Background and Objectives:Few studies exist on resistant starch in rice grains.The Okinawa Institute of Science and Technology Graduate University(OIST)has developed a new rice(OIST rice,OR)rich in resistant starch.Th...Background and Objectives:Few studies exist on resistant starch in rice grains.The Okinawa Institute of Science and Technology Graduate University(OIST)has developed a new rice(OIST rice,OR)rich in resistant starch.This study aimed to clarify the effect of OR on postprandial glucose concentrations.Methods and Study Design:This single-center,open,randomized,crossover comparative study included 17 patients with type 2 diabetes.All participants completed two meal tolerance tests using OR and white rice(WR).Results:The median age of the participants was 70.0[59.0-73.0]years,and the mean body mass index was 25.9±3.1 kg/m^(2).The difference in total area under the curve(AUC)of plasma glucose was-8223(95%confidence interval[CI]:-10100 to-6346,p<0.001)mg·min/dL.The postprandial plasma glucose was significantly lower with OR than with WR.The difference in the AUC of insulin was-1139(95%CI:-1839 to-438,p=0.004)μU·min/mL.The difference in the AUC of total gastric inhibitory peptide(GIP)and total glucagon-like peptide-1(GLP-1)was-4886(95%CI:-8456 to-1317,p=0.011)and-171(95%CI:-1034 to 691,p=0.673)pmol·min/L,respectively.Conclusions:OR can be ingested as rice grains and significantly reduced postprandial plasma glucose compared to WR independent of insulin secretion in patients with type 2 diabetes.OR could have escaped absorption not only from the upper small intestine but also from the lower small intestine.展开更多
基金funded by the Nichirei corporation,Okinawa Institute of Science and Technology Graduate University,JSPS KAKENHI(grant number JP20K19722)。
文摘Background and Objectives:Few studies exist on resistant starch in rice grains.The Okinawa Institute of Science and Technology Graduate University(OIST)has developed a new rice(OIST rice,OR)rich in resistant starch.This study aimed to clarify the effect of OR on postprandial glucose concentrations.Methods and Study Design:This single-center,open,randomized,crossover comparative study included 17 patients with type 2 diabetes.All participants completed two meal tolerance tests using OR and white rice(WR).Results:The median age of the participants was 70.0[59.0-73.0]years,and the mean body mass index was 25.9±3.1 kg/m^(2).The difference in total area under the curve(AUC)of plasma glucose was-8223(95%confidence interval[CI]:-10100 to-6346,p<0.001)mg·min/dL.The postprandial plasma glucose was significantly lower with OR than with WR.The difference in the AUC of insulin was-1139(95%CI:-1839 to-438,p=0.004)μU·min/mL.The difference in the AUC of total gastric inhibitory peptide(GIP)and total glucagon-like peptide-1(GLP-1)was-4886(95%CI:-8456 to-1317,p=0.011)and-171(95%CI:-1034 to 691,p=0.673)pmol·min/L,respectively.Conclusions:OR can be ingested as rice grains and significantly reduced postprandial plasma glucose compared to WR independent of insulin secretion in patients with type 2 diabetes.OR could have escaped absorption not only from the upper small intestine but also from the lower small intestine.
