Acute lung injury(ALI)is a severe disease caused by viral infection that triggers an uncontrolled inflammatory response.This study investigated the capacity of jasurolignoside(JO),a natural compound,to bind to Toll-li...Acute lung injury(ALI)is a severe disease caused by viral infection that triggers an uncontrolled inflammatory response.This study investigated the capacity of jasurolignoside(JO),a natural compound,to bind to Toll-like receptor 4(TLR4)and treat ALI.The anti-inflammatory properties of JO were evaluated in vitro through Western blotting,enzyme-linked immunosorbent assay(ELISA),immunofluorescence staining,and co-immunoprecipitation.The investigation utilized a lipopolysaccharide(LPS)-induced ALI animal model to examine the therapeutic efficacy and mechanism of JO in vivo.JO attenuated inflammatory symptoms in infected cells and tissues by modulating the NOD-like receptor family pyrin domain containing protein 3(NLRP3)inflammasome and the nuclear factorκB(NF-κB)/mitogen-activated protein kinase(MAPK)pathway.Molecular docking simulations revealed JO binding to TLR4 active sites,confirmed by cellular thermal shift assay.Surface plasmon resonance(SPR)demonstrated direct interaction between JO and TLR4 with a Kd value of 35.1μmol·L^(-1).Moreover,JO inhibited tumor necrosis factorα(TNF-α),interleukin-1β(IL-1β),and IL-6 secretion and reduced leukocyte,neutrophil,lymphocyte,and macrophage infiltration in ALI-affected mice.JO also enhanced lung function and reduced ALI-related mortality.Immunohistochemical staining demonstrated JO's ability to suppress TLR4 expression in ALI-affected mouse lung tissue.This study establishes that JO can bind to TLR4 and effectively treat ALI,indicating its potential as a therapeutic agent for clinical applications.展开更多
Adenine is commonly used to establish the animal models for chronic kidney injury and its renal interstitial fibrosis. As an endogenous substance, adenine-induced kidney damage has not yet been fully studied and eluci...Adenine is commonly used to establish the animal models for chronic kidney injury and its renal interstitial fibrosis. As an endogenous substance, adenine-induced kidney damage has not yet been fully studied and elucidated, except for inflammatory reaction. Here we analyzed the proteomics of kidney of rats after adenine overloading using LS-MS/MS assay, and observed the role of anemoside B4(B4). The results showed that adenine could down-regulate 285 proteins and up-regulate 164 proteins in rat kidney tissue compared with the normal group. Down-regulated proteins mainly affected related pathways, such as energy metabolism, while up-regulated proteins affected inflammatory response pathways and metabolic pathways. B4 could significantly reverse the down-regulation of about 40 proteins, which were involved in mitochondria, redox processes, extracellular exosomes, acetylation and other signaling pathways. Simultaneously, B4 could inhibit the up-regulation of five proteins caused by adenine, which were involved in cell cycle, oocyte meiosis, PI3 K-Akt and other signaling pathways. Further experimental results of mRNA expression using real-time PCR assay supported the proteomic analysis. Therefore, we proposed that the damage of rat kidney caused by adenine was more complicated, not only with an inflammatory reaction, but also with extensive effects to various metabolic processes in the body. This work provided a valuable clue for comprehensive understanding of adenine-induced renal damage.展开更多
The aim of this paper is to categorify the n-th tensor power of the vector representation of U（ ο（7,C））. The main tools are certain singular blocks and projective functors of the BGG category of the complex Lie a...The aim of this paper is to categorify the n-th tensor power of the vector representation of U（ ο（7,C））. The main tools are certain singular blocks and projective functors of the BGG category of the complex Lie algebra gln.展开更多
