In the practical operations of the sodium ion(Na^(+))batteries(SIBs),the fast transport of Na+is desired for the rate performance,because the other ions in an electrolyte are electrochemically inert.In this study,we u...In the practical operations of the sodium ion(Na^(+))batteries(SIBs),the fast transport of Na+is desired for the rate performance,because the other ions in an electrolyte are electrochemically inert.In this study,we use molecular dynamics simulations to investigate the partial conductivity of Na^(+)(σNa^(+))in the salt-in-ionic liquid electrolytes(SILEs)composed of 1-ethyl-3-methylimidazolium(EMIM+)and bis(fluorosulfonyl)imide(FSI^(-))with various molar fraction of Na FSI.The simulations show that while the ionic conductivity of the SILE decreases monotonically with the increase of salt fraction of Na FSI,σNa^(+)peaks in the SILE with 0.5 molar fraction of Na FSI.Detailed analyses indicate that with the increase of salt fraction,the coordination structure of FSI^(-)around Na^(+)changed from bidentate manner to monodentate manner which weakens the binding of FSI-to Na^(+).The effects are two folds.On one hand,the increased monodentate coordinations cause a large aggregate that hinders the transport of Na+within the aggregate;on the other hand,the large aggregate captures most FSI-to form percolating ion network,and thus leaves a small portion of Na^(+)'s that are not in the large aggregate to be more“free”to transport in the SILE.展开更多
Electron-positron colliders operating in the GeV center-of-mass range,or tau-charm energy region,have been proved to enable competitive frontier research due to several unique features.With the progress of high-energy...Electron-positron colliders operating in the GeV center-of-mass range,or tau-charm energy region,have been proved to enable competitive frontier research due to several unique features.With the progress of high-energy physics in the last two decades,a new-generation Tau-Charm factory,called the Super Tau-Charm Facility(STCF),has been actively promoted by the particle physics community in China.STCF has the potential to address fundamental questions such as the essence of color confinement and the matter-antimatter asymmetry within the next decades.The main design goals of the STCF are a center-of-mass energy ranging from 2 to 7 GeV and a luminosity surpassing 5×10^(34)cm^(−2)s^(−1)that is optimized at a center-of-mass energy of 4 GeV,which is approximately 50 times that of the currently operating Tau-Charm factory-BEPCII.The STCF accelerator has two main parts:a double-ring collider with a crab-waist collision scheme and an injector that provides top-up injections for both electron and positron beams.As a typical third-generation electron-positron circular collider,the STCF accelerator faces many challenges in both accelerator physics and technology.In this paper,the conceptual design of the STCF accelerator complex is presented,including the ongoing efforts and plans for technological research and develop-ment,as well as the required infrastructure.The STCF project aims to secure support from the Chinese central government for its construction during the 15th Five-Year Plan(2026-2030).展开更多
Unlike ensemble-averaging measurements,single-molecule tracking provides quantitative information on the kinetics of individual molecules within living cells in real time and may provide insight into the respective mo...Unlike ensemble-averaging measurements,single-molecule tracking provides quantitative information on the kinetics of individual molecules within living cells in real time and may provide insight into the respective molecular interactions behind that.The advancement of single-molecule tracking has been signi-cantly boosted by the development of high-resolution microscopy techniques.In this review,we will discuss this aspect with a particular focus on their recent advance in MINFLUX nanoscopy with feedback approaches where tracking is performed in real time.MINFLUX localization requires fewer than 100 photons from a-1 nm-sized°uorophore,enabling precise tracking.This approach,which demands over an order of magnitude fewer photons than other localization-based techniques(such as STORM,PLAM),allows molecular tracking with single-digit nanometer accuracy in less than 1 ms—an achievement previously unattainable.展开更多
The Kuye River Basin has experienced a rapid depletion of groundwater due to the increased coal production.In this study,by introducing the empirical equations derived from the three zone theory in the coal mining ind...The Kuye River Basin has experienced a rapid depletion of groundwater due to the increased coal production.In this study,by introducing the empirical equations derived from the three zone theory in the coal mining industry in China as a boundary condition,a calculation model was developed by coupling the soil and water assessment tool and visual modular three-dimensional finite-difference ground-water flow model(SWAT-VISUAL MODFLOW).The model was applied to several coal mines in the basin to quantify the groundwater impact of underground mining.For illustration purposes,two underground water observation stations and one water level station were selected for groundwater change simulation in 2009,producing the results that agreed well with the observed data.We found that groundwater level was closely related to the height of the fractured water-conducting zone caused by underground mining,and a higher height led to a lower groundwater level.This finding was further supported by the calculation that underground mining was responsible for 23.20mm aquifer breakages in 2009.Thus,preventing surface subsidence due to underground mining can help protecting the basin's groundwater.展开更多
Objective:To investigate the clinical efficacy of traditional Chinese medicine(TCM)syndrome differentiation in the treatment of patients with gouty nephropathy.Methods:From June 2023 to December 2024,80 patients with ...Objective:To investigate the clinical efficacy of traditional Chinese medicine(TCM)syndrome differentiation in the treatment of patients with gouty nephropathy.Methods:From June 2023 to December 2024,80 patients with gouty nephropathy were selected as samples and randomly divided into two groups:group A received TCM syndrome differentiation treatment,while group B received conventional treatment.The efficacy,laboratory indicators,symptom scores,and safety were compared between the two groups.Results:The efficacy of group A was higher than that of group B(P<0.05).The uric acid,blood urea nitrogen,serum creatinine,and 24-hour urinary protein levels in group A were lower than those in group B(P<0.05).The symptom score of group A was lower than that of group B(P<0.05).The adverse reactions of gouty nephropathy in group A were lower than those in group B(P<0.05).Conclusion:TCM syndrome differentiation treatment for gouty nephropathy can alleviate symptoms,protect renal function,and is highly effective and feasible.展开更多
