Achieving efficient adsorption and separation of C_(2)H_(2)/CO_(2)mixtures is a goal that people have always pursued to improve the situation of high energy consumption brought by traditional separation technologies i...Achieving efficient adsorption and separation of C_(2)H_(2)/CO_(2)mixtures is a goal that people have always pursued to improve the situation of high energy consumption brought by traditional separation technologies in industry today.High-nuclearity metal cluster-based MOFs with different functionalities are promising for this separation,but it is a complicated and difficult task to precisely control their structures.The strategy of pore-space partition(PSP)is a powerful way to construct this type MOFs,which has the characteristic of isostructural relationship,and can be resulted in a similar performance for them.Therefore,it is an interesting work to explore the effect of MOFs property by adjusting the size of PSP dividers.Herein,three tetranuclear Cu(Ⅱ)cluster-based MOFs(FJU-112/113/114)with dual functionalities has been successfully obtained by PSP strategy with various lengths of divider units.With the highest microporosity and unique functional site,FJU-114 realized a good improvement in the adsorption and separation performance of C_(2)H_(2)/CO_(2).The gas adsorption and lab-scale C_(2)H_(2)/CO_(2)breakthrough experiments demonstrated that FJU-114 exhibits the highest adsorption uptake of 77 cm^(3)/g for C_(2)H_(2),and shows the best separation factor of 4.2 among three MOFs.The GCMC simulation reveals that a stronger adsorption binding site of C_(2)H_(2)in FJU-114a located in the cage II near the unchanged tetranuclear copper node,combined with its high microporosity to achieve the effect of dual functionalities for the improvement performance of C_(2)H_(2)adsorption and separation.展开更多
Background: Pancreatitis is a common disease of the digestive system. Acute pancreatitis is one of the most common reasons for gastrointestinal hospital admission, and chronic pancreatitis significantly reduces qualit...Background: Pancreatitis is a common disease of the digestive system. Acute pancreatitis is one of the most common reasons for gastrointestinal hospital admission, and chronic pancreatitis significantly reduces quality of life. However, national epidemiological data on pancreatitis in China are lacking. This study aimed to quantify the disease burden of pancreatitis in China from 1990 to 2019.Methods: This study was based on the Global Burden of Disease Study 2019 dataset. Age-standardized rates of incidence (ASIR), prevalence (ASPR), mortality (ASMR), and disability-adjusted life years (DALYs) were used to describe the disease burden of pancreatitis, and estimated annual percentage change (EAPC) was used to indicate the average change in age-standardized rates. We also described the trend of pancreatitis-related mortality and DALYs, which are attributable to alcohol use by age and sex.Results: From 1990 to 2019, the ASIR, ASPR, ASMR, and age-standardized DALYs of pancreatitis in China decreased by 10.90, 1.50, 0.49, and 15.54 per 100,000, respectively, with EAPCs of -1.35 (95% uncertainty interval [UI]: -1.67, -1.02) and -0.37 (95% UI: -0.43, -0.31), -2.01 (95% UI: -2.07, -1.94) and -2.32 (95% UI: -2.37, -2.28), respectively. Recently, the numbers of incident and prevalent cases have risen, with estimates of 380,018 (95% UI: 308,669-462,767) and 493,765 (95% UI: 416,705-578,675), respectively, in 2019. Among men, the disease burden of pancreatitis was more severe than among women, and with variances in the distribution among different age groups. Age-standardized DALYs caused by alcohol-related pancreatitis have gradually worsened in the past decade, accounting for 34.09% of the total in 2019.Conclusions: The disease burden of pancreatitis in China has declined in the past 30 years, but the exacerbation of population aging poses a challenge to prevention and control of pancreatitis. Alcohol use has gradually become an important factor in the disease burden of pancreatitis in recent years.展开更多
Background:Gallbladder and biliary tract cancer(GBTC)has greatly damaged the health of patients and is accompanied by a dismal prognosis.The worldwide distribution of GBTC shows extensive variance and the updated data...Background:Gallbladder and biliary tract cancer(GBTC)has greatly damaged the health of patients and is accompanied by a dismal prognosis.The worldwide distribution of GBTC shows extensive variance and the updated data in China is lacking.This study was to determine the current status,trends,and predictions in the burden of GBTC over the past 30 years in China.Methods:This was a descriptive,epidemiological,secondary analysis of the Global Burden of Disease,Injuries,and Risk Factor Study 2019 data.Data including incidence,prevalence,mortality,and disability-adjusted life