We introduce a non-standard quantum group Xq（Bn） of type Bn which is a Hopf algebra. Then we replace the group of grouplike elements of Xq（Bn）, and obtain a weak Hopf algebra wXq（Bn）. Finally, we describe the Ex...We introduce a non-standard quantum group Xq（Bn） of type Bn which is a Hopf algebra. Then we replace the group of grouplike elements of Xq（Bn）, and obtain a weak Hopf algebra wXq（Bn）. Finally, we describe the Ext-quiver of wXq（Bn） as a coalgebra.展开更多
Let F be an algebraically closed field of characteristic 0,H be an eight-dimensional non-semisimple Hopf algebra which is neither pointed nor unimodular and M2（F）be the full matrix algebra of 2×2 over F.In this...Let F be an algebraically closed field of characteristic 0,H be an eight-dimensional non-semisimple Hopf algebra which is neither pointed nor unimodular and M2（F）be the full matrix algebra of 2×2 over F.In this paper,we discuss and classify all H-module algebra structures on M2（F）.展开更多
In this paper we give a categorification of the n-th tensor products of the spin modules of enveloping algebra of lie algebra of type D4 via some subcategories and projective functors of the BGG category of the genera...In this paper we give a categorification of the n-th tensor products of the spin modules of enveloping algebra of lie algebra of type D4 via some subcategories and projective functors of the BGG category of the general linear Lie algebra gln over the complex field C.展开更多
In view of the aging population in the country,college communities can better meet the needs of the elderly in the community by developing hardware facilities,environmental resources,and management systems.However,in ...In view of the aging population in the country,college communities can better meet the needs of the elderly in the community by developing hardware facilities,environmental resources,and management systems.However,in China,the research on elderly care in colleges is still in its infancy.The paper presents an analysis on the characteristics of the elderly group,outdoor activities,and space characteristics in college communities through the field survey of a university in the north,questionnaire survey and interview with the elderly.Suggestions for optimizing the outdoor activities space of the elderly in college communities are then provided,hoping to provide some reference for relevant research.展开更多
Objective: Anemoside B4(AB4), the most abundant triterpenoidal saponin isolated from Pulsatilla chinensis, inhibited influenza virus FM1 or Klebsiella pneumoniae-induced pneumonia. However, the anti-SARS-CoV-2 effect ...Objective: Anemoside B4(AB4), the most abundant triterpenoidal saponin isolated from Pulsatilla chinensis, inhibited influenza virus FM1 or Klebsiella pneumoniae-induced pneumonia. However, the anti-SARS-CoV-2 effect of AB4 has not been unraveled. Therefore, this study aimed to determine the antiviral activity and potential mechanism of AB4 in inhibiting human coronavirus SARS-CoV-2 in vivo and in vitro.Methods: The cytotoxicity of AB4 was evaluated using the Cell Counting Kit-8(CCK8) assay. SARS-CoV-2 infected HEK293T, HPAEpiC, and Vero E6 cells were used for in vitro assays. The antiviral effect of AB4 in vivo was evaluated by SARS-CoV-2-infected hACE2-IRES-luc transgenic mouse model. Furthermore,label-free quantitative proteomics and bioinformatic analysis were performed to explore the potential antiviral mechanism of action of AB4. Type Ⅰ IFN signaling-associated proteins were assessed using Western blotting or immumohistochemical staining.Results: The data showed that AB4 reduced the propagation of SARS-CoV-2 along with the decreased Nucleocapsid protein(N), Spike protein(S), and 3C-like protease(3CLpro) in HEK293T cells. In vivo antiviral activity data revealed that AB4 inhibited viral replication and relieved pneumonia in a SARS-CoV-2 infected mouse model. We further disclosed that the antiviral activity of AB4 was associated with the enhanced interferon(IFN)-β response via the activation of retinoic acid-inducible gene Ⅰ(RIG-1) like receptor(RLP) pathways. Additionally, label-free quantitative proteomic analyses discovered that 17 proteins were significantly altered by AB4 in the SARS-CoV-2 coronavirus infections cells. These proteins mainly clustered in RNA metabolism.Conclusion: Our results indicated that AB4 inhibited SARS-CoV-2 replication through the RLR pathways and moderated the RNA metabolism, suggesting that it would be a potential lead compound for the development of anti-SARS-CoV-2 drugs.展开更多