Objective Hilar cholangiocarcinoma(HC)is invariably fatal without surgical resection.The primary aim of the current study was to determine the safety of variable surgical resections for patient with HC and their survi...Objective Hilar cholangiocarcinoma(HC)is invariably fatal without surgical resection.The primary aim of the current study was to determine the safety of variable surgical resections for patient with HC and their survival after surgical resection.In addition,prognostic factor for the overall survival was also evaluated.Methods The study included 59 consecutive patients who were newly diagnosed with HC and underwent surgical resections with curative intend between February 2009 and February 2017.Patients were followed up at 3-6 months intervals after hospital discharge.Postoperative complications and overall survival were determined.Associations of clinicopathologic and surgeon-related factors with overall survival were evaluated through univariate analysis and Cox regression analysis.Results Of patients with Bismuth and Corlette(B&C)type HI(n=19)and IV(n=25)HC lesions,33(55.9%)were treated with hilar resection combined with major liver resection(MLR),while the other 11 patients with type HI and IV,and those with type I(n=8)and II(n=7)HC lesions were treated with hilar resection.The overall surgical mortality was 5.1%and surgical morbidity was 35.6%.There was no statistical difference in the mortality between MLR group and hilar resection group(6.1%vs.3.8%;X2=0.703,P=0.145).The median follow-up period was 18 months(range,1-94 months).The 1-,3-,5-year survival rate was 59.3%,36.5%,and 17.7%,respectively.The overall survival after resections was 18 months.In HC patients with B&C type III and IV lesions,the median survival was 23 months for hilar resection with MLR and 8 months for hilar resection alone;the 1-,3-,5-year cumulative survival rate was 63.9%,23.3%,and 15.5%,respectively for hilar resection with MLR,and 11.1%,0,and 0,respectively for hilar resection alone,with significant diflerene observed(HR,9.902;95%CI,2.636-19.571,P=0.001).Four factors were independently associated with overall survival:preoperative serum Cal9-9(HR,7.039;95%CI,2.803-17.678,P<0.001),histopathologic grade(HR,4.964;95%CI,1.046-23.552,?=0.044),surgical margins(P=0.031),andAJCC staging(P=0.015).Conclusions R0 resection is efficacious in surgical treatment of HC.MLR in combination with caudate lobe resection may increase the chance of R0 resection and improve survival of HC patients with B&C type IK and IV lesions.Preoperatively prepared for biliary drainage may ensure the safety of MLR in most HC patients.Novel adjuvant therapies are needed to improve the survival of HC patients with poor prognostic factors.展开更多
A simple, water-soluble, Fe3＋-selective fluorescent probe, derived from rhodamine B, was synthesized and characterized. The probe exhibits a fluorescence response toward Fe3＋ with acceptable sensitivity and selectiv...A simple, water-soluble, Fe3＋-selective fluorescent probe, derived from rhodamine B, was synthesized and characterized. The probe exhibits a fluorescence response toward Fe3＋ with acceptable sensitivity and selectivity and even facilitates visual or naked-eye detection of Fe3＋. The experiment results show that the response of the probe to Fe3＋ is pH-independent over a wide range of 4.0-10.0. In addition, fluorescence microscopic imaging experiments have proven that the probe is cell permeable and can be used for monitoring intracellular Fe3＋ in living cells.展开更多
Upon non-equilibrium solidifications, dendrite growth, generally as precursor of as-solidified structures,has severe effects on subsequent phase transformations. Considering synergy of thermodynamics and kinetics cont...Upon non-equilibrium solidifications, dendrite growth, generally as precursor of as-solidified structures,has severe effects on subsequent phase transformations. Considering synergy of thermodynamics and kinetics controlling interface migration and following conservation of heat flux in solid temperature field, a more flexible modeling for the dendrite growth is herein developed for multi-component alloys,where, two inherent problems, i.e. correlation between thermodynamics and kinetics(i.e. the thermokinetic correlation), and theoretical connection between dendrite growth model and practical processing,have been successfully solved. Accordingly, both the thermodynamic driving force G and the effective kinetic energy barrier Qeffhave been found to control quantitatively the dendrite growth(i.e. especially the growth velocity, V), as reflected by the thermo-kinetic trade-off. Compared with previous models, it is the thermo-kinetic correlation that guarantees quantitative connection between the practical processing parameters and the current theoretical framework, as well as more reasonable description for kinetic behaviors involved. Applied to the vertical twin-roll casting(VTC), the present model, realizes a good prediction for kissing points, which influences significantly alloy design and processing optimization.This work deduces quantitatively the thermo-kinetic correlation controlling the dendrite growth, and by proposing the parameter-triplets(i.e. G-Qeff-V), further opens a new beginning for connecting solidification theories with industrial applications, such as the VTC.展开更多
The influences of primary carbide size and type on the sliding wear behavior and rolling contact fatigue (RCF) properties of M50 bearing steel were systematically investigated under oil lubrication condition. A major ...The influences of primary carbide size and type on the sliding wear behavior and rolling contact fatigue (RCF) properties of M50 bearing steel were systematically investigated under oil lubrication condition. A major breakthrough was achieved in the influence of primary carbide on tribological behavior. The opposite effect brought by primary carbide size on the sliding wear resistance and RCF life of M50 bearing steel was determined. Wear resistance increased with an increase in the studied primary carbide size, whereas RCF life decreased significantly. Compared with the 0 R and R positions with a relatively small carbide size, the wear volume of the 1/2 R position with a large carbide size was the smallest. Compared with the 0 R and R positions, the L10 life of the 1/2 R position decreased by 82.7% and 84.8%, respectively. On the basis of the statistical correlation between primary carbide size and the two tribological properties, a critical maximum carbide size of 5-10 μm was proposed to achieve optimal tribological performance. This research suggests that the equivalent diameter of the primary carbide should be controlled to be smaller than 10 μm, but further decreasing primary carbide size to less than 5 μm is unnecessary. The influence of primary carbide type in M50 bearing steel on sliding wear resistance was also discussed. Results indicate that the MC-type carbides with higher elastic modulus and microhardness exhibit better wear resistance than the M2C-type carbides.展开更多