years(DALYs)of GBTC in China by year,age,and sex were assessed.Joinpoint regression analysis was conducted to evaluate trends of disease burden due to GBTC from 1990 to 2019.Nordpred age-period-cohort analysis was applied for the projection of mortality and incidence due to GBTC from 2019 to 2044.Results:Nationally,there were 38,634(95%uncertainty interval[UI]:27,350-46,512)new cases and 47,278(95%UI:32,889-57,229)patients due to GBTC,causing 34,462(95%UI:25,220-41,231)deaths,and 763,584(95%UI:566,755-920,493)DALYs in 2019.Both cases and rates of burden owing to GBTC were heavier among males and at old age.From 1990 to 2019,the age-standardized rates of incidence,prevalence,mortality,and DALYs of GBTC generally increased from 1990 to 2019,with average annual percentage change at 0.8%(95%confidential interval[CI]:0.6-1.0%),1.3%(95%CI:1.1-1.5%),0.4%(95%CI:0.2-0.6%),and 0.2%(95%CI:0.1-0.4%),respectively.Even though the age-standardized incidence rate and agestandardized mortality rate in both sexes were predicted to decline gradually from 2019 to 2044,the number of new cases and deaths were expected to grow steadily.Conclusions:GBTC is becoming a major health burden in China,particularly among males and older individuals.Given the aging population and increasing burden,effective strategies and measurements are urged to prevent or reduce the number of new cases and deaths of GBTC.展开更多
RNA interference(RNAi)has emerged as a powerful tool for developing novel management strategies for controlling insect pests.The 28-spotted ladybeetle,Henosepilachna vigintioctopunctata is one of the most important pe...RNA interference(RNAi)has emerged as a powerful tool for developing novel management strategies for controlling insect pests.The 28-spotted ladybeetle,Henosepilachna vigintioctopunctata is one of the most important pests attacking solanaceous plants in Asia.In this study,the potential of dietary RNAi to manage H.vigintioctopunctata was investigated using both in vitro synthesized and bacterially expressed double-stranded RNAs(dsRNAs)of HvvATPase A and HvvATPase E.The expression levels of HvvATPase A and HvvATPase E were higher in Malpighian tubules than in other tissue types.The silencing of HvvATPase A and HvvATPase E led to significant mortality in H.vigintioctopunctata larvae.In addition,the ingestion of HvvATPase A and HvvATPase E significantly deterred feeding behavior and subsequently arrested the development of H.vigintioctopunctata.Notably,the bacterially expressed dsRNAs consistently caused higher mortality in larvae and adults.Finally,the nontarget effects of the dsRNAs of H.vigintioctopunctata on the predatory ladybeetle Propylaea japonica were evaluated.P.japonica 1st instar larvae were administered vATPase A and vATPase E dsRNAs from H.vigintioctopunctata and P.japonica under the worst-case scenario,in which dsGFP served as negative control.There were significant effects of dsHvvATPase A on P.japonica at the transcriptional level but not at the organismal level,whereas dsHvvATPase E did not effect P.japonica at either the transcriptional or the organismal level.Collectively,the results of the study suggest that HvvATPase A and HvvATPase E can act as novel molecular targets for the control of H.vigintioctopunctata.展开更多
Background:Hypertension is associated with stroke-related mortality.However,the long-term association of blood pressure(BP)and the risk of stroke-related mortality and the influence path of BP on stroke-related death ...Background:Hypertension is associated with stroke-related mortality.However,the long-term association of blood pressure(BP)and the risk of stroke-related mortality and the influence path of BP on stroke-related death remain unknown.The current study aimed to estimate the long-term causal associations between BP and stroke-related mortality and the potential mediating and moderated mediating model of the associations.Methods:This is a 45-year follow-up cohort study and a total of 1696 subjects were enrolled in 1976 and 1081 participants died by the latest follow-up in 2020.COX proportional hazard model was used to explore the associations of stroke-related death with baseline systolic blood pressure(SBP)/diastolic blood pressure(DBP)categories and BP changes from 1976 to 1994.The mediating and moderated mediating effects were performed to detect the possible influencing path from BP to stroke-related deaths.E value was calculated in the sensitivity analysis.Results:Among 1696 participants,the average age was 44.38±6.10 years,and 1124 were men(66.3%).After a 45-year follow-up,a total of 201(11.9%)stroke-related deaths occurred.After the adjustment,the COX proportional hazard model showed that among the participants with SBP≥160 mmHg or DBP≥100 mmHg in 1976,the risk of stroke-related death increased by 217.5%(hazard ratio[HR]=3.175,95%confidence interval[CI]:2.297-4.388),and the adjusted HRs were higher in male participants.Among the participants with hypertension in 1976 and 1994,the risk of stroke-related death increased by 110.4%(HR=2.104,95%CI:1.632-2.713),and the adjusted HRs of the BP changes were higher in male participants.Body mass index(BMI)significantly mediated the association of SBP and stroke-related deaths and this mediating effect was moderated by gender.Conclusions:In a 45-year follow-up,high BP and persistent hypertension are associated with stroke-related death,and these associations were even more pronounced in male participants.The paths of association are mediated by BMI and moderated by gender.展开更多
