of China(Nos.61603040 and 61433003)Yunnan Applied Basic Research Project of China(No.201701CF00037)+1 种基金Guangdong Province Science and Technology Innovation Strategy Special Fund Project,China(No.skjtdzxrwqd2018001)Yunnan Provincial Science and Technology Department Key Research Program(Engineering),China(No.2018BA070)。
文摘Stochastic system state estimation subject to the unknown interference input widely exists in many fields,such as the control,communication,signal processing,and fault diagnosis.However,the research results are mostly limited to the stochastic system in which only the dynamic state model or the measurement model concerns the individual unknown interference input,and the state model and the measurement model are both with the same unknown interference input.State estimate of the stochastic systems where the state model and the measurement model contain dual Unknown Interference inputs(dual-UI)with different physical meanings and mathematical definitions is concerned here.Firstly,the decoupling condition with the Unknown Interference input in the State model(S-UI)is shown,which introduces the decoupled system with the adjacent Measurement concerned Unknown Interference inputs(M-UI)appearing in the state model and the measurement model.Then,through defining the Differential term of the adjacent M-UI(M-UID),the equivalent system with only M-UID in the state model is obtained.Finally,considering the design freedom of the equivalent system,the decoupling filter in the minimum mean square error sense and the adaptive minimum upper filter with different applicable conditions are represented to obtain the optimal and sub-optimal state estimate,respectively.Two simulation cases verify the effectiveness and superiority compared with the traditional methods.
基金supported by the National Natural Science Foundation of China (Grant Nos.62125503,62261160388,and 62101198)the Natural Science Foundation of Hubei Province of China (Grant Nos.2021CFB011 and 2023AFA028)+2 种基金the Key R&D Program of Hubei Province of China (Grant Nos.2020BAB001 and 2021BAA024)Shenzhen Science and Technology Program (Grant No.JCYJ20200109114018750)the Innovation Project of Optics Valley Laboratory (Grant Nos.OVL2021BG004 and OVL2023ZD004).
文摘Orbital angular momentum(OAM),described by an azimuthal phase term expej lθT,has unbound orthogonal states with different topological charges l.Therefore,with the explosive growth of global communication capacity,especially for short-distance optical interconnects,light-carrying OAM has proved its great potential to improve transmission capacity and spectral efficiency in the space-division multiplexing system due to its orthogonality,security,and compatibility with other techniques.Meanwhile,100-m freespace optical interconnects become an alternative solution for the“last mile”problem and provide interbuilding communication.We experimentally demonstrate a 260-m secure optical interconnect using OAM multiplexing and 16-ary quadrature amplitude modulation(16-QAM)signals.We study the beam wandering,power fluctuation,channel cross talk,bit-error-rate performance,and link security.Additionally,we also investigate the link performance for 1-to-9 multicasting at the range of 260 m.Considering that the power distribution may be affected by atmospheric turbulence,we introduce an offline feedback process to make it flexibly controllable.
基金the National Natural Science Foundation of China(Nos.81961138017 and 81703555)the Natural Science Foundation of Fujian Province(Nos.2021J011046 and 2020J01859)+4 种基金the Young and Middle-aged Teacher Education Research Project of Fujian Province(No.JAT200412)the Science and Technology Planning Projects of Fuzhou(No.2021S094)the Science and Technology Planning Projects of Fuzhou Institute of Oceanography(No.2021F08)the Belt&Road Program(No.KXPT-2021-3,CAST)the Ministry of Science and Technology of China(No.2015CB931804)。
文摘Objective:Primary tumor treatment through surgical resection and adjuvant therapy has been extensively studied,but there is a lack of effective strategies and drugs for the treatment of tumor metastases.Here,we describe a functional product based on a combination of compounds,which can be used as an adjuvant therapy and has well-known mechanisms for inhibiting cancer metastases,improving anti-cancer treatment,and enhancing immunity and antioxidant capacity.Our designed combination,named MVBL,consists of four inexpensive compounds:L-selenium-methylselenocysteine(MSC),D-α-tocopheryl succinic acid(VES),β-carotene(β-Ca),and L-lysine(Lys).Methods:The effects of MVBL on cell viability,cell cycle,cell apoptosis,cell migration,cell invasion,reactive oxygen species(ROS),and paclitaxel(PTX)-combined treatment were studied in vitro.The inhibition of tumor metastasis,antioxidation,and immune enhancement capacity of MVBL were determined in vivo.Results:MVBL exhibited higher toxicity to tumor cells than to normal cells.It did not significantly affect the cell cycle of cancer cells,but increased their apoptosis.Wound healing,adhesion,and transwell assays showed that MVBL significantly inhibited tumor cell migration,adhesion,and invasion.MVBL sensitized MDA-MB-231 breast cancer cells to PTX,indicating that it can be used as an adjuvant to enhance the therapeutic effect of chemotherapy drugs.In mice,experimental data showed that MVBL inhibited tumor metastasis,prolonged their survival time,and enhanced their antioxidant capacity and immune function.Conclusions:This study revealed the roles of MVBL in improving immunity and antioxidation,preventing tumor growth,and inhibiting metastasis in vitro and in vivo.MVBL may be used as an adjuvant drug in cancer therapy for improving the survival and quality of life of cancer patients.
基金supported by the National Natural Science Foundation of China (Nos.61603040 and 61433003)Yunnan Applied Basic Research Project of China (No.201701CF00037)Yunnan Provincial Science and Technology Department Key Research Program (Engineering), China (No.2018BA070)。
文摘Due to the pulse interference, measurement outliers and artificial modeling errors, the multivariate skew t noise widely exists in the real environment. However, to date, little attention has been paid to the state estimation for systems in which the process noise and the measurement noise are both modeled as the heavy-tailed and skew non-Gaussian noise. In this paper, the multivariate skew t distribution is utilized to model the heavy-tailed and skew non-Gaussian noise. Then a probabilistic graphical form of the multivariate skew t distribution is given and proved. Based on the probabilistic graphical form, a hierarchical Gaussian state space model for stochastic uncertain systems is proposed, which transforms the estimation problem for systems with the heavy-tailed and skew non-Gaussian noises into the one with a hierarchical Gaussian state space model. Next, given the designed Gaussian state space model, the robust Bayesian filter and smoother based on the variational Bayesian inference are proposed to approximately estimate the system state and the unknown noise parameters. Furthermore, the complexity analysis together with the controllability and observability for stochastic uncertain systems with multivariate skew t noises is given. Finally,the simulation results of the target tracking scenario verify the validity of the proposed algorithms.