Let D(n)be the finite dimensional non-pointed and non-semisimple Hopf algebra,which is a quotient of a prime Hopf algebras of GK-dimension one for an odd number n>1.In this paper,we investigate the structure of Yet...Let D(n)be the finite dimensional non-pointed and non-semisimple Hopf algebra,which is a quotient of a prime Hopf algebras of GK-dimension one for an odd number n>1.In this paper,we investigate the structure of Yetter-Drinfeld simple modules over D(n)and give iso-classes of them.展开更多
Millimeter-wave(mmWave)technology has been well studied for both outdoor long-distance transmission and indoor short-range communication.In the recently emerging fiber-to-the-room(FTTR)architecture in the home network...Millimeter-wave(mmWave)technology has been well studied for both outdoor long-distance transmission and indoor short-range communication.In the recently emerging fiber-to-the-room(FTTR)architecture in the home network of the fifth generation fixed networks(F5G),mmWave technology can be cascaded well to a new optical network terminal in the room to enable extremely high data rate communication(i.e.,>10 Gb/s).In the FTTR+mmWave scenario,the rapid degradation of the mmWave signal in long-distance transmission and the significant loss against wall penetration are no longer the bottlenecks for real application.Moreover,the surrounding walls of every room provide excellent isolation to avoid interference and guarantee security.This paper provides insights and analysis for the new FTTR+mmWave architecture to improve the customer experience in future broadband services such as immersive audiovisual videos.展开更多
Finite dimensional Hopf superalgebras Uq （sl（m│n）） corresponding to the Lie superalgebras s[（m│n） are constructed. The PBW type basis and the left and right integrals of uq（sl（m│n）） are obtained. Furtherm...Finite dimensional Hopf superalgebras Uq （sl（m│n）） corresponding to the Lie superalgebras s[（m│n） are constructed. The PBW type basis and the left and right integrals of uq（sl（m│n）） are obtained. Furthermore, the group of Hopf superalgebra automorphisms is described.展开更多
Let Uq(osp(1|2n)) be the quantized enveloping superalgebra corresponding to the Lie superalgebra osp(1|2n). In terms of semistandard Young tableaux satisfying some additional conditions, a realization of crystal graph...Let Uq(osp(1|2n)) be the quantized enveloping superalgebra corresponding to the Lie superalgebra osp(1|2n). In terms of semistandard Young tableaux satisfying some additional conditions, a realization of crystal graph of finite-dimensional irreducible modules of Uq(osp(1|2n)) is given. Also, the generalized LittlewoodRichardson rule for tensor product of crystal graphs is established.展开更多
We construct the Grothendieck rings of a class of 2n^(2)dimensional semisimple Hopf Algebras H_(2n)^(2),which can be viewed as a generalization of the 8 dimensional Kac-Paljutkin Hopf algebra H8.All irreducible H_(2n)...We construct the Grothendieck rings of a class of 2n^(2)dimensional semisimple Hopf Algebras H_(2n)^(2),which can be viewed as a generalization of the 8 dimensional Kac-Paljutkin Hopf algebra H8.All irreducible H_(2n)^(2)-modules are classified.Furthermore,we describe the Grothendieck rings r(H_(2n)^(2))by generators and relations explicitly.展开更多
A class of two-parameter quantum algebras Ur,s（s[（m｜n）） is constructed. It is shown that Ur,s（s[（m｜n）） is a Hopf superalgebra. Then the PBW basis of Ur,s（s[（m｜n）） is described. For this purpose, some co...A class of two-parameter quantum algebras Ur,s（s[（m｜n）） is constructed. It is shown that Ur,s（s[（m｜n）） is a Hopf superalgebra. Then the PBW basis of Ur,s（s[（m｜n）） is described. For this purpose, some commutative relations of root vectors of U^＋r,s（s[（m｜n）） are given展开更多
