Functional gastrointestinal disorders(FGIDs)are debilitating diseases of the digestive system that severely impair an individual’s qualityof life and impose a significant economic burden.However,themechanisms underly...Functional gastrointestinal disorders(FGIDs)are debilitating diseases of the digestive system that severely impair an individual’s qualityof life and impose a significant economic burden.However,themechanisms underlying the pathogenesis of FGIDs and effective treatment options remain unclear.Transcutaneous auricular vagus nerve stimulation(taVNS),a novel neuromodulation therapy,has shown promising therapeutic outcomes in the treatment of FGIDs.This study conducted a comprehensive analysis of the development of taVNS and its relationshipwith vagus nerve stimulation and explored the clinical application of taVNS inmanaging FGIDs,including functional dyspepsia,irritable bowel syndrome,and functional constipation.Additionally,this study investigated the pathophysiological mechanisms of taVNS in FGIDs and reviewed its application as a holistic treatment approach,aiming to provide new insights into its therapeutic potential.展开更多
基金supported by Scientific and Technological Research Program of Chongqing Municipal Education Commission:Mechanism of taVNS alleviate low-grade inflammation of duodenal mucosa through IRG1/GATA3 signaling pathway(No.KJ2023151103563799)General Program of Natural Science Foundation of Chongqing:Mechanism of auricular point stimulation via the vagus nerve in the treatment of FD based on GATA3 signaling pathway(No.CSTB2022NSCQ-MSX1559)+1 种基金General Program of Natural Science Foundation of Sichuan Province:The mechanism and clinical empirical study of the regulation of ITAGATA3 signaling pathway by AVNS in the treatment of chronic insomnia comorbidities dyspepsia in the elderly(No.24NSFSC1238)To investigate the mechanism of taVNS in treating insomnia based on brain-gut-bacteria axis(No.SQMS2024QNXM-019).
文摘Functional gastrointestinal disorders(FGIDs)are debilitating diseases of the digestive system that severely impair an individual’s qualityof life and impose a significant economic burden.However,themechanisms underlying the pathogenesis of FGIDs and effective treatment options remain unclear.Transcutaneous auricular vagus nerve stimulation(taVNS),a novel neuromodulation therapy,has shown promising therapeutic outcomes in the treatment of FGIDs.This study conducted a comprehensive analysis of the development of taVNS and its relationshipwith vagus nerve stimulation and explored the clinical application of taVNS inmanaging FGIDs,including functional dyspepsia,irritable bowel syndrome,and functional constipation.Additionally,this study investigated the pathophysiological mechanisms of taVNS in FGIDs and reviewed its application as a holistic treatment approach,aiming to provide new insights into its therapeutic potential.
