Chua＇s circuit is a well-known nonlinear electronic model, having complicated nonsmooth dynamic behaviors. The stability and boundary equilibrium bifurcations for a modified Chua＇s circuit system with the smooth deg...Chua＇s circuit is a well-known nonlinear electronic model, having complicated nonsmooth dynamic behaviors. The stability and boundary equilibrium bifurcations for a modified Chua＇s circuit system with the smooth degree of 3 are studied. The parametric areas of stability are specified in detail. It is found that the bifurcation graphs of the su- percritical and irregular pitchfork bifurcations are similar to those of the piecewise-smooth continuous （PWSC） systems caused by piecewise smoothness. However, the bifurcation graph of the supercritical Hopf bifurcation is similar to those of smooth systems. There- fore, the boundary equilibrium bifurcations of the non-smooth systems with the smooth degree of 3 should receive more attention due to their special features.展开更多
Information encoding plays a crucial role in neuroscience. One of the fundamental questions in cognitive ncu- roscienee is how the brain encodes external stimuli in the sensory cortex. We use a network model based on ...Information encoding plays a crucial role in neuroscience. One of the fundamental questions in cognitive ncu- roscienee is how the brain encodes external stimuli in the sensory cortex. We use a network model based on the Hodgkin-Huxley type to study the information transmitting including its storage and recall. The model is inspired by psychological and neurobiological evidence on sequential memories. The model contains excitatory and inhibitory neurons with all-to-all connections whose architecture has two layers. A lower layer represents consecutive events during the information encoding process, and the upper layer is used to tag sequences of events represented in the lower layer. The spike-timing-dependent plasticity learning rule is used for sequential storage of excitatory connections between the modules. Computer simulations demonstrate that the synchronization status of multiple neurons is dependent on the network connectivity patterns, and also this model has good performance for different sequences of storage and recall.展开更多
B-type natriuretic peptide(BNP)system is critical to cardiovascular physiological and pathological processes,especially in the development and progression of heart failure(HF)caused by dilated cardiomyopathy(DCMHF).1,...B-type natriuretic peptide(BNP)system is critical to cardiovascular physiological and pathological processes,especially in the development and progression of heart failure(HF)caused by dilated cardiomyopathy(DCMHF).1,2 Single nucleotide polymorphism(SNP)in the noncoding region,especially the promoter region,might correlate well with plasma BNP levels,and potentially affect the susceptibility of DCM-HF,through interacting with transcription factor and regulating natriuretic peptide B(NPPB)gene transcription.展开更多
Approximately 20%-25%of adults encounter metabolic syndrome(MetS)worldwide,and MetS is a riskfactorfor cognitive decline(CD)development.Patients with MetS have an 11.48-fold increased incidence of CD compared with tho...Approximately 20%-25%of adults encounter metabolic syndrome(MetS)worldwide,and MetS is a riskfactorfor cognitive decline(CD)development.Patients with MetS have an 11.48-fold increased incidence of CD compared with those without Mets.^(1) Ataxia-telangiectasia mutated(ATM)gene encodes ATM kinase,which belongs to the phosphatidylinositol 3-hydroxy kinase family.展开更多
Centenarians have delayed or absent onset and interaction of agerelated disturbances and might be a prototype of human longevity and successful aging.1 What are the factors and models of centenarian longevity?This iss...Centenarians have delayed or absent onset and interaction of agerelated disturbances and might be a prototype of human longevity and successful aging.1 What are the factors and models of centenarian longevity?This issue has confused humans for thousands of years.Studies comparing centenarians and other oldest-old individuals could identify the factors related to centenarian longevity,and analysis of their relationships in these oldest-old individuals could improve the models of centenarian longevity.1 All these factors and models could be used to identify therapeutic targets for the prevention of age-related disturbances and the promotion of centenarian longevity.展开更多
基金supported by the National Natural Science Foundation of China(Nos.U1204106,11372282,11272024,and 11371046)the National Basic Research Program of China(973 Program)(Nos.2012CB821200 and 2012CB821202)
文摘Chua＇s circuit is a well-known nonlinear electronic model, having complicated nonsmooth dynamic behaviors. The stability and boundary equilibrium bifurcations for a modified Chua＇s circuit system with the smooth degree of 3 are studied. The parametric areas of stability are specified in detail. It is found that the bifurcation graphs of the su- percritical and irregular pitchfork bifurcations are similar to those of the piecewise-smooth continuous （PWSC） systems caused by piecewise smoothness. However, the bifurcation graph of the supercritical Hopf bifurcation is similar to those of smooth systems. There- fore, the boundary equilibrium bifurcations of the non-smooth systems with the smooth degree of 3 should receive more attention due to their special features.