Objective: The effects of arsenic trioxide(As2O3) on hepatocellular carcinoma have been documented widely. Autophagy plays dual roles in the survival and death of cancer cells. Therefore, we investigated the exact rol...Objective: The effects of arsenic trioxide(As2O3) on hepatocellular carcinoma have been documented widely. Autophagy plays dual roles in the survival and death of cancer cells. Therefore, we investigated the exact role of autophagy in As2O3-induced apoptosis in liver cancer cells.Methods: The viability of hepatoma cells was determined using the MTT assay with or without fetal bovine serum. The rate of apoptosis in liver cancer cells treated with As2O3was evaluated using flow cytometry, Hoechst 33258 staining, and TUNEL assays. The rate of autophagy among liver cancer cells treated with As2O3was detected using immunofluorescence, Western blot assay and transmission electron microscopy.Results: Upon treatment with As2O3, the viability of HepG2 and SMMC-7721 cells was decreased in a time-and dose-dependent manner. The apoptosis rates of both liver cancer cell lines increased with the concentration of As2O3, as shown by flow cytometry. Apoptosis in liver cancer cells treated with As2O3was also shown by the activation of the caspase cascade and the regulation of Bcl-2/Bax expression.Furthermore, As2O3treatment induced autophagy in liver cancer cells;this finding was supported by Western blot, immunofluorescence of LC3-II and beclin 1, and transmission electron microscopy. In liver cancer cells, As2O3inhibited the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin(PI3K/AKT/mTOR) signal pathway that plays a vital role in both apoptosis and autophagy. The PI3K activator SC-79 partially reversed As2O3-induced autophagy and apoptosis. Furthermore, inhibiting autophagy with 3-methyladenine partially reversed the negative effects of As2O3on cell viability.Serum starvation increased autophagy and amplified the effect of As2O3on cell death.Conclusion: As2O3induces apoptosis and autophagy in liver cancer cells. Autophagy induced by As2O3may have a proapoptotic effect that helps to reduce the viability of liver cancer cells. This study provides novel insights into the effects of As2O3against liver cancer.展开更多
BACKGROUND Hepatectomy is the first choice for treating neuroendocrine tumor liver metastases.However,most patients with neuroendocrine tumor liver metastases are not suitable for hepatectomy.Ablation combined with he...BACKGROUND Hepatectomy is the first choice for treating neuroendocrine tumor liver metastases.However,most patients with neuroendocrine tumor liver metastases are not suitable for hepatectomy.Ablation combined with hepatectomy can be an alternative to liver resection.AIM To explore the clinical effect of microwave ablation combined with hepatectomy for the treatment of neuroendocrine tumor liver metastases.METHODS In this study,the data of patients who underwent microwave ablation combined with hepatectomy for the treatment of neuroendocrine tumor liver metastases from June 2015 to January 2018 were reviewed.Before the operation,the patients did not receive any treatment for liver neuroendocrine tumors.After a multidisciplinary expert group discussion,all patients were deemed unsuitable for liver resection.All patients were diagnosed with neuroendocrine tumors by pathology.The overall survival time and progression-free survival time were followed by telephone calls and outpatient visits after surgery.RESULTS Eleven patients with neuroendocrine tumor liver metastases were treated by microwave ablation combined with hepatectomy between June 2015 and January 2018.The median number of liver metastatic nodules was 4(range,2 to 43).The median number of lesions resected was 1(range,1 to 18),and the median number of lesions ablated was 3(range,1 to 38).The mean operation time was 405.6(±39.4)min.The median intraoperative blood loss was 600 mL(range,50 to 3000).Ten patients had a fever after surgery.The median duration of fever was 3 d(range,0 to 21).Elevated bilirubin levels occurred in all patients after surgery.The median bilirubin on the first day after surgery was 28.5(range,10.7 to 98.9)μmol/L.One patient developed respiratory failure,renal insufficiency,and pneumonia after the operation.No patient died postoperatively during hospitalization.The mean overall survival time after surgery was 34.1(±3.7)mo,and the median progression-free survival time was 8(range,2 to 51)mo.One year after surgery,ten patients survived and five patients survived without progression.Three year after surgery,eight patients survived and two patients survived without progression.CONCLUSION Microwave ablation combined with hepatectomy not only makes the patients obtain a survival rate similar to that of patients undergoing hepatectomy,but also has a low incidence of postoperative complications.展开更多
The effects of chloride salts(NaCl,MgCl2and NH4Cl)on the hydrolysis kinetics of MgH2prepared by hydridingcombustion synthesis and mechanical milling(HCS+MM)were discussed.X-ray diffraction(XRD)analyses show that high-...The effects of chloride salts(NaCl,MgCl2and NH4Cl)on the hydrolysis kinetics of MgH2prepared by hydridingcombustion synthesis and mechanical milling(HCS+MM)were discussed.X-ray diffraction(XRD)analyses show that high-purityMgH2was successfully prepared by HCS.Hydrolysis performance test results indicate that the chloride salt added during the millingprocess is favorable to the initial reaction rate and hydrogen generation yield within60min.A MgH2?10%NH4Cl composite exhibitsthe best performance with the hydrogen generation yield of1311mL/g and a conversion rate of85.69%in60min at roomtemperature.It is suggested that the chloride salts not only play as grinding aids in the milling process,but also create fresh surface ofreactive materials,favoring the hydrolysis reaction.展开更多
By considering collision-limited growth mode and short-range diffusion-limited growth mode simultaneously,an extended kinetic model for solid−liquid interface with varied kinetic prefactor was developed for binary all...By considering collision-limited growth mode and short-range diffusion-limited growth mode simultaneously,an extended kinetic model for solid−liquid interface with varied kinetic prefactor was developed for binary alloys.Four potential correlations arising from effective kinetics coupling the two growth modes were proposed and studied by application to planar interface migration and dendritic solidification,where the linear correlation between the effective thermodynamic driving force and the effective kinetic energy barrier seems physically realistic.A better agreement between the results of free dendritic growth model and the available experiment data for Ni−0.7at.%B alloy was obtained based on correlation between the thermodynamics and kinetics.As compared to previous models assuming constant kinetic prefactor,a common phenomenon occurring at relatively low undercoolings,i.e.the interface migration slowdown,can be ascribed to both the thermodynamic and the kinetic factors.By considering universality of the correlation between the thermodynamics and kinetics,it is concluded that the correlation should be considered to model the interface kinetics in alloy solidification.展开更多
Considering both the effect of nonisothermal nature of the solid/liquid interface and the microscopic solvability theory (MicST), a further improved version of free dendritic growth model for pure materials was propos...Considering both the effect of nonisothermal nature of the solid/liquid interface and the microscopic solvability theory (MicST), a further improved version of free dendritic growth model for pure materials was proposed. Model comparison indicates that there is a higher temperature at the tip of dendrite predicted by the present model compared with the corresponding model with the isothermal solid/liquid interface assumption. This is attributed to the sidewise thermal diffusion, i.e. the gradient of temperature along the nonisothermal interface. Furthermore, it is indicated that the distinction between the stability criteria from MicST and marginal stability theory (MarST) is more significant with the increase of bath undercoolings. Model test also indicates that the present model can give an agreement with the available experimental data. It is finally concluded that the nonisothermal nature of the solid/liquid interface and the stability criterion from MicST should be taken into account in modeling free dendritic growth.展开更多