Acetylene purification from methane is challenging in the field of porous organic polymers(POPs).Herein,we have provided one-pot Ullmann coupling reaction to synthesize a series of POPs with rich N-sites,named FJU-POP...Acetylene purification from methane is challenging in the field of porous organic polymers(POPs).Herein,we have provided one-pot Ullmann coupling reaction to synthesize a series of POPs with rich N-sites,named FJU-POP-n,wherein the low-cost and non-toxic Cu(acac)2 and environmental-friendly glycerol are employed as catalyst and solvent,respectively.展开更多
Measuring the information environment of firms using analyst(price)forecast bias and forecast dispersion before listing,we empirically examine the interactive influence of the information environment and market-wide s...Measuring the information environment of firms using analyst(price)forecast bias and forecast dispersion before listing,we empirically examine the interactive influence of the information environment and market-wide sentiment on the initial returns of initial public offerings(IPOs).We find the smaller the analyst forecast bias/dispersion,the lower the effect market-wide sentiment has on IPO initial returns.This finding indicates that information asymmetry is a basic reason for noise trading occurs and demonstrates the positive effect of financial analysts during IPOs.In addition,the effect of analyst forecasts is more pronounced during periods of rising markets and when IPO prices are not regulated.展开更多
It is challenging to model the performance of distributed graph computation.Explicit formulation cannot easily capture the diversified factors and complex interactions in the system.Statistical learning methods requir...It is challenging to model the performance of distributed graph computation.Explicit formulation cannot easily capture the diversified factors and complex interactions in the system.Statistical learning methods require a large number of training samples to generate an accurate prediction model.However,it is time-consuming to run the required graph computation tests to obtain the training samples.In this paper,we propose TransGPerf,a transfer learning based solution that can exploit prior knowledge from a source scenario and utilize a manageable amount of training data for modeling the performance of a target graph computation scenario.Experimental results show that our proposed method is capable of generating accurate models for a wide range of graph computation tasks on PowerGraph and GraphX.It outperforms transfer learning methods proposed for other applications in the literature.展开更多
As real-world graphs are often evolving over time, interest in analyzing the temporal behavior of graphs has grown. Herein, we propose Auxo, a novel temporal graph management system to support temporal graph analysis....As real-world graphs are often evolving over time, interest in analyzing the temporal behavior of graphs has grown. Herein, we propose Auxo, a novel temporal graph management system to support temporal graph analysis. It supports both efficient global and local queries with low space overhead. Auxo organizes temporal graph data in spatio-temporal chunks. A chunk spans a particular time interval and covers a set of vertices in a graph.We propose chunk layout and chunk splitting designs to achieve the desired efficiency and the abovementioned goals. First, by carefully choosing the time split policy, Auxo achieves linear complexity in both space usage and query time. Second, graph splitting further improves the worst-case query time, and reduces the performance variance introduced by splitting operations. Third, Auxo optimizes the data layout inside chunks, thereby significantly improving the performance of traverse-based graph queries. Experimental evaluation showed that Auxo achieved 2:9 to 12:1 improvement for global queries, and 1:7 to 2:7 improvement for local queries, as compared with state-of-the-art open-source solutions.展开更多
基金financially supported by the National Natural Science Foundation of China(Nos.21975044,21971038,21922810 and 22271046)the Fujian Provincial Department of Science and Technology(Nos.2023J01355,2023J011106 and 2022R1022001).
