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Numerical Investigation on the Aerodynamic Noise Generated by a Simplified Double-Strip Pantograph 被引量:2
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作者 Jiawei Shi shuai ge Xiaozhen Sheng 《Fluid Dynamics & Materials Processing》 EI 2022年第2期463-480,共18页
In order to understand the mechanism by which a pantograph can generate aerodynamic noise and grasp its farfield characteristics,a simplified double-strip pantograph is analyzed numerically.Firstly,the unsteady flow f... In order to understand the mechanism by which a pantograph can generate aerodynamic noise and grasp its farfield characteristics,a simplified double-strip pantograph is analyzed numerically.Firstly,the unsteady flow field around the pantograph is simulated in the frame of a large eddy simulation(LES)technique.Then the location of the main noise source is determined using surface fluctuating pressure data and the vortex structures in the pantograph flow field are analyzed by means of the Q-criterion.Based on this,the relationship between the wake vortex and the intensity of the aerodynamic sound source on the pantograph surface is discussed.Finally,the far-field aerodynamic noise is calculated by means of the Ffowcs Williams-Hawkings(FW-H)equation,and the contribution of each component to total noise and the frequency spectrum characteristics are analyzed.The results show that on the pantograph surface where vortex shedding or interaction with the wake of upstream components occurs,the pressure fluctuation is more intense,resulting in strong dipole sources.The far-field aerodynamic noise energy of the pantograph is mainly concentrated in the frequency band below 1500 Hz.The peaks in the frequency spectrum are mainly generated by the base frame,balance arm and the rear strip,which are also the main contributors to the aerodynamic noise. 展开更多
关键词 PANTOGRAPH aerodynamic noise vortex structures noise source FW-H equation
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乳腺X线影像组学标签在预测乳腺癌HER2表达中的价值 被引量:11
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作者 帅鸽 郁义星 +2 位作者 董佳 杨玲 胡春洪 《放射学实践》 CSCD 北大核心 2022年第1期41-47,共7页
目的:探讨乳腺X线摄影影像组学标签在预测乳腺癌HER2表达中的价值。方法:回顾性分析2018年1月-2020年10月在苏州大学附属第一医院及苏州市立医院经病理证实为乳腺癌患者的临床及X线资料。共入组222例女性患者,平均年龄(53.70±14.46... 目的:探讨乳腺X线摄影影像组学标签在预测乳腺癌HER2表达中的价值。方法:回顾性分析2018年1月-2020年10月在苏州大学附属第一医院及苏州市立医院经病理证实为乳腺癌患者的临床及X线资料。共入组222例女性患者,平均年龄(53.70±14.46)岁,其中HER2阳性患者59例,阴性患者163例,苏州大学附属第一医院患者设为训练集(n=154),苏州市立医院患者设为验证集(n=68),对比获得的双乳内外斜位(MLO)和头尾位(CC)X线图像,选取病灶面积较大的乳腺X线图像利用MaZda软件进行图像分割和影像组学特征提取。采用费希尔参数法(Fisher)、分类错误率联合平均相关系数法(POE+ACC)和相关信息测度法(MI)分别进行特征筛选,得到三组特征子集。将准确率最高的特征子集进行Z-Score标准化,再采用二元logistic回归进一步筛选,利用选择特征的线性融合构建影像组学标签,计算每例患者的组学标签得分,并进行受试者工作特征(ROC)曲线分析,计算其预测乳腺癌HER2表达的曲线下面积(AUC)、准确率、敏感度、特异度、阳性预测值和阴性预测值。结果:(POE+ACC)-NDA法筛选出的训练集特征子集准确率最高,为88.31%。在训练集利用逻辑回归筛选特征后获得影像组学标签Radscore=-2.149-0.548×WavEnLH;-4+0.475×Kurtosis-0.765×Perc.01%-0.703×WavEnHH;-5-0.513×Teta4+1.069×135dr;hrtREmp-3.831×WavEnHH;-1,在训练集HER2阳性组与阴性组乳腺癌的影像组学得分分别为0.159(-0.357,0.928)和-2.987(-3.997,-1.184),差异有统计学意义(Z=-8.088,P<0.001);在验证集HER2阳性组与阴性组乳腺癌的影像组学得分分别为0.475(-0.412,1.541)和-3.093(-4.126,-1.157),差异有统计学意义(Z=-4.865,P<0.001)。影像组学标签预测训练集乳腺癌HER2表达的AUC、准确率、敏感度、特异度、阳性预测值和阴性预测值分别为0.927(95%可信区间0.881~0.973)、85.4%、87.6%、71.4%、94.3%和87.0%;预测验证集乳腺癌HER2表达的AUC、准确率、敏感度、特异度、阳性预测值和阴性预测值分别为0.889(95%可信区间0.813~0.964)、94.4%、74.0%、56.7%、97.3%和79.4%。结论:乳腺X线摄影影像组学标签可用于术前预测乳腺癌患者HER2表达情况,具有较高的应用价值。 展开更多