BACKGROUND:Shared decision-making(SDM)has broad application in emergencies.Most published studies have focused on SDM for a certain disease or expert opinions on future research gaps without revealing the full picture...BACKGROUND:Shared decision-making(SDM)has broad application in emergencies.Most published studies have focused on SDM for a certain disease or expert opinions on future research gaps without revealing the full picture or detailed guidance for clinical practice.This study is to investigate the optimal application of SDM to guide life-sustaining treatment(LST)in emergencies.METHODS:This study was a prospective two-round Delphi consensus-seeking survey among multiple stakeholders at the China Consortium of Elite Teaching Hospitals for Residency Education.Participants were identified based on their expertise in medicine,law,administration,medical education,or patient advocacy.All individual items and questions in the questionnaire were scored using a 5-point Likert scale,with responses ranging from"very unimportant"(a score of 1)to"extremely important"(a score of 5).The percentages of the responses that had scores of 4-5on the 5-point Likert scale were calculated.A Kendall’s W coefficient was calculated to evaluate the consensus of experts.RESULTS:A two-level framework consisting of 4 domains and 22 items as well as a ready-touse checklist for the informed consent process for LST was established.An acceptable Kendall’s W coefficient was achieved.CONCLUSION:A consensus-based framework supporting SDM during LST in an emergency department can inform the implementation of guidelines for clinical interventions,research studies,medical education,and policy initiatives.展开更多
This work is based on a direct current(DC)natural current commutation topology,which uses load-carrying branch contacts carrying rated current and multiple sets of series arcing branch contacts in parallel to achieve ...This work is based on a direct current(DC)natural current commutation topology,which uses load-carrying branch contacts carrying rated current and multiple sets of series arcing branch contacts in parallel to achieve circuit breaking.The proposed topology can meet the new requirements of higher voltage DC switches in aviation,aerospace,energy and other fields.First,a magneto-hydrodynamic arc model is built using COMSOL Multiphysics,and the different arc breaking characteristics of the arcing branch contacts in different gas environments are simulated.Then,a voltage uniformity coefficient is used to measure the voltage sharing effect in the process of dynamic interruption.In order to solve the dispersion of arcing contact action,a structural control method is adopted to improve the voltage uniformity coefficient.The uniform voltage distribution can improve the breaking capacity and electrical life of the series connection structure.展开更多
In this editorial,we examined a recent article in the World Journal of Gastroenterology that focused on sepsis-associated liver injury(SLI)and its treatment.SLI is a serious complication of sepsis,primarily caused by ...In this editorial,we examined a recent article in the World Journal of Gastroenterology that focused on sepsis-associated liver injury(SLI)and its treatment.SLI is a serious complication of sepsis,primarily caused by microcirculatory disturbances,the gut-liver axis,and inflammatory responses.Specific treatment recommendations for SLI are lacking.The gut-liver axis represents a potential therapeutic target,with metformin showing promise in modulating the gut microbiome and enhancing intestinal barrier function.Although immunomodulatory therapies are being explored,anti-tumor necrosis factor agents and interleukin-1 receptor antagonists have not demonstrated significant clinical benefits.Statins may reduce liver inflammation and prevent injury in sepsis,but their clinical application is limited.Reduced D-related human leucocyte antigen expression on monocytes and lymphocytes suggests immune suppression in patients,indicating that corticosteroids could reverse clinical deterioration in severe infections and address adrenal cortical insufficiency.Current large-scale studies on glucocorticoid therapy for sepsis have yielded mixed results,likely due to inadequate assessment of the immune status of the host.Future research should prioritize the development of personalized immunotherapy tailored to patients’immune profiles,focusing on identifying novel indicators of immune status and advancing immunomodulatory targets and therapeutics for septic patients.展开更多
目的系统检索、评价和整合国内外关于妊娠期糖尿病(GDM)高危人群运动管理的最佳证据,为指导该人群预防GDM提供科学的运动依据。方法采用“6S”金字塔模型,检索UpToDate、BMJ Best Practice等临床决策支持系统及多个国际指南网站,并涵盖P...目的系统检索、评价和整合国内外关于妊娠期糖尿病(GDM)高危人群运动管理的最佳证据,为指导该人群预防GDM提供科学的运动依据。方法采用“6S”金字塔模型,检索UpToDate、BMJ Best Practice等临床决策支持系统及多个国际指南网站,并涵盖PubMed、Embase、Cochrane Library、中国知网等中英文数据库及6个相关协会中GDM高危人群运动干预的最佳证据。采用澳大利亚JBI证据预分级及证据推荐级别系统进行证据分级,依据JBI的证据FAME结构并结合JBI推荐强度分级原则进行证据强度推荐。结果最终纳入文献39篇,包括指南16篇、系统评价17篇、专家共识3篇与证据总结3篇,得到高质量文献21篇(53.8%)、中等质量18篇(46.2%)。共总结GDM高危人群运动前评估、运动风险、运动处方、其他建议及注意事项4个方面的54条最佳证据,其中,证据推荐条目等级为1级的有37条(68.5%)、2级1条(1.8%)、4级9条(16.7%)、5级7条(13.0%)。此外,强烈推荐证据为50条(92.6%)、弱推荐证据为4条(7.4%)。结论研究证据强调了GDM高危人群进行运动前评估的重要性与必要性,建议无禁忌证的GDM高危人群在整个孕期应进行规律的有氧、抗阻或混合性运动,达到每周至少150 min或每天至少30 min,且每周至少3次的中等强度运动来降低GDM的发生风险,减少围产期并发症。同时,鼓励在专业指导下开展个性化、精心设计、有监督的运动计划,以提高运动的安全性与依从性。展开更多
An adaptive support vector machine decision feedback equalizer（ASVM-DFE） based on the least square support vector machine（LS-SVM） is proposed,it solves linear system iteratively with less computational intensity.A...An adaptive support vector machine decision feedback equalizer（ASVM-DFE） based on the least square support vector machine（LS-SVM） is proposed,it solves linear system iteratively with less computational intensity.An adaptive non-singleton fuzzy support vector machine decision feedback equalizer（ANSFSVMDFE） is also presented,it adopts the non-singleton fuzzy Gaussian kernel function with similar characteristic of pre-filter and is modified with a space transformation based approach.Simulations under nonlinear time variant channels show that ASVM-DFE and ANSFSVM-DFE perform very well on nonlinear equalization and ANSFSVM-DFE acts especially well in resisting abrupt interference.展开更多
基金supported by National Natural Science Foundation of China(No.22273040)。
文摘In the practical operations of the sodium ion(Na^(+))batteries(SIBs),the fast transport of Na+is desired for the rate performance,because the other ions in an electrolyte are electrochemically inert.In this study,we use molecular dynamics simulations to investigate the partial conductivity of Na^(+)(σNa^(+))in the salt-in-ionic liquid electrolytes(SILEs)composed of 1-ethyl-3-methylimidazolium(EMIM+)and bis(fluorosulfonyl)imide(FSI^(-))with various molar fraction of Na FSI.The simulations show that while the ionic conductivity of the SILE decreases monotonically with the increase of salt fraction of Na FSI,σNa^(+)peaks in the SILE with 0.5 molar fraction of Na FSI.Detailed analyses indicate that with the increase of salt fraction,the coordination structure of FSI^(-)around Na^(+)changed from bidentate manner to monodentate manner which weakens the binding of FSI-to Na^(+).The effects are two folds.On one hand,the increased monodentate coordinations cause a large aggregate that hinders the transport of Na+within the aggregate;on the other hand,the large aggregate captures most FSI-to form percolating ion network,and thus leaves a small portion of Na^(+)'s that are not in the large aggregate to be more“free”to transport in the SILE.