文摘Achieving efficient adsorption and separation of C_(2)H_(2)/CO_(2)mixtures is a goal that people have always pursued to improve the situation of high energy consumption brought by traditional separation technologies in industry today.High-nuclearity metal cluster-based MOFs with different functionalities are promising for this separation,but it is a complicated and difficult task to precisely control their structures.The strategy of pore-space partition(PSP)is a powerful way to construct this type MOFs,which has the characteristic of isostructural relationship,and can be resulted in a similar performance for them.Therefore,it is an interesting work to explore the effect of MOFs property by adjusting the size of PSP dividers.Herein,three tetranuclear Cu(Ⅱ)cluster-based MOFs(FJU-112/113/114)with dual functionalities has been successfully obtained by PSP strategy with various lengths of divider units.With the highest microporosity and unique functional site,FJU-114 realized a good improvement in the adsorption and separation performance of C_(2)H_(2)/CO_(2).The gas adsorption and lab-scale C_(2)H_(2)/CO_(2)breakthrough experiments demonstrated that FJU-114 exhibits the highest adsorption uptake of 77 cm^(3)/g for C_(2)H_(2),and shows the best separation factor of 4.2 among three MOFs.The GCMC simulation reveals that a stronger adsorption binding site of C_(2)H_(2)in FJU-114a located in the cage II near the unchanged tetranuclear copper node,combined with its high microporosity to achieve the effect of dual functionalities for the improvement performance of C_(2)H_(2)adsorption and separation.
基金This study was supported by grants from the National Natural Science Foundation of China (Nos. 81773502, 82173589, and 82173590) and the National Key Research and Development Programs of China (Nos. 2016YFC1303601 and 2020YFC2002705) . The views and opinions expressed in this paper are those of the authors and do not necessarily reflect the official position of the study sponsors.
文摘Background: Pancreatitis is a common disease of the digestive system. Acute pancreatitis is one of the most common reasons for gastrointestinal hospital admission, and chronic pancreatitis significantly reduces quality of life. However, national epidemiological data on pancreatitis in China are lacking. This study aimed to quantify the disease burden of pancreatitis in China from 1990 to 2019.Methods: This study was based on the Global Burden of Disease Study 2019 dataset. Age-standardized rates of incidence (ASIR), prevalence (ASPR), mortality (ASMR), and disability-adjusted life years (DALYs) were used to describe the disease burden of pancreatitis, and estimated annual percentage change (EAPC) was used to indicate the average change in age-standardized rates. We also described the trend of pancreatitis-related mortality and DALYs, which are attributable to alcohol use by age and sex.Results: From 1990 to 2019, the ASIR, ASPR, ASMR, and age-standardized DALYs of pancreatitis in China decreased by 10.90, 1.50, 0.49, and 15.54 per 100,000, respectively, with EAPCs of -1.35 (95% uncertainty interval [UI]: -1.67, -1.02) and -0.37 (95% UI: -0.43, -0.31), -2.01 (95% UI: -2.07, -1.94) and -2.32 (95% UI: -2.37, -2.28), respectively. Recently, the numbers of incident and prevalent cases have risen, with estimates of 380,018 (95% UI: 308,669-462,767) and 493,765 (95% UI: 416,705-578,675), respectively, in 2019. Among men, the disease burden of pancreatitis was more severe than among women, and with variances in the distribution among different age groups. Age-standardized DALYs caused by alcohol-related pancreatitis have gradually worsened in the past decade, accounting for 34.09% of the total in 2019.Conclusions: The disease burden of pancreatitis in China has declined in the past 30 years, but the exacerbation of population aging poses a challenge to prevention and control of pancreatitis. Alcohol use has gradually become an important factor in the disease burden of pancreatitis in recent years.