关键词 乳腺肿瘤 HER2表达 乳腺X线摄影 影像组学
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MR T1WI瘤体及瘤周影像组学联合临床特征预测乳腺癌新辅助化疗疗效 被引量:20
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作者 徐海敏 戴瑶 +2 位作者 马雨竹 帅鸽 张妤 《中国医学影像技术》 CSCD 北大核心 2023年第10期1520-1525,共6页
目的观察MR T1WI瘤体和瘤周影像组学联合临床特征预测新辅助化疗(NAC)疗效的价值。方法回顾性分析110例接受NAC的乳腺癌患者,其中43例NAC后病理完全缓解(pCR)、67例为非pCR(non-pCR);按7∶3比例将其分为训练集(n=76,30例pCR、46例non-p... 目的观察MR T1WI瘤体和瘤周影像组学联合临床特征预测新辅助化疗(NAC)疗效的价值。方法回顾性分析110例接受NAC的乳腺癌患者,其中43例NAC后病理完全缓解(pCR)、67例为非pCR(non-pCR);按7∶3比例将其分为训练集(n=76,30例pCR、46例non-pCR)和测试集(n=34,13例pCR、21例non-pCR)。以单因素及多因素logistic回归分析训练集临床及MRI表现,筛选NAC用于乳腺癌疗效的独立预测因子,并建立临床模型;于训练集NAC前MR T1WI所示瘤体及瘤周感兴趣体积(VOI)提取并筛选最佳影像组学特征,构建NAC治疗乳腺癌效果预测模型,包括模型_(瘤体)、模型瘤周及模型_(瘤体+瘤周);联合瘤体及瘤周影像组学及临床相关独立预测因子建立联合模型。采用受试者工作特征(ROC)曲线评估模型诊断效能。结果淋巴结转移(OR=0.17)、人表皮生长因子受体2(OR=4.52)及孕激素受体表达(OR=0.20)均为临床相关独立预测因子(P均<0.05)。于瘤体及瘤周VOI各选出4个最佳影像组学特征并构建相应模型。联合模型在训练集的AUC为0.91,高于临床模型、模型_(瘤体)、模型瘤周及模型_(瘤体+瘤周)(AUC分别为0.85、0.72、0.72、0.74,P均<0.05);其在测试集的AUC为0.88,高于模型_(瘤体)(AUC=0.64,P<0.05),与上述各模型的AUC(0.79、0.75、0.75)差异均无统计学意义(P均>0.05)。结论MR T1WI瘤周及瘤体影像组学联合临床特征可有效预测NAC治疗乳腺癌效果。 展开更多
关键词 乳腺肿瘤 磁共振成像 影像组学 新辅助治疗
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Production of 5-Hydroxymethylfurfural from Fructose in Ionic Liquid Efficiently Catalyzed by Cr(III)-Al_(2)O_(3)Catalyst 被引量:1
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作者 Changhua Song Hui Liu +6 位作者 Yuan Li shuai ge Hongwei Wang Wenshuai Zhu Yonghui Chang Changri Han Huaming Li 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2014年第5期434-442,共9页
A series of metal-Al_(2)O_(3)catalysts were prepared simply by the conventional impregnation with Al_(2)O_(3)and metal chlorides,which were applied to the dehydration of fructose to 5-hydroxymethylfurfural(HMF).An agr... A series of metal-Al_(2)O_(3)catalysts were prepared simply by the conventional impregnation with Al_(2)O_(3)and metal chlorides,which were applied to the dehydration of fructose to 5-hydroxymethylfurfural(HMF).An agreeable HMF yield of 93.1%was achieved from fructose at mild conditions(100℃and 40 min)when employing Cr(III)-Al_(2)O_(3)as catalyst in 1-butyl-3-methylimidazolium chloride([Bmim]Cl).The Cr(III)-Al_(2)O_(3)catalyst was characterized via XRD,DRS and Raman spectra and the results clarified the interaction between the Cr(III)and the alumina support.Meanwhile,the reaction solvents([Bmim]Cl)collected after 1st reaction run and 5th reaction run were analyzed by ICP-OES and LC-ITMS and the results confirmed that no Cr(III)ion was dropped off from the alumina support dur-ing the fructose dehydration.Notably,Cr(III)-Al_(2)O_(3)catalyst had an excellent catalytic performance for glucose and sucrose and the HMF yields were reached to 73.7%and 84.1%at 120℃for 60 min,respectively.Furthermore,the system of Cr(III)-Al_(2)O_(3)and[Bmim]Cl exhibited a constant stability and activity at 100℃for 40 min and a fa-vorable HMF yield was maintained after ten recycles. 展开更多
关键词 5-HYDROXYMETHYLFURFURAL [Bmim]Cl Cr(III)-Al_(2)O_(3) FRUCTOSE
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