基金supported by the National Key Research and Development Program of China(No.2022YFA1602200)the National Natural Science Foundation of China(Nos.12341501 and 12405174)the Hefei Comprehensive National Science Center for the strong support on the STCF key technology research project.
文摘Electron-positron colliders operating in the GeV center-of-mass range,or tau-charm energy region,have been proved to enable competitive frontier research due to several unique features.With the progress of high-energy physics in the last two decades,a new-generation Tau-Charm factory,called the Super Tau-Charm Facility(STCF),has been actively promoted by the particle physics community in China.STCF has the potential to address fundamental questions such as the essence of color confinement and the matter-antimatter asymmetry within the next decades.The main design goals of the STCF are a center-of-mass energy ranging from 2 to 7 GeV and a luminosity surpassing 5×10^(34)cm^(−2)s^(−1)that is optimized at a center-of-mass energy of 4 GeV,which is approximately 50 times that of the currently operating Tau-Charm factory-BEPCII.The STCF accelerator has two main parts:a double-ring collider with a crab-waist collision scheme and an injector that provides top-up injections for both electron and positron beams.As a typical third-generation electron-positron circular collider,the STCF accelerator faces many challenges in both accelerator physics and technology.In this paper,the conceptual design of the STCF accelerator complex is presented,including the ongoing efforts and plans for technological research and develop-ment,as well as the required infrastructure.The STCF project aims to secure support from the Chinese central government for its construction during the 15th Five-Year Plan(2026-2030).
基金supported by the Science and Technology Commission of Shanghai Municipality(21DZ1100500)the Shanghai Municipal Science and Technology Major Project+2 种基金the Shanghai Frontiers Science Center Program(2021–2025 No.20)The National Natural Science Foundation of China(32471545)the Natural Science Foundation of Shanghai(24ZR1454300).
文摘Unlike ensemble-averaging measurements,single-molecule tracking provides quantitative information on the kinetics of individual molecules within living cells in real time and may provide insight into the respective molecular interactions behind that.The advancement of single-molecule tracking has been signi-cantly boosted by the development of high-resolution microscopy techniques.In this review,we will discuss this aspect with a particular focus on their recent advance in MINFLUX nanoscopy with feedback approaches where tracking is performed in real time.MINFLUX localization requires fewer than 100 photons from a-1 nm-sized°uorophore,enabling precise tracking.This approach,which demands over an order of magnitude fewer photons than other localization-based techniques(such as STORM,PLAM),allows molecular tracking with single-digit nanometer accuracy in less than 1 ms—an achievement previously unattainable.
基金National Key Research and Development Program of China,Grant/Award Number:2021YFC3201103-01Project Funds of Administration for Market Regulation Henan Province,Grant/Award Number:20241110011+1 种基金Special Funding for Basic Research Expenses for Central Government Departmentaffiliated Institutes,Grant/Award Number:HKYJBYW-2024-06The Open Foundation of the Yellow River Institute of Hydraulic Research,Grant/Award Number:LYBEPR202206。
文摘The Kuye River Basin has experienced a rapid depletion of groundwater due to the increased coal production.In this study,by introducing the empirical equations derived from the three zone theory in the coal mining industry in China as a boundary condition,a calculation model was developed by coupling the soil and water assessment tool and visual modular three-dimensional finite-difference ground-water flow model(SWAT-VISUAL MODFLOW).The model was applied to several coal mines in the basin to quantify the groundwater impact of underground mining.For illustration purposes,two underground water observation stations and one water level station were selected for groundwater change simulation in 2009,producing the results that agreed well with the observed data.We found that groundwater level was closely related to the height of the fractured water-conducting zone caused by underground mining,and a higher height led to a lower groundwater level.This finding was further supported by the calculation that underground mining was responsible for 23.20mm aquifer breakages in 2009.Thus,preventing surface subsidence due to underground mining can help protecting the basin's groundwater.
文摘Objective:To investigate the clinical efficacy of traditional Chinese medicine(TCM)syndrome differentiation in the treatment of patients with gouty nephropathy.Methods:From June 2023 to December 2024,80 patients with gouty nephropathy were selected as samples and randomly divided into two groups:group A received TCM syndrome differentiation treatment,while group B received conventional treatment.The efficacy,laboratory indicators,symptom scores,and safety were compared between the two groups.Results:The efficacy of group A was higher than that of group B(P<0.05).The uric acid,blood urea nitrogen,serum creatinine,and 24-hour urinary protein levels in group A were lower than those in group B(P<0.05).The symptom score of group A was lower than that of group B(P<0.05).The adverse reactions of gouty nephropathy in group A were lower than those in group B(P<0.05).Conclusion:TCM syndrome differentiation treatment for gouty nephropathy can alleviate symptoms,protect renal function,and is highly effective and feasible.