Finite dimensional ribbon Hopf （super） algebras play an important role in constructing invariants of 3-manifolds. In the present paper, the authors give a necessary and sufficient condition for the Drinfel＇d double...Finite dimensional ribbon Hopf （super） algebras play an important role in constructing invariants of 3-manifolds. In the present paper, the authors give a necessary and sufficient condition for the Drinfel＇d double of a finite dimensional Hopf superalgebra to have a ribbon element. The criterion can be seen as a generalization of Kauffman and Radford＇s result in the non-super situation to the Z2-graded situation, however, the derivation of the result in the Z2-graded case will be much more complicated.展开更多
基金supported by the National Natural Science Foundation of China(No.82260799)Guangxi Science and Technology Base and Talent Project(No.AA23026010)+3 种基金Undergraduate Innovation and Entrepreneurship Training Program(No.S202110600120)Guangxi Overseas“100 Persons’Plan”Highlevel Expert,University of Chinese Medicine(No.2022BS008)Guangxi University Young and Middle-aged Teachers Research Basic Ability Improvement Project(No.2023KY0303)Jiangxi Province 2022 Annual Graduate Student Innovation Special Fund Project(No.YC2022-B189)。
文摘Acute lung injury(ALI)is a severe disease caused by viral infection that triggers an uncontrolled inflammatory response.This study investigated the capacity of jasurolignoside(JO),a natural compound,to bind to Toll-like receptor 4(TLR4)and treat ALI.The anti-inflammatory properties of JO were evaluated in vitro through Western blotting,enzyme-linked immunosorbent assay(ELISA),immunofluorescence staining,and co-immunoprecipitation.The investigation utilized a lipopolysaccharide(LPS)-induced ALI animal model to examine the therapeutic efficacy and mechanism of JO in vivo.JO attenuated inflammatory symptoms in infected cells and tissues by modulating the NOD-like receptor family pyrin domain containing protein 3(NLRP3)inflammasome and the nuclear factorκB(NF-κB)/mitogen-activated protein kinase(MAPK)pathway.Molecular docking simulations revealed JO binding to TLR4 active sites,confirmed by cellular thermal shift assay.Surface plasmon resonance(SPR)demonstrated direct interaction between JO and TLR4 with a Kd value of 35.1μmol·L^(-1).Moreover,JO inhibited tumor necrosis factorα(TNF-α),interleukin-1β(IL-1β),and IL-6 secretion and reduced leukocyte,neutrophil,lymphocyte,and macrophage infiltration in ALI-affected mice.JO also enhanced lung function and reduced ALI-related mortality.Immunohistochemical staining demonstrated JO's ability to suppress TLR4 expression in ALI-affected mouse lung tissue.This study establishes that JO can bind to TLR4 and effectively treat ALI,indicating its potential as a therapeutic agent for clinical applications.
基金National Innovative Drugs 13th Five-Year Major Special Project of China(Grant No.2018ZX09301030-002)
文摘Adenine is commonly used to establish the animal models for chronic kidney injury and its renal interstitial fibrosis. As an endogenous substance, adenine-induced kidney damage has not yet been fully studied and elucidated, except for inflammatory reaction. Here we analyzed the proteomics of kidney of rats after adenine overloading using LS-MS/MS assay, and observed the role of anemoside B4(B4). The results showed that adenine could down-regulate 285 proteins and up-regulate 164 proteins in rat kidney tissue compared with the normal group. Down-regulated proteins mainly affected related pathways, such as energy metabolism, while up-regulated proteins affected inflammatory response pathways and metabolic pathways. B4 could significantly reverse the down-regulation of about 40 proteins, which were involved in mitochondria, redox processes, extracellular exosomes, acetylation and other signaling pathways. Simultaneously, B4 could inhibit the up-regulation of five proteins caused by adenine, which were involved in cell cycle, oocyte meiosis, PI3 K-Akt and other signaling pathways. Further experimental results of mRNA expression using real-time PCR assay supported the proteomic analysis. Therefore, we proposed that the damage of rat kidney caused by adenine was more complicated, not only with an inflammatory reaction, but also with extensive effects to various metabolic processes in the body. This work provided a valuable clue for comprehensive understanding of adenine-induced renal damage.
