Dear editor,Sepsis-induced myocardial dysfunction(SIMD)is a distinct type of heart failure(HF)that differs from other forms of HF in its rapid onset,immune storm-driven,and accompanied muti-organ dysfunction.Although ...Dear editor,Sepsis-induced myocardial dysfunction(SIMD)is a distinct type of heart failure(HF)that differs from other forms of HF in its rapid onset,immune storm-driven,and accompanied muti-organ dysfunction.Although SIMD dramatically increases the mortality rate of patients with sepsis from 10% to 40-70%,1 effective pharmacotherapies remain limited.Defects in branched-chain amino acid(BCAA)catabolism and the accumulation of BCAA have been recognized as metabolic hallmarks of HF induced by ischemic injury,hypertension,diabetes,and so on.展开更多
基金supported by grants from the National Natural Science Foundation of China(91849207,92149305,82030017,82271615)the National Key Research and Development Plan(2021YFA0804903,2020YFC2008003,2019YFA0801503)+2 种基金the Medical Epigenetics Research Center,Chinese Academy of Medical Sciences(2017PT31035,2018PT31015)the Science Fund for Excellent Young Scientists Fund(Liaoning Province)(2023JH3/10200014)supported by Xing Liao Ying Cai Programs-Young Talents.
文摘Dear editor,Sepsis-induced myocardial dysfunction(SIMD)is a distinct type of heart failure(HF)that differs from other forms of HF in its rapid onset,immune storm-driven,and accompanied muti-organ dysfunction.Although SIMD dramatically increases the mortality rate of patients with sepsis from 10% to 40-70%,1 effective pharmacotherapies remain limited.Defects in branched-chain amino acid(BCAA)catabolism and the accumulation of BCAA have been recognized as metabolic hallmarks of HF induced by ischemic injury,hypertension,diabetes,and so on.