文摘Objective Hilar cholangiocarcinoma(HC)is invariably fatal without surgical resection.The primary aim of the current study was to determine the safety of variable surgical resections for patient with HC and their survival after surgical resection.In addition,prognostic factor for the overall survival was also evaluated.Methods The study included 59 consecutive patients who were newly diagnosed with HC and underwent surgical resections with curative intend between February 2009 and February 2017.Patients were followed up at 3-6 months intervals after hospital discharge.Postoperative complications and overall survival were determined.Associations of clinicopathologic and surgeon-related factors with overall survival were evaluated through univariate analysis and Cox regression analysis.Results Of patients with Bismuth and Corlette(B&C)type HI(n=19)and IV(n=25)HC lesions,33(55.9%)were treated with hilar resection combined with major liver resection(MLR),while the other 11 patients with type HI and IV,and those with type I(n=8)and II(n=7)HC lesions were treated with hilar resection.The overall surgical mortality was 5.1%and surgical morbidity was 35.6%.There was no statistical difference in the mortality between MLR group and hilar resection group(6.1%vs.3.8%;X2=0.703,P=0.145).The median follow-up period was 18 months(range,1-94 months).The 1-,3-,5-year survival rate was 59.3%,36.5%,and 17.7%,respectively.The overall survival after resections was 18 months.In HC patients with B&C type III and IV lesions,the median survival was 23 months for hilar resection with MLR and 8 months for hilar resection alone;the 1-,3-,5-year cumulative survival rate was 63.9%,23.3%,and 15.5%,respectively for hilar resection with MLR,and 11.1%,0,and 0,respectively for hilar resection alone,with significant diflerene observed(HR,9.902;95%CI,2.636-19.571,P=0.001).Four factors were independently associated with overall survival:preoperative serum Cal9-9(HR,7.039;95%CI,2.803-17.678,P<0.001),histopathologic grade(HR,4.964;95%CI,1.046-23.552,?=0.044),surgical margins(P=0.031),andAJCC staging(P=0.015).Conclusions R0 resection is efficacious in surgical treatment of HC.MLR in combination with caudate lobe resection may increase the chance of R0 resection and improve survival of HC patients with B&C type IK and IV lesions.Preoperatively prepared for biliary drainage may ensure the safety of MLR in most HC patients.Novel adjuvant therapies are needed to improve the survival of HC patients with poor prognostic factors.
基金supported by Natural Science Foundation of Fujian Province(No.2013H0019)the Science Foundation of Education Department of Fujian Province(No.JA11064)+1 种基金the Open Foundation of the State Key Laboratory of Fine Chemicals(No.KF1307)the Open Foundation of Ministry of Education Key Laboratory of Synthetic and Natural Functional Molecular Chemistry
文摘A simple, water-soluble, Fe3＋-selective fluorescent probe, derived from rhodamine B, was synthesized and characterized. The probe exhibits a fluorescence response toward Fe3＋ with acceptable sensitivity and selectivity and even facilitates visual or naked-eye detection of Fe3＋. The experiment results show that the response of the probe to Fe3＋ is pH-independent over a wide range of 4.0-10.0. In addition, fluorescence microscopic imaging experiments have proven that the probe is cell permeable and can be used for monitoring intracellular Fe3＋ in living cells.
基金supported financially by the National Key R&D Program of China (Nos. 2017YFB0703001 and 2017YFB0305100)the Natural Science Foundation of China (Nos. 51790483,51790481,51134011,51431008 and 51671075)+3 种基金the Fundamental Research Funds for the Central Universities (No. 3102017jc01002)the Research Fund of the State Key Laboratory of Solidification Processing (Nos. 2019-TZ-01 and 2019-BJ-02)the China Postdoctoral Science Foundation (No. 2018M643729and 2019T120942)the Natural Science Basic Research Plan in Shaanxi Province of China(No. 2019JQ-091)
文摘Upon non-equilibrium solidifications, dendrite growth, generally as precursor of as-solidified structures,has severe effects on subsequent phase transformations. Considering synergy of thermodynamics and kinetics controlling interface migration and following conservation of heat flux in solid temperature field, a more flexible modeling for the dendrite growth is herein developed for multi-component alloys,where, two inherent problems, i.e. correlation between thermodynamics and kinetics(i.e. the thermokinetic correlation), and theoretical connection between dendrite growth model and practical processing,have been successfully solved. Accordingly, both the thermodynamic driving force G and the effective kinetic energy barrier Qeffhave been found to control quantitatively the dendrite growth(i.e. especially the growth velocity, V), as reflected by the thermo-kinetic trade-off. Compared with previous models, it is the thermo-kinetic correlation that guarantees quantitative connection between the practical processing parameters and the current theoretical framework, as well as more reasonable description for kinetic behaviors involved. Applied to the vertical twin-roll casting(VTC), the present model, realizes a good prediction for kissing points, which influences significantly alloy design and processing optimization.This work deduces quantitatively the thermo-kinetic correlation controlling the dendrite growth, and by proposing the parameter-triplets(i.e. G-Qeff-V), further opens a new beginning for connecting solidification theories with industrial applications, such as the VTC.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDC04040402)the financial and facility support for Liaoning Key Laboratory of Aero-engine Material Tribology.
文摘The influences of primary carbide size and type on the sliding wear behavior and rolling contact fatigue (RCF) properties of M50 bearing steel were systematically investigated under oil lubrication condition. A major breakthrough was achieved in the influence of primary carbide on tribological behavior. The opposite effect brought by primary carbide size on the sliding wear resistance and RCF life of M50 bearing steel was determined. Wear resistance increased with an increase in the studied primary carbide size, whereas RCF life decreased significantly. Compared with the 0 R and R positions with a relatively small carbide size, the wear volume of the 1/2 R position with a large carbide size was the smallest. Compared with the 0 R and R positions, the L10 life of the 1/2 R position decreased by 82.7% and 84.8%, respectively. On the basis of the statistical correlation between primary carbide size and the two tribological properties, a critical maximum carbide size of 5-10 μm was proposed to achieve optimal tribological performance. This research suggests that the equivalent diameter of the primary carbide should be controlled to be smaller than 10 μm, but further decreasing primary carbide size to less than 5 μm is unnecessary. The influence of primary carbide type in M50 bearing steel on sliding wear resistance was also discussed. Results indicate that the MC-type carbides with higher elastic modulus and microhardness exhibit better wear resistance than the M2C-type carbides.