文摘Background:Gallbladder and biliary tract cancer(GBTC)has greatly damaged the health of patients and is accompanied by a dismal prognosis.The worldwide distribution of GBTC shows extensive variance and the updated data in China is lacking.This study was to determine the current status,trends,and predictions in the burden of GBTC over the past 30 years in China.Methods:This was a descriptive,epidemiological,secondary analysis of the Global Burden of Disease,Injuries,and Risk Factor Study 2019 data.Data including incidence,prevalence,mortality,and disability-adjusted life years(DALYs)of GBTC in China by year,age,and sex were assessed.Joinpoint regression analysis was conducted to evaluate trends of disease burden due to GBTC from 1990 to 2019.Nordpred age-period-cohort analysis was applied for the projection of mortality and incidence due to GBTC from 2019 to 2044.Results:Nationally,there were 38,634(95%uncertainty interval[UI]:27,350-46,512)new cases and 47,278(95%UI:32,889-57,229)patients due to GBTC,causing 34,462(95%UI:25,220-41,231)deaths,and 763,584(95%UI:566,755-920,493)DALYs in 2019.Both cases and rates of burden owing to GBTC were heavier among males and at old age.From 1990 to 2019,the age-standardized rates of incidence,prevalence,mortality,and DALYs of GBTC generally increased from 1990 to 2019,with average annual percentage change at 0.8%(95%confidential interval[CI]:0.6-1.0%),1.3%(95%CI:1.1-1.5%),0.4%(95%CI:0.2-0.6%),and 0.2%(95%CI:0.1-0.4%),respectively.Even though the age-standardized incidence rate and agestandardized mortality rate in both sexes were predicted to decline gradually from 2019 to 2044,the number of new cases and deaths were expected to grow steadily.Conclusions:GBTC is becoming a major health burden in China,particularly among males and older individuals.Given the aging population and increasing burden,effective strategies and measurements are urged to prevent or reduce the number of new cases and deaths of GBTC.
基金supported by the National Key R&D Program of China(2017YFD0200900)National Natural Science Foundation of China(31972269)GDUPS(2017).
文摘RNA interference(RNAi)has emerged as a powerful tool for developing novel management strategies for controlling insect pests.The 28-spotted ladybeetle,Henosepilachna vigintioctopunctata is one of the most important pests attacking solanaceous plants in Asia.In this study,the potential of dietary RNAi to manage H.vigintioctopunctata was investigated using both in vitro synthesized and bacterially expressed double-stranded RNAs(dsRNAs)of HvvATPase A and HvvATPase E.The expression levels of HvvATPase A and HvvATPase E were higher in Malpighian tubules than in other tissue types.The silencing of HvvATPase A and HvvATPase E led to significant mortality in H.vigintioctopunctata larvae.In addition,the ingestion of HvvATPase A and HvvATPase E significantly deterred feeding behavior and subsequently arrested the development of H.vigintioctopunctata.Notably,the bacterially expressed dsRNAs consistently caused higher mortality in larvae and adults.Finally,the nontarget effects of the dsRNAs of H.vigintioctopunctata on the predatory ladybeetle Propylaea japonica were evaluated.P.japonica 1st instar larvae were administered vATPase A and vATPase E dsRNAs from H.vigintioctopunctata and P.japonica under the worst-case scenario,in which dsGFP served as negative control.There were significant effects of dsHvvATPase A on P.japonica at the transcriptional level but not at the organismal level,whereas dsHvvATPase E did not effect P.japonica at either the transcriptional or the organismal level.Collectively,the results of the study suggest that HvvATPase A and HvvATPase E can act as novel molecular targets for the control of H.vigintioctopunctata.
