Objective To diagnose 6 LQTS families by genetic analysis.Methods A total aof 6 LQTS pedigrees with 43 family members were brought together for genetic diagnosis by using short-sequence tandem-repeat(STR)markers or se...Objective To diagnose 6 LQTS families by genetic analysis.Methods A total aof 6 LQTS pedigrees with 43 family members were brought together for genetic diagnosis by using short-sequence tandem-repeat(STR)markers or sequencing.Genomic DNA was extracted from blood samples by standard procedure.STR markers or KCNQ1,KCNH2 and SCN5A were amplified.The haplotype analysis for LQTS was performed.If the family got the negative haplotype analysis,the sequencing was performed.Results LQTS patients were always linkaged with the SCN5A gene in family 1.KCNH2 was linkaged with the disease in family 2 to 5.21 gene carriers were identified from these 5 families.A mutation(A561V-KCNH2)was only found in the proband of family 6 and an SNP(G1691A)was found in all the members of the family.Conclusion Genetic diagnosis can not only improve presymptomatic diagnosis,but also provide the basis for personal therapy and research on disease-causing mutations.展开更多
A high-efficiency technique for optical vortex(OV) generation is proposed and demonstrated. The technique is based on liquid crystal fork gratings with space-variant azimuthal orientations, which are locally controlle...A high-efficiency technique for optical vortex(OV) generation is proposed and demonstrated. The technique is based on liquid crystal fork gratings with space-variant azimuthal orientations, which are locally controlled via polarization-sensitive alignment layers. Thanks to the optical rewritability of the alignment agent and the dynamic image generation of the digital micro-mirror device, fork gratings can be instantly and arbitrarily reconfigured.Corresponding optical vortices carrying arbitrary azimuthal and radial indices are demonstrated with a conversion efficiency of 98.5%, exhibiting features of polarization control and electrical switching. The technique may pave a bright road toward OV generation, manipulation, and detection.展开更多
An in-line,all-optical fiber modulator based on a stereo graphene–microfiber structure(GMF)utilizing the lab-on-rod technique was demonstrated in this study.Owing to its unique spring-like geometry,an ultra-long GMF ...An in-line,all-optical fiber modulator based on a stereo graphene–microfiber structure(GMF)utilizing the lab-on-rod technique was demonstrated in this study.Owing to its unique spring-like geometry,an ultra-long GMF interaction can be achieved,and a modulation depth of,7.5 dB(,2.5 dB)and a modulation efficiency of,0.2 dB mW^(-1)(,0.07 dB mW^(-1))were demonstrated for two polarization states.The modulation depth and modulation efficiency are more than one order of magnitude larger than those of other graphene–microfiber hybrid all-optical modulators,although at the cost of a higher insertion loss.By further optimizing the transferring and cleaning process,the upper limit of the modulation depth is mainly determined by the loss from the intrinsic absorption,which depends on the light–graphene interaction.Then,the modulator can quickly switch between the on-state and the off-state with a theoretically maximized modulation depth of tens of decibels.This modulator is compatible with the current fiber-optic communication systems and may be applied in the near future to meet the impending need for ultrafast optical signal processing.展开更多
Recently discovered reflective Pancharatnam-Berry phase(PB phase)from chiral anisotropic media(e.g.,cholesteric liquid crystal,CLC)has aroused great interest in the emerging frontier of planar optics.However,the singl...Recently discovered reflective Pancharatnam-Berry phase(PB phase)from chiral anisotropic media(e.g.,cholesteric liquid crystal,CLC)has aroused great interest in the emerging frontier of planar optics.However,the single chirality of common CLCs results in the intrinsic limitation of the same spin-selective PB phase manipulation,which means the reversal of the input spin cannot realize the conjugated PB phase.In this work,an innovative scheme based on opposite-chirality-coexisted superstructures is proposed to simultaneously modulate orthogonal circular polarization and get PB phase reversal.Through refilling CLC into a washed-out polymer network with opposite chirality and delicate photo-patterned structures,reflective optical vortex(OV)with opposite topological charges and vector beams with conjugated spiral PB phases are efficiently generated depending on the incident polarization.Furthermore,OV holograms are encoded to reconstruct polarization-selective OV arrays,indicating the strong capability of such opposite-chirality-coexisted anisotropic media.This work provides a new compact platform for planar optics,and sheds light on the architectures and functionalities of chiral superstructures.展开更多
We propose a depolarizer based on the principle of a collection of half-wave plates with randomly distributed optic axes. The design is demonstrated by means of dynamically photopatterning liquid crystal into randomly...We propose a depolarizer based on the principle of a collection of half-wave plates with randomly distributed optic axes. The design is demonstrated by means of dynamically photopatterning liquid crystal into randomly aligned homogeneous domains. We characterize the liquid crystal depolarizer for 1550 nm and C-band(1520–1610 nm). A degree of polarization of less than 5% is obtained for any linearly polarized light. This study provides a practical candidate for high-performance depolarizers.展开更多
基金supported by the National Natural Science Foundation of China(30772155)the Ningbo Youth and Doctor Foundation(2005A610016)+4 种基金the Natural Science Foundation of Zhejiang Province(Y206608)the Scientific and Technological Project of Zhejiang Province(2006C33038)Key Project of Ningbo City(2005C100004)the Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talentsthe Ningbo Program for the Health Technology Talents
文摘Objective To diagnose 6 LQTS families by genetic analysis.Methods A total aof 6 LQTS pedigrees with 43 family members were brought together for genetic diagnosis by using short-sequence tandem-repeat(STR)markers or sequencing.Genomic DNA was extracted from blood samples by standard procedure.STR markers or KCNQ1,KCNH2 and SCN5A were amplified.The haplotype analysis for LQTS was performed.If the family got the negative haplotype analysis,the sequencing was performed.Results LQTS patients were always linkaged with the SCN5A gene in family 1.KCNH2 was linkaged with the disease in family 2 to 5.21 gene carriers were identified from these 5 families.A mutation(A561V-KCNH2)was only found in the proband of family 6 and an SNP(G1691A)was found in all the members of the family.Conclusion Genetic diagnosis can not only improve presymptomatic diagnosis,but also provide the basis for personal therapy and research on disease-causing mutations.