基金supported by the grants from National Natural Science Foundation of China(No. 82074203, 82274328 and 81673655)。
文摘Objective: The effects of arsenic trioxide(As2O3) on hepatocellular carcinoma have been documented widely. Autophagy plays dual roles in the survival and death of cancer cells. Therefore, we investigated the exact role of autophagy in As2O3-induced apoptosis in liver cancer cells.Methods: The viability of hepatoma cells was determined using the MTT assay with or without fetal bovine serum. The rate of apoptosis in liver cancer cells treated with As2O3was evaluated using flow cytometry, Hoechst 33258 staining, and TUNEL assays. The rate of autophagy among liver cancer cells treated with As2O3was detected using immunofluorescence, Western blot assay and transmission electron microscopy.Results: Upon treatment with As2O3, the viability of HepG2 and SMMC-7721 cells was decreased in a time-and dose-dependent manner. The apoptosis rates of both liver cancer cell lines increased with the concentration of As2O3, as shown by flow cytometry. Apoptosis in liver cancer cells treated with As2O3was also shown by the activation of the caspase cascade and the regulation of Bcl-2/Bax expression.Furthermore, As2O3treatment induced autophagy in liver cancer cells;this finding was supported by Western blot, immunofluorescence of LC3-II and beclin 1, and transmission electron microscopy. In liver cancer cells, As2O3inhibited the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin(PI3K/AKT/mTOR) signal pathway that plays a vital role in both apoptosis and autophagy. The PI3K activator SC-79 partially reversed As2O3-induced autophagy and apoptosis. Furthermore, inhibiting autophagy with 3-methyladenine partially reversed the negative effects of As2O3on cell viability.Serum starvation increased autophagy and amplified the effect of As2O3on cell death.Conclusion: As2O3induces apoptosis and autophagy in liver cancer cells. Autophagy induced by As2O3may have a proapoptotic effect that helps to reduce the viability of liver cancer cells. This study provides novel insights into the effects of As2O3against liver cancer.
基金Peking University People’s Hospital Scientific Research Development Funds,No.RDY2017-28.
文摘BACKGROUND Hepatectomy is the first choice for treating neuroendocrine tumor liver metastases.However,most patients with neuroendocrine tumor liver metastases are not suitable for hepatectomy.Ablation combined with hepatectomy can be an alternative to liver resection.AIM To explore the clinical effect of microwave ablation combined with hepatectomy for the treatment of neuroendocrine tumor liver metastases.METHODS In this study,the data of patients who underwent microwave ablation combined with hepatectomy for the treatment of neuroendocrine tumor liver metastases from June 2015 to January 2018 were reviewed.Before the operation,the patients did not receive any treatment for liver neuroendocrine tumors.After a multidisciplinary expert group discussion,all patients were deemed unsuitable for liver resection.All patients were diagnosed with neuroendocrine tumors by pathology.The overall survival time and progression-free survival time were followed by telephone calls and outpatient visits after surgery.RESULTS Eleven patients with neuroendocrine tumor liver metastases were treated by microwave ablation combined with hepatectomy between June 2015 and January 2018.The median number of liver metastatic nodules was 4(range,2 to 43).The median number of lesions resected was 1(range,1 to 18),and the median number of lesions ablated was 3(range,1 to 38).The mean operation time was 405.6(±39.4)min.The median intraoperative blood loss was 600 mL(range,50 to 3000).Ten patients had a fever after surgery.The median duration of fever was 3 d(range,0 to 21).Elevated bilirubin levels occurred in all patients after surgery.The median bilirubin on the first day after surgery was 28.5(range,10.7 to 98.9)μmol/L.One patient developed respiratory failure,renal insufficiency,and pneumonia after the operation.No patient died postoperatively during hospitalization.The mean overall survival time after surgery was 34.1(±3.7)mo,and the median progression-free survival time was 8(range,2 to 51)mo.One year after surgery,ten patients survived and five patients survived without progression.Three year after surgery,eight patients survived and two patients survived without progression.CONCLUSION Microwave ablation combined with hepatectomy not only makes the patients obtain a survival rate similar to that of patients undergoing hepatectomy,but also has a low incidence of postoperative complications.
基金Projects(51571112,51171079,51471087) supported by the National Natural Science Foundation of ChinaProject(13KJA430003) supported by Jiangsu Higher Education Institutions of China+1 种基金Project supported by Qing Lan Project,ChinaProject supported by the Priority Academic Program Development(PAPD) of Jiangsu Higher Education Institutions,China
文摘The effects of chloride salts(NaCl,MgCl2and NH4Cl)on the hydrolysis kinetics of MgH2prepared by hydridingcombustion synthesis and mechanical milling(HCS+MM)were discussed.X-ray diffraction(XRD)analyses show that high-purityMgH2was successfully prepared by HCS.Hydrolysis performance test results indicate that the chloride salt added during the millingprocess is favorable to the initial reaction rate and hydrogen generation yield within60min.A MgH2?10%NH4Cl composite exhibitsthe best performance with the hydrogen generation yield of1311mL/g and a conversion rate of85.69%in60min at roomtemperature.It is suggested that the chloride salts not only play as grinding aids in the milling process,but also create fresh surface ofreactive materials,favoring the hydrolysis reaction.
基金The authors are grateful for the financial supports from the National Natural Science Foundation of China(51671075 and 51790481)the National Key R&D Program of China,(2017YFB0703001 and 2017YFB0305100)+3 种基金China Postdoctoral Science Foundation(2016M590970)the Fund of the State Key Laboratory of Solidification Processing in NWPU,China(SKLSP201606)the Fundamental Research Foundation for Universities of Heilongjiang Province,China(LGYC2018JC004)the Heilongjiang Postdoctoral Fund for Scientific Research Initiation,China(LBH-Q16118).