基金Supported by the National Natural Science Foundation of China under Grant Nos 11672107,11402294,11602224 and 11502062
文摘Information encoding plays a crucial role in neuroscience. One of the fundamental questions in cognitive ncu- roscienee is how the brain encodes external stimuli in the sensory cortex. We use a network model based on the Hodgkin-Huxley type to study the information transmitting including its storage and recall. The model is inspired by psychological and neurobiological evidence on sequential memories. The model contains excitatory and inhibitory neurons with all-to-all connections whose architecture has two layers. A lower layer represents consecutive events during the information encoding process, and the upper layer is used to tag sequences of events represented in the lower layer. The spike-timing-dependent plasticity learning rule is used for sequential storage of excitatory connections between the modules. Computer simulations demonstrate that the synchronization status of multiple neurons is dependent on the network connectivity patterns, and also this model has good performance for different sequences of storage and recall.
基金supported by grants from the Excellent Youth Incubation Program of Chinese People's Liberation Army General Hospital (No.2020-YQPY-007)the Natural Science Foundation of Hainan Province,China (No.821QN389,821MS117,823MS161,820MS124,821MS112,822MS198,820MS126,820QN383,822MS193)+8 种基金the Military Medical Science and Technology Youth Incubation Program (China) (No.20QNPY110,19QNPY060)the Key R&D Program of Hainan Province,China (No.ZDYF2023SHFZ145)the Health Care Project of PLA (China) (No.22BJZ30)the Clinical Medical Research Center Project of Hainan Province,China (LCYX202106,LCYX202201,LCYX202303)the National Key R&D Program of China (No.2018YFC2000400)the National S&T Resource Sharing Service Platform Project of China (No.YCZYPT[2018]07)the Specific Research Fund of Innovation Platform for Academicians of Hainan Province,China (No.YSPTZX202216)the Heatstroke Treatment and Research Center of PLA (China) (No.413EGZ1D10)the Major Science and Technology Programme of Hainan Province,China (No.ZDKJ2019012).
文摘B-type natriuretic peptide(BNP)system is critical to cardiovascular physiological and pathological processes,especially in the development and progression of heart failure(HF)caused by dilated cardiomyopathy(DCMHF).1,2 Single nucleotide polymorphism(SNP)in the noncoding region,especially the promoter region,might correlate well with plasma BNP levels,and potentially affect the susceptibility of DCM-HF,through interacting with transcription factor and regulating natriuretic peptide B(NPPB)gene transcription.
基金supported by grants from the Military Medical Science and Technology Youth Incubation Program(No.20QNPY110,19QNP060)the National Natural Science Foundation of China(No.81900357,81941021,81903392,81901252,82001476,81802804,81801251)+8 种基金the Excellent Youth Incubation Program of Chinese People's Liberation Army General Hospital(No.2020-YQPY-007)the Natural Science Foundation of Hainan Province,China(No.821QN389,821MS112,822MS198,820MS126,820QN383)the National Key R&D Program of China(No.2018YFC2000400)the National S&T Resource Sharing Service Platform Project of China(No.YCZYPT[2018]07)the Specific Research Fund of Innovation Platform for Academicians of Hainan Province,China(No.YSPTZX202216)the Medical Big Data R&D Project of Chinese People's Liberation Army General Hospital(No.MBD2018030)the China Postdoctoral Science Foundation Funded Project(No.2019M650359,2020M682816,2021T140298)the Heatstroke Treatment and Research Center of Chinese People's Liberation Army,the Simulation Training for Treatment of Heat Strokethe Major Science and Technology Programme of Hainan Province,China(No.ZDKJ2019012).
文摘Approximately 20%-25%of adults encounter metabolic syndrome(MetS)worldwide,and MetS is a riskfactorfor cognitive decline(CD)development.Patients with MetS have an 11.48-fold increased incidence of CD compared with those without Mets.^(1) Ataxia-telangiectasia mutated(ATM)gene encodes ATM kinase,which belongs to the phosphatidylinositol 3-hydroxy kinase family.
基金supported by grants from the National Key R&D Program of China(2018YFC2000400)the National Natural Science Foundation of China(81900357,81903392)+7 种基金the National S&T Resource Sharing service platform Project of China(YCZYPT[2018]07)the General Hospital of PLA Medical Big Data R&D Project(MBD2018030)the China Postdoctoral Science Foundation funded project(2019M650359)the National Geriatric Disease Clinical Medicine Research Center Project(NCRCG-PLAGH-2017-014)the Military Medical Science and Technology Youth Incubation Program(20QNPY110)the Sanya Medical and Health Science and Technology Innovation Project(2016YW21)the Sanya Institutional and Local Scientific and Technological Cooperation Project,the Military Medicine Youth Program of Chinese PLA General Hospital(QNF19069)the Clinical Scientific Research Supporting Fund of Chinese PLA General Hospital(2017FC-CXYY-3009).
文摘Centenarians have delayed or absent onset and interaction of agerelated disturbances and might be a prototype of human longevity and successful aging.1 What are the factors and models of centenarian longevity?This issue has confused humans for thousands of years.Studies comparing centenarians and other oldest-old individuals could identify the factors related to centenarian longevity,and analysis of their relationships in these oldest-old individuals could improve the models of centenarian longevity.1 All these factors and models could be used to identify therapeutic targets for the prevention of age-related disturbances and the promotion of centenarian longevity.