基金sponsored by the 973 programs (Nos. 2011CBA00200 and 2012CB921803)the NSFC programs (Nos. 61490714, 11304151, 61435008, and 61225026)+2 种基金the Ph.D. Programs Foundation of the Ministry of Education of China (No.20120091120020)the support from the Program for Changjiang Scholars and Innovative Research Team in University (No.IRT13021)PAPD
文摘A high-efficiency technique for optical vortex(OV) generation is proposed and demonstrated. The technique is based on liquid crystal fork gratings with space-variant azimuthal orientations, which are locally controlled via polarization-sensitive alignment layers. Thanks to the optical rewritability of the alignment agent and the dynamic image generation of the digital micro-mirror device, fork gratings can be instantly and arbitrarily reconfigured.Corresponding optical vortices carrying arbitrary azimuthal and radial indices are demonstrated with a conversion efficiency of 98.5%, exhibiting features of polarization control and electrical switching. The technique may pave a bright road toward OV generation, manipulation, and detection.
基金This work is sponsored by the National 973 program(2012CB921803 and 2011CBA00205)the National Science Fund of China under grants 61225026,61322503,61457069,61435008 and 61490714the Fundamental Research Funds for the Central Universities.
文摘An in-line,all-optical fiber modulator based on a stereo graphene–microfiber structure(GMF)utilizing the lab-on-rod technique was demonstrated in this study.Owing to its unique spring-like geometry,an ultra-long GMF interaction can be achieved,and a modulation depth of,7.5 dB(,2.5 dB)and a modulation efficiency of,0.2 dB mW^(-1)(,0.07 dB mW^(-1))were demonstrated for two polarization states.The modulation depth and modulation efficiency are more than one order of magnitude larger than those of other graphene–microfiber hybrid all-optical modulators,although at the cost of a higher insertion loss.By further optimizing the transferring and cleaning process,the upper limit of the modulation depth is mainly determined by the loss from the intrinsic absorption,which depends on the light–graphene interaction.Then,the modulator can quickly switch between the on-state and the off-state with a theoretically maximized modulation depth of tens of decibels.This modulator is compatible with the current fiber-optic communication systems and may be applied in the near future to meet the impending need for ultrafast optical signal processing.
基金This work was supported by the National Key R&D Program of China(No.2021YFA1202000)the National Natural Science Foundation of China(NSFC)(Nos.62175101,12004175,62035008,and 62105143)+3 种基金the Natural Science Foundation of Jiangsu Province(Nos.BK20212004,and BK20200311)the Innovation Program for Quantum Science and Technology(No.2021ZD0301500)the Fundamental Research Funds for the Central Universities(No.021314380185)the Innovation and Entrepreneurship Program of Jiangsu Province.
文摘Recently discovered reflective Pancharatnam-Berry phase(PB phase)from chiral anisotropic media(e.g.,cholesteric liquid crystal,CLC)has aroused great interest in the emerging frontier of planar optics.However,the single chirality of common CLCs results in the intrinsic limitation of the same spin-selective PB phase manipulation,which means the reversal of the input spin cannot realize the conjugated PB phase.In this work,an innovative scheme based on opposite-chirality-coexisted superstructures is proposed to simultaneously modulate orthogonal circular polarization and get PB phase reversal.Through refilling CLC into a washed-out polymer network with opposite chirality and delicate photo-patterned structures,reflective optical vortex(OV)with opposite topological charges and vector beams with conjugated spiral PB phases are efficiently generated depending on the incident polarization.Furthermore,OV holograms are encoded to reconstruct polarization-selective OV arrays,indicating the strong capability of such opposite-chirality-coexisted anisotropic media.This work provides a new compact platform for planar optics,and sheds light on the architectures and functionalities of chiral superstructures.
基金sponsored by the National Natural Science Foundation of China(NSFC)(Nos.11304151,61490714,61435008 and61575093)
文摘We propose a depolarizer based on the principle of a collection of half-wave plates with randomly distributed optic axes. The design is demonstrated by means of dynamically photopatterning liquid crystal into randomly aligned homogeneous domains. We characterize the liquid crystal depolarizer for 1550 nm and C-band(1520–1610 nm). A degree of polarization of less than 5% is obtained for any linearly polarized light. This study provides a practical candidate for high-performance depolarizers.