文摘By considering collision-limited growth mode and short-range diffusion-limited growth mode simultaneously,an extended kinetic model for solid−liquid interface with varied kinetic prefactor was developed for binary alloys.Four potential correlations arising from effective kinetics coupling the two growth modes were proposed and studied by application to planar interface migration and dendritic solidification,where the linear correlation between the effective thermodynamic driving force and the effective kinetic energy barrier seems physically realistic.A better agreement between the results of free dendritic growth model and the available experiment data for Ni−0.7at.%B alloy was obtained based on correlation between the thermodynamics and kinetics.As compared to previous models assuming constant kinetic prefactor,a common phenomenon occurring at relatively low undercoolings,i.e.the interface migration slowdown,can be ascribed to both the thermodynamic and the kinetic factors.By considering universality of the correlation between the thermodynamics and kinetics,it is concluded that the correlation should be considered to model the interface kinetics in alloy solidification.
基金Project(51671075) supported by the National Natural Science Foundation of ChinaProject(E201446) supported by the Natural Science Foundation of Heilongjiang Province,China+1 种基金Project(SKLSP201606) supported by Fund of the State Key Laboratory of Solidification Processing in NWPU,ChinaProject(2016M590970) supported by China Postdoctoral Science Foundation
文摘Considering both the effect of nonisothermal nature of the solid/liquid interface and the microscopic solvability theory (MicST), a further improved version of free dendritic growth model for pure materials was proposed. Model comparison indicates that there is a higher temperature at the tip of dendrite predicted by the present model compared with the corresponding model with the isothermal solid/liquid interface assumption. This is attributed to the sidewise thermal diffusion, i.e. the gradient of temperature along the nonisothermal interface. Furthermore, it is indicated that the distinction between the stability criteria from MicST and marginal stability theory (MarST) is more significant with the increase of bath undercoolings. Model test also indicates that the present model can give an agreement with the available experimental data. It is finally concluded that the nonisothermal nature of the solid/liquid interface and the stability criterion from MicST should be taken into account in modeling free dendritic growth.
基金supported by the China Medical BoardOpen Competition Program(20-378)Peking University Third Hospital Fund for Returned Scholars(BYSYLXHG2020004)+1 种基金JX was supported by the Peking Union Medical College Fund for Informatization of Postgraduate Courses(2021YXX001)YLZ was supported by the Sichuan University Graduate Education Reform Project(GSSCU2021046)。
文摘BACKGROUND:Shared decision-making(SDM)has broad application in emergencies.Most published studies have focused on SDM for a certain disease or expert opinions on future research gaps without revealing the full picture or detailed guidance for clinical practice.This study is to investigate the optimal application of SDM to guide life-sustaining treatment(LST)in emergencies.METHODS:This study was a prospective two-round Delphi consensus-seeking survey among multiple stakeholders at the China Consortium of Elite Teaching Hospitals for Residency Education.Participants were identified based on their expertise in medicine,law,administration,medical education,or patient advocacy.All individual items and questions in the questionnaire were scored using a 5-point Likert scale,with responses ranging from"very unimportant"(a score of 1)to"extremely important"(a score of 5).The percentages of the responses that had scores of 4-5on the 5-point Likert scale were calculated.A Kendall’s W coefficient was calculated to evaluate the consensus of experts.RESULTS:A two-level framework consisting of 4 domains and 22 items as well as a ready-touse checklist for the informed consent process for LST was established.An acceptable Kendall’s W coefficient was achieved.CONCLUSION:A consensus-based framework supporting SDM during LST in an emergency department can inform the implementation of guidelines for clinical interventions,research studies,medical education,and policy initiatives.
基金National Natural Science Foundation of China(No.51977002)the Third International Symposium on Insulation and Discharge Computation for Power Equipment(IDCOMPU2021).
文摘This work is based on a direct current(DC)natural current commutation topology,which uses load-carrying branch contacts carrying rated current and multiple sets of series arcing branch contacts in parallel to achieve circuit breaking.The proposed topology can meet the new requirements of higher voltage DC switches in aviation,aerospace,energy and other fields.First,a magneto-hydrodynamic arc model is built using COMSOL Multiphysics,and the different arc breaking characteristics of the arcing branch contacts in different gas environments are simulated.Then,a voltage uniformity coefficient is used to measure the voltage sharing effect in the process of dynamic interruption.In order to solve the dispersion of arcing contact action,a structural control method is adopted to improve the voltage uniformity coefficient.The uniform voltage distribution can improve the breaking capacity and electrical life of the series connection structure.
基金The Zhejiang Medical and Health Science and Technology Program,China,No.2021KY205 and No.2024KY139The Wenzhou Science and Technology Plan Project,China,No.Y2023111.
文摘In this editorial,we examined a recent article in the World Journal of Gastroenterology that focused on sepsis-associated liver injury(SLI)and its treatment.SLI is a serious complication of sepsis,primarily caused by microcirculatory disturbances,the gut-liver axis,and inflammatory responses.Specific treatment recommendations for SLI are lacking.The gut-liver axis represents a potential therapeutic target,with metformin showing promise in modulating the gut microbiome and enhancing intestinal barrier function.Although immunomodulatory therapies are being explored,anti-tumor necrosis factor agents and interleukin-1 receptor antagonists have not demonstrated significant clinical benefits.Statins may reduce liver inflammation and prevent injury in sepsis,but their clinical application is limited.Reduced D-related human leucocyte antigen expression on monocytes and lymphocytes suggests immune suppression in patients,indicating that corticosteroids could reverse clinical deterioration in severe infections and address adrenal cortical insufficiency.Current large-scale studies on glucocorticoid therapy for sepsis have yielded mixed results,likely due to inadequate assessment of the immune status of the host.Future research should prioritize the development of personalized immunotherapy tailored to patients’immune profiles,focusing on identifying novel indicators of immune status and advancing immunomodulatory targets and therapeutics for septic patients.
文摘An adaptive support vector machine decision feedback equalizer（ASVM-DFE） based on the least square support vector machine（LS-SVM） is proposed,it solves linear system iteratively with less computational intensity.An adaptive non-singleton fuzzy support vector machine decision feedback equalizer（ANSFSVMDFE） is also presented,it adopts the non-singleton fuzzy Gaussian kernel function with similar characteristic of pre-filter and is modified with a space transformation based approach.Simulations under nonlinear time variant channels show that ASVM-DFE and ANSFSVM-DFE perform very well on nonlinear equalization and ANSFSVM-DFE acts especially well in resisting abrupt interference.