文摘Background:Hypertension is associated with stroke-related mortality.However,the long-term association of blood pressure(BP)and the risk of stroke-related mortality and the influence path of BP on stroke-related death remain unknown.The current study aimed to estimate the long-term causal associations between BP and stroke-related mortality and the potential mediating and moderated mediating model of the associations.Methods:This is a 45-year follow-up cohort study and a total of 1696 subjects were enrolled in 1976 and 1081 participants died by the latest follow-up in 2020.COX proportional hazard model was used to explore the associations of stroke-related death with baseline systolic blood pressure(SBP)/diastolic blood pressure(DBP)categories and BP changes from 1976 to 1994.The mediating and moderated mediating effects were performed to detect the possible influencing path from BP to stroke-related deaths.E value was calculated in the sensitivity analysis.Results:Among 1696 participants,the average age was 44.38±6.10 years,and 1124 were men(66.3%).After a 45-year follow-up,a total of 201(11.9%)stroke-related deaths occurred.After the adjustment,the COX proportional hazard model showed that among the participants with SBP≥160 mmHg or DBP≥100 mmHg in 1976,the risk of stroke-related death increased by 217.5%(hazard ratio[HR]=3.175,95%confidence interval[CI]:2.297-4.388),and the adjusted HRs were higher in male participants.Among the participants with hypertension in 1976 and 1994,the risk of stroke-related death increased by 110.4%(HR=2.104,95%CI:1.632-2.713),and the adjusted HRs of the BP changes were higher in male participants.Body mass index(BMI)significantly mediated the association of SBP and stroke-related deaths and this mediating effect was moderated by gender.Conclusions:In a 45-year follow-up,high BP and persistent hypertension are associated with stroke-related death,and these associations were even more pronounced in male participants.The paths of association are mediated by BMI and moderated by gender.
基金This work was financially supported by the National Natural Science Foundation of China(grant nos.21975044,21971038 and 219722810)Fujian Provincial Department of Science and Technology(2018J07001,2019L3004,2019H6012 and 2021H0062).
文摘Acetylene purification from methane is challenging in the field of porous organic polymers(POPs).Herein,we have provided one-pot Ullmann coupling reaction to synthesize a series of POPs with rich N-sites,named FJU-POP-n,wherein the low-cost and non-toxic Cu(acac)2 and environmental-friendly glycerol are employed as catalyst and solvent,respectively.
基金sponsored by the Institute of Finance and Accounting at Shanghai University of Finance and Economics,National Natural Science Foundation of China(Project No.71172144)Major Project of Ministry of Education,Humanities and Social Science Research Base(Project No.11JJD790055)Program for New Century Excellent Talents in University(Project No.NCET-12-0902)
文摘Measuring the information environment of firms using analyst(price)forecast bias and forecast dispersion before listing,we empirically examine the interactive influence of the information environment and market-wide sentiment on the initial returns of initial public offerings(IPOs).We find the smaller the analyst forecast bias/dispersion,the lower the effect market-wide sentiment has on IPO initial returns.This finding indicates that information asymmetry is a basic reason for noise trading occurs and demonstrates the positive effect of financial analysts during IPOs.In addition,the effect of analyst forecasts is more pronounced during periods of rising markets and when IPO prices are not regulated.
文摘It is challenging to model the performance of distributed graph computation.Explicit formulation cannot easily capture the diversified factors and complex interactions in the system.Statistical learning methods require a large number of training samples to generate an accurate prediction model.However,it is time-consuming to run the required graph computation tests to obtain the training samples.In this paper,we propose TransGPerf,a transfer learning based solution that can exploit prior knowledge from a source scenario and utilize a manageable amount of training data for modeling the performance of a target graph computation scenario.Experimental results show that our proposed method is capable of generating accurate models for a wide range of graph computation tasks on PowerGraph and GraphX.It outperforms transfer learning methods proposed for other applications in the literature.
基金supported by the National High-Tech Development Plan of China (No. 2015AA015306)the National Natural Science Foundation of China (No. 61772302)
文摘As real-world graphs are often evolving over time, interest in analyzing the temporal behavior of graphs has grown. Herein, we propose Auxo, a novel temporal graph management system to support temporal graph analysis. It supports both efficient global and local queries with low space overhead. Auxo organizes temporal graph data in spatio-temporal chunks. A chunk spans a particular time interval and covers a set of vertices in a graph.We propose chunk layout and chunk splitting designs to achieve the desired efficiency and the abovementioned goals. First, by carefully choosing the time split policy, Auxo achieves linear complexity in both space usage and query time. Second, graph splitting further improves the worst-case query time, and reduces the performance variance introduced by splitting operations. Third, Auxo optimizes the data layout inside chunks, thereby significantly improving the performance of traverse-based graph queries. Experimental evaluation showed that Auxo achieved 2:9 to 12:1 improvement for global queries, and 1:7 to 2:7 improvement for local queries, as compared with state-of-the-art open-source solutions.