基金Supported by the Natural Science Foundation of Beijing(Grant No.1122006)the Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.201111103110011)Science and Technology Foundation of BJUT(Grant No.ykj-4787)
文摘The aim of this paper is to categorify the n-th tensor power of the vector representation of U（ ο（7,C））. The main tools are certain singular blocks and projective functors of the BGG category of the complex Lie algebra gln.
基金Supported by the National Natural Science Foundation of China(Grant Nos.11471186,11361056)the Natural Science Foundation of Beijing(Grant No.1162002)
文摘The GrSbner-Shirshov basis of the degenerate Ringel-Hall Algebras of type C3 is obtained by studying the generic extension monoid algebra.
基金Supported by the National Natural Science Foundation of China(Grant Nos.11671024 11471186)the Natural Science Foundation of Beijing(Grant No.1162002)
文摘We introduce a non-standard quantum group Xq（Bn） of type Bn which is a Hopf algebra. Then we replace the group of grouplike elements of Xq（Bn）, and obtain a weak Hopf algebra wXq（Bn）. Finally, we describe the Ext-quiver of wXq（Bn） as a coalgebra.
基金Supported by the National Natural Science Foundation of China(Grant Nos.1127104311471186)
文摘Let F be an algebraically closed field of characteristic 0,H be an eight-dimensional non-semisimple Hopf algebra which is neither pointed nor unimodular and M2（F）be the full matrix algebra of 2×2 over F.In this paper,we discuss and classify all H-module algebra structures on M2（F）.
基金Supported by National Natural Science Foundation of China(Grant No.11271043)Natural Science Foundation of Beijing(Grant No.1122006)Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.201111103110011)
文摘In this paper we give a categorification of the n-th tensor products of the spin modules of enveloping algebra of lie algebra of type D4 via some subcategories and projective functors of the BGG category of the general linear Lie algebra gln over the complex field C.
文摘In view of the aging population in the country,college communities can better meet the needs of the elderly in the community by developing hardware facilities,environmental resources,and management systems.However,in China,the research on elderly care in colleges is still in its infancy.The paper presents an analysis on the characteristics of the elderly group,outdoor activities,and space characteristics in college communities through the field survey of a university in the north,questionnaire survey and interview with the elderly.Suggestions for optimizing the outdoor activities space of the elderly in college communities are then provided,hoping to provide some reference for relevant research.
基金supported by National Natural Science Foundation of China(No.82341087,82073912)Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions.
文摘Objective: Anemoside B4(AB4), the most abundant triterpenoidal saponin isolated from Pulsatilla chinensis, inhibited influenza virus FM1 or Klebsiella pneumoniae-induced pneumonia. However, the anti-SARS-CoV-2 effect of AB4 has not been unraveled. Therefore, this study aimed to determine the antiviral activity and potential mechanism of AB4 in inhibiting human coronavirus SARS-CoV-2 in vivo and in vitro.Methods: The cytotoxicity of AB4 was evaluated using the Cell Counting Kit-8(CCK8) assay. SARS-CoV-2 infected HEK293T, HPAEpiC, and Vero E6 cells were used for in vitro assays. The antiviral effect of AB4 in vivo was evaluated by SARS-CoV-2-infected hACE2-IRES-luc transgenic mouse model. Furthermore,label-free quantitative proteomics and bioinformatic analysis were performed to explore the potential antiviral mechanism of action of AB4. Type Ⅰ IFN signaling-associated proteins were assessed using Western blotting or immumohistochemical staining.Results: The data showed that AB4 reduced the propagation of SARS-CoV-2 along with the decreased Nucleocapsid protein(N), Spike protein(S), and 3C-like protease(3CLpro) in HEK293T cells. In vivo antiviral activity data revealed that AB4 inhibited viral replication and relieved pneumonia in a SARS-CoV-2 infected mouse model. We further disclosed that the antiviral activity of AB4 was associated with the enhanced interferon(IFN)-β response via the activation of retinoic acid-inducible gene Ⅰ(RIG-1) like receptor(RLP) pathways. Additionally, label-free quantitative proteomic analyses discovered that 17 proteins were significantly altered by AB4 in the SARS-CoV-2 coronavirus infections cells. These proteins mainly clustered in RNA metabolism.Conclusion: Our results indicated that AB4 inhibited SARS-CoV-2 replication through the RLR pathways and moderated the RNA metabolism, suggesting that it would be a potential lead compound for the development of anti-SARS-CoV-2 drugs.
基金Supported by the Fundamental Research Program of Shanxi Province(Grant No.202303021212147)the National Natural Science Foundation of China(Grant No.12471038)。
文摘Let D(n)be the finite dimensional non-pointed and non-semisimple Hopf algebra,which is a quotient of a prime Hopf algebras of GK-dimension one for an odd number n>1.In this paper,we investigate the structure of Yetter-Drinfeld simple modules over D(n)and give iso-classes of them.
文摘Millimeter-wave(mmWave)technology has been well studied for both outdoor long-distance transmission and indoor short-range communication.In the recently emerging fiber-to-the-room(FTTR)architecture in the home network of the fifth generation fixed networks(F5G),mmWave technology can be cascaded well to a new optical network terminal in the room to enable extremely high data rate communication(i.e.,>10 Gb/s).In the FTTR+mmWave scenario,the rapid degradation of the mmWave signal in long-distance transmission and the significant loss against wall penetration are no longer the bottlenecks for real application.Moreover,the surrounding walls of every room provide excellent isolation to avoid interference and guarantee security.This paper provides insights and analysis for the new FTTR+mmWave architecture to improve the customer experience in future broadband services such as immersive audiovisual videos.
文摘Finite dimensional Hopf superalgebras Uq （sl（m│n）） corresponding to the Lie superalgebras s[（m│n） are constructed. The PBW type basis and the left and right integrals of uq（sl（m│n）） are obtained. Furthermore, the group of Hopf superalgebra automorphisms is described.
基金supported by National Natural Science Foundation of China (Grant Nos.10671016 10771014)Beijing Natural Science Foundation (Grant No. 1062003)
文摘Let Uq(osp(1|2n)) be the quantized enveloping superalgebra corresponding to the Lie superalgebra osp(1|2n). In terms of semistandard Young tableaux satisfying some additional conditions, a realization of crystal graph of finite-dimensional irreducible modules of Uq(osp(1|2n)) is given. Also, the generalized LittlewoodRichardson rule for tensor product of crystal graphs is established.
基金This work was supported by the National Natural Science Foundation of China(Grant Nos.11671024,11701019,11871301)the Science and Technology Project of Beijing Municipal Education Commission(Grant No.KM202110005012).
文摘We construct the Grothendieck rings of a class of 2n^(2)dimensional semisimple Hopf Algebras H_(2n)^(2),which can be viewed as a generalization of the 8 dimensional Kac-Paljutkin Hopf algebra H8.All irreducible H_(2n)^(2)-modules are classified.Furthermore,we describe the Grothendieck rings r(H_(2n)^(2))by generators and relations explicitly.
基金The second author was supported by Beijing Natural Science Foundation （Grant No. 1122006）, the Specialized Research Fund for the Doctoral Program of Higher Education of China （Grant No. 20111103110011） and partially supported by the National Natural Science Foundation of China （Grant No. 11271043, 11471186）.
文摘A class of two-parameter quantum algebras Ur,s（s[（m｜n）） is constructed. It is shown that Ur,s（s[（m｜n）） is a Hopf superalgebra. Then the PBW basis of Ur,s（s[（m｜n）） is described. For this purpose, some commutative relations of root vectors of U^＋r,s（s[（m｜n）） are given
基金supported by the National Natural Science Foundation of China(Nos.11701019,11671024)the Natural Science Foundation of Beijing(No.1162002)
文摘Finite dimensional ribbon Hopf （super） algebras play an important role in constructing invariants of 3-manifolds. In the present paper, the authors give a necessary and sufficient condition for the Drinfel＇d double of a finite dimensional Hopf superalgebra to have a ribbon element. The criterion can be seen as a generalization of Kauffman and Radford＇s result in the non-super situation to the Z2-graded situation, however, the derivation of the result in the Z2-graded case will be much more complicated.
